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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE251816 Palmitate suppresses CD8+ T cell antitumoral response by disrupting mitochondrial metabolism October 6, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE279515 Loss of SPHK1 fuels inflammation to drive KRAS-mutated lung adenocarcinoma October 6, 2025Contributors : Andreea C Luca ; Emilio Casanova ; Herwig P MollSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammation is a widely recognized key contributor to KRAS-driven lung adenocarcinoma. Tumor associated macrophages are integral part of the tumor microenvironment, creating a supportive niche to sustain tumor […]
- GSE278938 Challenging the Traditional Dormancy Assumption: Antibiotic Persisters are Metabolically Active, Non-Growing Cells October 6, 2025Contributors : K M Taufiqur Rahman ; Ruqayyah Amaratunga ; Xuan Y Butzin ; Abhyudai Singh ; Tahmina Hossain ; Nicholas C ButzinSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coliBacterial persisters are a subpopulation of multidrug-tolerant cells capable of surviving and resuming activity after exposure to lethal antib […]
- GSE309713 Acetate Triggers Epigenetic Activation of Cell Cycle Arrest via ACSS2-H2A.Zac Axis in Esophageal Squamous Cell Carcinoma [ChIP-seq] October 6, 2025Contributors : Zhenhui Chen ; Chenghao Li ; Yunxi Zhang ; Xuanxuan Gou ; Jiangcong Ma ; Wenyan Sun ; Jianzhong SuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensShort-chain fatty acids (SCFAs) are closely associated with cancer, yet their involvement in the progression of esophageal squamous cell carcinoma […]
- GSE295370 The DNA-binding-independent role of Znf711 in regulating cebpα expression during zebrafish neutrophil development October 6, 2025Contributors : Shuiyi Tan ; Huihui QianSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioThe development of neutrophils is regulated by various transcription factors and cofactors. In this study, we demonstrate that the zinc finger protein Znf711 and its interacting partner, the Phd finger protein Phf8, are critical for gr […]
- GSE227951 The Function of Tetrameric MADS-box Transcription Factors in Floral Fate Determination October 6, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaThis SuperSeries is composed of the SubSeries listed below.
- GSE215026 Synergistic targeting of TWIST1 and HOXA9 in MLL-AF9+ AML via combination of SD70 and MI-503 October 6, 2025Contributors : Xiaotong Ma ; Nan Wang ; Jing Yin ; Na YouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo identify the downstream targets of TWIST1 or Hoxa9, we carried out RNA sequencing to characterize transcriptional changes upon Twist1 deletion or Hoxa9 knockdown in LSCs from MLL-AF9+ AML mice.
- GSE306010 Increased Reproducibility of Brain Organoids through Controlled Fluid Dynamics October 6, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBrain organoids are a promising model for studying human neurodevelopment and disease. Despite the potential, their 3D structure exhibits high variability during differentiation across batches and cell lines, presenting a significant challenge for biomedical applications. […]
- GSE299416 TCRs enable traceability of CAR-T cells but impair function in dual target cell contexts [car_post_infusion] October 6, 2025Contributors : Carolin Moosmann ; Felix Drost ; Kilian SchoberSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensChimeric antigen receptor (CAR) T cells are powerful tools against cancer and autoimmunity. CARs are typically introduced into T cells with endogenous T cell receptors (TCRs), enabling clonotype tracking […]
- GSE306199 Expression profiling of THP-1 cells with and without infection by Francisella tularensis and with or without treatment with Dillapiole October 6, 2025Contributors : James Denvir ; Elliot M Collins ; Anthony Sako ; Kristen Sikorsky ; Jun Fan ; Donald A Primerano ; Deanna M Schmitt ; Stuart Cantlay ; Roger Seeber ; Francisco León ; Joseph HorzempaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn order to assess the effect of treatment by Dillapiole on human monocyte T […]
- GSE306100 Gene expression of Francisella tularensis LVS treated with and without Dillapiole October 6, 2025Contributors : James Denvir ; Elliot M Collins ; Anthony Sako ; Kristen Sikorsky ; Jun Fan ; Donald A Primerano ; Deanna M Schmitt ; Stuart Cantlay ; Roger Seeber ; Francisco León ; Joseph HorzempaSeries Type : Expression profiling by high throughput sequencingOrganism : Francisella tularensisRNA-seq analysis was conducted on F. tularensis incubated in the p […]
- GSE309325 Analysis of SARS-CoV-2 replication using human nasal organoids comprising olfactory and respiratory epithelium October 6, 2025Contributors : Mototsugu Eiraku ; Takeshi NodaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSARS-CoV-2 infects the nasal epithelium (NE) and can cause olfactory dysfunction. Because the virus cannot infect olfactory sensory neurons (OSNs) which detect odorants, the underlying mechanisms remain unknown. Here, using hum […]
- GSE309644 High-throughput characterization of transcription factors that modulate UV damage formation and repair at single-nucleotide resolution October 6, 2025Contributors : Hana I Wasserman ; Alexias Safi ; Gregory E Crawford ; Raluca Gordân ; Peng MaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensGenomic studies have revealed elevated damage and mutation rates in active transcription factor (TF) binding sites of UV-linked cancers. Previous research investigat […]
- GSE309701 CD3ε-targeted circRNA-LNP enables One-Step in vivo CAR-T cell therapy with durable solid tumor remission October 6, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study analyzed the transcriptional changes of CAR-T cells after co-culture and cytotoxic activity against gastric cancer cell lines HGC-27 and AGS using RNA sequencing. Compared with control Mock T cells, CAR-T cells co-cultured with HGC-27 showed upregulation of CXCL […]
- GSE251815 Palmitate suppresses CD8+ T cell antitumoral response by disrupting mitochondrial metabolism [RNA-seq] October 6, 2025Contributors : Silvia Tiberti ; Marine Romeo ; Carina Nava ; Ilir Sheraj ; Carlotta Catozzi ; Roberta Noberini ; Davide Olivari ; Tiziano Dallavilla ; Serena Galie’ ; Mattia Ballerini ; Alessia Loffreda ; Martin H Schaefer ; Eric Camerer ; Tiziana Bonaldi ; Luigi Nezi ; Sara Sdelci ; Teresa ManzoSeries Type : Expression profiling by high throughput sequencin […]