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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE206291 Therapeutic immune cell engineering with an mRNA : AAV-Sleeping Beauty composite system June 16, 2025Contributors : Stanley Lam ; Sidi ChenSeries Type : OtherOrganism : Homo sapiensWe evaluated the insertion site profile of the MAJESTIC (mRNA : AAV-Sleeping Beauty) CAR generation method.
- GSE271541 Multiway chromatin conformation analyses at the human immunoglobulin heavy chain locus reveal regulatory principles underlying somatic hypermutation [ATAC-Seq] June 16, 2025Contributors : Ursula E. Schoeberl ; Johanna Fitz ; Maximilian von der Linde ; Renan Valieris ; Bernd Bauer ; Daniel Malzl ; Kimon Froussios ; Julia Costea ; Franziska Schmidt ; Jeremy Pflaum ; Bianca Bartl ; Johanna Albrecht ; Eva-Maria Wiedemann ; Adriana Cantoran Garcia ; Mihaela Peycheva ; Marta Rizzi ; Anton Goloborodko ; Israel Tojal da Silva ; Rushad […]
- GSE269701 Homeostatic pockets of interferon lambda-stimulated gene production in the intestine are associated with localized exposure to bacterial microbiota June 16, 2025Contributors : David A Constant ; Jacob A Van Winkle ; Timothy J NiceSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTolerance of enteric microbiota and clearance of potential pathogens is critical for gut homeostasis. We previously found that the healthy small intestine of mice contains discrete pockets of antiviral ge […]
- GSE273431 Multiway chromatin conformation analyses at the human immunoglobulin heavy chain locus reveal regulatory principles underlying somatic hypermutation [PRO-Seq] June 16, 2025Contributors : Ursula E. Schoeberl ; Johanna Fitz ; Maximilian von der Linde ; Renan Valieris ; Bernd Bauer ; Daniel Malzl ; Kimon Froussios ; Julia Costea ; Franziska Schmidt ; Jeremy Pflaum ; Bianca Bartl ; Johanna Albrecht ; Eva-Maria Wiedemann ; Adriana Cantoran Garcia ; Mihaela Peycheva ; Marta Rizzi ; Anton Goloborodko ; Israel Tojal da Silva ; Rushad […]
- GSE271868 Kidney-specific selection of mitochondrial TrnE mutation leads to mitochondrial kidney disease [scRNA-Seq] June 16, 2025Contributors : Min Jiang ; Leping Zhang ; Guoshi ChaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHeteroplasmic pathogenic mitochondrial DNA (mtDNA) mutations are known to cause mitochondrial diseases with varied clinical symptoms. The tissue-specific selection of heteroplasmic pathogenic mtDNA mutations and its corr […]
- GSE277051 Mesenchymal SLMAP coordinates with MST3 to govern gut elongation during development (scRNA-Seq) June 16, 2025Contributors : Yuwei Pan ; Wuqi YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDeveloping gut in mice undergoes rapid elongation during late embryogenesis, yet significantly slows down after birth. Precise regulatory mechanism of this dynamic morphogenetic process remains unknown. Utilizing single-cell RNA-sequenci […]
- GSE276611 Mesenchymal SLMAP coordinates with MST3 to govern gut elongation during development June 16, 2025Contributor : Yuwei PanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDeveloping gut in mice undergoes rapid elongation during late embryogenesis, yet significantly slows down after birth. Precise regulatory mechanism of this dynamic morphogenetic process remains unknown. Utilizing scRNA-seq analysis, we show that YAP […]
- GSE299334 mRNA-Engineered CRISPR-Cas Epigenetic Editors Enable Durable and Efficient Gene Silencing in Vivo June 16, 2025Series Type : Methylation profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE298488 CDC42 inhibitors regulate genes involved in skin vasculaization June 16, 2025Contributors : Linh M Vuong ; Anand K GanesanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRhoJ protein has 55% homology with CDC42 and is highly expressed in endothelial cells. Both proteins regulate migration and contraction in endothelial cells through the activation of typrosine kinase receptors that control angio […]
- GSE299469 eIF4e Assembly into Germ Granules is Essential for its Repressive Function June 16, 2025Contributors : Carmen Herrera Sandoval ; Christopher Borchers ; Boyoon Yang ; Becky Boyd ; Heather A Hundley ; Scott T AokiSeries Type : OtherOrganism : Caenorhabditis elegansIn metazoans, germ cells play a fundamental role in ensuring the continuity of animal life. Germ cells contain germ granules, cytoplasmic non-membrane bound organelles also referred to […]
- GSE299452 Expression data from NE or CORT exposed ADXSCGX mice eye June 16, 2025Contributor : Satoru MasubuchiSeries Type : Expression profiling by arrayOrganism : Mus musculusAbnormal IOP or IOP rhythm can cause glaucoma development. Intraocular pressure (IOP) has circadian rhythm with nocturnal peak in both nocturnal and diurnal animals.We used microarrays to detail the mechamisms of circadian rhythm of intraocular pressure because SC […]
- GSE299529 scRNA-seq reveals persistent aberrant differentiation of nasal epithelium driven by TNFα and TGFβ in post-COVID syndrome June 16, 2025Contributors : K D Reddy ; Y Maluje ; F Ott ; R Saurabh ; A Schaaf ; A Bohnhorst ; S B Biedermann ; J Pierstorf ; S Winkelmann ; B Voß ; M Laudien ; T Bahmer ; J Heyckendorf ; F Brinkmann ; S Schreiber ; W Lieb ; C A Jakwerth ; C Schmidt-Weber ; G Hansen ; E von Mutius ; K F Rabe ; A M Dittrich ; N Maison ; B Schaub ; M V Kopp ; H Busch ; M Weckmann ; A Fähn […]
- GSE299543 Effects of alcohol on the transcriptome, methylome, and metabolome of in vitro gastrulating human embryonic cells [array] June 16, 2025Contributors : Essi Wallén ; Karita Rämö ; Jussi Vehviläinen ; Joonas Sokka ; Marko Lehtonen ; Timo Otonkoski ; Ras Trokovic ; Pauliina Auvinen ; Olli Kärkkäinen ; Nina Kaminen-AholaSeries Type : Methylation profiling by arrayOrganism : Homo sapiensPrenatal alcohol exposure (PAE) affects embryonic development, causing a variable fetal alcohol spectrum disord […]
- GSE299629 ATAC-seq analysis of wildtype and ETV2-overexpressing embryoid body-derived progenitor cells June 16, 2025Contributors : Kidus Hailemariam ; Satyabrata Das ; Xiao MaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusWild-type (WT) and Etv2-overexpressing (OE) mouse embryonic stem cells (mESC) were cultured and differentated to embryoid bodies (EBs) in mesodermal conditions. Induction of Etv2 in OE EBs was achieve […]
- GSE191189 Chromatin accessibility of young and aged muscle stem cells in response to prostaglandin E2 June 16, 2025Contributors : Helen M Blau ; Yu X Wang ; Glenn Markov ; Meenakshi RavichandranSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusAssessment of openly accessible chromatin regions in young and aged muscle stem cells and short term epigenetic response to prostaglandin E2 treatment.