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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE237820 Nanodrug modified with engineered cancer cell membrane targets CDKs to activate PD-L1 antibody immunotherapy against liver metastasis of immune-desert colon cancer July 19, 2026Contributors : Dongbing Ding ; Rongpu Liang ; Tan Li ; Tianyun LanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImmunotherapy based on the PD-1/PD-L1 axis blockade has no benefit for patients diagnosed with colon cancer liver metastasis (CCLM) for the MSS/pMMR subtype, which is known as an immune-desert cancer featuri […]
- GSE303038 Single-Cell Multiomic Profiling of the Mouse Hippocampus During Ageing and Memory Formation July 19, 2026Contributors : Andrew C Graham ; Paul M Lavender ; Albert K BassonSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe exact epigenetic changes underlying memory formation in the hippocampus, and how this changes with age, remain unclear. To investigate t […]
- GSE237844 Cell type alternation at single cell level of the germ-free mice colon colonized with BT strains July 19, 2026Contributors : Xingyu Wang ; Zhongle Cai ; Yingkai Sun ; Ruinxin LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntestinal epithelium is the direct interface between host and microbes and responds to the microbial metabolites. We used single cell RNA sequencing (scRNA-seq) to analyze the alternation of epithelial ce […]
- GSE304311 Genetic regulation of tRNA and its trans effect on genetic disease July 19, 2026Contributors : Ke Ding ; Jiuhong Nan ; Yi Zhang ; Xushen XiongSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensIn this study, we predicted multiple tRNA regulators based on large-scale smRNA-seq data and identified several potential regulators, including ZNF460 and MEF2C. To further validate the functions of these po […]
- GSE303253 The subcoeruleus nucleus mediates specific immune response in the lungs via sympathetic nerve July 19, 2026Contributors : Xiaoyu Sun ; Wanbing Dai ; Qiang Wang ; Sihan ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn this study, single-cell RNA sequencing (scRNA-seq) was conducted on lung tissues from adult C57BL/6J male mice under various experimental conditions. The mice were divided into control, LPS-treated, and SL […]
- GSE327212 A Phospho-Regulatory Switch Governs the Timing of Cortical Development [scRNA] July 19, 2026Contributors : Arun Mahesh ; Anuj K Dwiwedi ; Xuan Wang ; Souren Sadhukhan ; Vijay K TiwariSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe development of the cerebral cortex requires precise temporal control of transcription factor (TF) activity, yet how this is achieved remains unclear. Here we employ a comprehensi […]
- GSE327199 A Phospho-Regulatory Switch Governs the Timing of Cortical Development July 19, 2026Contributors : Arun Mahesh ; Anuj K Dwiwedi ; Xuan Wang ; Souren Sadhukhan ; Vijay K TiwariSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe development of the cerebral cortex requires precise temporal control of transcription factor (TF) activity, yet how this is achieved remains unclear. Here we employ […]
- GSE338091 Effect of semaglutide treatment in aged mice July 19, 2026Contributors : Marine Barthez ; Yufan Feng ; Danica ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSemaglutide is a GLP-1R agonist. We investigated the effect of semaglutide in aged mice. We treated 20-month-old female C57BL/6 mice with semaglutide for three months and performed RNA-sequencing analysis of liver sam […]
- GSE338538 Novel Mechanism of Gene Expression Regulation July 19, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Arabidopsis thalianaThis study describes a novel mechanism by which histones and transcription factors coordinately regulate gene expression in plants.
- GSE338539 Novel Mechanism of Gene Expression Regulation [RNA-Seq] July 19, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaThis study describes a novel mechanism by which histones and transcription factors coordinately regulate gene expression in plants.
- GSE338646 RNA-sequencing analysis of placental tissues from women with and without polycystic ovary syndrome July 19, 2026Contributor : Jie YuanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study performed bulk RNA sequencing of term placental tissues collected from women with polycystic ovary syndrome and control pregnancies. The placental transcriptomic analysis was conducted to explore potential molecular alterations associated w […]
- GSE338674 Lysyl oxidase (LOX) inhibition creates vulnerability to ferroptosis by disrupting mitochondrial homeostasis in TNBC July 19, 2026Contributors : Morag Park ; Genevieve Deblois ; Ozgur SahinSeries Type : OtherOrganism : Homo sapiensHigh degree of metabolic heterogeneity and plasticity of triple-negative breast cancer (TNBC) contributes to its aggressiveness and resistance to standard therapies, necessitating identification of novel therapeutic vulnerabilities. Here, we identify previous […]