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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE274007 The effects of NAT10 on heart development August 4, 2025Contributors : Zheng Chen ; Lei Shi ; Xinzhi LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe goal of this study is to investigate how NAT10 regulates heart development
- GSE266095 CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity August 4, 2025Contributors : Manuel M Gómez de las Heras ; Elisa Carrasco ; Álvaro Fernández-Almeida ; María MittelbrunnSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHealthy aging relies on a symbiotic host–microbiota relationship. The age-associated decline of the immune system can pose a threat in this delicate equilibrium. In th […]
- GSE284093 CHD4 Interacts With TBX5 to Maintain the Gene Regulatory Network [multiome] August 4, 2025Contributors : William Pu ; Mason Sweat ; Frank Conlon ; Wei ShiSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusAtrial fibrillation (AF), the most common sustained arrhythmia, affects 59 million individuals worldwide. The transcription factor TBX5 is ess […]
- GSE276457 Transcriptome analysis in HL-60 cells after combined treatment with ATRA and palbociclib August 4, 2025Contributors : Tomohisa Baba ; Soichiro Kumamoto ; Yoshikazu JohmuraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIt was reported that the CDK4/6 inhibitor, palbociclib, can enhance ATRA-induced myeloid differentiation in HL-60 cells. Therefore, in this study, the changes in mRNA expression patterns were precisely and […]
- GSE289348 Rapid production of modified cattle and sheep from spermatid-like stem cells [CUT&Tag] August 4, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Bos taurusHaploid androgenetic stem cells (haSCs) are invaluable resources for studying animal traits and greatly impact livestock breeding, but livestock haSCs have yet to be obtained. Here, we report the derivation of cattle and sheep haSCs using the recombined FACE me […]
- GSE288163 A Basophil-Fibroblast Pro-inflammatory Axis Fuels Type 2 Skin Inflammation [RNA-Seq] August 4, 2025Contributors : Ichiro Imanishi ; Raman Gill ; Andrew L JiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo better understand the contribution of basophils and fibroblast IL-4 signaling on type 2 skin inflammation, we conducted bulk-RNA seq on from normal and MC903 treated Isotype Cntrl + Mar1 and Il4rafl/fl + Il4raΔPdg […]
- GSE304079 Acetic acid produced by Staphylococcus epidermidis remodels chromatin architecture and suppresses gene expression in Malassezia restricta [Hi-C] August 4, 2025Contributors : Jae Min Lee ; Hyun Oh Yang ; Hideki Tanizawa ; Ken-ichi Noma ; Tae Kwon Lee ; Won Hee Jung ; Yong-Joon Cho ; Kyoung-Dong KimSeries Type : OtherOrganism : Malassezia restricta ; Malassezia sympodialisMalassezia restricta and Staphylococcus epidermidis are dominant members of the human skin microbiome that interact closely, yet the molecular bas […]
- GSE304370 PATCH treatment in vivo August 4, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAfter establishing a subcutaneous 4T1 tumor model in mice, we conducted PATCH treatment using HA-PCN. Tumors were harvested post-treatment for single-cell RNA sequencing to analyze cellular and transcriptional changes within the tumor microenvironment.
- GSE304083 Acetic acid produced by Staphylococcus epidermidis remodels chromatin architecture and suppresses gene expression in Malassezia restricta August 4, 2025Series Type : Expression profiling by high throughput sequencing ; Other ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Malassezia restricta ; Malassezia sympodialisThis SuperSeries is composed of the SubSeries listed below.
- GSE304082 Acetic acid produced by Staphylococcus epidermidis remodels chromatin architecture and suppresses gene expression in Malassezia restricta [ChIP-Seq] August 4, 2025Contributors : Jae Min Lee ; Hyun Oh Yang ; Hideki Tanizawa ; Ken-ichi Noma ; Tae Kwon Lee ; Won Hee Jung ; Yong-Joon Cho ; Kyoung-Dong KimSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Malassezia restrictaMalassezia restricta and Staphylococcus epidermidis are dominant members of the human skin microbiome that inter […]
- GSE304108 Drug Screening in 3D Microtumors Reveals DDR1/2-MAPK12-GLI1 as a Vulnerability in Cancer-Associated Fibroblasts August 4, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusInteractions between cancer cells and surrounding stromal cells are critical for tumor biology and treatment response. We compare drug screening results from conventional 2D cancer cell lines with 3D tumor tissues and find that, on average, three times more […]
- GSE304125 Evidence of emerging transcriptome mediators of Alzheimer's disease in canine cognitive dysfunction August 4, 2025Contributors : Shelby C Osburn ; Cali M McEntee ; Thomas J LaRoccaSeries Type : Expression profiling by high throughput sequencingOrganism : Canis lupus familiarisGrowing data suggest companion dogs may be a promising model of human brain aging and Alzheimer’s disease (AD). However, while pathology is similar in AD and canine cognitive dysfunction (CCD), the […]
- GSE304176 The Dual Role of CREPT in Glioblastoma: Promoting Proliferation and Shaping an Immunosuppressive Microenvironment through Chemo-MO and GZMK⁺ T Cell Interaction August 4, 2025Contributors : Guanhu Li ; Jianghua Li ; Shuai Wang ; He Yang ; Jiayu Wang ; Umar Farooq ; Bochen Zhu ; Jun Li ; Xiaotong Yang ; Zhijie ChangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensElevated CREPT promotes tumor cell proliferation and enhances CCL2 secretion, thereby recruiting Chemo-MOs. These Chemo-MOs then eng […]
- GSE244875 mRNA-seq of individual genetically identical Caenorhabditis elegans adults August 4, 2025Contributors : Amy K Webster ; John H Willis ; Erik Johnson ; Patrick C PhillipsSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansIndividual phenotypic differences persist even in genetically identical individuals, although separating genetic and environmental causation is difficult or impossible in most organis […]
- GSE304078 Acetic acid produced by Staphylococcus epidermidis remodels chromatin architecture and suppresses gene expression in Malassezia restricta [RNA-Seq] August 4, 2025Contributors : Jae Min Lee ; Hyun Oh Yang ; Hideki Tanizawa ; Ken-ichi Noma ; Tae Kwon Lee ; Won Hee Jung ; Yong-Joon Cho ; Kyoung-Dong KimSeries Type : Expression profiling by high throughput sequencingOrganism : Malassezia restrictaMalassezia restricta and Staphylococcus epidermidis are dominant members of the human skin microbiome that interact closely, y […]