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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE207192 Two-Stage CAR T-Cell Differentiation in Patients with Large B-Cell Lymphoma April 3, 2025Contributors : Jun Huang ; Justin P Kline ; Guoshuai Cao ; Yifei Hu ; Tony PanSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensTo investigate the CAR T-cell differentiation in vivo, we performed single-cell, multi-omics analyses of CD28-costimulated CAR T cells from patients with DLBCL who were successfully treat […]
- GSE200049 Genome-wide analysis of microRNA-mRNA gene regulatory networks reveals widespread involvement of microRNAs in visually guided eye emmetropization and myopia [miRNA sclera] April 3, 2025Contributors : Tatiana V Tkatchenko ; Andrei V TkatchenkoSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusDuring postnatal development, the optical geometry of the eye is refined through a process called emmetropization. During eye emmetropization, optical defocus triggers a signaling cascade that originates in the r […]
- GSE253894 PAX translocations remodel mitochondrial metabolism through altered leucine usage in rhabdomyosarcoma [pcHiC_HiC] April 3, 2025Contributors : Bhargab Kalita ; Gerard Martinez-Cebrian ; Brian David DynlachtSeries Type : OtherOrganism : Homo sapiensAlveolar rhabdomyosarcoma (ARMS) patients harboring PAX3-FOXO1 and PAX7-FOXO1 fusion proteins exhibit a greater incidence of tumor relapse, metastasis, and poor survival outcome, thereby underscoring the urgent need to develop effective the […]
- GSE241988 Single cell transcriptomics of several organs in K14HPV16/H2b and FVBN/H2b mice. April 3, 2025Contributors : Morgane Lecointre ; Jeremy Guillot ; Douglas Hanahan ; Rachel Marcone ; Nadine FournierSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIt is well established that symptomatic cancers evade immune destruction by coalescing lesional and tumor microenvironments to suppress adaptive immunity. Additionally, mo […]
- GSE263463 HDAC inhibitors sensitize colorectal cancer to ferroptosis via m6A modification of FSP1 April 3, 2025Contributors : Zhou Yang ; Mengying Xing ; Bing YaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFerroptosis therapy has been well-established in various cancers; however, colorectal cancer (CRC) is highly resistant to ferroptosis, which hinders the use of ferroptosis therapy in CRC. Through drug screening, we found h […]
- GSE263172 A Bacterial Artificial Chromosome system to uncover RNA Binding Protein functions in deep intronic regions [RNA-seq] April 3, 2025Contributors : Francesco Tomassoni-Ardori ; Mary E Palko ; Lino Tessarollo ; Melissa Galloux ; Bao Tran ; Yongmei Zhao ; Jyoti ShettySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe processing of long introns in alternative splicing of pre-mRNAs is still not well understood. Using bacterial artificial chromosome (BAC […]
- GSE293643 Peritoneal tumor spread in serous ovarian cancer-epithelial mesenchymal status and outcome April 3, 2025Contributor : Dietmar PilsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study we aimed to analyze the biological mechanisms underlying apparently different modes of peritoneal tumor spread in serous ovarian cancer: miliary (widespread, millet-like lesions) versus non-miliary (bigger, exophytically growing impl […]
- GSE263507 Cancer cell-secreted spermidine synthase induces skeletal muscle fibrosis upon radiotherapy (Gastrocnemius muscle) April 3, 2025Contributors : Xiaohui Zhang ; Wei YanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRadiotherapy (RT) reduces the risk of cancer recurrence and death, while accompanied by multiple side effects including muscle fibrosis and weakness, seriously affects the life quality of patients. However, the underlying mechanism is […]
- GSE293658 Potential mechanisms by which Jiawei Lianpu Yin inhibits Helicobacter pylori colonization and alleviates gastric mucosal inflammation and damage: Integrated transcriptomics, network pharmacology, and experimental validation April 3, 2025Contributors : Xinyue Zhang ; Lingyan Wang ; Lei Huang ; Guojun Cao ; Chaoqun Huang ; Yanjun Duan ; Wenliang LyuSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusEthnopharmacological relevance: Helicobacter pylori (H.pylori) infection is the leading cause of gastric mucosal damage and inflammation, and persistent inf […]
- GSE293654 Heterogeneity in Somatic Cell Nuclear Transfer Embryo Reprogramming Across Mammalian Species April 3, 2025Contributors : Weijian Li ; Xuguang WangSeries Type : Expression profiling by high throughput sequencingOrganism : Ovis ariesSomatic cell nuclear transfer (SCNT) enables the reprogramming of terminally differentiated somatic cells into a totipotent state, yet whether this process is governed by conserved mechanisms across mammalian species remains poorly und […]
- GSE293666 Identification of a Selective Pharmacologic IRE1/XBP1s Activator with Enhanced Tissue Exposure April 3, 2025Contributors : Jie Sun ; Kyunga Lee ; Sergei Kutseikin ; Adrian Guerrero ; Bibiana Rius ; Aparajita Madhavan ; Dorian A Rosen ; Leonard Yoon ; Maziar S Ardejani ; Jessica D Rosarda ; Alejandra Mendoza ; Enrique Saez ; Jeffer W Kelly ; R L WisemanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusActivation o […]
- GSE293714 Stress attenuation by the adrenergic-specific lncRNA NESPR prevents cell death in neuroblastoma cells [4C-seq] April 3, 2025Contributors : Louis Delhaye ; Pieter Mestdagh ; Eva D'haene ; Sarah Vergult ; Bjorn MentenSeries Type : OtherOrganism : Homo sapiensNeuroblastoma is a pediatric cancer of the sympathetic nervous system characterized by heterogeneous cell states that mirror normal differentiation trajectories. Each state is governed by a core regulatory transcriptional […]
- GSE293715 Stress attenuation by the adrenergic-specific lncRNA NESPR prevents cell death in neuroblastoma cells [RNA-seq] April 3, 2025Contributors : Louis Delhaye ; Dries Rombaut ; Pieter MestdaghSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNeuroblastoma is a pediatric cancer of the sympathetic nervous system characterized by heterogeneous cell states that mirror normal differentiation trajectories. Each state is governed by a core regulatory trans […]
- GSE293716 Stress attenuation by the adrenergic-specific lncRNA NESPR prevents cell death in neuroblastoma cells [ATAC-seq] April 3, 2025Contributors : Louis Delhaye ; Pieter Mestdagh ; Julliette Roels ; Pieter Van VlierbergheSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNeuroblastoma is a pediatric cancer of the sympathetic nervous system characterized by heterogeneous cell states that mirror normal differentiation trajectories. Each sta […]
- GSE293430 The impact of NR1H3 deficiency on gene expression in ovarian cancer cells April 3, 2025Contributor : Min LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNR1H3 is significantly influences cancer progression. Here, we identified the critical role of NR1H3 in the diagnosis and prognosis of ovarian cancer through bioinformatics analysis. Further functional experiments demonstrated that NR1H3 significantly p […]