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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE271315 Human fetal kidney organoids model early human nephrogenesis and notch-driven cell fate July 22, 2025Contributors : Michael Namestnikov ; Osnat Cohen-Zontag ; Dorit Omer ; Benjamin DekelSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPluripotent stem cell–derived kidney organoids (PSC-KOs) have been put forward as a preferred culture system in which to study human kidney development and disease. In contrast, the develo […]
- GSE303192 Transcriptomic analysis of ovarian cancer cells after drug administration and tRNA transfection at 10 and 24 hours July 22, 2025Contributors : Yuki Iimori ; Akio KanaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSLFN11 sensitizes cancer cells to DNA-damaging agents (DDAs) by cleaving and reducing tRNALeu(TAA). In this study, we investigated how the reduction of tRNALeu(TAA) contributes to cell death under Camptothecin (CPT) treatment. RNA-seq […]
- GSE275840 Gene expression profile of Cd45 positive cells in single cell level from KRASLSL.G12D/+P53LSL.R172H/+Pdx-Cre mice (KPC tumor mouse) model treated with stimulator of interferon genes (STING) and lymphotoxin-beta receptor (LTbR) agonist July 22, 2025Contributors : Junko Sawada ; Yasuhiro Kikuchi ; Fumiaki Kanamori ; Masanobu KomatsuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe combination treatment using STING and LTbR agonists improves the immune landscape in KPC tumor model. We used single-cell RNA sequence (scRNAseq) analysis to investigate the characteris […]
- GSE241109 Loss of the C-terminus of p63 leads to an increased expression of extracellular matrix genes in keratinocytes [RNA-seq] July 22, 2025Contributors : Artem Smirnov ; Anna M Lena ; Eleonora CandiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe transcription factor p63 is a master gene of epithelial development. p63 regulates expression of genes related to proliferation, differentiation and adhesion by binding epithelial enhancers. Biochemically, p63 […]
- GSE210238 The role of N6-Methyladenosine (m6A) methylation in pathological myopia July 22, 2025Contributors : Xiujuan Zhao ; Zhixi Li ; Lin Lu ; Huiying SongSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensTo explore the role of N6-Methyladenosine (m6A) methylation in pathological myopia,we performed a comparative gene expression profiling analysis of RNA-seq data for vitreous fluid of pathological myopia patient […]
- GSE265825 Iron deprivation affects aboveground cell wall biosynthesis in Populus and the role of PtrbHLH011 [RNA-seq] July 22, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Populus tremula x Populus alba ; Populus trichocarpaGrowing bioenergy crops like poplars on marginal land is appealing to minimize competition for arable land. However, this is hampered by a lack of insight into secondary cell wall (SCW) changes caused by environmental stress. Iron (F […]
- GSE262805 Hyperfunctioning MYC selectively redirects expression programs during human plasma cell differentiation II July 22, 2025Contributors : Matthew A Care ; Reuben M Tooze ; Panagiota VardakaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMYC acts as a rheostat during plasma cell (PC) differentiation, linking B-cell activation to cell growth and division. Tight control over MYC is an essential feature of the network controlling differentiatio […]
- GSE302869 The Role of the Microenvironment on the Localization of Hair and Skin Nonuniform Pigmented Spots in Mice with a Targeted Mutation in the Endothelin B Receptor July 22, 2025Contributors : Huirong Li ; Yu Chen ; Ling HouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn mammals, severe mutations in genes encoding factors critical for developing melanocytes often lead to a total loss of melanin-dependent skin and hair pigmentation. However, even null mutations in the gene encoding the G prot […]
- GSE302813 RNA sequencing of flow-sorted lung parenchymal CD226+ and CD226- CD8 T cells from mice chronically infected with Mycobacterium tuberculosis July 22, 2025Contributors : Tomoyo Shinkawa ; Samuel M BeharSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLung CD8⁺ T cells induced during chronic tuberculosis exhibit functional heterogeneity, comprising both effector and exhausted states. CD226 is the most differentially expressed gene distinguishing effector from exhausted CD8⁺ […]
- GSE302909 Effect of knockdown of miR-BART19-3p on gene expression of AGS EBV cells July 22, 2025Contributors : Runliang Gan ; Jing YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEBV microRNAs, especially rightward transcript (BART) microRNAs play key roles in the tumor growth of EBVaGC. However, the effects of EBV-miR-BART19-3p in EBVaGC remain largely unknown. Here, we report that EBV-miR-BART19-3p is highly […]
- GSE302904 Sulfur assimilation improves SAM-dependent methylation July 22, 2025Contributors : Xinchen Zhang ; Ying Wang ; Yingjin YuanSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeWe employed omic data and conducted comparative analysis in Saccharomyces cerevisiae strains with different S-adenosine-L-methionine (SAM) level. This strategy can help us locate the limiting factor for SAM […]
- GSE302974 Fat promotes growth and invasion in a 3D microfluidic tumor model of triple-negative breast cancer July 22, 2025Contributors : Maryam Kohram ; Carolina Trenado-Yuste ; Molly C Brennan-Smith ; Evelyn S Navarro Salazar ; Pengfei Zhang ; Jasmine E Hao ; Xincheng Xu ; Bharvi Chavre ; William Oh ; Sherry X Zhang ; Susan E Leggett ; Rolf-Peter Ryseck ; Joshua D Rabinowitz ; Celeste M NelsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapie […]
- GSE303025 Transglutaminase 2 regulates ovarian cancer metastasis by modulating the immune microenvironment July 22, 2025Contributors : Dalia Ibrahim ; Sarah Nersesian ; Barbara C VanderhydenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOvarian cancer is the most lethal gynecological malignancy. Deepening our knowledge of the interactions within the tumor microenvironment (TME) is important for discovering new targeted treatment strateg […]
- GSE303176 Early adipose tissue wasting in a preclinicl model of human lung cancer cachexia July 22, 2025Contributors : Deena B Snoke ; Jacob S Dearborn ; Devdoot Majumdar ; David J Seward ; Michael J TothSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCancer cachexia (CC), a syndrome of skeletal muscle and adipose wasting, reduces responsiveness to therapies and increases mortality. There are no approved treatments for CC […]
- GSE268811 Early-life ketone body signaling promotes beige fat biogenesis through changes in histone acetylome and β-hydroxybutyrylome [scRNA-seq] July 22, 2025Contributors : Fu J Lin ; Chung L Jiang ; Pei H LaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInfants experience distinct ketogenesis during the preweaning period, but its physiological significance remains unclear. Here, we show that preweaning ketosis enhances beige fat biogenesis and improves metabolic health in […]