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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE274855 APOBR is downregulated in EBV+ tonsils of children with obstructive sleep-disordered breathing October 31, 2025Contributor : Regie Santos-CortezSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensObstructive sleep-disordered breathing (oSDB) is a heterogeneous phenotype that is increasing in prevalence worldwide and has many potential co-morbidities that could severely affect quality of life. There is a need to identify biomarkers f […]
- GSE278799 Extracellular matrix glycation epigenetically regulates brain aging and neurodegeneration in the in vitro aged neurovascular model October 31, 2025Contributors : Minjeong Jang ; Hong Nam KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAdvanced glycation end-products (AGEs) accumulate in brain tissue with as we age, co-localizing with amyloid β and tau in the brains of elderly and Alzheimer’s disease patients. However, the link between increased AGE levels, agin […]
- GSE278292 Nuclear body reorganization by the viral RNA kaposin promotes Kaposi-sarcoma associated herpesvirus gene expression October 31, 2025Contributors : Jennifer A Corcoran ; Mariel Kleer ; Michael J JohnstonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Human gammaherpesvirus 8Kaposin is the most abundantly expressed viral RNA in tumours caused by the oncogenic virus Kaposi-sarcoma associated herpesvirus (KSHV); however, its role in viral replication […]
- GSE217660 Glioma immune microenvironment associated with malignant transformed cells Transcriptome sequencing October 31, 2025Contributors : Xiangtong Xie ; Ke Yan ; Xifeng Fei ; Chungang Dai ; Jie Wu ; Hanchun Chen ; Dongyi Jiang ; Haifeng Zhao ; Donghua Gu ; Wenyu Zhu ; Zhimin Wang ; Qiang HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRibonucleic acid sequencing (RNA-seq) of ihCTC, C12, ihDCTC, ihSTC-BM, precursor mesenchymal stem cel […]
- GSE278824 miR_122 Knockout mice October 31, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE252789 Multi-omics based dynamic molecular changes characterization in EV-A71-infected mice elucidating potential therapeutic targets October 31, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo explore the mechanisms underlying the pathogenesis of EV-A71 infection and to identify new therapeutic opportunities, we performed comprehensive proteogenomic characterization of the muscle tissue of BALB/c mice infected with EV-A71, including transcriptomic, proteomic […]
- GSE246071 Quantitative transcriptome N6-methyladenosine profiling reveals the mechanism of far-red regulated anthocyanin homeostasis in Arabidopsis October 31, 2025Contributors : Shun Liu ; Bochen Jiang ; Mengjie Chen ; Chuan HeSeries Type : Methylation profiling by high throughput sequencingOrganism : Arabidopsis thalianaN6-methyladenosine (m6A) is the most abundant messenger RNA modification in higher eukaryotes. Functional studies of the RNA m6A modification in plants have been limited by mapping individual m6A-modi […]
- GSE307469 Bulk RNA sequencing for gene expression profiling of iPSC-derived liver sinusoidal endothelial cells treated with Antithymocyte globulin compared with normal rabbit IgG October 31, 2025Contributors : Shuntaro Kawamura ; Yosuke Yoneyama ; Norikazu Saiki ; Takanori TakebeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAntithymocyte globulin (ATG) is a widely used immunosuppressive agent, yet its off-target vascular effects remain a clinical challenge in part due to a lack of relevant human models. To el […]
- GSE307468 Bulk RNA sequencing for gene expression profiling of iPSC-derived liver sinusoidal endothelial cells and arterial endothelial cells October 31, 2025Contributors : Shuntaro Kawamura ; Norikazu Saiki ; Takanori TakebeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLiver sinusoidal endothelial cells (LSECs) line liver sinusoids and regulate exchanges between blood and liver tissue, while maintaining hepatic vascular homeostasis through coagulation control, immune cell […]
- GSE308226 RBMXL3 binds a wide range of RNA molecules in human TCam-2 cells (eCLIP data) October 31, 2025Contributors : Natalia Rozwadowska ; Agata Barszcz ; Erik DassiSeries Type : OtherOrganism : Homo sapiensRBMXL3 is a primate-specific gene localized on the X chromosome, which expression is detectable mainly in the male gonad. So far, very little is known about RBMXL3 protein function and its molecular network but recent reports mention the RBMXL3 gene in th […]
- GSE307622 Western Diet-induced Visceral Adipose Tissue Inflammation Promotes Alzheimer's Disease Pathology via Microglial Activation in a Mouse Model October 31, 2025Contributors : Soyoung Kwak ; Hae Won Kim ; Ji Sun Lim ; Jeong-Ho Hong ; Mi-Hee Yu ; Mee-Na Park ; Junho KangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntroduction: Western diet (WD)-induced visceral adipose tissue (VAT) inflammation is characterized by adipocyte hypertrophy, hypoxia, and apoptosis. Epididymal whi […]
- GSE308336 PFOA impairs host immune response in viral infection October 31, 2025Contributors : Wang Hui ; Liang Yuejin ; Firose KhanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed scRNAseq on spleen cells pooled from 4 mice per group using the 10x Genomics scRNA-seq Flex assay, following the protocol outlined by the Chromium Fixed RNA Profiling Reagent Kit. Single cell sequencing of sp […]
- GSE308620 Effects of TCDCA-FXR on obesity-induced endothelial dysfunction and hypertension October 31, 2025Contributors : Wencheng Zhang ; Hanlin LuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRegarding the role of TCDCA in alleviating obesity-induced ED, we sought to identify the key targets that could directly clarify the biological effects of TCDCA. We carried out RNA-seq of human umbilical vein endothelial cells (HUVE […]
- GSE308621 Effects of TCDCA-FXR on obesity-induced endothelial dysfunction and hypertension II October 31, 2025Contributors : Wencheng Zhang ; Hanlin LuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRegarding the role of TCDCA in alleviating obesity-induced ED, we sought to identify the key targets that could directly clarify the biological effects of TCDCA. We carried out RNA-seq of human umbilical vein endothelial cells (HUVE […]
- GSE267157 Effect of HIPK3 depletion in tamoxifen-resistant EGFR-overexpressing MCF7 breast cancer cells October 31, 2025Contributors : Bob van de Water ; Lynn Wester ; Peter Bouwman ; Vera van der NoordSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOverexpression and activation of EGFR in breast cancer can cause resistance to antiestrogen treatmen. Using high-throughput screening, we have identified HIPK3 as a mediator of tamoxifen resi […]