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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE243099 Lipid-laden cancer cells transmit arachidonic acids to neutrophils to acquire resistance against combined anti-PD1 and paclitaxel treatment April 8, 2025Contributors : Fengshuo Liu ; Yichao Shen ; Liqun Yu ; Xiang ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe combination of immune checkpoint blockade and chemotherapies becomes standard-of-care for triple negative breast cancer (TNBC). However, tumors with initially significant responses can still develop recu […]
- GSE171741 Albumin treatment transcriptionally reprograms circulating immune cells in patients with acutely decompensated cirrhosis April 8, 2025Contributors : Ferran Aguilar ; Joan Clària ; Juan-José Lozano ; Laura Jiménez-Gracia ; Juan C Nieto ; Holger Heyn ; Vicente Arroyo ; Richard MoreauSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBACKGROUND AND AIMS: The effects of intravenous albumin on lymphocyte perturbations and defective neutrophil anti-microbial f […]
- GSE263543 Genomic instability of Jurkat clone E6-1 T-cell lines affect gene expression and function: implications for T-cell researchers April 8, 2025Contributors : Andrew Wilson ; Rachel Beddow ; Tina Lillis ; Tom Chin ; Robert Weinkove ; Michelle McCulleySeries Type : Genome variation profiling by SNP array ; Genome variation profiling by genome tiling arrayOrganism : Homo sapiensJurkat clone E6-1 is a human T-cell line derived from a paediatric case of acute leukaemia, and is frequently employed as a m […]
- GSE255522 mRNAseq profiles of gastrocnemius of 24-day-old Nnt-wt male mouse exposed to hypoxia April 8, 2025Contributors : Jingyi Song ; Evert van Schothorst ; Jaap Keijer ; Sander GrefteSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGene expression profiles from gastrocnemius of fasted Nnt-wt male mice exposed to hypoxia (12%O2) or normoxia for 6 hours (n=12 per group). Result showed that the FOXO1 was the main transcriptio […]
- GSE265849 Effects of overexpression of MrgD on human pulmonary artery smooth muscle cells. April 8, 2025Contributor : Hongyu ZhongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMrgD is a new member of the RAS system and belongs to a group of G protein-coupled receptors. The main function of these receptors is to sense and generate itching or pain signals. In recent years, more and more cardiovascular research has been co […]
- GSE264104 A single-cell atlas of the woodchuck liver maps an immune landscape and hepatocyte zonation patterns reflective of the human liver [scRNA-seq] April 8, 2025Contributors : Zoe A Clarke ; Xinle Wang ; Jawairia Atif ; Lewis Y Liu ; Damra Camat ; Sai Chung ; Xue-Zhong Ma ; Justin Manuel ; Si Lok ; Timothy Lau ; Tomasz I Michalak ; Ian D McGilvray ; Gary D Bader ; Sonya A MacParlandSeries Type : Expression profiling by high throughput sequencingOrganism : Marmota monaxThe mammalian liver plays important roles in met […]
- GSE293756 PANCREATIC DUCTAL ADENOCARCINOMAS RESISTANT TO KRAS INHIBITION ARE DRUGGABLE WITH AN ANTI-MUC1-C ADC April 8, 2025Contributor : Hiroki OzawaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTreatment of pancreatic ductal carcinomas (PDACs) has been advanced by the development of KRAS mutant inhibitors. Despite this progress, PDACs invariably develop resistance to these agents by mechanisms that largely remain unclear. The MUC1 gene, […]
- GSE271305 RNA-sequncing in UUO-induced PTC-specific p300 knockout mouse kidneys April 8, 2025Contributors : Ho-geun Yoon ; Hyunsik KimSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusp300 was knockout in renal proximal tubule cells of mouse kidney. Mouse was sacrificed 8 days after UUO sugery
- GSE293782 Argonaute-siRNA loading via the RNA binding protein RDE-4 in C. elegans April 8, 2025Contributor : Taiowa A MontgomerySeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Caenorhabditis elegansSmall RNAs associate with Argonaute proteins to control gene expression, impacting a wide range of cellular processes, such as antiviral defense, transposon silencing, and development. Plants and animals typically have several […]
- GSE293777 A high-risk osteoarthritis mutation in COL6A3 alters the mechanobiologic response of chondrocytes derived from human induced pluripotent stem cells April 8, 2025Contributors : Harissa Zainab ; Bloks Niek ; Steward Nancy ; Tufa Sara ; Keen Doug R ; Ramos Yolande FM ; Meulenbelt Ingrid ; Guilak FarshidSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOsteoarthritis (OA) is a complex disease arising from a combination of genetic, biological, and mechanical risk factors that act, in […]
- GSE293821 SALL4 recruits BAF to activate enhancers required for cranial neural crest cell specification April 8, 2025Contributors : Martina Demurtas ; Samantha M Barnada ; Zoe H Mitchell ; Laura L Deelen ; Marco TrizzinoSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensSALL4 is a critical transcription factor involved in early embryonic development. While its role in plu […]
- GSE294011 Endometrial assembloid model reveals endometrial adenogenesis regulation by estradiol-driven WNT7B expression [bulk RNA-seq] April 8, 2025Contributors : Xintong Li ; Jianlin Li ; Cheuk L Lee ; Philip C ChiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLittle is known about the adenogenesis of human endometrial glands. This study explored endometrial adenogenesis using a novel three-dimensional endometrial assembloid model that integrates human endometri […]
- GSE294012 Endometrial assembloid model reveals endometrial adenogenesis regulation by estradiol-driven WNT7B expression April 8, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE271615 Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell [scATAC-Seq] April 8, 2025Contributors : Swarnabh Bhattacharya ; Ramesh A ShivdasaniSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusEnterocytes and four classic secretory cell types derive from intestinal epithelial stem cells. Based on morphology, location, and canonical markers, goblet and Paneth cells are considered distinct sec […]
- GSE293754 Serum exosome small RNA array analysis identifies 5'tiRNA-PheGAA and tRF-1-IleAAT as potential biomarkers for rheumatoid arthritis April 8, 2025Contributors : Yuanyuan Li ; Meiling XuSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensTo screen differentially expressed tsRNA in serum exosomes of rheumatoid arthritis (RA) patients and healthy controls and conduct bioinformatics analysis for exploring the role and potential clinical application value of tsRNAs in the pathogenesis of […]