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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE268527 Isolation, Structure Elucidation, and Biological Activity of the Selective TACR2 Antagonist Tumonolide and its Aldehyde from a Marine Cyanobacterium May 14, 2025Contributors : Sofia Kokkaliari ; Hendrik LueschSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensA cyanobacterium secondary metabolite was discovered and in order to determine the effect of the comnppound on transcript levels we carried out an RNAseq experiment using HCT116 colorectal carcinoma cells
- GSE275305 Chromasome accessibility profiles at single cell level of Drug-tolerant persister cells induced by targeted therapy in lung adenocarcinoma. May 14, 2025Contributors : Yang Tian ; Hideo Watanabe ; Feng JiangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensDrug-tolerant persister (DTP) stage is viewed as a major source of non-genetic drug resistance. We use single cell ATAC seq to reveal the epigenetic heterogeniety of DTP stage
- GSE274598 RNAseq analysis of human neutrophils from people with rheumatoid arthritis May 14, 2025Contributor : Helen L WrightSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe report gene expression profiles of blood neutrophils from (1) people newly-diagnosed with rheumatoid arthritis (early RA) before commencement of disease-modifying anti-rheumatic drug therapy, (2) DMARD-refractory RA (severe RA) before commenc […]
- GSE228749 Novel ex vivo culture of purified mouse mesenchymal stromal cells reveals tissue-dependent niche heterogeneity in bone marrow and functional interaction with macrophages May 14, 2025Contributors : Yuko Kawano ; Hiroki Kawano ; Stephanie Busch ; Allison J Li ; Noah A Salama ; Emily R Quarato ; Chunmo Chen ; Mary Georger ; Mitra Azadniv ; Daniel K Byun ; Elizabeth A LaMere ; Mark W LaMere ; Jane L Liesveld ; Michael W Becker ; Laura M CalviSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMesenchymal s […]
- GSE276059 Complete Remission with Conventional Chemoradiotherapy in Radiation-Induced Glioma Harboring Co-amplification of PDGFRA, KIT, and KDR: A Case Report and Literature Review May 14, 2025Contributor : Mitsuaki ShirahataSeries Type : Methylation profiling by arrayOrganism : Homo sapiensBackground: One of the most serious complications of cranial radiotherapy is the development of radiation-induced glioma, which is estimated to occur in 1 to 4% of patients who have received cranial irradiation and has a worse prognosis than sporadic glioblasto […]
- GSE254925 RARa restrains CD8 T cell effector program [scRNA-seq] May 14, 2025Contributors : Chang Kim ; Patrick NiekampSeries Type : Expression profiling by high throughput sequencingOrganism : MusScRNA-seq for tumor-bearing RARα-KO, or RARα-TG mice bearing MC38 tumors was performed.
- GSE245826 Metastatic site influences driver gene function in pancreatic cancer [scMultiome] May 14, 2025Contributors : Kaloyan M Tsanov ; Yu-Jui Ho ; Scott W LoweSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusDriver gene mutations can increase the metastatic potential of the primary tumor, but their role in sustaining tumor growth at metastatic sites is p […]
- GSE296877 Unexpected combination of increased protein translation and decreased endoplasmic reticulum stress during pancreatic cancer initiation May 14, 2025Contributors : Maxime Libert ; Sophie Quiquempoix ; Leyre Lopez ; Christiane Zorbas ; Ludivine Wacheul ; Sabine Cordi ; Denis Lafontaine ; Patrick JacqueminSeries Type : OtherOrganism : Mus musculusBackground & Aims: Tumorigenesis is usually associated with increased protein synthesis rates coupled with increased endoplasmic reticulum (ER) stress. In the […]
- GSE296541 2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction May 14, 2025Contributors : Harshita Kaul ; Aleksandra TrifunovicSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMitochondria play a crucial role in regulating cellular homeostasis in response to intrinsic and extrinsic cues by changing cellular metabolism to meet these challenges. However, the molecular underpinnings […]
- GSE297027 Abundance of tRNA fragments in Tau-RNA complexes from Tau-mutant PS19 (human P301S Tau transgenic) mice hippocampus May 14, 2025Contributor : Ami KobayashiSeries Type : Non-coding RNA profiling by arrayOrganism : Mus musculusWe report the binding between tRNA fragments and Phosphorylated Tau pS396 from the hippocampus of WT controls and Tau-mutant PS19 (human P301S Tau transgenic) mice. We show tRNA fragments abundance in Tau-RNA complexes changes between the two groups. Specific tRN […]
- GSE296926 Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants II May 14, 2025Contributors : Jiekun Yang ; Genevieve M Boland ; Manolis KellisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCD38, an ecto-enzyme involved in NAD+ catabolism, is highly expressed in exhausted CD8+ T cells and has emerged as an attractive target to improve response to immune checkpoint blockade (ICB) by blunting T cel […]
- GSE297031 Metastatic site influences driver gene function in pancreatic cancer [scRNA-seq] May 14, 2025Contributors : Kaloyan M Tsanov ; Yu-Jui Ho ; Scott W LoweSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDriver gene mutations can increase the metastatic potential of the primary tumor, but their role in sustaining tumor growth at metastatic sites is poorly understood. A paradigm of such mutations is inactivation of S […]
- GSE297097 The ImmgenT Open-Source project May 14, 2025Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE297168 Histone ChIP-Seq of B16-F10 melanoma cell lines (mouse) May 14, 2025Contributors : Jacob L Edmondson ; Megan R Reed ; Daniel Fil ; Billie Heflin ; Alyson McKinnon ; Michael A Bauer ; Nathan L Avaritt ; Mary Phillips ; Sean D Taverna ; Alan J Tackett ; Brian KossSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusUnleashing the immune anti-tumor response through immune checkpoi […]
- GSE267462 Gene expression profiles at single cell level of CD4 T Cells infected with HIV Nano Cre May 14, 2025Contributors : Donald V Doanman ; Gerrit Schmidt ; Benjamin K ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo study the mechanisms of early HIV latency establishment, we used EHILT to infect primary CD4+ T cells and test the ability of the system to track similar EHILT phenotypes in primary CD4+ T cells