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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE131864 CARM1 is an integral component of the NuRD chromatin remodeling complex (RNA-Seq) May 19, 2025Contributors : Wen Liu ; Ming-Feng Huang ; Wen-Juan Zhang ; Xu PanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe nucleosome remodeling and deacetylase (NuRD) complex is a large multi-subunit complex that couples ATP-dependent chromatin-remodeling and histone deacetylase activities. Emerging evidence suggested that […]
- GSE278688 Integrated Single-Cell and Spatial Transcriptomics Uncover Distinct Cellular Subtypes Involved in Neural Invasion in PDAC [scRNA-Seq] May 19, 2025Contributors : Min-Min Chen ; Qinhang Gao ; Huiheng Ning ; Kang Chen ; Yang Gao ; Chaoqun Liu ; Linnan Zhu ; Wei Zhou ; Jieying Pan ; Lusheng Wei ; Dingwen Zhang ; Min Yu ; Qingling Zhang ; Rufu Chen ; Zemin ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study aims to explore the role of nerves in tumor biolo […]
- GSE203555 Genome-wide analysis of gene regulatory networks in chickens reveals dynamic temporal changes in retinal signaling cascade underlying compensation to lens-imposed optical defocus [1d] May 19, 2025Contributors : Tatiana V Tkatchenko ; Andrei V TkatchenkoSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusDuring postnatal development, the optical geometry of the eye is refined through a process called emmetropization. During eye emmetropization, positive optical defocus inhibits eye growth whereas negative optical de […]
- GSE150917 IGF2BP3 may contributes to lung tumorigenesis by regulating the alternative splicing of PKM. May 19, 2025Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE242705 Global transcriptional profiles of primary and secondary cellular senescence in vivo by oncogene-induced senescence (OIS) and stress-induced senescence (SIS) [scRNA-seq] May 19, 2025Contributors : Yuko Sogabe ; Mio Kabata ; Yasuhiro Yamada ; Takuya YamamotoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe physiological roles of cellular senescence in vivo are largely unknown. We report primary and secondary senescence-induced transcriptional alteration by oncogene-induced senescence (OIS, ERK act […]
- GSE203629 Genome-wide analysis of gene regulatory networks in chickens reveals dynamic temporal changes in retinal signaling cascade underlying compensation to lens-imposed optical defocus [lens induced] May 19, 2025Contributors : Tatiana V Tkatchenko ; Andrei V TkatchenkoSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusDuring postnatal development, the optical geometry of the eye is refined through a process called emmetropization. During eye emmetropization, positive optical defocus inhibits eye growth whereas negative optical de […]
- GSE297183 A dietary intervention following incretin analog treatment restores adipose tissue functions in diet-induced obese mice May 19, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity is associated with the development of type 2 diabetes. In recent years, incretin analogs are prescribed at a high rate for treatment of obesity and diabetes due to their potent effects on lowering bodyweight and improving glucose homeostasis. However, many patients […]
- GSE267949 Multiomics coupled with vibrational spectroscopy identify early mechanisms of experimental aortic valve stenosis [RNA] May 19, 2025Contributors : Giannis Vatselas ; Marios Miliotis ; Manolis Mavroidis ; Artemis Hatzigeorgiou ; C D Anagnostopoulos ; Dennis Cokkinos ; Konstantinos ToutouzasSeries Type : Expression profiling by high throughput sequencingOrganism : Oryctolagus cuniculusCalcific aortic valve stenosis (CAVS), characterized by calcium deposition in the aortic valve in a multia […]
- GSE297211 PDK1 regulates metabolic balance in osteosarcoma stem cells May 19, 2025Contributors : Kazuya Tokumura ; Kazuya Fukasawa ; Jiro Ichikawa ; Koki Sadamori ; Manami Hiraiwa ; Eiichi HinoiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens143B cells cultured under tumorsphere (OSCs) and adherent (non-OSCs) conditions
- GSE297194 OTTR ribosome profiling in Mettl14 knockout mESC May 19, 2025Contributors : Shino Murakami ; Samie R JaffreySeries Type : OtherOrganism : Mus musculusDegradation of mRNA containing N6-methyladenosine (m6A) is essential for cell growth, differentiation, and stress responses. Here, we show that m6A markedly alters ribosome dynamics and that these alterations mediate the degradation effect of m6A on mRNA. We find that m6 […]
- GSE297299 Mismanagement of Cellular Iron Leads to Ferroptosis Susceptibility in Cancer Cells Surviving Chemotherapy May 19, 2025Contributors : Luke V Loftus ; Christopher Cherry ; Michael PatatanianSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDespite centuries of research, metastatic cancer remains incurable due to resistance against all conventional cancer therapeutics. Alternative strategies leveraging non-proliferative vulnerabilities in c […]
- GSE297330 TNFR2 loss prevents TOX upregulation in CD8+TIM3+ T cells and affords improved responses to tumor and chronic LCMV May 19, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPreview PDF Abstract Exhaustion represents a collection of programmed T cell differentiation states and an important mode of T cell dysfunction. T cell progression from progenitor to terminal exhaustion is associated with upregulation of the transcription factor TOX and ex […]
- GSE297413 Genomic and transcriptomic determinants of clinical outcomes in patients with AML and DNMT3A mutations May 19, 2025Contributors : Feng-Ming Tien ; Sao-Chih NiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAcute myeloid leukemia (AML) and DNMT3A mutations (DNMT3Amut) are considered to carry intermediate risk under the 2022 European LeukemiaNet (ELN-2022) classification in the absence of other co-mutations or cytogenetic abnormalitie […]
- GSE278681 DNA methylation protects cancer cells against non-canonical senescence May 19, 2025Contributors : Kosuke Yamaguchi ; Fumihito Miura ; Xiaoying Chen ; Takashi Ito ; Pierre-Antoine DefossezSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensAberrant DNA methylation patterns are a hallmark of human cancers, prompting targeting of DNA methylation machinery to be explored as an anti-tumor strategy. DNA methyl […]
- GSE297134 PIEZO1 mediates mechanical reprogramming of neutrophils for proangiogenic specialization in the lung May 19, 2025Contributors : Jin Wang ; Jing WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeutrophils are the most abundant immune cells that constantly patrol or marginate inside vascular beds to support immune homeostasis. The extent to which neutrophils undergo reprogramming in response to the changes in vascular architectu […]