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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE242795 C5a-C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms September 8, 2025Contributor : Kampei ShimizuSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusSubarachnoid hemorrhage due to rupture of intracranial aneurysm (IA) still has poor prognosis once after the onset in spite of modern technical advancement in medical care. The development of the novel therapeutic strategy based on molecula […]
- GSE279542 Open Chromatin Guided Interpretable Machine Learning Reveals Cancer-Specific Chromatin Features in Cell-free DNA September 8, 2025Contributors : Gunarathna D Sakuntha ; Nagornyuk Aerica ; Belabbaci A Nazim ; Nguyen Regina ; Ghosh Bappa ; Ganai Sabha ; Lemke Tabatha ; Garry Cassy ; Saotome Mika ; Yu Muhan ; Takada Mamoru ; Wang Xusheng ; Takaku MotokiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCell-free DNAs (cfDNAs) are DNA fragm […]
- GSE276496 Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2 despite distinct functions during early mouse development. September 8, 2025Contributors : Xinjian D He ; Louis F Taylor ; Jesse MagerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMammalian preimplantation development culminates in the formation of a blastocyst which undergoes extensive gene expression regulation to successfully implant into the maternal endometrium. Zinc-finger HIT domain-co […]
- GSE301239 SETBP1 variants outside the degron disrupt DNA-binding, transcription and neuronal differentiation capacity to cause a heterogeneous neurodevelopmental disorder [induced neurons] September 8, 2025Contributors : Maggie M Wong ; Simon E FisherSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDifferent types of germline de novo SETBP1 variants cause clinically distinct and heterogeneous neurodevelopmental disorders: Schinzel-Giedion syndrome (SGS, via missense variants at a critical degron region) and SETBP1-haploins […]
- GSE301238 SETBP1 variants outside the degron disrupt DNA-binding, transcription and neuronal differentiation capacity to cause a heterogeneous neurodevelopmental disorder [fibroblast] September 8, 2025Contributors : Maggie M Wong ; Simon E FisherSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDifferent types of germline de novo SETBP1 variants cause clinically distinct and heterogeneous neurodevelopmental disorders: Schinzel-Giedion syndrome (SGS, via missense variants at a critical degron region) and SETBP1-haploins […]
- GSE306965 Slc22a17 governs postnatal neurogenesis by maintaining the iron homeostasis in hippocampus [ATAC-Seq] September 8, 2025Contributors : Lei Tao ; Long Teng ; Ligong ChenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusIron transporters are essential for maintaining cellular iron homeostasis. Among them, SLC22A17 mediates lipocalin-2 (LCN-2)-dependent iron transport, but its precise role in the brain remains unclear. Here, we […]
- GSE306466 RNA-seq of dTAG-NUDT21 HCT116 cells treated with DMSO+JTE-607 or dTAGV1+JTE-607. September 8, 2025Contributor : Hun-Way HwangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe performed RNA-seq on dTAG-NUDT21 HCT116 cells treated with DMSO+JTE-607 or dTAGV1+JTE-607 for 48 hours with 4 biological replicates
- GSE306969 Slc22a17 governs postnatal neurogenesis by maintaining the iron homeostasis in hippocampus [RNA-Seq neurosphere] September 8, 2025Contributors : Lei Tao ; Long Teng ; Ligong ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIron transporters are essential for maintaining cellular iron homeostasis. Among them, SLC22A17 mediates lipocalin-2 (LCN-2)-dependent iron transport, but its precise role in the brain remains unclear. Here, we show that Slc2 […]
- GSE306966 Slc22a17 governs postnatal neurogenesis by maintaining the iron homeostasis in hippocampus [RNA-Seq hippocampus] September 8, 2025Contributors : Lei Tao ; Long Teng ; Ligong ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIron transporters are essential for maintaining cellular iron homeostasis. Among them, SLC22A17 mediates lipocalin-2 (LCN-2)-dependent iron transport, but its precise role in the brain remains unclear. Here, we show that Slc2 […]
- GSE307173 RNA-seq profiling of cervical tissue in a lipopolysaccharide-induced rat model of preterm birth September 8, 2025Contributors : Yijie Gao ; Ming Liu ; Ping Ru ; Lulu Meng ; Yun Liu ; Xiaotian NI ; Ling WangSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusThis study aims to investigate the alterations in cervical remodeling and the underlying molecular mechanisms in a lipopolysaccharide (LPS)-induced rat model of preterm birth […]
- GSE307179 Polystyrene MiPolystyrene Microplastics Induce Radiotherapy Resistance in Lung Cancer by Suppressing Ferroptosis through NF-κB Activationcroplastics Induce Radiotherapy Resistance in Lung Cancer by Suppressing Ferroptosis through NF-κB Activation September 8, 2025Contributors : Heng Zhou ; Yali Liu ; Yanxian Ren ; Ningzu Jiang ; Ao Sun ; Song Wu ; Tianyi Zhu ; Jin Li ; Chenghao LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAims: Polystyrene microplastics (PS-MPs) are emerging environmental pollutants, but their impact on lung cancer treatment remains unclear. This study inve […]
- GSE307221 HIF1A regulated genes in MCF10A cells after treatment with Oncostatin M or control ligands September 8, 2025Contributors : Ian C McLean ; Sean M Gross ; Tiera Liby ; Mark A Dane ; Daniel S Derrick ; Laura M HeiserSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensWe employed a single-cell RNA sequencing approach to study the role of Oncostatin M (OSM) in inducing collective cell migration in MCF10A cells and its upregula […]
- GSE307237 SUMO E3 ligase SIZ1 sustains nuclear condensate-mediated immune activation in plants September 8, 2025Contributors : Yangnan Gu ; Min Jia ; Enrico CalvaneseSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaSIZ1, a major plant SUMO E3 ligase, has diverse roles in development and immunity. Although loss-of-function studies have positioned SIZ1 as a negative immune regulator, the pleiotropic effects of its broad subs […]
- GSE307247 Deciphering the cis-regulatory code of alternative splicing in human cell lines September 8, 2025Contributors : Samantha E Koplik ; Angela M Yu ; Georg SeeligSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensAlternative splicing (AS) is a key mechanism of gene expression diversity, and dysregulation of AS is implicated in many human diseases. Identifying variants that disrupt splicing and characterizing their […]