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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE215284 HOTAIR-YTHDF3 interaction in promoting breast cancer cell metastasis [ATAC-seq] October 10, 2025Contributors : Liuyi Yang ; Xinhui Li ; Jin Xu ; Qing MaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensLong noncoding RNA HOTAIR (HOX antisense intergenic RNA) is an important regulator of breast cancer metastasis. Studies showed that HOTAIR reprograms chromatin state through interacting with Polycomb Rep […]
- GSE309552 Cilia Spin the Reissner fiber, an extracellular thread required for morphogenesis October 10, 2025Contributors : Elizabeth Bearce ; Samuel Bertrand ; Zoe Irons ; Adamend Freda ; Calvin Chmelir ; Sophie Fisher ; Samara Williams ; Daniel GrimesSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Danio rerioThe Reissner fiber (RF) is an extracellular thread composed of the glycoprotein SCO-spondin (Sspo) that forms within cereb […]
- GSE262641 Discovery of golcadomide (CC-99282) as a promising drug candidate for diffuse large B-cell lymphoma (DLBCL) October 10, 2025Contributors : Diana Jankeel ; Yan KaiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensDiffuse large B-cell lymphoma (DLBCL) is an aggressive, heterogeneous disease with poor prognosis associated with high-risk molecular features. We report the discovery of golcadomide (CC-99282), a novel cereblon-modulatin […]
- GSE245090 Small RNA-Seq analysis of liver tissues in AAV9-Tnnt2-Cre and AAV9-Tnnt2-Cre-miR122 injected mice October 10, 2025Contributors : Luzi Yang ; Zhanzhao Liu ; Yuxuan GuoSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusThe cardiac troponin T (Tnnt2) promoter is broadly utilized for cardiac specific gene expression, particularly via adeno-associated virus (AAV)-based gene transfer. However, these vectors drive lower-level ectopic gen […]
- GSE279182 Development of mRNA expression signatures for Nao Yi Kang decoction in treating intracerebral hemorrhage October 10, 2025Contributors : Zhe Yu ; Teng Li ; Tao Tang ; En HuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo identify the potential mRNA asscociated with Nao Yi Kang decoction (NYKD) in treating intracerebral hemorrhage (ICH), we have employed mRNA expression profiling. 2405 and 1806 mRNAs were identified in the ICH vs sham gro […]
- GSE274042 Spatiotemporal liver dynamics shapes hepatocellular heterogeneity and impacts in vivo gene engineering [MERFISH] October 10, 2025Contributors : Michela Milani ; Francesco Starinieri ; Marco Monti ; Stefano Beretta ; Ivan Merelli ; Alessio CantoreSeries Type : OtherOrganism : Mus musculus ; synthetic constructHepatocytes are the main liver cells, pivotal for metabolism and relevant in vivo gene therapy targets. While prior research has explored liver homeostasis and regeneration, growt […]
- GSE306968 SALL1 is an orchestrator of uterine receptivity in part via titration of estrogen signaling [ChIP-seq] October 10, 2025Contributors : Jeannine Basta ; Lynn Robbins ; Meade Haller ; Yan Yin ; Michael Rauchman ; Liang MaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusSALL1 is a critical regulator of embryonic development across a wide swath of tissues, including vital organs, but little is known about its function in adult t […]
- GSE279613 CRISPR knockout (CRISPR KO) screens on the PC cell line October 10, 2025Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensTo quantitively evaluate MetroSCREEN’s performance in predicting MRs, we performed CRISPR knockout (CRISPR KO) screens on the PC cell line, targeting four well-known MRs: CTNNB159, ATF460, MYC61, and JUN62.
- GSE308482 Transcriptomic analysis of ALPK1-dependent responses in BMDMs from WT and ALPK1 knockout C57BL/6 mice upon ADP-Hep stimulation October 10, 2025Contributors : Xiaoying Tian ; Jiaqi Liu ; Yuanhanyu Luo ; Ping Zhou ; Feng ShaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe ALPK1 pathway is a cytosolic sensor for the bacterial metabolite ADP-heptose (ADP-Hep), triggering innate immune signalling. To investigate ALPK1-dependent transcriptional responses, bone m […]
- GSE307815 Diabetes-associated MYT1 and ST18 regulate human b-cell insulin secretion and survival via other diabetes-risk genes October 10, 2025Contributors : Ruiying Hu ; Nala Hamilton ; Yu Wang ; Qi Liu ; Lau Ken ; Xanwen Xu ; Alan J. Simmons ; Guoqiang GuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGenetic and environmental factors together cause islet beta-cell failure, leading to Type 2 diabetes (T2D). Here, we study how two members of the Myelin transc […]
- GSE308610 Transcriptomic profiling of THP-1 and RPMI-8226 cells stimulated with innate immune agonists October 10, 2025Contributors : Xiaoying Tian ; Jiaqi Liu ; Yuanhanyu Luo ; Feng ShaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study aimed to investigate the transcriptional responses of human THP-1 monocytes and RPMI-8226 multiple myeloma cells to various innate immune agonists. Cells were treated with ALPK1 agonist (ADP-Hep […]
- GSE308907 Challenge agent strain selection and characterization for a first-in-human Salmonella Typhimurium controlled human infection model October 10, 2025Contributors : Xiaojun Zhu ; Lijuan Luo ; Christopher SmithSeries Type : Expression profiling by high throughput sequencingOrganism : Salmonella enterica subsp. enterica serovar TyphimuriumNontyphoidal Salmonella (NTS) infections cause significant illness worldwide, particularly in sub-Saharan Africa, where invasive NTS (iNTS) disease leads to life-threateni […]
- GSE309532 SPOCK1 promotes colorectal cancer stemness and tumorigenesis by regulating Wnt/β-catenin pathway October 10, 2025Contributors : Yi Li ; Chuying Huang ; Chu Zhang ; Lian Feng ; Jiannan Yao ; Shu LuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensColorectal cancer (CRC) rates are increasing worldwide and disease intractability and chemorefractivity remain a significant clinical challenge. Strong evidence demonstrates that CRC arises […]
- GSE290075 Next Generation Sequencing analysis of the global expression profiling in bone marrow-derived macrophages (BMDMs) from wild-type and RBP4-deficient mice. October 10, 2025Contributors : Hejiao Zhao ; Yingli ShangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the influence of retinol-binding protein 4 (RBP4) deficiency on the expression of genes related to cholesterol metabolism, we examined the expression profiling of global genes in BMDMs from wild-type(WT) and RBP4-defi […]
- GSE306967 SALL1 is an orchestrator of uterine receptivity in part via titration of estrogen signaling [RNA-seq] October 10, 2025Contributors : Meade Haller ; Yan Yin ; Liang MaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSALL1 is a critical regulator of embryonic development across a wide swath of tissues, including vital organs, but little is known about its function in adult tissues. Recent work from our group demonstrates that SALL1 is inv […]