Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE285866 RNA-Seq analysis of roots of Stylosanthes guianensis in response to manganese toxicity January 4, 2026
  Contributor : Zhijian ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Stylosanthes guianensisStylo (Stylosanthes guianensis) is an important tropical legume with superior tolerance to manganese (Mn) toxicity, which severely constrains plant growth especially in tropical acid soils. However, the underlying mechanisms of Mn toler […]
• GSE282881 Ultra high-throughput single-cell transcriptome and epitope profiling of healthy human PBMCs using SCITO-seq2 January 4, 2026
  Contributors : Su-Hyeon Lee ; Bo-yeong Jin ; Murim Choi ; Byungjin HwangSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis study presents comprehensive single-cell transcriptome and surface protein profiling using SCITO-seq2, an enhanced platform that improves the recovery of unique transcripts while enabling […]
• GSE294253 RNA-seq of HFL-1 Cells Overexpressed GFP, GFP-ERG or GFP-ERG-ΔIDR13 January 4, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis dataset contains rawRNA-seq data from HFL-1 Cells Overexpressed GFP, GFP-ERG or GFP-ERG-ΔIDR13. The experiment aims to explore the downstream genes of ERG and its phase separation-deficient mutant to uncover the role of ERG's LLPS activity in regulating gene expr […]
• GSE292915 Photorespiration is linked to DNA methylation by formate as a one-carbon source [BiSulfite-seq] January 4, 2026
  Contributors : Valentin Hankofer ; Martin GrothSeries Type : Methylation profiling by high throughput sequencingOrganism : Arabidopsis thalianaDNA methylation is a key epigenetic modification regulating genome organization, stability, and gene expression. Stable DNA methylation critically relies on methyl groups provided through folate-mediated one-carbon (C […]
• GSE300765 Acidosis and hypoxia responsive gene expression profiles of U87MG glioblastoma cells January 4, 2026
  Contributors : Anna Bång-Rudenstam ; Myriam Cerezo-Magaña ; Marton Horvath ; Hugo Talbot ; Emma Gustafsson ; Stevanus Jonathan ; Chaitali Chakraborty ; Itzel Nissen ; Kelin Gonçalves de Oliveira ; Axel Boukredine ; Sarah Beyer ; Julio  Enriquez Perez ; Maria C Johansson ; Lena Kjellén ; Emil Tykesson ; Anders Malmström ; Toin H van Kuppevelt ; Karin Forsberg […]
• GSE299759 An integrated clinical genomic and transcriptomic subgrouping of central chondrosarcoma January 4, 2026
  Contributors : Debora M Meijer ; Judith V BoveeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChondrosarcoma, a malignant cartilage-producing bone tumor, is the second most-common bone sarcoma. Chondrosarcomas are histologically graded, which is so far the best predictor of survival. Early mutations in isocitrate dehyd […]
• GSE314681 Mouse myocardial infarction January 4, 2026
  Contributor : Mingyu ZhangSeries Type : Non-coding RNA profiling by arrayOrganism : Mus musculusCardiac ischemia-reperfusion (I/R) injury is a leading cause of disability and mortality worldwide, but the underlying mechanism remains largely unknown. Despite the emerging recognition of circular RNAs (circRNAs) as pivotal regulators in cardiac development and […]
• GSE300771 Clariom D Pico gene array of primary GBM cells grown as 3D (LD⁺) spheroid cultures or 2D (LD⁻) cultures January 4, 2026
  Contributors : Anna Bång-Rudenstam ; Myriam Cerezo-Magaña ; Marton Horvath ; Hugo Talbot ; Emma Gustafsson ; Stevanus Jonathan ; Chaitali Chakraborty ; Itzel Nissen ; Kelin Gonçalves de Oliveira ; Axel Boukredine ; Sarah Beyer ; Julio  Enriquez Perez ; Maria C Johansson ; Lena Kjellén ; Emil Tykesson ; Anders Malmström ; Toin H van Kuppevelt ; Karin Forsberg […]
• GSE315229 RNA-seq analysis of QRICH1 knockdown in Huh7 cells January 4, 2026
  Contributor : Su-Yeon ParkSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study investigates the transcriptomic changes following QRICH1 knockdown in Huh7 hepatocellular carcinoma cells using RNA sequencing.
• GSE314790 A cell-type-resolved human brain atlas of microRNAs and tRNA fragments. January 4, 2026
  Contributors : Serafima Dubnov ; Lihen Laski ; Ido Zchut ; Ofek Avidan ; Estelle R Bennet ; David S Greenberg ; Adi Tujerman ; Mor Nitzan ; Iddo Paldor ; Hermona SoreqSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensSmall non-coding RNAs (sncRNAs), including microRNAs (miRs) and tRNA fragments (tRFs), regulate divers […]
• GSE315249 SOX11 Downregulation and IL-7/IL22RA2 Upregulation Might be a Potential Mechanism of Exosome in Promoting Schwann Cell Proliferation January 4, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe characterization process was performed by transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and Western blot. SCs were co-cultured with menstrual blood-derived MenSCs-Exos to assess their proliferation through CCK-8 assay and flow cytometry. […]
• GSE315250 TDP-43 pathology triggers neuroinflammation and cognitive impairment by inducing microglial necroptosis January 4, 2026
  Contributors : Shenrui Guo ; Weiwei ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPathological TAR DNA-binding protein-43 (TDP-43) is a defining feature of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Alzheimer’s disease (AD). However, the me […]
• GSE315346 Cardiac Thoracic DRG Poly RNAseq Data in rats post MI January 4, 2026
  Contributors : Hanjun Wang ; Samuel GillmanSeries Type : Expression profiling by high throughput sequencingOrganism : RattusThe overall goal is to detect any signficant changes in the rat thoracic DRG mRNA expressions post myocardial infarction.
• GSE223775 The effect of culture medium from ferroptotic BMDMs on microglia January 4, 2026
  Contributors : Shujie Zhao ; Guoyong Yin ; Xuan ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the altered gene expression levels in microglia treated with culture medium from ferroptotic BMDMs and normal BMDMs. Each group had a biological repeat (n=3). Results provide insight into the effect of cult […]
• GSE308970 Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish January 4, 2026
  Contributors : Emma K Costa ; Jingxun Chen ; Ian H Guldner ; Man-Ru Wu ; Param P Singh ; Anne Brunet ; Tony Wyss-CoraySeries Type : Expression profiling by high throughput sequencingOrganism : Nothobranchius furzeriAging is associated with progressive tissue dysfunction, leading to frailty and mortality. Characterizing aging features, such as changes in gene […]