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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE276295 Quantitative proteome and acetylome analyses uncover integrated drought resistance mechanisms in rice September 4, 2025Contributors : Wei Ding ; Shoujun Chen ; Zhen Wu ; Liang Chen ; Qiaojun LouSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Oryza sativaDrought stress significantly reduces rice productivity, necessitating efforts to understand resistance mechanisms. This study utilizes quantitative proteomic and lysine acetylomic anal […]
- GSE269110 Inflammatory cytokines induce novel cancer dependencies September 4, 2025Contributors : Collins K Cheruiyot ; Ashwin V Kammula ; Kathleen B Yates ; Robert T MangusoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTumor cells respond and adapt to environmental stresses, including cytokine-mediated inflammation, to facilitate growth in hostile environments. However, cytokine responses also indu […]
- GSE279821 Adult human subventricular zone microglia promote a protective niche for neuronal progenitors in Parkinson’s Disease September 4, 2025Contributors : Sara Pecoraro ; Marloes Verkerke ; Jacqueline A Sluijs ; Bert van het Hof ; Miriam van Strien ; Carlie de Vries ; H. Elga de Vries ; Wilma D J. van de Berg ; Elly M Hol ; Vanessa DonegaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNeural stem cells (NSCs) of the subventricular zone (SVZ) of the mammalia […]
- GSE276366 T cell phenotype changes associated with oncolytic virotherapy combined with Nivolumab September 4, 2025Contributors : Roger Li ; Nancy Villa ; Xiaoqing YuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThere is a critical unmet need for safe and efficacious neoadjuvant treatment for cisplatin-ineligible patients with muscle invasive bladder cancer. We launched a Phase 1b study using the combination of intravesical cretos […]
- GSE298706 Human microglia reduce alpha-synuclein aggregation and are neuroprotective in adult mouse brain September 4, 2025Contributors : Katrina Albert ; Sara Kälvälä ; Šárka LehtonenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusMicroglia, brain-resident immune cells, are involved in pathophysiology of several neurodegenerative diseases, including Parkinson’s disease. Given significant species-specific differences in micro […]
- GSE291083 Effect of LPS and Nicotine on gene expression in the hippocampus and PFC September 4, 2025Contributors : Griffioen Mina ; Hoeffer CharlesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGene expression changes have been identified in the response to immune challenges such as LPS, yet there is little information on whether there are changes in response to nicotine exposure. In order to observe whether nicotine […]
- GSE306762 Developmental regulation of long-range neuroblast migration by Eph/ephrin signaling September 4, 2025Contributors : Daria Yeroshenko ; Chamalka De Silva ; Anika Burli ; Sarah Bellizzi ; Vijender Singh ; Joanne ConoverSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn the developing mouse anterior forebrain, the rostral migratory stream (RMS) supports continued proliferation and efficient transportation of large quantit […]
- GSE307209 KRAS inhibition activates an actionable CD24 "Don't eat me" signal in pancreatic cancer September 4, 2025Contributors : Yongkun Wei ; Jun Yao ; Wantong Yao ; Haoqiang YingSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusKRASG12C inhibitors (G12Ci) have produced encouraging, albeit modest and transient, clinical benefit in pancreatic ductal adenocarcinoma (PDAC). Identifying and targeting resistance mechanisms to G12Ci treat […]
- GSE306903 Transcriptomic profiile of B16F10 melanoma cell treated with Olive oil and Ozoanted olive oil September 4, 2025Contributors : Seong-jin An ; Jun-ichi Kashiwakura ; Sumihito Togi ; Tadashi MatsudaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the transcriptional effects of ozonated olive oil, we performed a comprehensive gene expression analysis of B16F10 murine melanoma cells treated with either ozonated olive oi […]
- GSE306902 Transcriptomic profiile of A375 melanoma cell treated with Olive oil and Ozoanted olive oil September 4, 2025Contributors : Seong-jin An ; Jun-ichi Kashiwakura ; Sumihito Togi ; Tadashi MatsudaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the transcriptional effects of ozonated olive oil, we performed a comprehensive gene expression analysis of A375 human melanoma cells treated with either ozonated olive oil o […]
- GSE306956 Adoptive Macrophages Suppress Glioblastoma Growth by Reversing Immunosuppressive Microenvironment through Programmed Phenotype Repolarization September 4, 2025Contributors : Yang Fan ; Hang Yin ; Jing Zhao ; Bolin Yao ; Guangli Cheng ; Yaqi Yang ; Minghao Yang ; Luo Chen ; Jian Chen ; Ji Zhou ; Ren Li ; Botao Zhao ; Xiao-Yong Zhang ; Cong Wang ; Xihui Gao ; Cong LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGlioblastoma (GBM) is a highly lethal brain tumor resistant to im […]
- GSE306960 Foxn3 is part of a transcriptional network that regulates primary cilia in the developing mouse retina [CUT & RUN] September 4, 2025Contributors : David L Turner ; Fan Meng ; Huanqing ZhangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusAnalysis of retinas from mice with a targeted disruption of the Foxn3 gene revealed additional displaced amacrine interneurons and additional retinal astrocytes in the inner plexiform layer and in the g […]
- GSE306964 Foxn3 is part of a transcriptional network that regulates primary cilia in the developing mouse retina [RNA-Seq] September 4, 2025Contributors : David L Turner ; Fan Meng ; Huanqing ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAnalysis of retinas from mice with a targeted disruption of the Foxn3 gene revealed additional displaced amacrine interneurons and additional retinal astrocytes in the inner plexiform layer and in the ganglion cell l […]
- GSE212822 Transepithelial barrier dysfunction drives microbiota dysbiosis to initiate epithelial clock-driven inflammation [Cep] September 4, 2025Contributors : Yu-Chen Pai ; Yi-Hsuan Li ; Linda C YuSeries Type : OtherOrganism : Mus musculusA time-series alteration in intestine epithelial microbiota was linked to the emergence of intraepithelial bacteria and a unique transcriptome profile in the mouse colon during IBD development.
- GSE306722 Diminished osteogenic capacity in mature periodontal ligament stem cells via RELB downregulation September 4, 2025Contributors : Xin Shao ; Fan Wu ; Yang Song ; Peng Gao ; Kun Qi ; Liying WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlthough periodontal ligament stem cells (PDLSCs) are pivotal for periodontal tissue regeneration, their regenerative capacity diminishes with the PDL maturity. This study aims to elucidate the m […]