Gene Expression Omnibus Announcements -Study Releases

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE267918 Gene Regulatory Programs that Specify Age-Related Differences during Thymocyte Development (ATAC-Seq) June 4, 2025
  Contributors : Divya Ganapathi Sankaran ; Viviana I Maymi ; Brian D Rudd ; Andrew W GrimsonSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusT cell development is fundamental to immune system establishment, yet how this development changes with age remains poorly understood. Here, we construct a transcriptio […]
• GSE185194 Gastruloids enable modeling of the earliest stages of human cardiac and hepatic vascularization June 4, 2025
  Contributors : Oscar J Abilez ; Joseph C Wu ; Ioannis KarakikesSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere we show that spatially micropatterned human pluripotent stem cell (hPSC)-derived gastruloids enable in vitro modeling of the earliest developmental stages of cardiac vascularization, roughly corresponding […]
• GSE267923 Gene Regulatory Programs that Specify Age-Related Differences during Thymocyte Development June 4, 2025
  Contributors : Divya Ganapathi Sankaran ; HongYa Zhu ; Viviana MaymiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusT cell development is fundamental to immune system establishment, yet how this development changes with age remains poorly understood. Here, we construct a transcriptional and epigenetic atlas of T cell de […]
• GSE267922 Gene Regulatory Programs that Specify Age-Related Differences during Thymocyte Development (RNA-Seq) June 4, 2025
  Contributors : Divya Ganapathi Sankaran ; Viviana I Maymi ; Brian D Rudd ; Andrew W GrimsonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusT cell development is fundamental to immune system establishment, yet how this development changes with age remains poorly understood. Here, we construct a transcriptional and epigen […]
• GSE298885 The mechanosensitive adhesion G protein-coupled receptor GPR133/ADGRD1 enhances bone formation – a potential new target for osteoporosis treatment June 4, 2025
  Contributors : Juliane Lehmann ; Christian Ullmann ; Luisa Bayer ; Torsten Schöneberg ; Martina Rauner ; Jinpeng Sun ; Ines LiebscherSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOsteoporosis poses an increasing health and socioeconomic burden on aging societies. Current therapeutic options often present potentially s […]
• GSE269049 The embryonic DPPA3 gene stimulates the expression of pregnancy-related genes in bovine endometrial cells June 4, 2025
  Contributors : Jessica Townsend ; Nicole Gross ; Zongkai Peng ; Francisco Peñagaricano ; Zhibo Yang ; Nagib Ahsan ; Hasan KhatibSeries Type : Expression profiling by high throughput sequencingOrganism : Bos taurusExtracellular vesicles (EVs) released by cells contain mRNAs, miRNAs, lncRNAs, lipids, and proteins, playing crucial roles in cell-cell communicati […]
• GSE297578 NEXN protects against vascular calcification by promoting SERCA2 SUMOy-lation and stabilization June 4, 2025
  Contributors : Canzhao Liu ; Hanyan Yang ; Wenjie Guo ; Wenjing Guo ; Boliang Chen ; Zexuan Lin ; Zhuohua WenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensVascular calcification, a key risk factor for cardiovascular diseases, is driven by the phenotypic transition of vascular smooth muscle cells (VSMCs) from a contrac […]
• GSE176504 Synergistic behavioral and neuroinflammatory effects of amyloid neuropathology and sepsis survival in a murine model of Alzheimer’s disease I June 4, 2025
  Contributors : Angela C Bustamante ; Marc Padilla ; Zhuoer Zeng ; Michael W Newsteadt ; Benjamin H SingerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSynergistic behavioral and neuroinflammatory effects of amyloid neuropathology and sepsis survival in a murine model of Alzheimer’s disease. 40 post-mortem perfused bra […]
• GSE298630 A deep learning framework for the reconstruction of gene expression profiles derived from formalin-fixed paraffin-embedded samples June 4, 2025
  Contributors : Lingli He ; Kai Song ; Ying Li ; Yujuan Dong ; Cherry Y N Wong ; Lin Qi ; Xianrui Zhang ; Kristiaan Lenos ; Tim de Back ; Clara Elbers ; Chenchen Xu ; Yinghan Zhang ; Feng Gao ; Yufeng Chen ; Simon Siu-Man Ng ; Shentao Zhou ; Louis Vermeulen ; Xin WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis d […]
• GSE298372 The SIRT6-TDO2/KYNA-mTOR Axis Mediates Synaptic Plasticity and Cognitive Impairments in Fetal Growth Restriction Offspring June 4, 2025
  Contributors : Shujuan Chang ; Wen Chen ; Wei Zhu ; Nana Liu ; Yuhang Wang ; Jianguo Li ; Jiuhong KangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFetal growth restriction (FGR) can lead to cognitive impairment in offspring, but the underlying mechanisms remain unclear. This study found that hippocampal excitatory ne […]
• GSE298648 Embryonic thermal conditioning and post-hatch heat challenge in broiler chicks reveal changes in hypothalamic expression of genes related to appetite, thermoregulation, and stress modulation June 4, 2025
  Contributor : Elizabeth GilbertSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusEmbryonic heat conditioning (EHC; exposing the chick embryo to elevated temperatures transiently during incubation) has been associated with greater stress resiliency later in life, although mechanisms are unclear but likely involve the hypo […]
• GSE298819 Inhibiting FOXM1 Promotes Polyploidization and Metabolic Maturation in Human iPSC-Derived Hepatocytes by Modulating the Wnt/β-Catenin Pathway [Hi-C] June 4, 2025
  Contributors : Telles-Silva Kayque Alves ; Fishman Veniamin ; Gridina Maria ; Panchenko DariaSeries Type : OtherOrganism : Homo sapiensDifferentiating induced pluripotent stem cells (iPSCs) into hepatocytes represents a key advancement in regenerative medicine and disease modeling. However, existing protocols mainly produce fetal cells, limiting accurate rep […]
• GSE298820 Inhibiting FOXM1 Promotes Polyploidization and Metabolic Maturation in Human iPSC-Derived Hepatocytes by Modulating the Wnt/β-Catenin Pathway [ATAC-seq] June 4, 2025
  Contributor : Telles-Silva Kayque AlvesSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensDifferentiating induced pluripotent stem cells (iPSCs) into hepatocytes represents a key advancement in regenerative medicine and disease modeling. However, existing protocols mainly produce fetal cells, limiting accurat […]
• GSE176506 Synergistic behavioral and neuroinflammatory effects of amyloid neuropathology and sepsis survival in a murine model of Alzheimer’s disease June 4, 2025
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE291288 RNA sequencing of High Grade Serous Ovarian cancer June 4, 2025
  Contributors : Lena Rai ; Antonella Ravaggi ; Eliana Bignotti ; Franco Odicino ; Ahmed AhmedSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study we have validated the prognostic strength of the Oxford Classic-defined EMT in an independent cohort of HGSOC patients- 'Brescia Ovarian Tumour'. Additionall […]