Quick Links : Search PubMed , Finding Full Text , PubMed Advanced Search , Clinical Queries , Single Citation Matcher , FAQs & User Guide , Explore MeSH Database , Explore PubMed Journals
Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE195644 A novel conserved transcription factor Mycth_90344 regulates cellulase genes expression through controlling the Hac-1 and Cbh-1 in thermophilic fungus Myceliophthora thermophila January 28, 2025Contributors : Qian Liu ; Defei Liu ; Chaoguang TianSeries Type : Expression profiling by high throughput sequencingOrganism : Thermothelomyces thermophilus ATCC 42464In thermophilic fungi, work on the ER stress and UPR signalling is largely unknown,we here identified a new Cys2His2 transcription factor and found its knockout strain with significantly decrea […]
- GSE223949 High throughput sequencing of small cell lung cancer chemosensitive H69 and corresponding chemoresistant H69AR January 28, 2025Contributors : Yueqin Sun ; Weitao Shen ; Shulu Hu ; Qiong LyuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSmall cell lung cancer (SCLC) is the most aggressive subtype of lung cancer. Although most patients are initially sensitive to first-line chemotherapy with combined cisplatin and etoposide, chemotherapy drugs re […]
- GSE197125 Identification and characterization of circular RNAs in the A549 cells following Influenza A virus infection January 28, 2025Contributors : Ming Duan ; Yidi Guo ; Xiaohang Yu ; Ning Su ; Ning ShiSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensTo identify the dysregulated circRNAs expression during IAV infection, A549 cells were inoculated with PR8 (MOI = 2) and harvested at 24 h p.i., while uninfected samples were regarded as controls. Subsequently the high-t […]
- GSE248669 Single-cell characteristics of longitudinal immune profiling in subjects with breakthrough infections caused by Omicron BA.5 sublineages January 28, 2025Contributors : George F Gao ; Yanhua Li ; Shijie Qin ; Lei DongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground Omicron subvariants have led to millions of coronavirus disease 2019 (COVID-19) cases worldwide. Although Omicron breakthrough infections (BTIs) exhibit lower hospitalization rates than previous vari […]
- GSE237839 RNA profiling of lung endothelial cells of mice under normal and high fat diet (HFD). January 28, 2025Contributors : Marta Hergueta ; Osvaldo Graña-Castro ; Hector PeinadoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn order to analyze the genes and molecular pathways modulated by diet in the lungs of mice under DIO model, we performed RNA-seq on CD45-, CD31+ lung endothelial cells from mice under HFD, and compared t […]
- GSE262445 Inhibiting CXCR4 Attenuates TOX-Programmed Exhausted Phenotype of CD8+ T cells via Regulating JAK2/STAT3 Pathway [scRNA_VDJ-seq] January 28, 2025Contributors : Canhui Cao ; Miaochun Xu ; Ye Wei ; Ting Peng ; Shitong Lin ; Xiaojie Liu ; Yashi Xu ; Tian Chu ; Shiyi Liu ; Bai Hu ; Wencheng Ding ; Li Li ; Ding Ma ; Peng WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusT-cell exhaustion (Tex) phenotype has limited the efficacy of single-agent immune checkpoint block […]
- GSE255182 Inhibiting CXCR4 Attenuates TOX-Programmed Exhausted Phenotype of CD8+ T cells via Regulating JAK2/STAT3 Pathway January 28, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE286504 Serum and Tear Autoantibodies from NOD and NOR Mice as Potential Diagnostic Indicators of Local and Systemic Inflammation in Sjögren's Disease [MCF_SSK_546] January 28, 2025Contributors : Shruti S Kakan ; Yaping Ju ; Maria Edman ; Indu Raman ; J A Mackay ; Prithvi Raj ; Sarah Hamm-AlvarezSeries Type : Protein profiling by protein arrayOrganism : Mus musculus ; blank sampleSjögren's Disease (SjD) is an autoimmune disease characterized by lymphocytic infiltration of salivary and lacrimal glands (LG). The LG produces the prot […]
- GSE286503 Serum Autoantibodies from NOD Mice as Potential Diagnostic Indicators of Local and Systemic Inflammation in Sjögren's Disease [IgG_MCF_SH_179] January 28, 2025Contributors : Yaping Ju ; Maria Edman ; Chengsong Zhu ; Indu Raman ; J A Mackay ; Prithvi Raj ; Sarah Hamm-AlvarezSeries Type : Protein profiling by protein arrayOrganism : Mus musculus ; blank sampleMale Non-Obese Diabetic (NOD) mice develops autoimmune dacryoadenitis beginning 6-8 weeks of age including lymphocytic infiltration of the lacrimal glands, red […]
- GSE287567 Global gene expression profiling of circulating endothelial cells in SARS-CoV-2-infected cynomolgus macaques January 28, 2025Contributors : Hyewon Chung ; Seung Hyeok SeokSeries Type : Expression profiling by high throughput sequencingOrganism : Macaca fascicularisVascular disruption caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to elevated levels of circulating endothelial cells (CECs); however, the role of CECs in SARS-CoV-2 remains uncharacterized […]
- GSE287274 A super-enhancer actuated by heterodimerization of a specific YAP1 splicing variant, YAP1-2α, with TAZ endows cancer stemness and drug resistance January 28, 2025Contributors : Takuya Ooki ; Masanori HatakeyamaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCancer cells with homologous recombination defects are particularly susceptible to PARP inhibitors (PARPi) and experience synthetic lethality. We found that the development of PARPi resistance in these cancer cells is associa […]
- GSE287836 Next Generation Sequencing of OVA-treated MutuDC Transcriptome January 28, 2025Contributors : Yaxin Liu ; Zhongfei Ma ; Xuetao CaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe goal of this study is to get the profile of the OVA-treated MutuDC transcriptome. Based on the dada of transcriptome, we processed our sgRNA sequencing data of genome-wide CRISPR/Cas9 screening. Briefly, after we have […]
- GSE287958 Canonical prolactin signaling and global mRNA expression in the skin of Holstein heifers carrying the SLICK1 allele of the prolactin receptor gene. January 28, 2025Contributors : Montana D Altman ; Alice T Mathews ; M Belen Rabaglino ; Russell C Hovey ; Anna C DenicolSeries Type : Expression profiling by high throughput sequencingOrganism : Bos taurusThe SLICK1 allele of the prolactin receptor gene (SLICK1) is associated with a short hair coat and thermotolerance in cattle. SLICK1 includes a single base pair deletion t […]
- GSE288150 Pro-inflammatory Pathways Contribute to Pathogenesis of Clostridioides difficile Infection in a Murine Model - A Spatial Transcriptomics Study January 28, 2025Contributors : Niloufar Ghahari ; Ahmed AbdelKhalek ; Sanjeev Narayanan ; Deepti PillaiSeries Type : OtherOrganism : Mus musculusClostridioides difficile (C. difficile) is a common cause of antibiotic-induced diarrhea and causes the highest number of nosocomial infections. Only two antibiotics are currently recommended for treating C. difficile infection (CD […]
- GSE263607 Cardiac Organoids for Cardiomyopathy January 28, 2025Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.