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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE237881 Neuroblastoma plasticity during metastatic progression stems from the dynamics of an early sympathetic transcriptomic trajectory September 13, 2024Contributors : Benjamin Villalard ; Arjan Boltjes ; Florie Reynaud ; Olivier Imbaud ; Karine Thoinet ; Severine Croze ; Gianluigi Atzeni ; Joël Lachuer ; Jan J Molenaar ; Godelieve M Tytgat ; Valérie Castellani ; Céline Delloye-BourgeoisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDespite their indisputable importanc […]
- GSE245926 A potent and selective small-molecule degrader of ENL suppresses leukemia progression in vivo (RNA-Seq) September 13, 2024Contributors : Zhaoyu Xue ; Hongwen Xuan ; Hong WenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensENL, a stoichiometric component of the Super Elongation Complex (SEC) as well as the histone H3K79 methyltransferase DOT1L complex, is involved in the regulation of transcription elongation. Loss-of-function studies of ENL […]
- GSE245175 Neuroblastoma single cell RNA-seq analysis of primary tumour and bone marrow metastases: plasticity, metastatic progression, and intra-patient heterogeneity September 13, 2024Contributors : Arjan Boltjes ; Caroline Hochheuser ; Kaylee Keller ; Ilse Timmerman ; Lieve Tytgat ; Jan MolenaarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis GEO series contains human scRNA-seq data of Neuroblastoma patients, used in two manuscripts.n=7 paired samples, primary tumour vs. bone marrow metastasesn= […]
- GSE249559 ChIP-seq assay for BRG1 in human SUP-B15 and Nalm-6 cell lines September 13, 2024Contributors : Qian Kang ; Dan Ma ; Peng Zhao ; Jishi WangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAbstract: BRG1 is highly expressed in adult B-cells acute lymphoblastic leukemia and is associated with poor prognosis. High expression of BRG1 promotes the proliferation and resistance to apoptosis of […]
- GSE247182 Isl1 identifies the extraembryonic mesodermal / allantois progenitors and required for placenta morphogenesis and vasculature formation [RNA-Seq] September 13, 2024Contributors : Xingqun Liang ; Yunfu Sun ; Zeyue Zhu ; Qicheng Zou ; Chunxiao WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe transcription factor Isl1 is expressed in the progenitors of the Ex-Mes and allantois, however its role in the placentation remains unclear. Our studies showed that deletion of Isl1 cause […]
- GSE260683 Single Nuclei RNA Sequencing of Uterine Serous Carcinoma September 13, 2024Contributors : Grace K Foley ; Julie J KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSignificant racial disparities exist between Black and White patients with uterine serous carcinoma (USC). While the reasons for these disparities are unclear, but several studies have demonstrated significantly distinct rates of d […]
- GSE255768 Chondrocytes differentiation and immune cells interactions of Endplate Cells in Human Intervertebral Disc Degeneration September 13, 2024Contributors : Chenhao Shi ; Shuangfei Ni ; Yonggang Fan ; Xiusheng HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe performed the single-cell RNA-sequencing analysis (scRNA-seq) of the cells focusing on degenerative human endplates. By unsupervised clustering of the 8,534 single-cell based on the gene expression […]
- GSE274922 The Regulation of MicroRNA-21 by Interleukin-6 and its Role in the Development of Fibrosis in Endometriotic Lesions September 13, 2024Contributors : Maria A Bernal ; Yong Song ; Niraj Joshi ; Gregory W Burns ; Emmanuel N Paul ; Erin Vegter ; Samantha Hrbek ; Lorenzo F Sempere ; Asgerally T FazleabasSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Papio anubisEndometriosis is one of the most common causes of chronic pelvic pain and infertility that affects 10% […]
- GSE274307 Ulp1 Regulates Cell Proliferation through INO1 in Pichia pastoris September 13, 2024Contributors : Junjie Yang ; Bo Zhong ; Lan Yang ; Guodong ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Komagataella pastorisPichia pastoris is extensively employed as a host for expressing foreign proteins, and its secretion system is especially advantageous for efficient protein purification. Ulp1 is essential for the cell […]
- GSE276633 A Ralstonia solanacearum effector targets splicing factor SR34a to reprograms alternative splicing and suppress host immunity September 13, 2024Series Type : Expression profiling by high throughput sequencingOrganism : Solanum lycopersicumThis study investigates the regulatory effects of Type III secretion system effectors from Ralstonia solanacearum strain GMI1000 on alternative splicing (AS) in tomato plants. Through RNA-seq and qRT-PCR analyses, the splicing regulatory functions of these effector […]
- GSE276505 mRNA sequencing after BMSC treatment of BDL-induced liver fibrosis September 13, 2024Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCholestatic liver disease (CLD) represents a severe pathological condition that can advance to cirrhosis and hepatocellular carcinoma. The activation of hepatic stellate cells (HSCs) is integral to the pathogenesis of CLD. Previous research has indicated that bone marrow m […]
- GSE276665 Nonfunctional coq10 mutants maintain the ERMES complex and reveal true phenotypes associated with the loss of the coenzyme Q chaperone protein Coq10 September 13, 2024Contributors : Noelle A Novales ; Kelsey J Feustel ; Kevin L He ; Guillaume F Chanfreau ; Catherine F ClarkeSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeCoenzyme Q (CoQ) is a redox-active lipid molecule that acts as an electron carrier in the mitochondrial electron transport chain. In Saccharomyces cerevi […]
- GSE276681 EAPP is essential for tri-snRNP biogenesis and controls cell fate and tumor growth via the alternative splicing of MDM4 September 13, 2024Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPrecursor messenger RNA (pre-mRNA) splicing is catalyzed by the spliceosome, a highly dynamic machinery with sequentially assembled small nuclear ribonucleoproteins (snRNPs) and splicing factors. Aberrant spliceosome composition and function result in the dysregulation of […]
- GSE276882 Transcriptomic analysis of gene expression pathways impacted by metaxin-2 (MTX-2) deficiency in a C. elegans mutant (mtx-2 KO, (gk444)) vs Wild-type worms (N2 Bristol) September 13, 2024Contributors : Benjamin Saintpierre ; Franck Letourneur ; Chloe TalarminSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansMandibuloAcral Dysplasia associated to MTX2 gene (MADaM) is a recently described progeroid syndrome (accelerated aging disease) whose clinical manifestations include skin abnormalities, growt […]
- GSE228539 Single cell RNA-sequencing reveals an important role of SRSF1 and SRSF2 in the development of diabetes. September 13, 2024Contributors : Xue You ; Ying FengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSingle-cell sequencing of islet cells from WT , ASF knock-out, SC35 knock-out mice reveals different mechanisms of diabetes formation and development.