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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE295408 Targeting serotonin-driven histone serotonylation suppresses lineage plasticity and progression of NEPC December 16, 2025Contributors : Cheng-Wei Ju ; Yiyi Ji ; Lei Chen ; Jiangbo WeiSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensNeuroendocrine prostate cancer (NEPC) is an aggressive, therapy-resistant subtype of prostate cancer characterized by lineage plasticity. While […]
- GSE289577 Feed-forward regulatory loops by NR5A2 ensure robust gene activation during pre-implantation development [RNA-seq] December 16, 2025Contributors : Wataru Kobayashi ; Siwat Ruangroengkulrith ; Eda N Arslantas ; Adarsh Mohanan ; Kikuë TachibanaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe pioneer transcription factor NR5A2 plays multiple roles in regulating zygotic genome activation and expression of lineage-determining factor during mouse pre-i […]
- GSE307220 Dgat1 detoxifies androgen receptor signaling to promote antitumor CD8+ T cell responses December 16, 2025Contributors : Alaa Madi ; Guoliang Cui ; Xi WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe role of fatty acid (FA) oxidation 31 in T cell responses has been extensively studied, but whether FA esterification to triacylglycerol (TAG) regulates T cell exhaustion is unknown. Dgat1 catalyzes the rate-limiting step […]
- GSE301438 TopBP1 controls conventional dendritic cell development and Flt3L-driven cDC1 differentiation via PU.1 and IRF8 [ChIP-Seq] December 16, 2025Contributors : Min-Suk Cha ; Yong-Soo BaeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusDNA topoisomerase II-binding protein 1 (TopBP1) plays a vital role in V(D)J recombination during B and T cell development. However, its role in the development of conventional dendritic cells (cDCs) remains unexplored. […]
- GSE278975 Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity - scRNA-seq of co-injection murine models December 16, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusClinical trials targeting cancer-associated fibroblasts (CAFs)—crucial pro-tumoral factors in cancer—have almost all failed. This may be ascribed to their intrinsic functional plasticity and the opaque regulatory circuits underlying their heterogeneous phenotypes within tu […]
- GSE221166 Molecular fingerprints of alcohol craving in the hippocampus December 16, 2025Contributors : Roberto Pagano ; Ahmad Salamian ; Edyta Skonieczna ; Bartosz Wojtas ; Bartek Gielniewski ; Malgorzata Piechota ; Anna Cały ; Robbert Havekes ; Ted Abel ; Kasia RadwanskaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDifferentially expressed transcripts in High and Low-alcohol drinkers mice were character […]
- GSE313348 Regulation of the Yersinia pseudotuberculosis Type III Secretion System by the CpxAR Two-Component System December 16, 2025Contributors : Karen Hug ; David Balderas ; Victoria AuerbuchSeries Type : Expression profiling by high throughput sequencingOrganism : Yersinia pseudotuberculosisThe type III secretion system (T3SS) is a cell envelope-spanning injectisome found in many Gram negative pathogens. Expression of the T3SS is controlled by extracellular signals such as cell envelo […]
- GSE281554 Nuclear exosome targeting complex safeguards hematopoietic stem cell self-renewal and genomic integrity through resolving R loops December 16, 2025Contributors : Yinghao Pan ; Hongna Zuo ; Hu WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPervasive transcription of the mammalian genome produces a vast repertoire of non-functional nascent transcripts, generating R loops and R-loop-induced DNA breaks. Such a coupling between continual transcription and a burst […]
- GSE313438 Icariin Ameliorates Exercise-Induced Fatigue by Promoting TFEB-Dependent Mitochondrial Clearance and Metabolic Re-programming December 16, 2025Contributor : Liang ZhengSeries Type : Expression profiling by high throughput sequencing ; Third-party reanalysisOrganism : Rattus norvegicusIcariin Ameliorates Exercise-Induced Fatigue by Promoting TFEB-Dependent Mitochondrial Clearance and Metabolic Re-programming, which reveals a novel molecular mechanism underlying icariin’s anti-fatigue efficacy and hi […]
- GSE313400 Functional Remodeling of iNKT Cells by Sulfatide-Reactive Type II NKT Cells Reprograms Alveolar Macrophages to Alleviate Lung Ischemia-Reperfusion Injury December 16, 2025Contributor : Qingqing LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLung ischemia-reperfusion injury (LIRI) is a serious complication in critical clinical situations. Despite its importance, the specific role of type II natural killer T (NKT) cells in LIRI remains unclear.
- GSE313497 Cell-specific effects of acute sleep deprivation on transcriptomic signatures of non-neuronal cells in the mouse hippocampus and prefrontal cortex December 16, 2025Contributors : Junko Kasuya ; Yutong Wong ; Yann Vanrobaeys ; Marcos Frank ; Ted AbelSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSleep is essential for maintaining cognitive, emotional, metabolic, and immune functions in animals. Although much research on sleep homeostasis has focused on neurons, non-neuronal cells […]
- GSE313525 TAK1 is a key regulator of oncogenic signaling and differentiation blockade in rhabdomyosarcoma December 16, 2025Contributors : Anh T Vuong ; Aniket S Joshi ; Anirban Roy ; Kavya Mathukumalli ; Phuong T Ho ; Raksha Bhat ; Meiricris Tomaz da Silva ; Meghana Trivedi ; Bin Guo ; Benny A Kaipparettu ; Ashok KumarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRhabdomyosarcoma (RMS) is a malignant soft tissue sarcoma with a skeletal mu […]
- GSE313591 Optics-free reconstruction of shapes, images and volumes with DNA barcode proximity graphs December 16, 2025Contributors : Hanna Liao ; Sanjay Kottapalli ; Yuqi Huang ; Matthew Chaw ; Jase Gehring ; Olivia Waltner ; Melissa Phung-Rojas ; Riza M Daza ; Frederick A Matsen IV ; Cole Trapnell ; Jay Shendure ; Sanjay SrivatsanSeries Type : OtherOrganism : synthetic constructSpatial genomics technologies include imaging- and sequencing-based methods. Sequencing-based sp […]
- GSE289568 Feed-forward regulatory loops by NR5A2 ensure robust gene activation during pre-implantation development [CUT&Tag, CUT&RUN, TIP-seq] December 16, 2025Contributors : Wataru Kobayashi ; Siwat Ruangroengkulrith ; Eda N Arslantas ; Adarsh Mohanan ; Kikuë TachibanaSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Mus musculusThe pioneer transcription factor NR5A2 plays multiple roles in regulating zygotic genome activation and expression of lineage-determining fac […]
- GSE313336 CALD1/IGF2BP1 complex mediates cisplatin resistance in bladder cancer via enhancing RFC4 mRNA stability in an m⁶A-dependent manner. December 16, 2025Contributor : Wei WenjieSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCisplatin-based chemotherapy is the first-line treatment for muscle-invasive and metastatic bladder cancer, but most patients develop drug resistance within a short period. M⁶A modification (N⁶-methyladenosine) has been extensively validated as a ke […]