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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE291103 Dissecting the Role of Myf6 in Facilitating Fibroblast Conversion into Myogenic Progenitor and Differentiated Cells March 4, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE291102 Dissecting the Role of Myf6 in Facilitating Fibroblast Conversion into Myogenic Progenitor and Differentiated Cells [scRNA-Seq] March 4, 2026Contributors : Giada Bacchin ; Adhideb Ghosh ; Falko Noé ; Ori Bar-NurSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusConversion of fibroblasts into skeletal muscle cells by overexpression of the transcription factor MyoD has been widely employed over past decades in a multitude of experimental settings. However, the po […]
- GSE291194 Comparative analyses of the Pacific oyster larvae exposed to the retiniic acid and its inhibitor Ro-41-5232 March 4, 2026Contributors : Kudoh Tetsuhiro ; Shimizu Keisuke ; Endo KazuyoshiSeries Type : Expression profiling by high throughput sequencingOrganism : Magallana gigasPacific oyster larvae were cultured at 22'C with or without 1uM retiniic acid or the 1uM retiniic acid receptor inhibitor, Ro-41-5232 with triplicate. At 9hpf, RNAs were isolated, cDNA libraries were […]
- GSE291138 Innovative cancer-targeting antibody production strategy by using cancer-derived small Extracellular Vesicles (sEV) March 4, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAbstract Introduction: With all the advancements in the development of tumor-targeting agents, most of the research has showed that only less than 0.7% of targeted therapy arrives at the tumor site, suggesting high levels of off-target adverse reactions [1-3]. Therefore, d […]
- GSE279379 Monocytes provoke breast cancer cells to express PD-L1 via a cell-to-cell interaction involving CD44 and Moesin March 4, 2026Contributors : Saya Matsumoto ; Kenta YamamotoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn recent years, immunotherapy using immune checkpoint inhibitors has been conducted for TNBC patients. While a limited proportion of patients show excellent response, about a half of the patients do not significantly respond t […]
- GSE322753 M2 Macrophage-Derived Exosomes Ameliorate BPD by Inhibiting Ferroptosis via Suppression of the ZAKα-p38 Signaling Pathway March 4, 2026Contributors : Yahan Pu ; Mingyue Lv ; Ru Yan ; Honglian Zhang ; Lihui Yu ; Weilai Jin ; Le Zhang ; Zhiwei Yu ; Yahui ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Bronchopulmonary dysplasia (BPD) is a common lung disease in premature infants. Hyperoxia-induced oxidative stress and ferroptosis are key […]
- GSE320197 Epigenetic Activation of SIRT6 Protects the Aging Intervertebral Disc March 4, 2026Contributors : Pranay Ramteke ; Makarand RisbudSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAging is one of the important risk factors for Intervertebral disc degeneration, a major contributor to chronic low back and neck pain. Our recent work has demonstrated a promising role for SIRT6, a nuclear NAD⁺- dependent dea […]
- GSE291099 Dissecting the Role of Myf6 in Facilitating Fibroblast Conversion into Myogenic Progenitor and Differentiated Cells [ATAC-Seq] March 4, 2026Contributors : Giada Bacchin ; João P Agostinho de Sousa ; Adhideb Ghosh ; Falko Noé ; Ori Bar-NurSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusConversion of fibroblasts into skeletal muscle cells by overexpression of the transcription factor MyoD has been widely employed over past decades in a multitude […]
- GSE321676 Dural scRNA-seq in two organoids derived from malignant ascites of the same gastric cancer patient before (Primary) and after (Resistance) resistant to paclitaxel March 4, 2026Contributors : Leilei Guo ; Wenshuai LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe have employed a single sequencing(scRNA-seq) approach using 10× Genomics scRNAseq of organoids to study paclitaxel resistance in gastric cancer(GC). Patient-derived organoids (PDOs) can recapitulate majority aspects of tissue wher […]
- GSE320429 Epigenetic Activation of SIRT6 Protects the Aging Intervertebral Disc [scRNA-Seq] March 4, 2026Contributors : Pranay Ramteke ; Olivia Ottone ; Makarand RisbudSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAging is one of the important risk factors for Intervertebral disc degeneration, a major contributor to chronic low back and neck pain. Our recent work has demonstrated a promising role for SIRT6, a nuclear NAD […]
- GSE321690 Neddylation E2 enzyme UBE2F promotes colitis and colon tumorigenesis by targeting the PTPRN-pSTAT5 axis March 4, 2026Contributors : Zhijian Li ; Yi SunSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe inflammatory bowel diseases (IBDs) and colitis-associated colon cancers are common human diseases. Whether and how neddylation enzyme mechanistically regulates the process of these diseases are largely elusive. Here we report that UBE2 […]
- GSE322198 Female iPSC X-chromosome inactivation (XCI) erosion and its transcriptomic effects during CRISPR gene editing and neural differentiation March 4, 2026Contributors : Jubao Duan ; Zhiping Pang ; Hanwen Zhang ; Christina ThapaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman induced pluripotent stem cells (hiPSC) and iPSC-differentiated neural cells, in combination with CRISPR editing, are commonly used for studying neurodevelopmental and other brain disorders. Fema […]
- GSE322654 RNA-seq analysis of carbon framework-mediated metabolic reprogramming in senescent cells: effects of C3N nanosheets and photoactivation March 4, 2026Contributors : Xuelian Wang ; Hanyu Ma ; Zhen LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis RNA-seq dataset investigates the senolytic effects of carbon nitride quantum dots (C3N QDs) combined with irradiation on senescent human umbilical vein endothelial cells (HUVECs). The study compares three experimental co […]
- GSE291101 Dissecting the Role of Myf6 in Facilitating Fibroblast Conversion into Myogenic Progenitor and Differentiated Cells [RNA-Seq] March 4, 2026Contributors : Giada Bacchin ; Giada Bacchin ; Adhideb Ghosh ; Falko Noé ; Ori Bar-NurSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusConversion of fibroblasts into skeletal muscle cells by overexpression of the transcription factor MyoD has been widely employed over past decades in a multitude of experimental settings. […]
- GSE317127 Regulation of Downstream Processing by Different Expression Levels of FLP-17 March 4, 2026Contributors : Carrie Sheeler ; Ashley FrakesSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansOur work seeks to understand the role of neuropeptide signaling in the regulation of metabolism and cellular stress. The primary goal of this sequencing experiment was to determine how whole animal expression of FLP-17 […]