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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE295634 Decitabine-Primed CAR T-Cell Therapy for Relapsed/Refractory Non-Hodgkin's Lymphoma: A Phase 1/2 Clinical Study Demonstrating Enhanced Efficacy and Prolonged Survival March 5, 2026Contributors : Yao Wang ; Yipeng Zhang ; Weidong HanSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensRelapsed/refractory Non-Hodgkin's lymphoma (R/R NHL) remains a therapeutic challenge despite advances in immune checkpoint inhibitors (ICIs). While chimeric antigen receptor (CAR) T-cell therapy has shown pro […]
- GSE313740 Transcriptomic and Epigenomic profiles analysis during human adaptation to simulated High-Altitude Hypoxia March 5, 2026Contributors : Alessandra Giannella ; Simona Mrakic-Sposta ; Alessandra Vezzoli ; Arianna Magrini ; Narjis Khatoon ; Giacomo Strapazzon ; Hannes Gatterer ; Christoph Siebenmann ; Maja Schlittler ; Giulio Ceolotto ; Sandro MalacridaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHypobaric hypoxia (HH) is characterized by […]
- GSE297722 Genomic characterization of sub-populations in human pluripotent stem cell-derived retinal progenitor cells that drive retinal layer structure March 5, 2026Contributors : Yasusaki Iwama ; Tomohiro Masuda ; Mika Yoshimura ; Masayo Takahashi ; Itoshi Nikaido ; Michiko MandaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe mechanisms of layer formation of retinal spheroids were investigated using Rax::GFP-positive retinal progenitor cells (RPCs) obtained from human embryon […]
- GSE173547 Loss of BAP1 cooperates with TP53 deficiency to transform a common myelo-erythroid progenitor (ChIP-seq - mus musculus) March 5, 2026Contributor : Alexandros TzatsosSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusWe performed RNA-seq and ChIP-seq in lineage depleted bone marrow cells isolated from single and double Bap1 and Trp53 knockout mice to identify transcriptional and epigenetic programs that drive erythroleukemia.
- GSE322929 Parkinson’s Disease-Associated Pink1 Loss Disrupts Ensheathing Glia And Causes Dopaminergic Neuron Synapse Loss March 5, 2026Contributors : Lorenzo Ghezzi ; Sabine Kuenen ; Ulrike Pech ; Nils Schoovaerts ; Ayse Kilic ; Suresh Poovathingal ; Kristofer Davie ; Jochen Lamote ; Roman Praschberger ; Patrik VerstrekenSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterParkinson’s disease (PD) is commonly associated with the loss of dopaminer […]
- GSE227004 Aging-induced Suppression of Cirbp Compromises DHODH-Mediated Ferroptosis Defense and Attenuates Hypothermic Cardioprotection during Heart Transplantation [RNA-seq] March 5, 2026Contributors : Yifan Zhu ; Chenyu Jiang ; Yiwei Liu ; Hao ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusThe purpose of this study was to explore the potential mechanism of attenuated hypothermic cardioprotection in the aging donor heart during transplantation and investigate its translational values.
- GSE226992 Effect of knocking down of PTBP1 on gene expression in HSC cells March 5, 2026Contributors : Yajun Zhou ; Feifan XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the function PTBP1 in liver fibrosis, we transfected siPTBP1 and sicontrol as a control in primary HSC cells.We then performed gene expression profiling analysis using data obtained from RNA-seq.
- GSE320572 A noncanonical function of SCIMP restricts JAK1 activity to counteract immune evasion in bladder cancer March 5, 2026Contributors : Yongqiang You ; Hui Zhang ; Jiayin Sun ; Liang Wang ; Chao Huang ; Guosong JiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDespite the fact that immunotherapy is reshaping the therapeutic landscape of bladder cancer, immune evasion remains a major obstacle to durable clinical benefit. In this study, […]
- GSE320505 Single cell and spatial sequencing analysis of cancer associated fibroblasts in the brain metastasis tumor microenvironment March 5, 2026Contributors : Thomas Simon ; David N Buckley ; Zeyi Yang ; Chikako Matsuba ; Ben Y Tew ; Gerald C Gooden ; Kyle Hurth ; Steven A Toms ; David D Tran ; Gabriel Zada ; Matthew P Salomon ; Bodour SalhiaSeries Type : OtherOrganism : Homo sapiensBrain metastasis (BM) remains largely incurable. Cancer-associated fibroblasts (CAFs) can either support or inhibit tu […]
- GSE322502 Gene expression during primary Hepatic Stellate Cells activation March 5, 2026Contributors : Thi Nga Ha ; Hyon-Seung YiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA-seq was conducted to investigate transcriptional dynamics during in vitro activation of primary hepatic stellate cells (HSCs). Cells were collected at Day 1, Day 4, and Day 7 of culture to represent progressive activation stages […]
- GSE322487 Epigenetic alterations of the imprinted SLC22A18 gene contributed to congenital "Allergy-Short-stature-fatty liver" syndrome by via β-catenin-Ascl2 axis March 5, 2026Contributors : Jing Qiao ; Zhiyan ZhanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEpigenetic syndrome is a multisystem, eternal, and devastating disease associated with imprinted gene variants. Our previous study showed a strong correlation between the SLC22A18 and the "Allergy-Short stature-fatty liver" ( […]
- GSE322566 Fibro-Adipogenic Progenitor cells from murine SMA muscles are intrinsically adipogenic March 5, 2026Contributors : Yangyi E. Luo ; Elisabeth R. BartonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSpinal muscular atrophy is a neurodegenerative disorder caused by mutations in the SMN1 gene. Although classically viewed as a neurogenic disease, SMA patients exhibit poor skeletal muscle regeneration and increased fatty-f […]
- GSE322703 IRF1 rs2057656 Polymorphism Regulates IRF1-AS1 Transcription and Immune Dysfunction in ARDS via Allele-Specific Epigenetic Repression March 5, 2026Contributors : Shi Zhang ; Yuanyuan ZhangSeries Type : Other ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAcute respiratory distress syndrome (ARDS) is a severe and life-threatening variant of respiratory failure. Effective targeted therapies are lacking, and patient heterogeneity is substantial. Interferon regulat […]
- GSE322707 9-PAHSA orchestrates TCR-T cell fate to boost anti-tumor immunity [KPC] March 5, 2026Contributor : Xiaozhen ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe identify the endogenous lipid 9-PAHSA as a potent enhancer of T cell anti-tumor function and stemness, validated in murine models and a clinical trial. Mechanistically, we identify ICAM2 as a direct surface sensor for 9-PAHSA and delineate a […]
- GSE287747 Brucella tRNA-derived fragment tRF-Leu-CAG reprograms macrophage polarization for intracellular survival via up-regulation of IL13RA1 expression March 5, 2026Contributors : Guan Yin Zhang ; Hong Rong Hong ; Chang Xian Wu ; Feng Dong Zhu ; Yu Peng Fang ; Shuang Yan Xiao ; Zheng Fei LiuSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Brucella melitensis M5-90Outer membrane vehicles (OMVs) are secreted from gram-negative bacterium to enable bacterial survival and regulate microbial inte […]