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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE292291 Loss of Ambp ameliorates MASLD progression via generating protective ROS and activating PPAR signaling pathway June 10, 2026Contributors : Lei Zhou ; Mei Wu ; Xiaoyu Li ; Jingjing ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioBackground: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a widespread and severe hepatic disease, affecting approximately 30% of the global population. Despite its prevalence, the precise pa […]
- GSE296666 lncRNA-operated stem cell fate control: RPS3 organizes the in situ Gm16751-Zhx3 interactome to program spermatogonial differentiation [RIC-Seq] June 10, 2026Contributors : Weijun Gao ; Ji WuSeries Type : OtherOrganism : Mus musculusLong non-coding RNAs (lncRNAs) play pivotal regulatory roles in mammalian male gametogenesis. Advances in high-throughput technologies have demonstrated that lncRNAs orchestrate robust, flexible, and context-specific gene regulatory networks through dynamic interactions with proteins, […]
- GSE292606 Clonal analysis and transcriptional profiling of ex vivo expanded mobilized peripheral blood hematopoietic stem and progenitor [scRNAseq] June 10, 2026Contributors : Matteo Barcella ; Erika Zonari ; Matteo Maria Naldini ; Bernhard GentnerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensClonal analysis and transcriptional profiling of ex vivo expanded mobilized peripheral blood hematopoietic stem and progenitor We characterized mPB CD34+ cell population dynamics (n=2 do […]
- GSE300443 Sequencing analysis of the single-cell transcriptome of Cellulomonas_iranensis June 10, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Cellulomonas iranensisWe have employed a single cell sequencing approach using MobiMicrobe platform to study the consister of Cellulomonas iranensis.
- GSE299560 Endothelial miR-33 protects from atherosclerotic lesion initiation and acute inflammation June 10, 2026Contributors : Kathryn M Citrin ; Yajaira SuarezSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman aortic endothelial cells (HAEC) were treated with TNF, or TNF and LDL, in order to determine how cholesterol loading influences HAEC inflammatory responses to TNF. Cells were also transfected with a miR-33 mimic to dete […]
- GSE309648 Poised enhancer chromosomal conformation analysis in unperturbed and CRISPRa-targeted human pluripotent stem cells by 4C-seq June 10, 2026Contributors : Marina C Nocente ; Monica Della Rosa ; George Lister ; Isabella Savin ; Peter Rugg-Gunn ; Mikhail SpivakovSeries Type : OtherOrganism : Homo sapiensIn primed human pluripotent stem cells (hPSCs) resembling post-implantation epiblast, numerous lineage-specific enhancers assume the poised chromatin state, co-marked by H3K4me1 and Polycomb-associ […]
- GSE306229 Recurrent cycles of drought stress led to low transcriptional reprogramming and greater accumulation of epigenetic marks in apple trees June 10, 2026Contributors : Amanda Malvessi-Cattani ; Patricia Mallegol ; Sylvain Hanteville ; Skander Hatira ; Béatrice Bonnet ; Maryline Cournol ; Anne-Laure Fanciullino ; Sandrine Balzergue ; Jean-Marc CeltonSeries Type : Expression profiling by high throughput sequencingOrganism : Malus domesticaThe differences observed in plant physiology, gene expression, and DNA m […]
- GSE334603 Bacteroides Fragilis enterotoxin engagement of the colonic epithelium is associated with early YAP1 activation and colon tumorigenesis June 10, 2026Contributors : Franck Housseau ; Nile Liu ; Ada TamSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEnterotoxigenic Bacteroides fragilis (ETBF) promotes colonic inflammation and tumorigenesis, but the epithelial signaling events linking toxin (BFT2)-induced junctional injury to tumor development remain incompletely defin […]
- GSE334521 Atlas of tissue-specific and tissue-preferential gene expression in ecologically and economically significant conifer Pinus sylvestris June 10, 2026Contributors : Ojeda I Dario ; Cervantes Sandra ; Ruttink Tom ; Kujala T Sonja ; Kärkkäinen Katri ; Verta Jukka-Pekka ; Cervantes Sandra ; Vuosku Jaana ; Mattila M Tiina ; Pyhäjärvi TanjaSeries Type : Expression profiling by high throughput sequencingOrganism : Pinus sylvestrisWe provide an atlas of gene expression patterns for conifer Pinus sylvestris acros […]
- GSE334651 Alternative splicing- and gene fusion-derived neoepitopes in MASLD-associated hepatocellular carcinoma June 10, 2026Contributors : Lina Zhao ; Jesper AndersenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMetabolic dysfunction-associated steatotic liver disease (MASLD)-driven hepatocellular carcinoma (HCC) exhibits reduced responsiveness to immune checkpoint blockade compared with viral or other etiologies, suggesting underlying dif […]
- GSE334629 RelB Drives Integrin-Mediated Stress Tolerance and Relapse in High-Grade Serous Ovarian Cancer June 10, 2026Contributors : Mikella Robinson ; Omar Lujano-Olazaba ; Nathan Wong ; Carrie HouseSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHigh-grade serous ovarian cancer (HGSOC) often relapses after chemotherapy due to chemoresistant cancer stem-like cells (CSCs). NF-κB signaling, previously shown to enhance stemness traits, w […]
- GSE334700 Germanium embedded bioactive fabric reduces bacteria bioburden and modulates fibroblast and macrophage behavior in vitro June 10, 2026Contributors : Lynn Pezzanite ; Lyndah ChowSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSurgical site infections (SSIs) occur in 2 to 4% of all surgical cases. Wearable bioactive fabrics (BAF) containing semiconductor germanium are shown to generate negative ions and emit far-infrared radiation that are reported to p […]
- GSE334981 Cortical organoids reveal human-specific role of METTL5 in neurodevelopment via regulation of CHCHD2 [scRNA-seq] June 10, 2026Contributors : Elena M Turkalj ; Gugene Kang ; Michael C Oldham ; Caroline VissersSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMETTL5 catalyzes N6-methyladenosine (m6A) modification on 18S rRNA. In humans, loss-of-function mutations in METTL5 cause severe microcephaly and intellectual disability, whereas Mettl5 knock […]
- GSE334998 Transcription machinery clustering by Integrator synchronizes histone gene expression June 10, 2026Contributors : Feiyue Lu ; Brandon J Park ; Rina Fujiwara ; Jeremy E Wilusz ; David S Gilmour ; Ruth Lehmann ; Timothee LionnetSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterNumerous components of the transcription machinery, including RNA polymerase II (Pol II), accumulate in high-concentratio […]
- GSE280975 Single-cell transcriptomics reveals markers of regulatory T cell dysfunction in Gestational Diabetes Mellitus June 10, 2026Contributors : Mensah Nana ; Shangaris PanicosSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensGestational Diabetes Mellitus (GDM) is a common pregnancy complication and the role of regulatory T cells (Tregs) in this disease is ambiguous. This study aims to determine the aberrant transcriptional landscape in Treg […]