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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE204669 The miR-3648/FRAT1-FRAT2/c-Myc feedback loop modulates the metastasis and invasion of gastric cancer cells May 20, 2025Contributor : Jide WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA-seq were used to screen differentially expressed genes in AGS transfected with NC and miR-3648 mimics.
- GSE267783 Age-associated adipose-derived stem cell activity is dictated by IGF2BP3-dependent regulation of glutamine and BCAA catabolism May 20, 2025Contributors : Zichao Li ; Liangliang Shen ; Dahai HuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCultured human adipose-derived stem cells(hASCs) are considered as a homogeneous population in vitro. We used single cell RNA sequencing (scRNA-seq) to reveal the cellular heterogeneity of hASCs and identify aging-relate […]
- GSE267176 Myeloid ATG7 Functions as a Sentinel for Pulmonary Defense Against Infection with Nontuberculous Mycobacteria May 20, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNontuberculous mycobacterial pulmonary diseases (NTM-PD) are becoming increasingly prevalent and incident, and heightened antibiotic resistance presents a considerable challenge to clinicians. Despite this, our understanding of the factor(s) contributing to host defense ag […]
- GSE277615 TNBC response to CDK4/6 inhibitors plus RANKL inhibitors May 20, 2025Contributors : Inês Gomes ; Luis Costa ; Sandra CasimiroSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCDK4/6i alone have proven to be largely ineffective in TNBC, even in the presence of functional retinoblastoma protein (pRB). In this study, we investigated the role of the RANK pathway in the response to CDK4/6i in p […]
- GSE277295 RNA-seq Reveals Paxillin as a Key Facilitator of Endothelial Cell Migration and Angiogenesis after Spinal Cord Injury May 20, 2025Contributors : Manjeet Chopra ; Jaidev Sharma ; Aditya A Singh ; Zarna Pathak ; Priyanka P Vats ; Vibhor Kumar ; Amit Mandoli ; Hemant KumarSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusSpinal cord injury (SCI) is a catastrophic condition resulting in significant neurological deficits. To map the altered pathways […]
- GSE297431 Disrupted MOS signaling alters meiotic cell cycle regulation and the egg transcriptome May 20, 2025Contributors : Gisela Cairo ; Olha Kholod ; Olivia Palmer ; Brittany A Goods ; Soni LacefieldSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLoss of MOS in female mice disrupts metaphase II arrest, potentially causing infertility and germ cell tumors. Single-egg RNA sequencing revealed widespread gene expression changes […]
- GSE279118 Cellular and Molecular Characteristics of Drug Resistance in AML cells Unveiled by Multi-Omics Analysis May 20, 2025Contributors : Yulong Zhang ; Yanfang LuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAcute myeloid leukemia (AML) exhibits a spectrum of responses to chemotherapy, with drug resistance being a significant clinical challenge. This study employs a multi-omics approach, particularly multiplexed single-cell RNA sequencin […]
- GSE297165 Sustained neuronal stimulation activates paraventricular thalamus astrocytes for maintenance of chronic neuropathic pain in mice May 20, 2025Contributors : Yi Zhao ; Peiwen Jian ; Guo Chen ; Cheng zhouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOngoing nociceptive inputs from peripheral tissues and nerve injuries lead to maladaptive alterations in central nervous system, which drive the transition from acute to chronic pain. Although astrocytes act as dy […]
- GSE297162 Transcriptomic study of PGPR-induced Brassica rapa plant gene expression towards aphids May 20, 2025Contributors : Beng-Soon Teh ; Mayalagu Sevugan ; Sanjay SwarupSeries Type : Expression profiling by high throughput sequencingOrganism : Brassica rapaThe aim of this study is to explore the gene expression of Brassica rapa with and without inoculation with PGPR bacteria in response to aphids attack on day 5 and day 10. We expect to find many genes regulated […]
- GSE297261 H3 Acetylation and H2A.Z Levels Interplay to Regulate Gene Expression and Plant Development May 20, 2025Contributors : Israel Ausin ; Yafei Wang ; Yingpei Su ; Qin Hu ; Weiye Qian ; Min Liu ; Chao Xu ; Junjie XuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Arabidopsis thalianaH2A.Z is a conserved histone variant that plays essential roles in various DNA-templated processes across eukaryotes. H2A.Z and histone post-tra […]
- GSE297212 Development of early-stage alpha-synucleinopathy is not governed by myelin status in mice of either sex May 20, 2025Contributors : Rachel N Clark ; Reese E Landes ; Muslim Abbas ; Victoria G Mistretta ; Kieran A DeLoatch ; Jun Chen ; Kelvin C Luk ; Xiaoming Hu ; Rehana K LeakSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLewy body disorders are characterized by alpha-synucleinopathic inclusions that tend to develop in neurons extend […]
- GSE297286 Hypercapnia induces long-term DNA methylation changes in skeletal muscle. May 20, 2025Contributor : Andy MadridSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSkeletal muscle dysfunction and elevated CO2 in the blood, or hypercapnia, are both associated with higher mortality in acute and chronic pulmonary diseases. Hypercapnia causes accelerated protein degradation, reduced protein synthesis, and dysfunc […]
- GSE297342 Assessing the Effects of Silver Nanoparticles on ARPE-19 Cells via High-Throughput Phenotypic Profiling with the Cell Painting Assay. May 20, 2025Contributors : Gabrielle Byrd ; Alice Goldstein-Plesser ; Jo Nyffeler ; Clinton M Willis ; Anna Fisher ; William K Boyes ; Joshua A HarrillSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIncreasing commercialization of silver nanoparticles (AgNPs) has resulted in elevated opportunity for human exposure and outpaced trad […]
- GSE297344 Analysis of a BCOR internal tandem duplication in mouse embryonic stem cell to neuronal precursor differentiation May 20, 2025Contributors : Zuzer Dhoondia ; Mitzi I KurodaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBCOR (BCL-6 corepressor) is a component of variant Polycomb Repressive Complex 1.1 (vPRC1.1), one of several vPRC1 complexes that catalyze histone H2A ubiquitination thought to play an important role in PRC2 binding and the dep […]
- GSE203487 Whole genome bisulfite sequence in heat treated rice seeds May 20, 2025Contributors : Ishibashi Yushi ; Suriyasak ChetphilinSeries Type : Methylation profiling by high throughput sequencingOrganism : Oryza sativaWe report the relationship between transgenerational growth and profiling of DNA methylation in rice seeds treated with heat.