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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE284761 Compromised Intestinal Barrier Resilience to Disruption in People with HIV [ileum] December 17, 2025Contributors : Maliha W Shaikh ; Shalini Singh ; Ali Keshavarzian ; Mohamed Abdel-MohsenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPeople living with HIV (PLWH) experience chronic intestinal barrier dysfunction (gut leakage), which persists despite viral suppression by antiretroviral therapy (ART) and contributes t […]
- GSE284476 CXCR4/CXCR7-SDF1 Axis-Based Targeting Treatment of Huntington’s Disease with Blood-Brain Barrier Permeable Neural Stem Cell-Derived Nanovesicles Reinforced by Biomimetic Nanozymes December 17, 2025Contributors : Ling Long ; Hao Tian ; Yixin Zhang ; Yanteng Xu ; Yu Tao ; Mingqiang LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCommencing with the production of toxic mutant huntingtin protein, many pathogenic factors, including mitochondrial dysfunction, overproduced reactive oxygen species (ROS) and neuroinflam […]
- GSE293373 Coordinate tumor-antigen uptake and dendritic cell activation by chimeric antigen receptors. [TCR-seq] December 17, 2025Contributors : Nadine Fournier ; Rachel Marcone ; Yahya Mohammadzadeh ; Michele De PalmaSeries Type : OtherOrganism : Mus musculusEffective anti-tumor immunity requires dendritic cells (DCs) to internalize, process and present tumor antigens to T cells. Adoptive transfer of DCs loaded ex vivo with tumor antigens has been shown to stimulate anti-tumor immunit […]
- GSE284815 Extracellular matrix flow guides emergent morphogenesis December 17, 2025Contributors : Abdel Rahman Abdel Fattah ; Deniz Conkar ; Myriam Roussigne ; Francesca Sgualdino ; Lorenzo Mattolini ; Suresh Poovathingal ; Kristofer Davie ; Katlijn Vints ; Natalia V Gunko ; Giulio Superti-Furga ; Jesse Veenvliet ; Bertrand Bénazéraf ; Adrian RangaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMorpho […]
- GSE310031 Gut microbiota promote immune tolerance at the maternal-fetal interface December 17, 2025Contributors : Julia A Brown ; Mohammed Amir ; Shui Yu ; Daniel S Wong ; Jinghua Gu ; Uthra Balaji ; Christopher Parkhurst ; Seunghee Hong ; Lucy R Hart ; Hannah C Carrow ; Mamadou Bah ; Aparna Ananthanarayanan ; Katherine Z Sanidad ; Mengze Lyu ; Anisa Siddikova ; Marina Lima Silva Santos ; Inna Serganova ; Gretchen E Diehl ; Josef Anrather ; Naohiro Inohar […]
- GSE301457 Dicer accumulates in cytoplasmic foci upon alphavirus infection and plays a proviral role in Myotis myotis bat cells December 17, 2025Contributors : Léa Gaucherand ; Hugo Marie ; Julie Cremaschi ; Sébastien PfefferSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiens ; Myotis myotisBats are reservoirs for many viruses that frequently cause epidemics in humans and animals. It is thus critical to better understand their immune system and mechanisms of an […]
- GSE313548 Multi-omics Analysis of Metabolic Characteristics and Validation of HBEGF-Mediated Regulatory Mechanisms of Metabolism during Catch-Up Growth in Small-for-Gestational-Age Infants December 17, 2025Contributors : Li Zhang ; Jingfei Liu ; Yingwei Lin ; Zhihe Ren ; Dianyong Gao ; Yufan Yao ; Xuanzhe Zhan ; Tian Tian ; Shichao Zhang ; Dong LiSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusSmall-for-gestational-age (SGA) is a globally recognized public health concern. Infants born SGA may experience metabolic dis […]
- GSE312940 Granzyme B-mimicking nanozyme-containing nanovesicles for tumour-targeting delivery December 17, 2025Contributors : Xueyan Hu ; Qiqi Liu ; Helong Kang ; Ming Zhao ; Zheng Zhou ; Yuanke Li ; Weicheng Peng ; Tianyi Qi ; Ruming Liu ; Li Jiao ; Jie Zhuang ; Yijin Liu ; Stephen Mann ; Xinglu HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCytotoxic T lymphocytes play a crucial role in anti-tumour immunity, with granzym […]
- GSE313663 Lung derived extracellular vesicles have distinct pro-repair effects, depending on the age of their source tissue December 17, 2025Contributors : Qi Chen ; Sally Y Kim ; Charlotte H Dean ; Paulson Tseng ; Celia D Nicieza ; Fiona J CulleySeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusMany age-related lung diseases encompass aberrant repair mechanisms. To develop novel treatments for these diseases, it is critical to understand how biology and r […]
- GSE313585 Lcariin Ameliorates Exercise-Induced Fatigue by Promoting TFEB-Dependent Mitochondrial Clearance and Metabolic Re-programming December 17, 2025Contributor : Liang ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusLcariin Ameliorates Exercise-Induced Fatigue by Promoting TFEB-Dependent Mitochondrial Clearance and Metabolic Re-programming, which reveals a novel molecular mechanism underlying icariin’s anti-fatigue efficacy and highlights its potential as […]
- GSE313670 Circulating angiogenic profiles in ischemic stroke and intracranial atherosclerosis (ICAD) December 17, 2025Contributors : Nestor R Gonzalez ; Sofia Ramirez-Guerrero ; Maria Paula Aguilera-Pena ; Santiago Mendoza-Ayus ; Miguel David Quintero-Consuegra ; Hongyu Liu ; Nicholas Tatonetti ; Sofia Balanay ; Shlee S Song ; Konrad H Schlick ; Jeffrey L Saver ; Jennifer Harris ; Alexis N Simpkins ; Parneet Grewal ; Kwan Leung Ng ; Jose GutierrezSeries Type : Non-coding RN […]
- GSE313894 Single cell characterization of the gastrointestinal HIV reservoir reveals heterogeneous cellular phenotypes. December 17, 2025Contributors : Jackson J Peterson ; Nancie M Archin ; Edward P BrowneSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensHuman gastrointestinal (GI) tissues are a major site of HIV-1 viral persistence, but the nature of the GI reservoir remains poorly described. To characterize the GI HIV reservoir, we profiled cell […]
- GSE313929 Effect of B cell receptor class-switching on lymphoma cells December 17, 2025Contributors : Tooki Chu ; Pavel TolarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlthough immunoglobulin class-switching from IgM to IgG enhances B cell receptor (BCR) signalling and antibody responses, certain subsets of B cell lymphomas retain unswitched IgM BCRs despite signs of class-switching in the immunoglob […]
- GSE263643 Inhibition of Wnt signaling in primary human hepatocytes promotes Plasmodium falciparum liver stage development December 17, 2025Contributors : Abhishek Kanyal ; Geert-Jan van Gemert ; Haoyu Wu ; Alex van der Starre ; Johannes H de Wilt ; Teun Bousema ; Robert W Sauerwein ; Richard Bartfai ; Annie S YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Plasmodium falciparumAfter infection of the human host, the first stage of the Plasmodium falc […]
- GSE313546 Expression data from rat heart tissue ischemia/reperfusion (I/R) treated for 12,24 hours December 17, 2025Contributors : Yun-Long Zhang ; Xiao HanSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusAcute pancreatitis (AP), a common inflammatory disorder, can lead to systemic complications such as myocardial injury. However, the dynamic transcriptomic changes and key molecular mechanisms behind these pancreatic-associated cardiac complications […]