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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE254960 Transcriptional profiling of colon cancer tumors in mice with Trim21 gene Knock out August 22, 2025Contributors : Hua Wu ; Xiaoqin YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the biological function Trim21 in the colon cancer, we compared the gene expression profiles of colon tumor tissues from Trim21 +/+ and Trim21 -/- mice treated with the carcinogen azoxymethane (AOM) and the proinflammatory […]
- GSE267450 Loss of Nuclear Receptor Nr4a3 Alleviates Cellular Senescence to Promote Adult Direct Cardiac Reprogramming (RNA-Seq) August 22, 2025Contributors : Li Wang ; Mengxin Liu ; Zhangyi YuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDirect cardiac reprogramming of fibroblast to cardiomyocytes represents a potential means of restoring cardiac function following injury. However, aged and adult fibroblast are less efficient for reprogramming compared with […]
- GSE267447 Loss of Nuclear Receptor Nr4a3 Alleviates Cellular Senescence to Promote Adult Direct Cardiac Reprogramming (ATAC-Seq) August 22, 2025Contributors : Li Wang ; Mengxin Liu ; Zhangyi YuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusDirect cardiac reprogramming of fibroblast to cardiomyocytes represents a potential means of restoring cardiac function following injury. However, aged and adult fibroblast are less efficient for reprogramming […]
- GSE273784 tRNA-overlapping long non-coding RNAs repress codon-biased genes in trans August 22, 2025Contributors : Sameen Ahmed ; Jacob L Fine ; Jordan J Chalmers ; Katerina Kiriakopulos ; Lindsay A Clarke ; Carla Casanova Suárez ; Katty Soleimanpour ; Winona Oliveros ; Kate Delfosse ; Milad Mokhtaridoost ; Cassandra J Wong ; Anne-Claude Gingras ; Brian Ciruna ; Marc Fabian ; Benjamin J Blencowe ; Philipp G MaassSeries Type : Expression profiling by high t […]
- GSE271623 Effect of metformin in the mouse ileum gene expression August 22, 2025Contributors : JungHo Nam ; ChanWoo Kang ; JuHun Oh ; EunKyung Wang ; Soo hyun Lee ; Cheol Ryong KuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMetformin is first line treatment for type 2 diabetes, however its exact mechanisms remain incompletely understood. Furthermore, the role of glucose transporter in intestine […]
- GSE211773 RNA-seq in human neuroblastoma SK-N-BE(2)-C cells treated with DMSO, TSA or E6R August 22, 2025Contributors : Julien Olivet ; SoonGang Choi ; Tina M O'Grady ; Tong Hao ; David E Hill ; Franck Dequiedt ; Jean-Claude Twizere ; Marc VidalSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAs part of a larger study identifying novel HDAC complex inhibitors, cells were treated with 0.8% DMSO, 1 μM TSA, or 25 μM E6R t […]
- GSE305978 Thyroid Hormone Promotes Fetal Neurogenesis [CosMx] August 22, 2025Contributors : Federico Salas-Lucia ; Sergio Escamilla ; Amanda Charest ; Hanzi Jiang ; Randy Stout ; Antonio C BiancoSeries Type : OtherOrganism : Homo sapiens ; Mus musculusMaternal low thyroxine (T4) serum levels during the first trimester of pregnancy correlate with cerebral cortex volume and mental development of the progeny, but why neural cells during […]
- GSE295218 Click-code-seq mapping of oxidized guanines in cells exposed to DNMT1 inhibitor GSK-3484862. Click-code-seq mapping of oxidized guanines and abasic sites in plasmids with site-specific DNA modifications. August 22, 2025Contributors : Vakil Takhaveev ; Navnit K SinghSeries Type : OtherOrganism : Escherichia coli ; Homo sapiensBy relating the numbers of oxidized guanines in different sequence contexts to the abundance of these contexts in the human genome, we observed that the probability of guanine to be or remain oxidized is low if this guanine is preceded by cytosine (CpG […]
- GSE289118 New Cell lines Expanding the Diversity of Ewing Sarcoma Models August 22, 2025Series Type : Expression profiling by high throughput sequencing ; Methylation profiling by array ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE303898 ZNF512B associates with mitotic spindles, regulates metaphase exit and is crucial for stem cell differentiation August 22, 2025Contributors : Lena W Paasche ; Nadine Daus ; Johannes J Groos ; Felix Diegmüller ; Carlotta Kreienbaum ; Erekle Kobakhidze ; Jie Lan ; Stefanie Wunderlich ; Annette Borchers ; Joel P Mackay ; Tim M Wunderlich ; Sandra B HakeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusZinc finger proteins are a large family of DNA-b […]
- GSE295295 DNA methylation profiling of cells exposed to DNMT1 inhibitor GSK-3484862 or DMSO (vehicle) August 22, 2025Contributors : Vakil Takhaveev ; Navnit K SinghSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensBy relating the numbers of oxidized guanines in different sequence contexts to the abundance of these contexts in the human genome, we observed that the probability of guanine to be or remain oxidized is low if this guanine is prece […]
- GSE305222 Distinct molecular processes mediate donor-derived cell-free DNA release from kidney transplants in different disease states. August 22, 2025Contributor : Jessica ChangSeries Type : Expression profiling by arrayOrganism : Homo sapiensBackground: Among all biopsies in the Trifecta kidney study (ClinicalTrials.gov #NCT04239703), elevated plasma dd-cfDNA correlated most strongly with molecular antibody-mediated rejection (ABMR) (JASN 33:387, 2022), but was also elevated in other states: T cell-media […]
- GSE305649 Decreased ALKBH5 in neutrophil correlates with disease activity in rheumatoid arthritis and ALKBH5 modulates neutrophil autophagy August 22, 2025Contributors : Qing Luo ; Mengfan Lan ; Zhiwei Wu ; Shiqian Wang ; Peng Fu ; Qiuyun Xiao ; Biqi FuSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensNeutrophils are key immune components in rheumatoid arthritis (RA), but the role of ALKBH5 in neutrophil function and RA progression remains unclear. METTL3, METTL14, […]
- GSE305660 TTK defines a high-risk Oral Squamous Cell Carcinoma subtype through dual mTORC1/NF-κB activation August 22, 2025Contributors : Huan Jin ; Tianjie Liu ; Yucheng Guo ; Wenqing Bu ; Fei Liu ; Yuxia HouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOral squamous cell carcinoma (OSCC) remains challenging to treat due to significant tumor heterogeneity, highlighting the need for identifying molecular subtypes with distinct therapeutic […]
- GSE245777 FXR1 dominates mRNA export fate via riboregulation during hESC differentiation August 22, 2025Contributors : Jiabin Yang ; Zhongyang Chen ; Yanni Ma ; Jia YuSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensmRNA export is required for its translation into functional protein, facilitated by the interaction between mRNA transporters and nuclear pore complex (NPC). However, only a few mRNA transporters associ […]