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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE240475 Single-cell Sequencing of human induced pluripotent stem cells (hiPSC) during cardiac differentiation and EHM August 1, 2025Contributors : Jana-Charlotte Hegenbarth ; Federica De Majo ; Giulia Spanò ; Dena Esfandyari Shahvar ; Malte Tiburcy ; Wolfgang H Zimmermann ; Monika Stoll ; Leon De WindtSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study, we set out to map the transcriptomes of human induced pluripotent stem cells (hiPSCs) t […]
- GSE222292 Starvation induced circulating miR-33a secretion remodeled extracellular matrix of tumor microenvironment by altering polyamine metabolism [CAF EV] August 1, 2025Contributors : Sheng Hu ; Wei YanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBreast cancer cells secret different kinds of cargoes through extracellular vesicles (EVs) especially under stress conditions. However, the underling mechanism and function is poorly defined. Here, we found RNA binding protein ACO1 could bi […]
- GSE271882 Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development [RNA-Seq] August 1, 2025Contributors : Yuhan Yang ; Logan Rivera ; Shaohai Fang ; Maryn Cavalier ; Ashley Suris ; Yubin Zhou ; Yun HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOur study suggested a direct link between maternal high-fat diet exposure and TET-mediated epigenetic regulation during heart development. Furthermore, we also u […]
- GSE263027 Highly-metastatic colorectal cancer cell released Nidogen 1-Enriched Extracellular Vesicles promote liver metastasis by activating hepatic stellate cells and forming the neutrophilextracellulartraps August 1, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe liver is frequently affected by metastasis in colorectal cancer patients; however, the precise interaction between the liver microenvironment and metastatic colorectal cancer cells remains elusive. Our study reveals that NID1, present in extracellular vesicles (EVs) de […]
- GSE274032 ATAC-Seq of sorted murine LT-HSCs segemented on intial CUX1 levels with and without CUX1 knockdown. August 1, 2025Contributors : Megan E McNerney ; Tanner C MartinezSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHematopoietic stem cells (HSCs) possess properties of both self-renewal and multipotent differentiation; however, the regulation of these opposing properties remains elusive. Using a novel reporter mouse, we […]
- GSE273215 Hepatic progenitor cell-originated ductular reactionfacilitates liver fibrosis through activation of hedgehogsignaling August 1, 2025Contributors : Yonghong Hu ; Jian Wu ; Ping Liu ; Jiamei ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: It is poorly understood what cellular types participate in ductular reaction (DR) andwhether DR facilitates recovery from injury or accelerates hepatic fibrosis. The aim of this study is to gaininsigh […]
- GSE303340 Hells protects mitochondrial integrity via Nr2f2 suppression during osteoclast differentiation August 1, 2025Contributors : Jueng Soo You ; Myoung Jun KimSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOsteoclasts are bone-resorbing cells essential for skeletal remodeling. The chromatin remodeler Hells has been implicated in epigenetic regulation during cellular differentiation, but its role in osteoclastogenesis remains uncle […]
- GSE303733 Cerebellar Dysfunction in a Mouse Model of Childhood-Onset Manganese-Induced Dystonia Parkinsonism August 1, 2025Contributors : Alexander N Rodichkin ; Amanda M Brown ; Pavani Devabathini ; Jennifer L McGlothan ; Si Chen ; Ajith Pattammattel ; Yong S Chu ; Tao Lin ; Daniel D Pontow ; Karam Abilmouna ; Ritishka Kapoor ; Sarah E Hardin ; Yulia Pushkar ; Roy V Sillitoe ; Tomás R GuilarteSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculu […]
- GSE303431 Transcriptomic Profiling of Scleroderma Monocytes Reveals Links with Cardiovascular Complications, Implicating Notch and Interferon Pathways August 1, 2025Contributors : Mehmed T Dinc ; Fatima El-Adili ; Justin K Lui ; Kripesh Subedi ; Michael York ; Marcin Trojanowski ; Giovanni Ligresti ; Robert Lafyatis ; Maria Trojanowska ; Andreea M BujorSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensObjectives: Recent research has highlighted the critical role of monocytes and macr […]
- GSE303418 Selective inhibition of BRAF and CRAF sensitizes NF1-deficient malignant peripheral nerve sheath tumors to MEK inhibitors August 1, 2025Contributors : Angelina Vaseva ; Siyuan Zheng ; Funan HeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Treatment for patients with malignant peripheral nerve sheath tumors (MPNST) is an unmet clinical need. Loss of NF1 in MPNST leads to hyperactivation of RAS oncoproteins, however little is known about rele […]
- GSE303695 Long-chain fatty acid β-oxidation regulates embryonic development by H3K18 acetylation in mice [RNA-seq] August 1, 2025Contributors : Qingran Kong ; Hao Li ; Qi Zhao ; Kefan Zheng ; Hongdi Cui ; Entong SongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFatty acids are not only important as energy sources, but also playing crucial roles in maintaining cellular homeostasis.Inhibition of long-chain fatty acid β-oxidation (LCFAO) results i […]
- GSE303698 A human microphysiological model of afferent DRG nociceptor-spinal cord dorsal horn circuitry August 1, 2025Contributors : Frank Seipel ; Kevin Pollard ; Nisha R Iyer ; Randolph S Ashton ; Michael MooreSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe generated single cell RNA-seq data to measure the transctiptional profiles of cervicothoracic human pluripotent stem cell-derived dorsal horn spheroids cultured together with h […]
- GSE303730 Brief exposure to oral antibiotics has age-dependent effects on morphine reward and gene expression in the medial prefrontal cortex of adolescent and adult mice_1 August 1, 2025Contributors : Rebecca S Hofford ; Jonathon P Sens ; Ava L Shipman ; Violet M Kimble ; Christina Coric ; Katherine R Meckel ; Drew D KiralySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAdolescence is a critical period for the initiation of problematic drug use, which significantly increases the risk of developing subs […]
- GSE211056 Formation of an active epigenetic mark and its recycling is mediated by cell cycle-specific RNAs [RIP-seq] August 1, 2025Contributors : Alexander K Ebralidze ; Simone Ummarino ; Emanuele Monteleone ; Annalisa Di Ruscio ; Daniel G TenenSeries Type : OtherOrganism : Homo sapiensThe mechanisms by which epigenetic modifications are established in gene regulatory regions of active genes remain elusive. The data presented show that the establishment and recycling of a major epigenet […]
- GSE303179 SRSF12 is a primate-specific splicing factor that induces a tissue-specific gene expression program August 1, 2025Contributors : Ly Jimmy ; Cady Sarah ; Khalizeva Ekaterina ; Haug Sofia ; Cheeseman IainSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusAlternative splicing expands proteomic diversity and is tightly regulated by splicing factors, including the serine/arginine-rich (SR) protein family. Here, we analyze th […]