Quick Links : Search PubMed , Finding Full Text , PubMed Advanced Search , Clinical Queries , Single Citation Matcher , FAQs & User Guide , Explore MeSH Database , Explore PubMed Journals
Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE182975 PTEN controls alternative splicing of autism spectrum disorder-associated transcripts in primary neurons August 16, 2025Contributors : Sebastian Rademacher ; Marco Preußner ; Marie C Rehm ; Joachim Fuchs ; Bernd Timmermann ; Florian Heyd ; Britta EickholtSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: To identify alternative splicing events in primary Pten-/- neurons as a model for autism spectrum disorder (ASD).Methods: RNA iso […]
- GSE211557 Effect of SRPK1 inhibitor on gene expression of rat corpus cavernosum endothelial cells August 16, 2025Contributors : Rui-Li Guan ; Xiao-Hui TanSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusTo investigate the effect of SRPK1 inhibitor on gene expression of rat corpus cavernosum endothelial cells (RCCECs), we used SRPK1 inhibitor SPHINX31 to treat primary cells, which were then subjected to RNA-seq.
- GSE182977 The human U5 snRNP assembly factor, AAR2, regulates gene expression dependent on the PRPF8 protein August 16, 2025Contributors : Marco Preussner ; Gert Weber ; Florian Heyd ; Markus C WahlSeries Type : Expression profiling by arrayOrganism : Homo sapiensSmall nuclear ribonucleoprotein complexes (snRNPs) represent the main subunits of the spliceosome. While the assembly of snRNP core particles has been well characterized, the incorporation of snRNP-specific proteins and […]
- GSE275018 Dynamic magneto-mechanical force in lysosomes instructs durable macrophage repolarization for antitumor immunity August 16, 2025Contributors : Yingze Li ; Mengge Zheng ; Zhenyan Zhu ; Yajuan Zhang ; Weiwei Yang ; Yichao Tang ; Haipeng Liu ; Chang Chen ; Yu ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMechanical forces are the emerging physical cue to regulate biochemical signals of immune cells for antitumor immunity. Here we used single […]
- GSE241004 FcRL3 expression defines specialized cytotoxic human memory T lymphocytes August 16, 2025Contributors : Niccolò Bianchi ; Silvia MonticelliSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo characterize the FcRL3+ T cell subset in memory helper CD4+, CD8+, and CD4+ regulatory lymphocytes, we performed RNA-sequencing analysis using T cells, separated by the expression of FcRL3, from the peripheral blood of 5 […]
- GSE295685 TNG260, a novel small-molecule CoREST inhibitor, sensitizes STK11-mutant tumors to anti-PD-1 immunotherapy August 16, 2025Contributors : Leanne G Ahronian ; Soumyadip Sahu ; Ayushi S Patel ; Kwok-Kin Wong ; Yuan HaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNon-small cell lung cancer (NSCLC) patients with loss of the tumor suppressor gene STK11 are resistant to immune checkpoint therapies like anti-PD-1. Our in-vivo CRISPR screen iden […]
- GSE294739 Counteracting Osteoclastic Resorption and Development of Osteoporosis via Rebalancing Gut Microbiota and thus Metabolite TMAO by Traditional Decoction Medicine August 16, 2025Contributors : Re-Wen Wu ; Chao-Wei Kao ; Yu-Han Lin ; Cheng-Hsiu Lu ; Yu-Shan Chen ; Shao-Yu Wang ; Holger Jahr ; Csaba Matta ; Feng-Sheng Wang ; Wei-Shiung LianSeries Type : OtherOrganism : Mus musculusOsteoporosis represents a significant health challenge, particularly in postmenopausal women. While traditional medicine offers potential solutions, the mec […]
- GSE296023 Effect of overexpression different alleles C/G at locus rs149707223 of LINC02449 on gene expression in the mPFC of mice August 16, 2025Contributor : Tengfei YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLong non-coding RNA (LncRNA) is a significant epigenetic regulatory factor, and its allele-specific expression (ASE) may play an important role in mental disorders. Therefore, clarifying the relationship between allele-specific expression (ASE) of […]
- GSE295729 Effect of overexpression different alleles C/G at locus rs149707223 of LINC02449 on gene expression of SK-N-SH cells(Human neuroblastoma cell line) August 16, 2025Contributor : Tengfei YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLong non-coding RNA (LncRNA) is a significant epigenetic regulatory factor, and its allele-specific expression (ASE) may play an important role in mental disorders. Therefore, clarifying the relationship between allele-specific expression (ASE) of […]
- GSE302561 Comprehensive transcriptomic characterization of two melanoma cell lines with acquired dual resistance to BRAF and MEK inhibitors: toward understanding and reversing therapy resistance August 16, 2025Contributors : Tomasz Kujawa ; Tomasz KobielaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo elucidate the molecular mechanisms underlying acquired resistance to dual BRAF and MEK inhibition, we performed transcriptomic profiling of two melanoma cell lines, Hs294T and WM9, rendered resistant to the combination of vem […]
- GSE304603 Mechanosensory PNECs drive airway inflammation via secretoneurin-Slc23a2 August 16, 2025Contributors : Masahiro Nemoto ; Masahiro Kiuchi ; Chiaki Iwamura ; Hiroyuki Yagyu ; Masaaki Seki ; Norie Hamaguchi ; Satoshi Yasuda ; Satoshi Ogasawara ; Kaori Tsuji ; Tsuguko Tomita ; Kanae Ohishi ; Takahisa Hishiya ; Atsushi Sasaki ; Kohei Kusakari ; Astushi Onodera ; Kazuhiro Furuhashi ; Keinosuke Hizuka ; Takeshi Kawasaki ; Motoko Y Kimura ; Shinichiro […]
- GSE305082 CUT&Tag-seq of H3k27me3 in vehicle and DOPAC-treated CD8+ T cells August 16, 2025Contributors : Penghu Han ; Jing Shen ; Shuzheng Chu ; Yatai Chen ; Shiyang Li ; Detian YuanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTo investigate epigenetic alterations in vehicle and DOPAC-treated CD8+ T cells
- GSE305365 UV induced translation capacity is developmentaly regulated in fungi August 16, 2025Contributors : Quyen Hong ; Shira Milo ; Dibya Mukherjee ; Shay CovoSeries Type : Expression profiling by high throughput sequencingOrganism : Fusarium mangiferae ; Fusarium oxysporumIn fast-growing cells, most RNA molecules encode ribosomal subunits. During growth arrest caused by DNA damage, ribosome biogenesis is reduced because it is an highly energy dem […]
- GSE305594 Interbacterial AI-2 communication drives stage-specific genetic programs to support Salmonella colonisation in the murine gut August 16, 2025Contributors : Anmol Singh ; Abhilash V Nair ; R S Rajmani ; Dipshikha ChakravorttySeries Type : Expression profiling by high throughput sequencingOrganism : Salmonella enterica subsp. enterica serovar TyphimuriumThe cooperative response through AI-2 allows Salmonella to coordinate and regulate its community behaviours crucial for its survival and infection. […]