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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE296760 Comparison of the expression levels of AML12-control and AML12-DEX at 17 h and 25 h, and comparison of the expression levels of HL-1-control and HL-1-CM at 16 h and 28 h in the AML12-HL-1 co-culture system in vitro May 8, 2026Contributors : chao lu ; chunting zhuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis experiment was designed to identify the cellular processes of rhythmic communication between hepatocytes and cardiomyocytes in vitro
- GSE299767 Estrogen receptor beta action in mouse granulosa cells in response to LH surge [ERb] May 8, 2026Contributors : Thao Dinh ; Darryl RussellSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusEstrogen signalling is crucial for follicle development, ovulation, ovarian identity maintenance and female fertility. The canonical pathway for estrogen signalling is through the activation of estrogen receptor alpha […]
- GSE297144 The HFE H63D variant in pancreatic cancer promotes epithelial-to-mesenchymal transition at the expense of cell cycle May 8, 2026Contributors : Federica Rubbino ; Paolo Kunderfranco ; Luca Lambroia ; Luigi LaghiSeries Type : OtherOrganism : Homo sapiensThis study examines the biological and clinical relevance of the HFE H63D variant in pancreatic ductal adenocarcinoma (PDAC), a highly aggressive cancer with limited biomarkers. We analyzed its prevalence in PDAC cohorts and explored as […]
- GSE210587 Two MADS-box transcription factors mediate epigenetic control of tomato fruit ripening [Bisulfite-seq] May 8, 2026Contributors : Qingfeng Niu ; Yaping Xu ; Huan Huang ; Zhaobo LangSeries Type : Methylation profiling by high throughput sequencingOrganism : Solanum lycopersicumUsing BS-Seq to provide single-base resolution of DNA methylation status in WT tomato AC and dml2 mutant at 25 dpa (days post anthesis) and 34 dpa (Breaker stage) and pCBC::RIN-3xFLAG/dml2-3 plants […]
- GSE300034 Estrogen receptor action in mouse granulosa cells in response to LH surge May 8, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE281091 A distinct vagus-beta cell neural circuit senses glucose and modulates insulin secretion May 8, 2026Contributors : Santosh Kumar ; Young Jae Bahn ; Sushil G RaneSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusVagal sensory neurons (VSN) communicate information regarding the peripheral glycemic state to the brain. However, the vagal circuits that sense and respond to continuous fluctuations in peripheral glucose levels […]
- GSE225655 Post-transcriptional regulation of a protein chaperone by the mRNA encoding the major pneumococcal virulence factor PspA May 8, 2026Contributors : Jens S Pettersen ; Mikkel G JørgensenSeries Type : Expression profiling by high throughput sequencingOrganism : Streptococcus pneumoniaeThis study investigates regulatory activity of the 3'UTR of the mRNA encoding the pneumocococal surface protein A.
- GSE329565 Gene expression profiling by RNA-Seq analysis of mice carrying an inner-ear conditional knockout of Esrrg. May 8, 2026Contributor : Lisa S NolanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEstrogen-related receptor gamma (ESRRG), an orphan nuclear receptor with structural homology to the classical estrogen receptors, is widely recognised as a key metabolic regulator. Clinical studies have suggested a link between ESRRG and auditory […]
- GSE328222 Acute rapamycin treatment reveals novel mechanisms of dysfunction in a maternal inflammation mouse model May 8, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE330182 The tumor suppressor Tip60 inhibits TOR signaling in response to the microbiota to promote autophagy and enterocyte differentiation [RNAseq_Tip60] May 8, 2026Contributors : Juliana Batista ; Paula I WatnickSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterThe differentiation of enterocyte precursors into mature enterocytes is a complex process that is essential for intestinal homeostasis, and the accumulation of undifferentiated precursors is a harbinger of malignan […]
- GSE329919 Tumor microbial burden drives immune responses through regulation of Interferon signaling May 8, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the mechanisms involved in tumor microbial-associated immunotherapy sensitivity, we performed RNA sequencing on mouse MC38 tumor tissues upon local microbial depletion.
- GSE330261 Mating-type locus structure affects gene expression in unidirectional mating-type switching fungi May 8, 2026Contributors : F A Lane ; B D Wingfield ; M J Wingfield ; P M WilkenSeries Type : Expression profiling by high throughput sequencingOrganism : Ceratocystis albifundusFungal species are typically either fully self-fertile or self-sterile, but some filamentous ascomycetes can transition from self-fertility to self-sterility through unidirectional mating-type s […]
- GSE330266 Hepatocyte Hedgehog Signaling Controls Ferroptosis to Alleviate Aging-related Organ Dysfunction May 8, 2026Contributors : RajeshKumar Dutta ; AnnaMae DiehlSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAging drives systemic metabolic dysfunction (SMD) and increases the risk of chronic illnesses such as metabolic dysfunction–associated steatotic liver disease (MASLD) and chronic kidney disease (CKD). However, mechanisms that […]
- GSE330314 Mutant IDH1 blocks neutropoiesis by repressing myeloid progenitor programs [scRNA-seq] May 8, 2026Contributors : Mariam Hakobyan ; Mark Hartmann ; Daniel B LipkaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIDH1 and IDH2 are frequently mutated in various cancers, including acute leukemias. However, the distinct mechanisms by which mutant IDH1 or IDH2 drive hematopoietic neoplasms remain poorly understood. Here, we […]
- GSE294811 Cytochrome P450 and metallothionein activation in human lung organoids following particulate matter exposure May 8, 2026Contributors : Seri Choi ; Seung-Yeon Kim ; Ji Won Beak ; Won Keun Oh ; Kee K. Kim ; Eun-Mi KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensParticulate matter (PM) has raised increasing concerns regarding its adverse impact on respiratory health. Although numerous studies have investigated PM effects under varying co […]