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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE270438 Single-cell RNA-seq reveals immune cell heterogeneity and increased Th17 cells in keloid January 6, 2025Contributor : ChengCheng DengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe immune response is postulated to exert a pivotal role in the occurrence and progression of keloid. In recent years, the impact of the peripheral immune microenvironment on keloid has garnered significant attention in scholarly investigation […]
- GSE268554 Single-cell joint analysis of DNA oxidative damage and transcriptome [Hela paired damage] January 6, 2025Contributors : Dongsheng Bai ; Zhenkun Cao ; Chenxu ZhuSeries Type : Other ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe used a new technology, named Paired-Damage, to perform simultaneous profiling of DNA oxidative damage and transcriptome on Hela cells and mouse cortex at single-cell level. We also performed ma […]
- GSE193227 Mapping the genomic occupancy by flag-tagged APOBEC3B protein January 6, 2025Contributors : Chi Zhang ; Yu-jing Lu ; Jianbin Yan ; Bingjie Chen ; Konstantinos Mitsopoulos ; Marcello Totoricci ; Olivia Rossanese ; Paul A Clarke ; Paul WorkmanSeries Type : Other ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensApolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3B) is a key m […]
- GSE285876 DNA methylation analysis of HepG2 cells overexpressing DNMT3A January 6, 2025Contributors : Yang Liu ; Xumeng Wang ; Yuetong Li ; Xin Yu ; Yanping Zhang ; Changlong Bi ; Aixia ZhaiSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensChronic hepatitis B virus (HBV) infection is the main etiology of liver fibrosis (LF), leading to cirrhosis and liver tumors. DNA methylation caused by HBV protein chang […]
- GSE243185 Activation of the imprinted Prader-Willi Syndrome locus by CRISPR-based epigenome editing [RNA-seq] January 6, 2025Contributors : Dahlia Rohm ; Charles A GersbachSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEpigenome editing with DNA-targeting technologies such as CRISPR-dCas9 can be used to dissect gene regulatory mechanisms and potentially treat associated disorders. For example, Prader-Willi Syndrome (PWS) is caused by loss of […]
- GSE193231 RNA-seq of T-47D cells treated with 17-beta-estradiol and/or APOBEC3B-targeting siRNA January 6, 2025Contributors : Chi Zhang ; Yu-jing Lu ; Jianbin Yan ; Bingjie Chen ; Konstantinos Mitsopoulos ; Marcello Totoricci ; Olivia Rossanese ; Paul A Clarke ; Paul WorkmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensApolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3B, A3B) is a key molecular driver i […]
- GSE285305 Activation of the imprinted Prader-Willi Syndrome locus by CRISPR-based epigenome editing [ATAC-seq] January 6, 2025Contributors : Dahlia Rohm ; Charles A GersbachSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensEpigenome editing with DNA-targeting technologies such as CRISPR-dCas9 can be used to dissect gene regulatory mechanisms and potentially treat associated disorders. For example, Prader-Willi Syndrome (PWS) is cau […]
- GSE263935 Differential regulation of brain microvessel transcriptome and brain metabolome by Western and heart-healthy dietary patterns in Ossabaw pig January 6, 2025Contributors : Gloria Solano-Aguilar ; Gregory Matuszek ; Nirupa R Matthan ; Alice H Lichtenstein ; Xuedi Wang ; Sukla Lakshman ; Kathryn Barger ; Joseph F Urban ; Aleksey Molokin ; Rachel E Bennett ; Bradley T Hyman ; Stefania Lamon-FavaSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaDiet is a potentially modifiable neur […]
- GSE285535 The m6A Demethylase ALKBH5 Maintains Stemness and Therapeutic Resistance of Glioblastoma Stem Cells [Polysome-seq] January 6, 2025Contributors : TianZhi Huang ; Xiaobing Jiang ; Xuan WangSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensOne prevalent modification, N6-methyladenosine (m6A), is a dynamic and reversible process regulated by methyltransferases (the "writers"), demethylases (the "erasers"), and m6A-binding pro […]
- GSE285506 Single cell transcriptomic changes in the THY-Tau22 mouse model of Alzheimer's disease at 17 months of age January 6, 2025Contributors : Muhammad Ali ; Pierre Garcia ; Laetitia P Lunkes ; Alessia Sciortino ; Melanie Thomas ; Tony Heurtaux ; Kamil Grzyb ; Rashi Halder ; Alex Skupin ; Luc Buée ; David Blum ; Manuel Buttini ; Enrico GlaabSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlzheimer's disease (AD) displays sex-specific differ […]
- GSE285734 Lactylated histone promotes rheumatoid arthritis progression by increasing NFATc2 expression and the production of anti-lactylated histone autoantibodies [II] January 6, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe elevated lactate in the joint microenvironment of patients with rheumatoid arthritis (RA) is crucial for disease progression, although the underlying mechanism remains to be elucidated. In this study, we observed significantly increased global lactylation levels within […]
- GSE285752 Transcriptomic Analysis of Asthma from The Asthma BioRepository for Integrative Genomic Exploration (Asthma BRIDGE) Project January 6, 2025Contributors : Benjamin A Raby ; Vincent CareySeries Type : Expression profiling by arrayOrganism : Homo sapiensMicroarray gene expression analysis of various cell types was performed. Gene expressions were compared between patients with asthma and the control groups.
- GSE285819 Whole-transcript expression array analysis of intestinal epithelial cells from vehicle, TNBS-induced colitis BALB/cJ mice treated with vehicle or I3C January 6, 2025Contributors : Manikandan Palrasu ; Philip Brandon Busbe ; Mitzi Nagarkatti ; Prakash NagarkattiSeries Type : Expression profiling by arrayOrganism : Mus musculusWhole-transcript expression array analysis of intestinal epithelial cells from TNBS-induced colitis mice treated with vehicle or I3C demonstrated several differentially expressed genesDownregulation […]
- GSE268552 Single-cell joint analysis of DNA oxidative damage and transcriptome [bulk damage] January 6, 2025Contributors : Dongsheng Bai ; Zhenkun Cao ; Chenxu ZhuSeries Type : Other ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusWe used a new technology, named Paired-Damage, to perform simultaneous profiling of DNA oxidative damage and transcriptome on Hela cells and mouse cortex at single-cell level. We al […]
- GSE285302 Activation of the imprinted Prader-Willi Syndrome locus by CRISPR-based epigenome editing [bisulphite-seq_neurons] January 6, 2025Contributors : Dahlia Rohm ; Charles A GersbachSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensEpigenome editing with DNA-targeting technologies such as CRISPR-dCas9 can be used to dissect gene regulatory mechanisms and potentially treat associated disorders. For example, Prader-Willi Syndrome (PWS) is caused by loss o […]