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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE282513 RACK7 Senses and Fine-Tunes Enhancer Activity [Chromatin associated RNA-seq] July 3, 2025Contributors : Li Dong ; Wenqi Xu ; Hongjie ShenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEnhancers regulate dynamic gene expression in a spatiotemporal specific manner. A number of positive as well as negative regulators of enhancers have been reported so far. However, whether and how these regulators sense enhan […]
- GSE277334 Defining an NK cell-enriched rejection-like phenotype in liver transplant biopsies from the INTERLIVER study July 3, 2025Contributor : Jessica ChangSeries Type : Expression profiling by arrayOrganism : Homo sapiensBackground: Initial analysis of liver transplant biopsies in the INTERLIVER study (#NCT03193151) using rejection-associated transcripts failed to find an antibody-mediated rejection state (i.e. rich in NK cells and with interferon-gamma effects). We recently develope […]
- GSE286485 A distinct subset of the Arabidopsis group S1 basic leucine zipper transcription factors controls plant resource management during starvation and recovery July 3, 2025Contributors : Cezary Smaczniak ; Kerstin Kaufmann ; Christoph Weiste ; Wolfgang Dröge-LaserSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Arabidopsis thalianaPlants possess an enormous plasticity to adapt their metabolism to the fluctuating energy supply in a natural environment. Using dark-induced senescence (DIS) […]
- GSE283270 RACK7 Senses and Fine-Tunes Enhancer Activity [ChIP-Seq] July 3, 2025Contributors : Li Dong ; Wenqi Xu ; Hongjie ShenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensEnhancers regulate dynamic gene expression in a spatiotemporal specific manner. A number of positive as well as negative regulators of enhancers have been reported so far. However, whether and how these regulato […]
- GSE246115 MYST-mediated epigenetic regulation determines the adaptive artemisinin-resistant in Plasmodium falciparum [scRNA-Seq] July 3, 2025Contributors : Jincan He ; Cizhong Jiang ; Qingfeng ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Plasmodium falciparumTo investigate the artemisinin resistance mechanism, we conducted a systematical evaluation of histone acetyltransferase expression in 45 cloned P. falciparum parasites and 30 wild-type field isolates. Remar […]
- GSE301557 Carboxy-Methylation of PP2Ac Integrates Methionine Availability with Cancer Cell Proliferation July 3, 2025Contributors : Anna Andronicos ; Peter KaiserSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCancer cells exhibit a well-documented, yet poorly understood, dependence on exogenous methionine, despite retaining the capacity to convert homocysteine to methionine. In contrast, non-tumorigenic cells can proliferate when met […]
- GSE300897 Single-cell RNA-seq profiling of treatment-naïve chemo-refractory and chemo-sensitive ovarian cancer July 3, 2025Contributors : Daria Afenteva ; Matias Marin Falco ; Anna Pirttikoski ; Erdogan Pekcan Erkan ; Sampsa Hautaniemi ; Anna VähärautioSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis dataset contains single-cell RNA-seq data from treatment-naïve biopsies of nine patients diagnosed with ovarian high-grade serous carcinom […]
- GSE251764 RNA-seq of sorted small intestinal tuft cells from naïve and Spib-deficient mice July 3, 2025Contributor : Jiali WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGenes significantly unregulated in Spib-deficient tuft cells included those associated with type 2 immune responses or induced by type 2 immune stimuli.
- GSE301274 Multiple long-range cis interactions generate CTCF insulator-dependent viral chromatin domains in quiescent HSV-1 genomes July 3, 2025Contributor : Frietze SethSeries Type : OtherOrganism : Homo sapiensIn cellular genomes, CTCF insulators impact transcription over small distances in a one-dimensional manner and over much longer distances in a three-dimensional manner by maintaining chromatin loops. We have previously shown that the latent HSV-1 genome contains CTCF insulators that function […]
- GSE301251 sham: Control vs. different time point post spinal cord injury July 3, 2025Contributors : Xu Xu ; Gao Feng ; Qixin Chen ; Bairu Chen ; Wenyu Liang ; Runzhi Huang ; Yuchen Liu ; Zhibo Liu ; Yanjing Zhu ; Guafa Lin ; Bei Ma ; Letao Yang ; Shaorong Gao ; Rongrong Zhu ; Liming ChengSeries Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Mus musculusAnalysis of the transcriptional expression and m6A mod […]
- GSE301404 Collecting Duct Gene Expression in a Mouse Vasopressin-Excess Model without Hyponatremia July 3, 2025Contributors : Hiroaki Kikuchi ; Adrian Rafael Murillo-de-Ozores ; Shuo-Ming Ou ; Euijung Park ; Chin-Rang Yang ; Viswanathan Raghuram ; Shaza Khan ; Chung-Lin Chou ; Lihe Chen ; Mark A KnepperSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusIntroduction. […]
- GSE301434 Single-cell RNA-sequencing data of human medial ganglionic eminence organoids July 3, 2025Contributors : Maria C Varela ; Miranda P Walker ; Jeyoon BokSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe analysed scRNA-seq data in human pluripotent stem cell-derived medial ganglionic eminence (MGE) organoids. This in vitro system recapitulates some key aspects of humam MGE development including inhibitory cort […]
- GSE301542 STAMP: Single-Cell Transcriptomics Analysis and Multimodal Profiling through Imaging [scRNA-seq] July 3, 2025Contributors : Emanuele P Pitino ; Anna Pascual-Reguant ; Felipe S Dezem ; Kellie Wise ; Irepan S Martinez ; Helena L Crowell ; Maycon Marção ; Sara Ruiz ; Elise Courtois ; William F Flynn ; Santhosh Sivajothi ; Emily Soja ; Ginevra Caratù ; German A Mora Roldan ; Dredge B Kate ; Yutian Liu ; Hannah Chasteen ; Monika Mohenska ; Juan C Nieto ; Raymond K H. Yi […]
- GSE263568 Gene expression profile at single embryo level of 0-3h old hybrid Drosophila embryos July 3, 2025Contributors : Adelheid Lempradl ; J E Perez-Mojica ; Kin H LauSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterWe used single-embryo RNA-sequencing (RNA-seq) to characterize early zygotic gene expression in Drosophila. To assess the accurate transcriptional activation for zygotic genes, we analyze the paterna […]
- GSE299860 NSD1 heterozygosity disrupts fetal growth and neonatal survival and placental abnormalities in mice July 3, 2025Contributor : Musashi Kubiura-IchimaruSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigates the developmental consequences of Nsd1 haploinsufficiency in mice. NSD1 is a histone methyltransferase that catalyzes H3K36me2 and plays a key role in transcriptional regulation during development. Although homo […]