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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE318897 L-DOPA treatment promotes sustained neurovascular and synaptic homeostasis in the diabetic retina July 20, 2026Contributors : Eli Chlan ; Chenxing Li ; Katie Bales ; Levi Wood ; Machelle T PardueSeries Type : Expression profiling by high throughput sequencingOrganism : Purpose: Previous work has shown a sustained protective effect of levodopa (L-DOPA) on retinal function in early-stage diabetic retinopathy in humans. Here, we quantify neurovascular function, investig […]
- GSE314929 Cohesin mutations suppress HLA class II gene expression to promote immune evasion during the progression to acute leukemia in children with Down syndrome [ChIP-seq] July 20, 2026Contributors : Austin C Boucher ; Wojciech Rosikiewicz ; Lahiri Konada ; John D CrispinoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Children with Down syndrome have a 150-fold increased risk of developing the myeloid leukemia of Down syndrome (ML-DS). ML-DS is preceded by transient abnormal myelopoiesis (TAM), whi […]
- GSE327962 Effects of CRISPR-mediated knockout of Mitf, Tfe3 and Tfeb on the transcriptome of mouse BMDMs from WT and Grn KO animals [hex001130] July 20, 2026Contributors : Catherine Heffner ; Thomas Sandmann ; Connie Ha ; Gilbert Di PaoloSeries Type : Expression profiling by high throughput sequencingOrganism : Previous single-cell RNA sequencing of microglia from aged WT and Grn KO mice revealed a microglial subset with transcriptomic signatures that were highly specific to Grn KO. Further epigenetic analysis d […]
- GSE325754 Targeting EHMT2 Enhances NK Cell Maturation and Antitumor Activity [CUT&Tag] July 20, 2026Contributors : Minghang Yu ; Xinhua Liu ; Yang Li ; Xi WangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Integrated RNA-seq and H3K9me2 CUT&Tag profiling reveal that Ehmt2 loss reduces the repressive histone mark H3K9me2 and derepresses transcriptional programs associated with NK cell differentiation and cytotox […]
- GSE272357 Transcriptional response of BMDMs to CRISPR KO of key lysosomal genes [HEX000527] July 20, 2026Contributors : Leon Tejwani ; Thomas Sandmann ; Connie Ha ; Gilbert Di PaoloSeries Type : Expression profiling by high throughput sequencingOrganism : WT BMDMs were nucleofected with sgRNA/Cas9 RNPs to induce knockouts of genes encoding lysosomal proteins of interest, and bulk RNA-seq was performed at day 4 and d13 post-CRISPR.
- GSE339195 Fecal miRNome profile of young individuals from two areas of the Campania region July 20, 2026Contributors : Paola De Lisa ; Giulio Ferrero ; Alessio Naccarati ; Barbara Pardini ; Sonia Tarallo ; Luigi MontanoSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Recent studies highlighted fecal microRNAs as promising non-invasive biomarkers for investigating the effects of environmental factors on the gut, while also strength […]
- GSE338807 Dual lineages of Langerhans cells cooperate to restore the immune barrier after skin injury (bulkRNA-seq) July 20, 2026Contributors : Axel D Schmitter-Sánchez ; Sangbum ParkSeries Type : Expression profiling by high throughput sequencingOrganism : Langerhans cells (LCs) are key immune sentinels of the epidermis. How this network reorganizes to safeguard epidermal immunity after injury has remained unclear. Here, we uncover a previously unrecognized two-lineage program of LC […]
- GSE293789 The effects of WNT mimetic R2M3-26 + RSPO2 on mouse liver cells July 20, 2026Contributors : Russell B Fletcher ; Chenggang Lu ; Helene Baribault ; Caroline Broderick ; Wen-Chen Yeh ; Yang LiSeries Type : Expression profiling by high throughput sequencingOrganism : We compared the effects on liver cells of dosing a control antibody or a combination of an antibody-based WNT mimetic plus RSPO2 to activation Wnt signaling. We applied scR […]
- GSE338810 Plasmodium blood-stage induces trained immunity in hepatocytes July 20, 2026Contributors : Elizabeth K Glennon ; Alexis KaushanskySeries Type : Expression profiling by high throughput sequencingOrganism : Plasmodium parasites, the causative agents of malaria, are transmitted at high levels in endemic areas and sequential infections are common. Using a mouse model of infection we discovered liver burden was suppressed in blood-stage […]
- GSE338808 Dual lineages of Langerhans cells cooperate to restore the immune barrier after skin injury (scRNA-seq) July 20, 2026Contributors : Axel D Schmitter-Sánchez ; Sangbum ParkSeries Type : Expression profiling by high throughput sequencingOrganism : Langerhans cells (LCs) are key immune sentinels of the epidermis. How this network reorganizes to safeguard epidermal immunity after injury has remained unclear. Here, we uncover a previously unrecognized two-lineage program of LC […]
- GSE338812 Plasmodium blood-stage induces trained immunity in hepatocytes - ATAC-seq July 20, 2026Contributors : Elizabeth K Glennon ; Alexis KaushanskySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Plasmodium parasites, the causative agents of malaria, are transmitted at high levels in endemic areas and sequential infections are common. Using a mouse model of infection we discovered liver burden was suppressed i […]
- GSE338813 Temporal phase-resolved transcriptomics reveals host determinants of Marek’s disease virus reactivation in transformed chicken T cells July 20, 2026Contributors : Haji Akbar ; Yung-Tien Tien ; Nagendraprabhu Ponnuraj ; Kathrine V Etten ; Keith W JarosinskiSeries Type : Expression profiling by high throughput sequencingOrganism : Marek’s disease virus (MDV) establishes latency in CD4⁺ T cells and can reactivate to initiate productive replication and viral dissemination.To define host and viral mechanisms […]
- GSE338930 A Blood-Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN-Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1 July 20, 2026Contributors : Qingjian Xie ; Yanbo Zhu ; Wenhua Jiang ; Haobo Xie ; Yaojia Li ; Mengjie Hu ; Kezheng Li ; Huan Yu ; Yixuan Pan ; Chaoyi Jiang ; Xueqin Song ; Dongsheng Fan ; Binbin DengSeries Type : Expression profiling by high throughput sequencingOrganism : Peripheral factors that systemically regulate amyotrophic lateral sclerosis (ALS) have remained elu […]
- GSE308598 Integrated Sensing of Viral RNA and RNase L-Driven Intron Retention Orchestrates Anti-Poxvirus Immunity July 20, 2026Contributors : Ruilin Zhang ; Xiang Ye ; Andrew Dixson ; Yang Zhao ; Alissa Weaver ; John KarijolichSeries Type : Expression profiling by high throughput sequencingOrganism : The recognition of double-stranded RNA (dsRNA) is a critical component of antiviral innate immune responses, yet how distinct sensors integrate their activities to enforce restriction r […]
- GSE338796 Insulin Signaling Functions as a Topological Switch That Couples Aging and Heat Stress Responsiveness July 20, 2026Contributors : Manny J Widuch ; Sanda M Siepka ; Richard W CarthewSeries Type : Expression profiling by high throughput sequencingOrganism : While aging and thermal stress are phenotypically intertwined, their transcriptomic signatures remain paradoxically distinct in Drosophila. Here, we demonstrate that this parallel modularity is not an inherent genomic c […]