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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE272289 Adverse proinflammatory responses in the kidney after FGF23 administration in murine kidney disease models July 15, 2025Contributors : Matthias B Moor ; Mikhail Burmakin ; Jaakko Patrakka ; Hannes OlausonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFGF23 is a biomarker associated with morbidity and mortality, but controversies remain if a causative link exists between FGF23 excess and adverse renal consequences in chronic kidney disea […]
- GSE271821 Astragaloside IV improves autism-like behaviors in BTBR mice by modulating CAMK2N2-dependent OXPHOS and neurotransmission in the mPFC July 15, 2025Contributors : Mei Chen ; Jiahui Shi ; Tianyao Liu ; Xiaotang FanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAutism spectrum disorder (ASD) represents a multifaceted set of neurodevelopmental conditions marked by challenges with social interaction and communication, restricted and repetitive behavior. Astragaloside […]
- GSE229901 An aberrant INSM1-dependent intermediate neuronal progenitor state drives tumorigenesis in a human stem cell model of glioblastoma July 15, 2025Contributors : Patrick A DeSouza ; Jeffrey R Millman ; Albert H KimSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensGlioblastoma (GBM) is an aggressive, incurable brain tumor driven by heterogeneity between tumor cell-intrinsic and -extrinsic states for r […]
- GSE208267 RNA-Seq of MCF7 treated with Cannabis extract CANN14 for 18 hrs July 15, 2025Contributors : Elazar Besser ; David MeiriSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA sequencing of differentially expressed genes from MCF7 cells treated with a Cannabis extract or DMSO control. Hypothesis was ESR1 would be downregulated and genes related to estrogen signaling would be affected. We explored the […]
- GSE249252 An ancient enhancer rapidly evolving in the human lineage promotes neural development and cognitive flexibility July 15, 2025Contributors : Kun Tan ; Miles F WilkinsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAn unsolved mystery in biology is how human-specific traits were acquired during evolution. Here, we report that an evolutionary ancient non-coding element—human accelerated region 123 (HAR123)—has undergone rapid evolution specifi […]
- GSE239619 Cell Density Regulates Neural Stem Cells of Cellular Contact and Differentiation in 3D Hydrogel Culture System July 15, 2025Contributors : Yuyun Liang ; Xiaonan Wang ; Chaoyong He ; Jing Yang ; Ziyan Chen ; Hexu Zhang ; Cheng Zhao ; Liyang ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusNeural Stem Cells (NSCs) of biological behaviors are frequently regulated by the three-dimensional (3D) niches that they located in. The impact of ce […]
- GSE299930 Transcriptionally and phenotypically dysfunctional neutrophils have a suppressive role in macrophage activation syndrome July 15, 2025Contributors : Natsumi Inoue ; Kairavee Thakkar ; Nathan Salomonis ; Grant S SchulertSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMacrophage activation syndrome (MAS) is a life-threatening cytokine storm syndrome that complicates rheumatic diseases including systemic juvenile idiopathic arthritis (SJIA). Though neutr […]
- GSE256443 A postnatal molecular switch drives the activity-dependent maturation of parvalbumin interneurons. July 15, 2025Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE302063 Whole transcriptome analysis reveals ELK3 as a key driver of metastasis through regulation of 3D migration and stemness in triple-negative breast cancer cells July 15, 2025Contributors : Daniel Cruceriu ; Loredana Balacescu ; Oana Sava ; Stefan Miron ; Irma-Lidia Szigyarto ; Alexandrina Burlacu ; Manuela Banciu ; Ovidiu BalacescuSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo investigate the key mechanisms regulated by the transcription factor ELK3 relevant for cancer metastasis, we emplyed whole-genome mi […]
- GSE301702 Bulk RNAseq of in vitro human Rett syndrome neurons with addition of NAD supplementation July 15, 2025Contributors : William Lowry ; Abril MoralesSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere we employed RNA-seq on neuronal cultures differentiated from human induced pluripotent stem cells (hIPSCs) derived from Rett syndrome patients. The study aims to understand the effects of PARP stimulation through the treatme […]
- GSE302068 Single-Cell Atlas of Pan-Cancer Immunotherapy Reveals the Role of Ferroptosis in Exhausted Macrophages and Immune Therapy Resistance July 15, 2025Contributors : Yuanyan Xiong ; Zhijie Hu ; Xinyu PanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSLC40A1 (also known as ferroportin) is a key iron exporter that maintains intracellular iron homeostasis and regulates macrophage function. In this study, we found that a metabolically reprogrammed SLC40A1+ subset of tumo […]
- GSE302082 CHIP protects lysosomes from CLN4 mutant-induced membrane damage July 15, 2025Contributors : Juhyung Lee ; Natalie Chin ; Jizhong Zou ; Wan Mazli ; Michal Jarnik ; Layla Saidi ; Yue Xu ; Eutteum Jeong ; Jessica Suh ; John Replogle ; Michael E Ward ; Juan S Bonifacino ; Wei Zheng ; Ling Hao ; Yihong YeSeries Type : OtherOrganism : Homo sapiensUnderstanding how cells mitigate lysosomal damage is critical for unraveling pathogenic mechan […]
- GSE302236 Daphnane diterpenoids for cancer therapy by suppressing ATR-mediated DNA damage response pathway July 15, 2025Contributors : Sheng Yin ; Shuqi Wu ; Leiming WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study, 26 structurally diverse daphnane diterpenoids (1-26) including six undescribed ones (1-6) were isolated from the whole plants of Daphne odora. Compounds 1 and 2 were the most active with IC50 values of 3.57 ± 0 […]
- GSE268635 Identification of differentially methylated sites in COPD by exposure to biomass smoke July 15, 2025Contributors : SALVADOR GARCIA CARMONA ; GLORIA PEREZ RUBIOSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensChronic obstructive pulmonary disease (COPD) is a complex and multifactorial pathology. It is characterized by persistent respiratory symptoms and is due, among other causes, to airway and/or alveolar abnormalities, gene […]
- GSE299842 microRNA expression profile of human thymus populations corresponding to 8 sequential T-cell developmental stages isolated from 3 independent pediatric thymus samples. July 15, 2025Contributors : M L Toribio ; S González-GarcíaSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensT-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy arising from the neoplastic transformation of immature T cells during their development in the thymus. Deciphering the developmental programs whose dysregulat […]