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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE286542 Nitric oxide drives proteomic diversity through alternative splicing [Fibroblast RNA-Seq] May 21, 2026Contributors : Joseph C Schindler ; Puneet Seth ; Alfred Hausladen ; Ricky Chan ; Jun Yang ; Jun Qin ; Zhaoxia Qian ; Divya Seth ; Kathleen Lundberg ; Joseph M Luna ; Richard T Premont ; Jonathan S StamlerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRedox signaling by nitric oxide (NO) is estimated to control the lar […]
- GSE292680 The DLX/Notch axis is necessary for spatiotemporal regulation of neural cell fate May 21, 2026Contributors : Ryan F Leung ; Michael See ; Ankita M George ; Paddy L Barry ; Natalie Charitakis ; Mirana Ramialison ; Maree C Faux ; David D EisenstatSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusThe neuronal-glial cell fate switch in the developing v […]
- GSE291236 Gene networks are conserved across reproductive development between the fern Ceratopteris richardii and the flowering plant Arabidopsis thaliana May 21, 2026Contributors : Andrew R.G. Plackett ; Marco CatoniSeries Type : Expression profiling by high throughput sequencingOrganism : Ceratopteris richardiiHow plants first invented seeds is a longstanding unresolved evolutionary question. Seed-bearing plants arose from within seedless vascular plants, with ferns as their closest relatives, but how seed development o […]
- GSE298399 Expression profiling of MET TKI resistant Hs746T cells. May 21, 2026Contributor : William W LockwoodSeries Type : Expression profiling by arrayOrganism : Homo sapiensMET exon 14 skipping mutations (METΔex14) are oncogenic drivers in ~3-5% of lung cancer, which can be targeted with MET tyrosine kinase inhibitors (TKIs). The emergence of resistance limits long-term responses and is commonly mediated by secondary genomic altera […]
- GSE297634 Transcriptomic comparison of hyaluronan-stimulated aTC1-6 cells and type 1 diabetes a cells May 21, 2026Contributor : Akiko MizokamiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusType 1 diabetes (T1D) is driven by the immune-mediated destruction of pancreatic b cells. Hyaluronan (HA), an extracellular matrix glycosaminoglycan, accumulates in pancreatic islets in patients with T1D and animal models, and has been implicate […]
- GSE304966 Transcriptomic profiling of A549 cells in response to dexamethasone, in the context of light-controlled GR degradation using novel GR-PhotoPROTACs May 21, 2026Contributors : Robin Scheuplein ; Karina M Freitag ; Chiara Orlacchio ; Bohan Zhang ; Vincent Fischer ; Erick M Carreira ; Katharina GappSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlucocorticoid receptor (GR) signaling, activated by dexamethasone (Dex), induces a reversible dormancy state in non-small cell lung can […]
- GSE300125 An evaluation of transcriptomic points of departure and gene expression profiles for larval fathead minnows (Pimephales promelas) exposed to 22 chemicals with known modes of action May 21, 2026Contributors : Camille G Baettig ; Jenna E Cavallin ; Kendra Bush ; Alex Kasparek ; Peter Schumann ; Kevin Flynn ; Daniel L VilleneuveSeries Type : Expression profiling by high throughput sequencingOrganism : Pimephales promelasThere is a need to generate hazard information for chemicals already in production. This can be costly and time consuming. Higher-th […]
- GSE331492 Transcriptome analysis of estrogen-related receptor (ERR) knockout in adult Drosophila females May 21, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterERR is a conserved metabolic nuclear receptor required for energy metabolism. Here, we took an RNA sequencing approach to identify candidate ERR targets in adult Drosophila females. We found that loss of ERR downregulates enzymes associated with glycolysis and t […]
- GSE331479 Male-biased immune ageing in a polygynous bat May 21, 2026Contributors : Adams M Danielle ; Wilkinson S Gerald ; Rayner G JackSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiens ; Mus musculus ; Phyllostomus hastatus ; Rattus norvegicusBats have attracted considerable interest for their extraordinary longevity and ability to withstand infection by a range of pathogens without major har […]
- GSE332586 Mevalonate pathway activation in Ewing sarcoma reveals a 3D-specific synergy between statins and BCL-xL inhibition May 21, 2026Contributors : Branka Radic-Sarikas ; Marica Markovic ; Martha M Zylka ; Caterina Sturtzel ; Mathias Ilg ; Didier Surdez ; Martin Metzelder ; Martin Distel ; Aleksandr Ovsianikov ; Florian Halbritter ; Heinrich KovarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBone sarcomas are rare and aggressive pediatric cancers w […]
- GSE332549 Overexpression of KRAS-Q25A mutant with enhanced GTPase activity inhibits the progression of KRAS-G12D colorectal cancer May 21, 2026Contributors : Juncheng Su ; Xuehan Yan ; Yingjie Xu ; Zheng WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe high mutation rate of KRAS in cancers leads to consistent activation of downstream signaling and eventually promoting malignancy. While restoring GTP hydrolysis in KRAS-mutant tumors represents a promisin […]
- GSE332595 RNA transcript changes in Itpr3 p.R2523C Effector Memory CD4+ T cells May 21, 2026Contributors : Ashutosh Shukla ; Pratibha Bhalla ; Katelyn Boetel ; Nicolai Van OersSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMutations in inositol trisphosphate receptor type 3 (ITPR3) have been linked to immunodeficiency, including an expansion of effector memory (EM) CD4+ T cells within peripheral tissues. We d […]
- GSE332708 Hybrid In Vivo Breast Cancer Model Reveals Transcriptomic Insights into Cancer Progression with Age May 21, 2026Contributors : Hawthorne Lauren ; Bahcecioglu Gokhan ; Howe Erin ; Aleksandrovic Emilija ; Zhang Siyuan ; Zorlutuna PinarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAging is a key risk factor for breast cancer; however, the independent effects of the aged extracellular matrix (ECM) remain understudied. To address th […]
- GSE332729 A Fibroblast-Mediated Desmoplastic Reaction Restrains Gastric Cancer via YAP-CTRB1-driven Competitive Fitness May 21, 2026Contributors : Zhangting Zhao ; Shan Zhang ; Cuiwei Zhang ; Hui Zhang ; Shi Jiao ; Liwei An ; Zhaocai ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: To explore the molecular mechanism of CTRB1 boosts host endows cell fitness to outcompete tumor cells, RNA sequencing was performed to analyzeand compare the […]
- GSE233554 mRNA sequencing of kidney and lung cancer cell lines before and after stimulation with GSK-J4 May 21, 2026Contributors : Montse Sanchez-Cespedes ; Octavio R Ferraro ; Andrea V PortaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe performed RNA sequencing to assess changes in gene expression in two models of SMARCB1 deficient cells. Total RNA was extracted from the cells, before and after treatment with GSK-J4 and before a […]