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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE278841 Natural plant-derived superoxide dismutase nanoenzyme for sepsis-induced liver injury therapy. September 11, 2025Contributor : Chonglei ZhongSeries Type : Expression profiling by high throughput sequencingOrganism : Sepsis-induced liver injury is an important cause of septicemia deaths, this injury is characterized by an overproduction of reactive oxygen species (ROS) within the liver, which activates the inflammatory response and results in the release of numerous inf […]
- GSE285375 CpG ODN-functionalized gold nanorods for better immune activation and its potential mechanism September 11, 2025Contributors : Shiwen Zhang ; Changqiang WangSeries Type : Expression profiling by high throughput sequencingOrganism : Background: Immune escape in the treatment by functionalized gold nanorods (Au NRs) should not be ignored. Whether CpG ODN, an immune adjuvant, can synergize with Au NRs to activate the immune response and its potential mechanism is not cle […]
- GSE281726 Effect of Early Diet on Gene Expression in Gastrointestinal Tract, Liver and Brain Regions of Neonatal Piglets September 11, 2025Contributors : Xuan He ; Shannon Shoff ; Carolyn M SlupskySeries Type : Expression profiling by high throughput sequencingOrganism : We leveraged neonatal piglets as a preclinical model for human infants, with a system-level approach that integrates evidence from serum, urine, liver, brain and the gastrointestinal tract (GIT), with the bioactive function of […]
- GSE190309 Single nuclei RNA and ATAC sequencing of mouse trigeminal ganglia at baseline and in atopic dermatitis-like disease. September 11, 2025Contributors : Aaron M Ver Heul ; Brian S KimSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Type 2 inflammation contributes to the pathology of skin diseases such as atopic dermatitis and urticaria. Itch is a common symptom accompanying type 2 skin inflammation. Ye […]
- GSE307676 A SOX2-VSX2 axis modulates a core cis-regulatory circuitry to safeguard retinal neural competence [ChIP-Seq] September 11, 2025Contributors : Fuyun Bian ; Kimia Golestaneh ; Emily Davis ; Abdullah Khan ; Marwa Daghsni ; Brendan Nicholson ; Keevon Flohr ; Silvia Liu ; Susana da Silva ; Len Pennacchio ; Issam AldiriSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Retinal neurogenesis is mediated by the coordinated activities of a complex gene re […]
- GSE261162 Gene expression profiles in fibroblast growth factor 23 (FGF23)-producing tumors provide new insights on diagnostic and therapeutic intervention. September 11, 2025Contributors : Sofia Gronskaia ; Ruslan Deviatiiarov ; Yuriy Buklemishev ; Vladimir Chekhonin ; Sergei Popov ; Roman Fedotov ; Svetlana Rodionova ; Liudmila Rozhinskaya ; Oleg Gusev ; Zhanna BelayaSeries Type : Expression profiling by high throughput sequencingOrganism : Tumor-induced osteomalacia (TIO) is a rare disorder caused by phosphaturic mesenchymal t […]
- GSE242842 Mitotic endosomes regulate spindle organization and function via Occludin and FIP5 binding September 11, 2025Contributor : Zichao ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : The genetic basis of vertebrate emergence is a major unanswered question in metazoan evolution. Understanding vertebrate-specific genes, such as Occludin (Ocln), may help answer this question. Here, we show that mammary glands lacking Ocln exhibit retarded br […]
- GSE307280 Time-restricted feeding provides limited microglial immunometabolic improvements in diet-induced obese rats September 11, 2025Contributors : Han Jiao ; Jarne Jermei ; Xian Liang ; Hendrik JP van der Zande ; Frank Vrieling ; Valentina S Rumanova ; Milan Dorscheidt ; Anhui Wang ; Ewout Foppen ; Bob Ignacio ; Dirk Jan Stenvers ; Tiemin Liu ; Kimberly Bonger ; Rinke Stienstra ; Zhi Zhang ; Andries Kalsbeek ; Chun-Xia YiSeries Type : Expression profiling by high throughput sequencingOrg […]
- GSE306836 Integrated biochemical and transcriptomic analyses elucidate the physiological mechanisms in rainbow trout (Oncorhynchus mykiss) head kidney under hypoxia stress September 11, 2025Contributors : Jinqiang Huang ; Zhijia GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Hypoxia has emerged as a critical threat to the stability of aquatic ecosystems and the sustainability of aquaculture industries. Rainbow trout (Oncorhynchus mykiss), a globally significant economic fish species, exhibits remarkable sensitivit […]
- GSE307311 Hypoxia promotes BCMA loss and a suppressive secretome thereby hindering CAR T cell therapy in multiple myeloma September 11, 2025Contributors : Arne Van der Vreken ; Chenggong Tu ; Fien Meeus ; Lauren van den Broecke ; Jack Brons ; Karine Breckpot ; Eline MenuSeries Type : Expression profiling by high throughput sequencingOrganism : Multiple myeloma (MM) develops in a hypoxic bone marrow (BM) microenvironment, which alters tumor behavior and immune responses. While hypoxia is known to […]
- GSE307296 Multidimensional Deep Receptor Scanning Reveals Constraints on GPCR Biosynthesis [Ribo-Seq] September 11, 2025Series Type : OtherOrganism : G protein-coupled receptors (GPCRs) mediate a variety of signaling pathways and are among the most common pharmacological targets. While advances in structural biochemistry have provided deep functional insights into dozens of key receptors, many of the 800+ human GPCRs remain understudied. In the following, we introduce a versa […]
- GSE307324 Organ-on-a-chip reveals the synergistic effect of mregDC and Treg in non-small cell lung cancer September 11, 2025Contributors : Qiming Shen ; Jie Liang ; Xinwen ZhongSeries Type : Expression profiling by high throughput sequencingOrganism : Since the introduction of the first lung alveolus organ-on-a-chip, organ-on-a-chip technology has evolved over 15 years and is now widely applied in disease modeling, drug development, toxicological assessment, and personalized prec […]
- GSE307512 Single-nucleus transcriptomics reveals sepsis-related neurovascular dysfunction in the human hippocampus September 11, 2025Contributors : Liu Liu ; Pengfei Li ; Hongkuan FanSeries Type : Expression profiling by high throughput sequencingOrganism : Sepsis is increasingly recognized as a major precipitant of long-term cognitive impairment, yet the cellular mechanisms underlying hippocampal vulnerability remain elusive. Using single-nucleus RNA sequencing of human hippocampal tissu […]
- GSE307648 snRNAseq for Modeling long QT syndrome using gene-edited pigs September 11, 2025Series Type : Expression profiling by high throughput sequencingOrganism : To date, KCNH2 mutations identified in patients with long QT syndrome type 2 (LQT2) have been extensively studied using heterologous expression systems. While these systems allow for the evaluation of the pathogenicity of specific hERG mutations through the overexpression of mutant ch […]
- GSE272016 Gene expression data for keratinocyte grown on different substrates September 11, 2025Contributors : Chee-Wai Wong ; Deirdre CoombeSeries Type : Expression profiling by arrayOrganism : The study performed whole genome microarray gene expression profiling on primary human keratinoctyes cultured on collagen I, adult dermal fibroblast-derived ECM or foetal dermal fibroblast-derived ECM. Our gene array data showed that primary human keratinocytes […]