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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE216828 MATRIN3 deficiency leads to cGAS-STING activation (PAR-CLIP) October 28, 2025Contributors : Zohir Islam ; Bryan Chim ; Amir K Foroushani ; Stefan MuljoSeries Type : OtherOrganism : Homo sapiensTo explore the role of MATR3 as an RNA-binding protein, we performed Photoactivatable-Ribonucleotide-Enhanced Crosslinking and Immunoprecipitation (PAR-CLIP) of MATR3 in HAP1 cells, together with a MATR3 KO negative control.
- GSE160348 Genome-wide transcriptional profiling of Bacillus subtilis in response to Hermetia illucens larvae extract October 28, 2025Contributors : Qian Zhang ; Diana Wolf ; Thorsten MascherSeries Type : Expression profiling by high throughput sequencingOrganism : Bacillus subtilisThe black soldier fly, Hermetia illucens, is a promising source for sustainable production of proteins, lipids and bioactive substances. Feeding on a variety of decomposing organic substrates which are typically […]
- GSE267767 Myeloid lineage (CD45+ CD11b+ cells) analysis sorted from stromal vascular fraction of visceral and subcutaneous adiposetissue in mice in different diet conditions or after rosiglitazone treatment October 28, 2025Contributor : Yun LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusUnlike visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) can play a protective role against the development of insulin resistance and metabolic dysfunction in obesity. These changes are associated with higher induction of pro-inflammator […]
- GSE217011 Comprehensive analysis of transcriptome-wide N6-methyladenosine methylomes in the rat Barrett’s esophagus October 28, 2025Contributors : Ke Zou ; Hui Dong ; Meng-Meng Li ; Ying ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusTo investigate the mRNA m6A modification pattern in Barrett’s esophagus,we performed transcriptome-wide maps of m6A methylation，foreseeing a molecular mechanism of m6A-mediated gene in Barrett’s esophagus. […]
- GSE280107 Single cell RNA sequencing analysis of native fat tissue, RMF pallets, and expanded ADSCs October 28, 2025Contributors : Ru-Lin Huang ; Jing Yang ; Xiya Yin ; Kang Zhang ; Qingfeng LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensObjectives: 1. To explore cell population changes after a 4-week in vitro self-reaggregation culture, comparing RMF pellets, native fat tissue, and expanded ADSCs.2. To analysis the cellular compo […]
- GSE269489 Effects of dexamethasone stimulation on gene expression in human trabecular meshwork cells October 28, 2025Contributors : Yang Zhang ; Ruiqi Han ; Shushu Xu ; Bingqiao Shen ; Huan Yu ; Junjue chen ; Huiping Yao ; Shouyue Huang ; Yisheng ZhongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe changes in the trabecular meshwork in steroid-induced glaucoma are similar to those in human primary open-angle glaucoma. To explore t […]
- GSE280808 TNFR2 blockade promotes anti-tumoral immune response in PDAC by targeting activated Treg and reducing T cell exhaustion October 28, 2025Contributors : Caroline Pilon ; Wilfrid Richer ; José Cohen ; Ilaria CasconeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, highly resistant to standard chemotherapy and immunotherapy. Regulatory T cells (Tregs) expressing TNFα receptor 2 (TN […]
- GSE296532 Prevotella copri facilitates wound healing in mice through the sphingosine-CerS1-ceramide metabolic pathway October 28, 2025Contributor : Hailiang LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSkin wound repair constitutes a sophisticated biological process involving spatiotemporally coordinated molecular cascades, with emerging evidence highlighting the dynamic regulatory role of skin microbiota. Utilizing a broad-spectrum antibiotic-t […]
- GSE280842 Developing exocrine glands harbour a distinct macrophage population that is maintained by ILC2 derived GM-CSF [scRNA-seq] October 28, 2025Contributors : Frederike Westermann ; Selma Tuzlak ; Victor Kreiner ; Burkhard BecherSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGranulocyte-macrophage colony-stimulating factor (GM-CSF) has a non-redundant role in the emergence and maintenance of alveolar macrophages (AMs). However, its role in steady-state myelopo […]
- GSE280841 Developing exocrine glands harbour a distinct macrophage population that is maintained by ILC2 derived GM-CSF [bulk RNA-seq] October 28, 2025Contributors : Frederike Westermann ; Selma Tuzlak ; Victor Kreiner ; Burkhard BecherSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGranulocyte-macrophage colony-stimulating factor (GM-CSF) has a non-redundant role in the emergence and maintenance of alveolar macrophages (AMs). However, its role in steady-state myelopo […]
- GSE280882 Developing exocrine glands harbour a distinct macrophage population that is maintained by ILC2 derived GM-CSF [CD45 scRNA-seq] October 28, 2025Contributors : Frederike Westermann ; Selma Tuzlak ; Victor Kreiner ; Burkhard BecherSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGranulocyte-macrophage colony-stimulating factor (GM-CSF) has a non-redundant role in the emergence and maintenance of alveolar macrophages (AMs). However, its role in steady-state myelopo […]
- GSE293712 Piwi-piRNA complex-mediated silencing of transposable elements through transcription termination October 28, 2025Contributors : Kensaku Murano ; Yaning Wu ; Toshiya NakaharaSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterPiwi protein, guided by Piwi-interacting RNA (piRNA), establishes sequence-specific heterochromatin on transposable elements (TEs) in a […]
- GSE295057 Impacts of DNA methylation on H2A.Z deposition and nucleosome stability October 28, 2025Contributors : Rochelle M Shih ; Yasuhiro Arimura ; Hide A Konishi ; Hironori FunabikiSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Methylation profiling by high throughput sequencingOrganism : Xenopus laevisDNA methylation and the histone variant H2A.Z are maintained in mutually exclusive sections of the genome. How this a […]
- GSE160347 Transcriptomic study of Bacillus subtilis lacking seven extracytoplasmic function (ECF) σ factors October 28, 2025Contributors : Qian Zhang ; Diana Wolf ; Thorsten MascherSeries Type : Expression profiling by high throughput sequencingOrganism : Bacillus subtilisBacillus subtilis encodes seven extracytoplasmic function (ECF) σ factors, σM, σW, σX, σY, σZ, σV and σYlaC, that mediate response to cell envelop-active compounds. In this study, we aimed to define the transcri […]
- GSE280364 Activin-A production by recruited alveolar macrophages exacerbates pulmonary fibrosis following acute lung injury October 28, 2025Contributor : Ting PanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Acute respiratory distress syndrome (ARDS) is a complicated pathological cascade process of excessive pulmonary inflammation and alveolar epithelial cells apoptosis which results in respiratory dysfunction and failure. Some ARDS can result […]