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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE273379 Antifungal drug responses in two Candida glabrata strains July 29, 2025Contributors : Weronika A Danecka ; Delma S Childers ; Edward W WallaceSeries Type : Expression profiling by high throughput sequencingOrganism : Nakaseomyces glabratusTranscriptomic responses of Candida glabrata strains, BG2 and CBS138, to two azole antifungal drugs, Fluconazole and Voriconazole.
- GSE303079 mTORC1-Driven DDA1 Phosphorylation Promotes DNA Repair and Glioblastoma Progression July 29, 2025Contributors : Xing Chen ; Xiaozhong PengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDDA1 is a protein involved in protein degradation, cell cycle regulation, and DNA damage repair. Interestingly, recent studies have revealed its differential expression across various tumor types. However, how DDA1 functions as a tu […]
- GSE273471 Dimethyl itaconate alleviates Escherichia coli-induced endometritis by activating the guanosine-CXCL14 axis via increasing the abundance of Muribaculaceae July 29, 2025Contributors : Yuhang He ; Xufeng Xie ; Jiapei Cai ; Yongguo CaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEndometritis, a prevalent reproductive system disease with high incidence, leads to reproductive dysfunction and potential miscarriage in both humans and animals, impacting human health and the dairy industry, […]
- GSE303087 A pan-immunotherapy signature to predict intratumoral CD8+ T cell expansions [bulkTCRseq_FTY] July 29, 2025Contributors : Munetomo Takahashi ; Mikiya Tsunoda ; Hiroyasu Aoki ; Masaki Kurosu ; Haru Ogiwara ; Shigeyuki Shichino ; David Bending ; Shumpei Ishikawa ; James Thaventhiran ; Kouji Matsushima ; Satoshi UehaSeries Type : OtherOrganism : Mus musculusEffective cancer immunotherapy relies on the clonal proliferation and expansion of CD8+ T cells in the tumor. […]
- GSE303086 A pan-immunotherapy signature to predict intratumoral CD8+ T cell expansions [bulkTCR_control] July 29, 2025Contributors : Munetomo Takahashi ; Mikiya Tsunoda ; Hiroyasu Aoki ; Masaki Kurosu ; Haru Ogiwara ; Shigeyuki Shichino ; David Bending ; Shumpei Ishikawa ; James Thaventhiran ; Kouji Matsushima ; Satoshi UehaSeries Type : OtherOrganism : Mus musculusEffective cancer immunotherapy relies on the clonal proliferation and expansion of CD8+ T cells in the tumor. […]
- GSE210103 Transcriptome analysis of the binucleate ciliate Tetrahymena thermophila cells after mating and re-feeding. July 29, 2025Contributors : Linying Zhang ; Marcella Cervantes ; Simin PanSeries Type : Expression profiling by high throughput sequencingOrganism : Tetrahymena thermophilaDuring macronuclear development the five germline chromosomes undergo massive rearrangement, and the entire epigenome is remodeled from an obligate heterochromatic to obligate euchromatic state. The ~1 […]
- GSE303724 Collagen-disrupting attIL12 TIL therapy boosts deep T-cell infiltration via dual signaling activation and CCKAR reduction in sarcomas July 29, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTumor-targeted T-cell therapies of various types have been booming, but T-cell therapy is limited by its inability to penetrate the collagen barrier surrounding tumors. The destruction of tumor collagen is significant because collagen both suppresses T cells and contribute […]
- GSE303433 Nox1 and Npy1r mark regional colon stem cell populations that serve as cancer origins in vivo [RNA-seq2] July 29, 2025Contributors : Maxime Gasnier ; Tanysha C Chen ; Swathi Yada ; Sowmya Sagiraju ; Yusuke Yoshikawa ; Stefano Perna ; Grace H Lim ; Bernett Lee ; Nick BarkerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCurrent colorectal cancer (CRC) mouse models lack either colon specificity, limiting progression towards more advanced […]
- GSE303295 Nox1 and Npy1r mark regional colon stem cell populations that serve as cancer origins in vivo [RNA_seq] July 29, 2025Contributors : Maxime Gasnier ; Tanysha C Chen ; Swathi Yada ; Sowmya Sagiraju ; Yusuke Yoshikawa ; Stefano Perna ; Grace H Lim ; Bernett Lee ; Nick BarkerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCurrent colorectal cancer (CRC) mouse models lack either colon specificity, limiting progression towards more advanced […]
- GSE303533 RNA sequencing of colonic ILC2s sorted from mice with DSS-induced colitis July 29, 2025Contributors : Yanyan Cui ; Qiuheng Tian ; Yatai Chen ; Shiyang LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA sequencing was performed for ILC2s sorted from the colon of DSS- or H2O-treated C57BL/6 mice (n = 3 per group).
- GSE303434 Nox1 and Npy1r mark regional colon stem cell populations that serve as cancer origins in vivo [scRNA_seq] July 29, 2025Contributors : Maxime Gasnier ; Tanysha C Chen ; Swathi Yada ; Sowmya Sagiraju ; Yusuke Yoshikawa ; Stefano Perna ; Grace H Lim ; Bernett Lee ; Nick BarkerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCurrent colorectal cancer (CRC) mouse models lack either colon specificity, limiting progression towards more advanced […]
- GSE303587 Chemogenetic tuning reveals optimal MAPK signaling for cell-fate programming July 29, 2025Contributors : Brittany A Lende-Dorn ; Kate E GallowaySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCell states evolve through the combined activity of signaling pathways and gene regulatory networks. While transcription factors can direct cell fate, these factors rely on a cell state that is receptive to transitions […]
- GSE303651 H3K4 methylation-promoted transcriptional memory supports faithful zygotic genome activation and development July 29, 2025Contributors : Meghana S Oak ; Marco Stock ; Matthias Mezes ; Tobias Straub ; Antony M Hynes-Allen ; Jelle van den Ameele ; Ignasi Forne ; Andreas Ettinger ; Axel Imhof ; Antonio Scialdone ; Eva HörmansederSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Xenopus laevisAccurately established transcriptional programs are […]
- GSE303705 Spatial and temporal transcriptomic dynamics during intestinal regeneration July 29, 2025Contributors : Rachel Ofer ; Tyler Tran ; Ping He ; Xinyu Hu ; Qiu Xia ; Emmanual Zachariah ; Curtis Krier ; Ankit Saxena ; Jiekun Yang ; Michael VerziSeries Type : OtherOrganism : Mus musculusThe highly proliferative intestine is prone to damage, making it an ideal model for studying tissue regeneration. We performed spatial transcriptomics to characterize […]
- GSE267556 Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action July 29, 2025Contributors : William C Johnson ; Bree B AldridgeSeries Type : Expression profiling by high throughput sequencingOrganism : Mycobacterium tuberculosisTreatments for tuberculosis remain lengthy, motivating a search for new drugs with novel mechanisms of action. However, it remains challenging to elucidate the direct targets of a drug, and even more so, to de […]