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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE272725 P53 dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance April 24, 2025Contributors : Xiangli Jiang ; Ali Baig ; Giuliana Palazzo ; Toman Bortecen ; Sven Groessl ; Esther Zaal ; Celia Berkers ; Cinthia A Ramirez ; Alexander Kowar ; Daniela Aviles-Huerta ; Wilhelm Palm ; Jeroen Krijgsveld ; Darjus Tscharahganeh ; Rossella Del Pizzo ; Fabricio Loayza-PuchSeries Type : OtherOrganism : Homo sapiensCellular senescence is characteriz […]
- GSE270191 Innate immunity and Nfkb pathway control prostate stem cell plasticity, reprogramming and tumor initiation April 24, 2025Contributors : Chen Jiang ; Yura Song ; Cédric BlanpainSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusProstate epithelium develops from multipotent stem cells (SCs) which are replaced in adult life by different lineage-restricted basal and luminal unipotent SCs that sustain the homeostasis in a regionaliz […]
- GSE279480 Longitudinally stable T cell and innate immune activity distinguish healthy adult immunotypes I April 24, 2025Contributors : Megan E Smithmeyer ; Alex Hu ; Matthew J Dufort ; Anne M Hocking ; Alice E Wiedeman ; Kayla J Fasano ; Troy R Torgerson ; Kxiaojun Li ; Qiuyu Gong ; S. Alice Long ; Adam Lacy-Hulbert ; Claire E Gustafson ; Jane H Buckner ; Cate SpeakeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUsing cytometric, proteo […]
- GSE275758 PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation April 24, 2025Contributors : Qi Dai ; Jiayu Wen ; Li HeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusBMP signalling acts as an instructive cue in various developmental processes such as tissue patterning, stem cell proliferation, and differentiation. However, it is not fully understood how this signalling pathway gene […]
- GSE266419 IGF2BP1 stabilizes OTX2 mRNA in an m6A-dependent manner to restrict human germ cell fate by repressing TFAP2C [m6A-seq] April 24, 2025Contributors : Jin Zhang ; Yashi Gu ; Lingling Tong ; Boshi Feng ; Ziqi Wang ; Qizhe shao ; Yanxi Chen ; Huanchang Tu ; Shenghua Dong ; Honglin Yu ; Xiang Li ; Yueqi Wang ; Ziying Lin ; Xueting Wang ; Zhipeng Ai ; Yangquan Xiang ; Peng XiaSeries Type : OtherOrganism : Homo sapiensN6-methyladenosine (m6A) is the most abundant and reversible modification on me […]
- GSE247221 Transcriptome induced by DNMT degrader in ccRCC cells April 24, 2025Contributors : Yong Wang ; Weibo LuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlobal gene changes by DNMT degrader SGI1027 in VHL-deficient ccRCC cells
- GSE293189 Histologic variants in bladder cancer share aggressive molecular features including a CA125+ cell state and targetable TM4SF1 expression April 24, 2025Contributors : Heiko Yang ; Hanbing Song ; Sima P Porten ; Franklin W HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHistologic variant (HV) subtypes of bladder cancer are clinically aggressive tumors that are more resistant to standard therapy compared to conventional urothelial carcinoma (UC). Little is known ab […]
- GSE268150 Clemastine fumarate accelerates accumulation of disability in progressive multiple sclerosis by enhancing pyroptosis. April 24, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMultiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). Clemastine fumarate, the over-the-counter antihistamine and muscarinic receptor blocker, has remyelinating potential in MS. A clemastine arm was added to an ongoing pla […]
- GSE293725 Mucinous Cystic Neoplasms of the Pancreas and Liver share a similar DNA methylation profile with mucinous ovarian tumors April 24, 2025Contributors : Mihnea P Dragomir ; Teodor G CalinaSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensMucinous cystic neoplasms (MCN) remain a major riddle in hepato-pancreato-biliary pathology. These cystic tumors are defined by their mucinous epithelium and ovarian-like stroma, with an estimated 10% risk of progression to invas […]
- GSE293449 Defining neuronal responses to the neurotropic parasite Toxoplasma gondii April 24, 2025Contributors : Hannah J Johnson ; Joshua A Kochanowsky ; Anita A KoshySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA select group of pathogens infect neurons in the brain. Prior dogma held that neurons were "defenseless” against infecting microbes, but many studies suggest that neurons can mount anti-microbial d […]
- GSE294262 TAT-CRE inhalation enables tumor induction corresponding to adenoviral Cre-recombinase in a lung cancer mouse model April 24, 2025Contributors : Tabea Gewalt ; Anna M Dmitrieva ; Felix Elsner ; Xinlei Zhao ; Daniel D Sieber ; Ilayda G Kocak ; Qian Yang ; Claudia V Orschel ; Naja M Eckert ; Bianca Goebel ; Marieke Nill ; Franziska Peter ; Arndt Hartmann ; Filippo Beleggia ; Margarete Odenthal ; Hans C Reinhardt ; Roland T Ullrich ; Frederik Graw ; Lydia MederSeries Type : Expression pro […]
- GSE294473 HIF transcriptome in clear cell renal carcinoma cells April 24, 2025Contributors : Yong Wang ; Weibo LuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlobal gene changes by HIF-1/2alpha loss or VHL expression in cancer cells
- GSE295252 Lysine Pyruvylation Mediated by HAT1/p300-SIRT3 Couples Glycolytic Flux to Epigenetic Regulation [RNA-Seq] April 24, 2025Contributors : Xiaohan Song ; Panan Peng ; Haonan Zheng ; Yanan Zheng ; Qianjing Wang ; Yu Ge ; Doudou Tan ; He HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPost-translational modifications (PTMs) serve as critical regulatory mechanisms connecting metabolism and protein functions. Following our prior discovery o […]
- GSE270189 Innate immunity and Nfkb pathway control prostate stem cell plasticity, reprogramming and tumor initiation April 24, 2025Contributors : Chen Jiang ; Yura Song ; Cédric BlanpainSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusProstate epithelium develops from multipotent stem cells (SCs) which are replaced in adult life by different lineage-restricted basal and luminal unipotent SCs that sustain the homeostasis in a regionalized manner. Del […]
- GSE292739 RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations April 24, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.