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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE262785 HNF4α is a target of the Wnt/β-catenin pathway and regulates colorectal carcinogenesis June 1, 2026Contributors : Lei Sang ; Weiyu Bai ; Junling Shen ; Jianwei SunSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHepatocyte nuclear factor 4alpha (HNF4α) is a transcription factor involved in liver function. Dysregulation of HNF4α leads to hepatocarcinogenesis. However, the role and mechanism of HNF4α in colorectal cance […]
- GSE284389 DNMT1 RFTS mutation alters RNA splicing and drives neurodegeneration via its RNA-binding function [RNA-BisSeq] June 1, 2026Contributors : Guoping Fan ; Ganlu HuSeries Type : OtherOrganism : Homo sapiensDNA Methyltransferase 1 (DNMT1) is a key enzyme in maintaining DNA methylation. Mutations in the RFTS domain of DNMT1 are associated with two neurodegenerative diseases: Hereditary sensory and autonomic neuropathy type 1E with dementia and hearing loss (HSAN1E) and Autosomal domin […]
- GSE272574 Timely NODAL Inhibition Driven by Consecutive Lefty1 and Lefty2 Is Required for Epiblast Patterning June 1, 2026Contributors : Minming Wang ; Zachary D Smith ; Helene KretzmerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe mouse genome encodes two Lefty genes, novel TGF-β superfamily members that antagonize the Nodal signaling gradient during symmetry breaking within the gastrulation-stage embryo. Despite their reported roles […]
- GSE295678 Sensory neurons drive pancreatic cancer progression through glutamatergic cancer-neuron pseudo-synapses. June 1, 2026Contributors : Rouzanna Istvánffy ; Lei Ren ; Ekin DemirSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe results provide significant insights into the role of Grin2D in regulating the secretion of neurotrophic factors that promote neuritogenesis. Transcriptomic analysis of orthotopically transplanted PDAC cancer cell […]
- GSE290910 Cellular mechanisms of early brain overgrowth in autistic children: elevated levels of GPX4 and resistance to ferroptosis June 1, 2026Contributors : Siwei Chen ; Anna Shcherbina ; Simon T Schafer ; Zoe A Mattingly ; Janani Ramesh ; Cyndhavi Narayanan ; Sravani Banerjee ; Brianna Heath ; Melissa Regester ; Ivette Chen ; Sudhir Thakurela ; Joachim Hallmayer ; Ruth O’Hara ; Marjorie Solomon ; Christine W Nordahl ; David G Amaral ; Sundari ChettySeries Type : Expression profiling by high throu […]
- GSE300834 Persistent chromatin alterations and gene expression reprogramming follow widespread DNA damage in glioblastoma [BiSulfite-seq] June 1, 2026Contributors : Aram S Modrek ; Keerthivasan R Chandradoss ; Catherine Do ; Ravesanker Ezhilarasan ; Theodore Sakellaropoulos ; Jerome Karp ; Yingwen Ding ; Ze-Yan Zhang ; Melanie Graciani ; Giulia Cova ; Jennifer E Phillips-Cremins ; Erik P Sulman ; Jane A SkokSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensWe introduc […]
- GSE298934 Activation of M3 muscarinic ameliorates experimental autoimmune encephalomyelitis by restoring microglial quiescence June 1, 2026Contributors : Kaichun Wang ; Jianrong XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe cholinergic system serves as a crucial signaling mediator in neuroimmune regulation. Our previous study has shown that muscarinic acetylcholine receptors (mAChRs) contributed to microglial inflammatory response. However, its rol […]
- GSE333498 Transcriptomic profiling of Candida glabrata under eltrombopag (ETP) treatment June 1, 2026Contributors : Shih-Ju Wu ; Ying-Lien ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Nakaseomyces glabratusThis study aimed to investigate the transcriptional responses of Candida glabrata to eltrombopag (ETP) treatment. RNA sequencing analysis identified 122 differentially expressed genes under ETP treatment, including 44 upr […]
- GSE333494 Hippocampal CA3 Nex+ neuronal TNFR2 alleviates chronic neuropathic pain by sex-dependently engaging opioid and endocannabinoid pathways June 1, 2026Contributors : Sreejita Arnab ; Payam Fathi ; Erin Jones ; Aravind Meyyappan ; Kayla L Nguyen ; Valerie Bracchi-Ricard ; Shruti Gupta ; Roman Fischer ; Veronica J Tom ; John R BetheaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChronic neuropathic pain develops due to persistant neuroinflammation and maladaptive synap […]
- GSE333566 Emergence of Disease-relevant Aberrant Epithelial Cell States in Human Alveolar Organoids June 1, 2026Contributors : McCall A. Scott ; Kropski Jonathan A.Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSingle-cell RNA-sequencing of human lung epithelial cell organoids cultured with permutations of SFFFM and ADM media as well as pharmacologic activation and manipulation of hypoxia-inducible factors.
- GSE333520 The flame retardant triphenyl phosphate induces varying responses in genetically diverse mouse induced pluripotent stem cells June 1, 2026Contributors : Madison Armstrong ; Kathryn Janeczko ; Hannah B Dewey ; Anne Czechanski ; Qiongyu Chen ; Emily Swanzey ; Callan O’Connor ; Steven C Munger ; Laura G ReinholdtSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGenetic variation impacts the biological response to chemical and environmental exposures, contribut […]
- GSE333646 Transcriptomic analysis of (S)-1,3-butanediol degradation pathway in Pseudomonas putida KT2440 June 1, 2026Contributors : Nandakumar Arumugam ; Joon Young Park ; Minchang Jang ; Donghyuk Kim ; Sung Kuk Lee ; Sunghoon ParkSeries Type : Expression profiling by high throughput sequencingOrganism : Pseudomonas putida KT2440(S)-1,3-butanediol [(S)-1,3-BDO] is a chiral diol and stereoisomer of (R)-1,3-BDO with potential applications in the chemical and pharmaceutical i […]
- GSE333729 ChIP-seq data for Nitrogenase regulation in Vibrio natriegens differs from other γ-proteobacteria June 1, 2026Contributors : Nicholas W Haas ; Emma E Wiesler ; Ankur B Dalia ; Xindan Wang ; James B McKinlaySeries Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Vibrio natriegens NBRC 15636 = ATCC 14048 = DSM 759Regulation of nitrogenase, which converts nitrogen gas (N2) into ammonium (NH4+), typically involves a conserved set […]
- GSE333830 Dichlorobenzene Rat S1500+ June 1, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicus1,2‑Dichlorobenzene (1,2‑DCB) is a chlorinated aromatic hydrocarbon that is widely used in industrial applications, including as a solvent for waxes, resins, and paints, and it serves as an ingredient in the production of disinfectants and deodorants. 1,4‑Dichlorobenz […]
- GSE235096 Novel PAX3-FOXO1 functions in rhabdomyosarcoma [RNA-seq] June 1, 2026Contributors : Jie Fang ; Shivendra Singh ; Hongjian Jin ; Jun YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study is to investigate the novel functions of PAX3-FOXO1 in rhabdomyosarcoma. We found that ASS1 is the direct target of PAX3-FOXO1 which regulates urea cycle of rhabdomyosarcoma cells.