Quick Links : Search PubMed , Finding Full Text , PubMed Advanced Search , Clinical Queries , Single Citation Matcher , FAQs & User Guide , Explore MeSH Database , Explore PubMed Journals
Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE226010 Single-cell genomics demonstrates cellular and molecular dynamics in the malignancy of colorectal cancer [scRNA-seq] May 15, 2025Contributor : jing wangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe report the application of single cell rna -seq and single cell ATAC-seq in the mouse CRC model with with APC mutation
- GSE248034 Contribution of UPF1 and RCOR1 to androgen response of prostate cancer cells. May 15, 2025Contributors : Hannelore Heemers ; Eduardo CortesSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe ligand-activated androgen receptor is a transcription factor that drives prostate cancer growth. Blocking androgen-activation of androgen receptor via androgen deprivation therapy is the default treatment for metastatic […]
- GSE229953 LLC cancer cells from primary tumors from Padi4f/f-Mrp8Cre- (WT) and Padi4f/f-Mrp8Cre+ (PAD4-DN) mice bulk RNA-seq data May 15, 2025Contributors : Jose M Adrover ; Mikala EgebladSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLLC cancer cells from primary tumors from Padi4f/f-Mrp8Cre- (WT) and Padi4f/f-Mrp8Cre+ (PAD4-DN) mice bulk RNA-seq data
- GSE263569 Bisphenol A enhances retinoic acid-HOX genes signaling disrupting brain development: human May 15, 2025Contributors : Kenya Ueno ; Keiko Iida ; Akira Hirasawa ; Tatsuyuki TakadaSeries Type : Expression profiling by arrayOrganism : Homo sapiensPlastic pollution and exposure to endocrine- disrupting chemicals (EDCs) like Bisphenol A (BPA) are emerging environmental concerns with potential impacts on human health and development. Despite evidence from epidemiolo […]
- GSE254930 MORC-1 is a key component of the C. elegans CSR-1 germline gene licensing mechanism (ChIP-Seq) May 15, 2025Contributors : Jessica A Kirshner ; Colette L Picard ; Natasha E Weiser ; Nicita Mehta ; Suhua Feng ; Victoria Murphy ; Anna Vakhnovetsky ; Connie Xiao ; Kai Inoki ; Sonia El Mouridi ; Christian Frøkjær-Jensen ; Steven E Jacobsen ; John K KimSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Caenorhabditis elegansThe Arg […]
- GSE268804 Effect of depletion of hypoxia-inducible factor (HIFs) on gene expression in MDA231-BrM2 breast cancer brain-selective metastatic cells with RNA-Seq. May 15, 2025Contributors : Yongkang Yang ; Gregg L SemenzaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBrain metastasis is a major cause of breast cancer mortality, but the molecular basis and pathological mechanisms are poorly understood. Here, we determined that integrin β3 (ITGB3) expression mediated by hypoxia-inducible fact […]
- GSE267543 Integrative miRNOMe profiling reveals the miR-195-5p-CHEK1 axis and its impact on luminal breast cancer outcomes May 15, 2025Contributors : Veronika Boušková ; Marie Ehrlichová ; Alžběta Spálenková ; Ivona Krus ; Simona Šůsová ; Viktor Hlaváč ; Renata Koževnikovová ; Markéta Trnková ; David Vrána ; Jiří Gatěk ; Kateřina Kopečková ; Marcela Mrhalová ; Soňa Měšťáková ; Pavel SoučekSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensThe luminal subtype (estrogen rec […]
- GSE296835 Preclinical and first-in-human of Purinostat Mesylate, a novel selective HDAC I/IIb inhibitor, in relapsed or refractory multiple myeloma and lymphoma May 15, 2025Contributors : Linyu Yang ; Qiang Qiu ; Yi Wen ; Yunyu Feng ; Ting Niu ; Lijuan ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurinostat Mesylate (PM), a highly selective HDAC I/IIb inhibitor, exhibits excellent antitumor activity in multiple MM and lymphoma cell lines and multiple mouse models, outperforming the […]
- GSE296833 Preclinical and first-in-human of Purinostat Mesylate, a novel selective HDAC I/IIb inhibitor, in relapsed or refractory multiple myeloma and lymphoma [PDX] May 15, 2025Contributors : Linyu Yang ; Qiang Qiu ; Yi Wen ; Yunyu Feng ; Ting Niu ; Lijuan ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurinostat Mesylate (PM), a highly selective HDAC I/IIb inhibitor, exhibits excellent antitumor activity in multiple MM and lymphoma cell lines and multiple mouse models, outperforming the […]
- GSE297217 Single-cell genomics demonstrates cellular and molecular dynamics in the malignancy of colorectal cancer (APC_Kras_mutation) May 15, 2025Contributors : Jing Wang ; Wei LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe report the application of single cell rna -seq and single cell ATAC-seq in the mouse CRC model with with APC mutation
- GSE297112 Coordinated Histone Methylation Loss and MYC Activation Promote Translational Capacity Under Amino Acid Restriction May 15, 2025Contributors : Chen Cheng ; Siavash K KurdistaniSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEpigenetic mechanisms underlying cellular adaptation to and recovery from nutrient deficiency are incompletely understood. Here, we report an adaptive epigenetic response to amino acid (AA) restriction that primes cells for r […]
- GSE297221 TimeLapse-seq after translation inhibition in Mettl14 knockout mESC May 15, 2025Contributors : Shino Murakami ; Samie R JaffreySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDegradation of mRNA containing N6-methyladenosine (m6A) is essential for cell growth, differentiation, and stress responses. Here, we show that m6A markedly alters ribosome dynamics and that these alterations mediate the degra […]
- GSE297222 TimeLapse-seq after translation inhibition in YTHDF-depleted Hela cells May 15, 2025Contributors : Shino Murakami ; Samie R JaffreySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDegradation of mRNA containing N6-methyladenosine (m6A) is essential for cell growth, differentiation, and stress responses. Here, we show that m6A markedly alters ribosome dynamics and that these alterations mediate the degra […]
- GSE297223 Single-cell genomics demonstrates cellular and molecular dynamics in the malignancy of colorectal cancer (CDX derived tumor) May 15, 2025Contributors : Jing Wang ; Wei LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe report the application of single cell rna -seq on Cell Line-Derived Xenograft (CDX) derived tumor
- GSE297225 scRNAseq of the lymph nodes from the wild type mice due to tamoxifen treatment [LYMPH_NODES] May 15, 2025Contributors : Jing Wang ; Wei LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe report the application of single cell rna -seq on lymph nodes from the wild type mice due to tamoxifen treatment