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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE315117 Gene expression changes in Ube2i-deleted mouse uterus on postnatal day 21 (PND21). December 30, 2025Contributor : Ji-Long LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe specifically deleted Ube2i in the female reproductive tract using the Pgr-Cre driver. To portray the molecular mechanism for Ube2i function in uterus, uterine tissues were collected from Ube2i f/f and Ube2i d/d mice on PND21 and subjected to RNA […]
- GSE299582 Transcriptome analysis of circulating microRNAs associated with Chagas disease susceptibility and chronic Chagas cardiomyopathy severity December 30, 2025Contributors : Eric H Roma ; Fabielle Marques-Santos ; Alinne R Rezentti ; Luciana F Portela ; Filipe P da Costa ; Alejandro M Hasslocher-Moreno ; Marcelo T de Holanda ; Luiz H Sangenis ; Andréa R da Costa ; Joseli Lannes-Vieira ; Tania C Araujo-Jorge ; Roberto R Ferreira ; Roberto M Saraiva ; Maria G Bonecini-AlmeidaSeries Type : Non-coding RNA profiling by […]
- GSE247823 RNA-seq for the soybean nodule December 30, 2025Contributors : Cuiyue Liang ; Jiang Tian ; Tianqi WangSeries Type : Expression profiling by high throughput sequencingOrganism : Glycine maxTo uncover the underlying molecular mechanisms of nodule by Bac.B and Bra.Q2 co-inoculation, a transcriptome analysis was performed. Compared to the individual inoculation of Bra.Q2, the co-inoculation of Bac.B and Bra.Q […]
- GSE224843 Sex-(in)dependent Signatures of Estrogen Exposure: Transcriptomic, Morphological, and Histological responses in Embryonic Japanese Quail (Coturnix japonica) December 30, 2025Contributors : Yeon-Seon Jeon ; Ejimedo Madogwe ; Emily Boulanger ; Raj Duggavathi ; Doug Crump ; Jessica HeadSeries Type : Expression profiling by high throughput sequencingOrganism : Coturnix japonicaThe present study aims to assess the importance of sex in designing toxicological experiments that are based on avian early-life stage tests and transcriptomi […]
- GSE282360 Adaptability of Cobetia marina to growth at different temperatures December 30, 2025Contributors : M A Dinamarca ; Claudia Ibacache-Quiroga ; Karoll González-Pizarro ; Ignacio Plaza González ; Milan StehlíkSeries Type : Expression profiling by high throughput sequencingOrganism : Cobetia marinaThe bacteria Cobetia marina is globally distributed in different oceanic ecosystems and is able to grow in a wide range of temperatures from 0°C to 4 […]
- GSE269328 Glucagon receptor agonism and treatment withdrawal effect on liver transcriptomes of diet-induced obese mice December 30, 2025Contributors : Shelly R Nason ; William C Roell ; Kirk M Habegger ; Scot J MatkovichSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGlucagon is historically viewed as the main counter-regulatory hormone to insulin in glucose homeostasis. Although chronic glucagon receptor (GCGR) agonism induces hyperglycemia and glucose […]
- GSE315057 Single-cell transcriptomics reveals tissue architecture in breast carcinosarcoma December 30, 2025Contributor : Meiling WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBreast carcinosarcoma is a rare and highly aggressive subtype of metaplastic breast cancer.Single-cell RNA sequencing revealed a heterogeneous cellular ecosystem within breast carcinosarcoma.
- GSE285538 The Role of CDCP1 in Carotid Artery Stenosis: Implications for Mitochondrial Autophagy and Therapeutic Potential of 8-isopentenylnaringenin December 30, 2025Contributor : Xin JiSeries Type : Expression profiling by high throughput sequencingOrganism : RattusCarotid artery stenosis (CAS) is a major cause of cardiovascular diseases, such as myocardial infarction and stroke. Mitochondrial dysfunction can trigger the onset of these conditions. CUB Domain Containing Protein 1 (CDCP1) is a transmembrane protein that h […]
- GSE315111 Chromatin accessibility and transcriptome in human neuronal model exposed to Parkinson's environmental toxins [RNA-Seq] December 30, 2025Contributors : Jingchao Hong ; Juanjuan HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensParkinson's disease is a complex neurodegenerative disorder where environmental factors play a predominant role in sporadic cases. While environmental toxins are implicated in PD pathogenesis via epigenetic pathways, the sp […]
- GSE315059 The cytokine receptor Fn14 is a molecular brake on neuronal activity that mediates circadian function in vivo December 30, 2025Contributors : Austin Ferro ; Dominic J Vita ; Trevor Fallon ; Anosha Arshad ; Leah Boyd ; Tess Stanley ; Qianyu Lin ; Adrian Berisha ; Uma Vrudhula ; Adrian M Gomez ; Irene Sanchez-Martin ; Jeremy C Borniger ; Lucas CheadleSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo survive, organisms must adapt to a staggering […]
- GSE315113 Chromatin accessibility and transcriptome in human neuronal model exposed to Parkinson's environmental toxins [ATAC-Seq] December 30, 2025Contributors : Jingchao Hong ; Juanjuan HuangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensParkinson's disease is a complex neurodegenerative disorder where environmental factors play a predominant role in sporadic cases. While environmental toxins are implicated in PD pathogenesis via epigenetic pa […]
- GSE315114 Gene expression data of distal colon mucosa from young and old human December 30, 2025Contributors : Tingyi Sun ; Deshan ZhouSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe disruption of the mucosal barrier of the digestive tract is a common pathological change in the elderly, which often causes inflammatory bowel disease among old people. Given that RNA molecules are dysregulated in numerous diseases, we performed high‑ […]
- GSE315116 Gene expression changes in UBE2I-knockdown primary human endometrial stromal cells (hESCs) compared to control cells December 30, 2025Contributor : Ji-Long LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo portray the molecular mechanism for UBE2I function in hESCs, cell treated with siUBE2I and siNC were subjected to RNA-seq analysis.
- GSE291085 Transcriptomic Profiling of Kinase Inhibitor Treated Cancer Cell Lines Reveals Insights into Drug Response Mechanisms December 30, 2025Contributor : [contributor] Gujral Lab gujrallab@fredhutch.orgSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensProtein kinases regulate essential cellular processes, including growth, differentiation, and apoptosis, and their dysregulation is implicated in cancer progression. Kinase inhibitors have emerged as critical th […]
- GSE315048 RNA Sequencing of 16D Prostate Cancer Cell Lines with genetic knockout and rescue of OGDHL December 30, 2025Contributors : Andrew Goldstein ; Matthew BernardSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe goal of this study was to perform transcriptomics of prostate cancer cells with genetic knockout and rescue of OGDHL treated with the Androgen Receptor Pathway Inhibitor Enzalutamide (Enza) or Vehicle (DMSO)