Gene Expression Omnibus Announcements -Study Releases

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE276868 INNATE IMMUNE TRAINING IN THE NEONATAL RESPONSE TO SEPSIS May 7, 2025
  Contributors : Jaimar C Rincon ; Dayuan Wang ; Valerie E Polcz ; Evan L Barrios ; Marvin L Dirain ; Ricardo F Ungaro ; Dina C Nacionales ; Leilani Zeumer ; Feifei Xiao ; Philip A Efron ; Lyle L Moldawer ; Guoshuai Cai ; Shawn D LarsonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeonates, especially those born prematu […]
• GSE278288 Engineering Fibroblast with Reprogramming and Spheronization for Bone Defect Repair May 7, 2025
  Contributors : Yanjiao Li ; Bin Jiang ; Zhen Wu ; Zhaoxia Ma ; Lihua Qiu ; Wen Cui ; Yunhui Zhao ; Jinghe Yan ; Daiping Ma ; Xingfei Wu ; Shu Liang ; Sitao Wang ; Yanqun Zhao ; Mengting Wang ; Min HuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBone diseases profoundly affect patients, particularly the elderly, leadin […]
• GSE277841 DNA methylation in primary myelofibrosis is partly associated with driver mutations and distinct from other myeloid malignancies I May 7, 2025
  Contributors : Esra Dursun Torlak ; Vithurithra Tharmapalan ; Kim Kricheldorf ; Joelle Schifflers ; Madeline Caduc ; Martin Zenke ; Steffen Koschmieder ; Wolfgang WagnerSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensPrimary myelofibrosis (PMF) is a clonal blood disorder linked to mutually exclusive mutations in JAK2, CALR, o […]
• GSE223422 Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease [BulkRNAseq_Dataset3_4M] May 7, 2025
  Contributors : Kimitoshi Kimura ; Ayshwarya Subramanian ; Zhuoran Yin ; Yufan Wu ; Danyang He ; Madhumita Das ; Karen Dixon ; Udbhav K Chitta ; Ruihan Tang ; Thomas Pertel ; Aastha Aastha ; Masashi Nomura ; Vasundhara Singh ; Lei Liu ; Conner Lambden ; Neha Gupta ; Yiran C Cheng ; Sebastian Silveira ; Huiyuan Zhang ; Aamir Suhail ; Toni Delorey ; Orit Rosenb […]
• GSE280381 Investigating therapy-induced senescence as a reversible escape mechanism of drug resistance in breast cancer cells using high-dose doxorubicin treatment May 7, 2025
  Contributors : Eszter Bajtai ; Csaba Kiss ; Sandor Spisak ; Andras FurediSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe emergence of drug resistance remains a critical challenge in cancer treatment, significantly contributing to high mortality rates. Here, we investigate therapy-induced senescence (TIS) as a revers […]
• GSE271120 TRAIL-induced cytokine production via NFKB2 pathway promotes neutrophil chemotaxis and immune suppression in triple negative breast cancers [MDA-MB-231] May 7, 2025
  Contributors : Manjari Kundu ; Stanley LipkowitzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potential cancer therapeutic that selectively induces apoptosis in cancer cells sparing the non-malignant cells. While the effective cytotoxic effect of TRA […]
• GSE244416 Small RNA Landscape of Platelet Dust: Platelet-Derived Extracellular Vesicles from Patients with Non-Small-Cell Lung Cancer May 7, 2025
  Contributors : Mafalda Antunes-Ferreira ; Ilias Glogovitis ; Diogo Fortunato ; Silvia D’Ambrosi ; Mariona Colom Saborit ; Galina Yahubyan ; Vesselin Baev ; Michael Hackenberg ; Natasa Zarovni ; Thomas Wurdinger ; Danijela Koppers-LalicSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensAbstract: Background: Platelet-der […]
• GSE295689 Intestinal inflammation promotes gut commensal-specific CD4 T cell to initiate molecular mimicry-mediated neuroinflammation May 7, 2025
  Contributors : Zachary White ; Teruyuki Sano ; Margarette Clevenger ; Nicolas ChevrierSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe microbiota has been recognized as a critical contributor to various diseases, with multiple reports of changes in the composition of the gut microbiome in the context of not only infl […]
• GSE295643 Intestinal inflammation promotes gut commensal-specific CD4 T cell to initiate molecular mimicry-mediated neuroinflammation May 7, 2025
  Contributors : Teruyuki Sano ; Zachary White ; Linghan Mei ; Nicolas ChevrierSeries Type : OtherOrganism : Mus musculusThe microbiota has been recognized as a critical contributor to various diseases, with multiple reports of changes in the composition of the gut microbiome in the context of not only inflammatory bowel disease (IBD), but also neurodegenerati […]
• GSE296179 Autophagy related 14 regulates liver homeostasis and function May 7, 2025
  Contributor : X C DongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAutophagy regulated 14 (ATG14) is a key regulator of autophagy; however, its role in the liver remains poorly understood. This study aimed to investigate the hepatocyte-specific function of ATG14 in vivo. We generated Atg14 hepatocyte-specific knockou […]
• GSE295936 Gene expression profile at single cell level of CD45+ cells from the mouse melanoma after treatment with M1 or M1-mutIL-18 May 7, 2025
  Contributors : Zhen Fan ; Jifu Zhang ; Jiankai LiangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCD45+ immune cells play an important role in immunotherapy.To investigate the effect of CD45+ immune cells on the efficacy of oncolytic viruses M1 and M1-mutIL-18, We used single cell RNA sequencing (scRNA-seq) to analyze […]
• GSE296182 Transcriptomic profiling following TRIM28 and PARP1 silencing in 786-O kidney cancer cells May 7, 2025
  Contributors : Bin fu ; Songhui Xu ; Xiangpeng ZhanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapienslobal gene expression changes by TRIM28 or PARP1 knockdown in 786-O renal cancer cells
• GSE296188 Method for deletion of variant surface antigen genes at subtelomeric region of Plasmodium falciparum. May 7, 2025
  Contributors : Shiroh Iwanaga ; Farahana DewayantiSeries Type : OtherOrganism : Plasmodium falciparum 3D7Plasmodium falciparum expresses variant surface antigens (VSAs), including PfEMP1, RIFIN, and STEVOR, on the surface of infected red blood cells. These antigens interact with host receptors on vascular endothelial and immune cells, contributing to both pa […]
• GSE296228 The robust inflammatory responses caused by MjHKU4r-S mediated cell fusion May 7, 2025
  Contributors : Shua Xia ; Fanke Jiao ; Jing Chen ; Lijue Wang ; Tianyu Lu ; Shibo Jiang ; Lu LuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has extremely high virulence and pathogenicity in human, but some MERS-related coronaviruses (bat-CoV HKU4, bat-CoV HK […]
• GSE272914 STAT3 inhibitors synergize with KRAS G12C inhibitors in NSCLC by restricting adaptive resistance of STAT3 signaling and augmenting NK cell cytotoxicity May 7, 2025
  Contributors : Zehao Pan ; Xuming Song ; Gaochao Dong ; Feng JiangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensKRASG12C inhibitors have demonstrated clinical efficacy in KRASG12C-mutant non-small cell lung cancer (NSCLC), yet adaptive resistance limits their sustained therapeutic benefit. Through high-t […]