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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE292934 Mechanistic deconvolution reveals DHODH as the key target of the KDM4 inhibitor QC6352 [RNA-Seq] March 31, 2026Contributors : Jayden Sterling ; Jacinda R Holtsmark ; George L Joun ; Karen Tran ; Tian Y Du ; Mani Kuchibhotla ; Terrance G Johns ; Antoine deWeck ; Lipin Loo ; Gregory G Neely ; Chloe Shard ; Guillermo Gomez ; Angus Saxton ; Jennifer R Baker ; Yuchen Feng ; Andreas Kraemer ; Susanne Mueller ; Paul Workman ; Lenka MunozSeries Type : Expression profiling by […]
- GSE291395 Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation [SMART-seq] March 31, 2026Contributors : Ting Li ; Qian LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPolycomb Repressive Complexes (PRCs) sustain regulatory T (Treg) cell identity through transcriptional silencing, yet their role in modulating Treg functional plasticity during immune adaptation remains unclear. Here, we identify KDM2B, a de […]
- GSE296275 Distinct tissue niches contribute to prostate TRM cell differentiation and heterogeneity [Spatial Transcriptomics] March 31, 2026Contributors : Kennidy Takehara ; Miguel Reina-Campos ; Ananda GoldrathSeries Type : OtherOrganism : Mus musculusThe prostate is an important exocrine organ, a barrier tissue of the male reproductive system, and a common site of malignancy, yet prostate CD8+ T cells remain largely uncharacterized. Here, we show that a protective, heterogeneous pool of long-l […]
- GSE293489 Single-cell RNA Sequencing of non-cardiomyocytes from mouse after MI March 31, 2026Contributors : Xiaoying Chen ; Xinyang HuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusProgrammed cell death protein 1 (PD1) is crucial for adaptive immunity regulation, showing considerable effects in various diseases especially in tumor field. In order to deeply investigate the expression characteristics of PD1+ T c […]
- GSE304456 Single cell transcriptomic analysis of salivary epithelial cells reveals large-scale dysregulation in bitter taste dysfunction. March 31, 2026Contributors : Shveta Jaishankar Iyer ; David Schaeper ; Sarath Chandra Janga ; Mythily SrinivasanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study utilized Parse Biosciences's Evercode WT technology to perform scRNA-sequencing of saliva samples from individuals experiencing long COVID associated dysgeusia […]
- GSE299387 Comparative transcriptomics reveals emergent cortical architecture and plasticity at the metatherian-eutherian split [snRNA-Seq] March 31, 2026Contributors : Joshua T Trachtenberg ; Ryan GorzekSeries Type : Expression profiling by high throughput sequencingOrganism : Monodelphis domesticaThe neocortex supports mammalian cognition through a conserved columnar architecture, but variation in the transcriptomic organization of cortical columns across deep mammalian divergences has not been directly exa […]
- GSE325921 Lidocaine inhibits hepatocellular carcinoma cell proliferation, migration, and invasion through the downregulation of SLC6A3 March 31, 2026Contributors : Xi Yang ; Peiyang Li ; Wulan Tong ; Hong He ; Hao LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Lidocaine, a widely used local anesthetic, has been reported to exert anti-cancer activity against hepatocellular carcinoma (HCC). However, its molecular mechanisms remain incompletely understo […]
- GSE267881 Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for effector Treg cell differentiation [ATAC-Seq] March 31, 2026Contributors : Ryuichi Murakami ; Norihito Hayatsu ; Suzu Kawagoe ; Shohei HoriSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMechanisms by which diverse transcription factors (TFs), particularly the master regulator Foxp3, shape the heterogeneous transcriptional and epigenetic landscape of regulatory T ( […]
- GSE326052 A Postnatal Chondro-Hematopoietic Axis Generates Functional Hematopoietic Stem Cells via Endothelial Transition March 31, 2026Contributors : Runfeng Chen ; Wenjiong Shi ; Debao Li ; Zhiguo Ling ; Yi ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusConventional understanding holds that definitive hematopoietic stem cells (HSCs) form only during embryogenesis and subsequently colonize bone marrow (BM). We challenge this by identifying a post […]
- GSE325931 Microglial dynamics and ferroptosis induction in human iPSC-derived neuron-astrocyte-microglia tri-cultures March 31, 2026Contributors : Masato Yugami ; Hiroko Ohmiya ; Yan LingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe dynamics of microglial activity within neuron-astrocyte-microglia tri-cultures derived from human induced pluripotent stem cells (iPSCs) present a complex interplay and offer an opportunity to obtain new insights i […]
- GSE326090 Inertia-driven, self-powered electrotherapy for enhanced wound regeneration March 31, 2026Contributors : Jae Hoon Kim ; Hye-Min Lee ; Hye-Min Park ; Hyun-Ji Park ; Hanjun Ryu ; Jeong-Kee YoonSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensSkin serves as the primary barrier against hazardous substances, and timely wound closure is an essential initial step in wound regeneration. However, intrinsic skin re […]
- GSE326106 Long-read RNA-seq of human (Homo sapiens), gorilla (Gorilla gorilla), orangutan (Pongo abelii) and cynomolgus macaque (Macaca fascicularis) induced pluripotent stem cell and neural precursor cell lines March 31, 2026Contributors : Geuder Johanna ; Stefan Krebs ; Spurk Paulina ; Térmeg Anita ; Enard Wolfgang ; Hellmann InesSeries Type : Expression profiling by high throughput sequencingOrganism : Gorilla gorilla ; Homo sapiens ; Macaca fascicularis ; Pongo abeliiWe generated Oxford Nanopore long-read RNA-seq data to compare transcript isoform usage across four primate sp […]
- GSE326326 Spatiotemporal transcriptome atlas of human embryos after gastrulation March 31, 2026Contributors : Jiexue Pan ; Yuejiao Li ; Zhongliang Lin ; Qing Lan ; Ying Zhang ; Huixi Chen ; Shengwei Sui ; Man Zhai ; Lijian Zhao ; Hongbo Yang ; Ya Gao ; Guolian Ding ; Xun Xu ; Hefeng HuangSeries Type : OtherOrganism : Homo sapiensThe comprehensive spatiotemporal atlas of gene expression during early human embryonic development is critical for insights […]
- GSE285194 Oocyte transcriptome changes in E18.5 Taf4b-deficient female mice March 31, 2026Contributors : Kimberly Abt ; Richard FreimanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFemale reproductive senescence results from the regulated depletion of a finite pool of oocytes called the ovarian reserve. This pool of oocytes is initially established during fetal development, but the oocytes that comprise it […]
- GSE325892 Role of LIN-15A on the binding of LIN-15B and LIN-35 March 31, 2026Contributors : Julien Lambert ; Francesco Carelli ; Alex Appert ; Stéphane Roth ; Julie Ahringer ; Sophie JarriaultSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Caenorhabditis elegansChIP-seq was performed in C. elegans to characterize the genomic binding profiles of LIN-35 (DREAM complex), LIN-15B, and LIN-15A, and […]