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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE313190 Cell-free RNA reveals host and microbial correlates of broadly neutralizing antibody development against HIV March 13, 2026Contributors : Mark Kowarsky ; Mercedes Dalman ; Mira N Moufarrej ; Jennifer Okamoto ; Yike Xie ; Norma F Neff ; Salim S Abdool Karim ; Nigel J Garrett ; Penny L Moore ; Joan Camunas-Soler ; Stephen R QuakeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAn effective broadly reactive antibody response is crucial to preve […]
- GSE324475 Transcriptional profiling of CRP-V5 and K52Q-V5 Vibrio cholerae C6706 grown in M9 minimal medium with maltose or trehalose as sole carbon source March 13, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Vibrio cholerae C6706RNA-seq was performed to compare the transcriptomes of Vibrio cholerae C6706 strains expressing V5-tagged wild-type CRP (CRP-V5) or the acetylation-mimicking mutant K52Q-V5 during growth in M9 minimal medium supplemented with 0.8% maltose or 0.8% trehalose as the […]
- GSE314837 EHMT2-mediated chromatin reprogramming in 5-fluorouracil (5-FU) resistant colorectal cancer March 13, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study generated transcriptomic datasets to investigate the role of EHMT2 in acquired 5-fluorouracil resistance in colorectal cancer models. RNA sequencing was performed in parental and 5-FU resistant HCT116 cell lines under genetic and pharmacological modulation of EH […]
- GSE290226 Clusia genomes shed light on the evolution and diversity of CAM physiotypes March 13, 2026Contributors : Hannes M Kramml ; Johannes B Herpell ; Clara Priemer ; Zoe Wessely ; Florian Schindler ; Stefan Plott ; Tamara Schmidt ; Peter Kerpan ; Leila Afjehi-Sadat ; Palak Chaturvedi ; Arindam Ghatak ; Iro Pierides ; Lena Fragner ; Eva M Temsch ; Fabio Trevisan ; Menriti Ibrahim ; Felix Fromwald ; Anke Bellaire ; Oleg Simakov ; Werner Huber ; Ovidiu Pa […]
- GSE261792 Effect of Ethoxysanguinarine treatment on gene expression after Angiotensin-II infused C57BL/6 mice March 13, 2026Contributors : Jun Peng ; Aling Shen ; Ying Cheng ; Yi Xie ; Bihan XuanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe goals of this study is to identify the differential expressed genes in cardiac tissue of C57BL/6 mice with or without Angiotensin II (AngII) treatment, and compare the differential expressed genes i […]
- GSE291921 Linking trajectories of cerebrovascular remodeling and dysfunction to cross-species brain vessel transcriptome in Alzheimer’s disease March 13, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGrowing evidence implicates dysfunctional brain vasculature occurring early in Alzheimer’s disease (AD) progression. Few studies have attempted to bridge transcriptomic signatures with early neuroimaging observations of vascular abnormalities. We leveraged longitudinal in […]
- GSE291097 Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation [scRNA-Seq] March 13, 2026Contributors : Nathaniel Hogrebe ; Mason Schmidt ; Punn Augsornworawat ; Jeffrey MillmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study, we performed single-cell RNA sequencing and single-nuclei multiomic sequencing (RNA+ATAC) at various stages during the differentiation of human pluripotent stem cells to […]
- GSE324239 The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling [RNA-seq] March 13, 2026Contributors : Anthony E Jones ; Ajit S DivakaruniSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMetabolites and metabolic co-factors can shape the innate immune response, though the pathways by which these molecules adjust inflammation remain incompletely understood. Here we show that the metabolic cofactor Coenzyme A […]
- GSE324183 Lactylation Converts ABHD6 into a Mitochondrial Regulator that Drives Lenvatinib Resistance in Hepatocellular Carcinoma March 13, 2026Contributor : Zhiyuan TangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHepatocellular carcinoma (HCC) frequently develops resistance to lenvatinib, a frontline tyrosine kinase inhibitor. Resistance arises from heterogeneous mechanisms involving metabolic reprogramming and mitochondrial adaptation, implicating regulat […]
- GSE324241 RNA binding proteins Pcbp1 and Pcbp2 are indispensable for B cell development [scRNA-seq] March 13, 2026Contributors : Xing Chang ; Li Lin ; Tuan Qi ; Geng LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusB-cell development in the bone marrow is a tightly regulated process requiring precise control of gene expression at both transcriptional and post-transcriptional levels. Here, we identify the RNA-binding proteins Pcbp1 […]
- GSE324240 The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling [ATAC-seq] March 13, 2026Contributors : Anthony E Jones ; Ajit S DivakaruniSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMetabolites and metabolic co-factors can shape the innate immune response, though the pathways by which these molecules adjust inflammation remain incompletely understood. Here we show that the metabolic cofac […]
- GSE324242 RNA binding proteins Pcbp1 and Pcbp2 are indispensable for B cell development [scRNA-seq ko] March 13, 2026Contributors : Xing Chang ; Li Lin ; Tuan Qi ; Geng LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusB-cell development in the bone marrow is a tightly regulated process requiring precise control of gene expression at both transcriptional and post-transcriptional levels. Here, we identify the RNA-binding proteins Pcbp1 […]
- GSE324243 ST36 acupoint implantation of an astragaloside IV–glycyrrhizic acid drug eluting suture enhances immune function in weaned lambs by modulating the Treg/Th17 balance March 13, 2026Contributors : Hai Zhou ; Ke Zhou ; Zhizhen ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Ovis ariesWeaning is a critical period in young animals and is often accompanied by immunosuppression and intestinal immune imbalance caused by stress and nutritional transition. In this study, an astragaloside IV- and glycyrrhizic acid- […]
- GSE324277 miRNA Expression data from human heatstroke patients March 13, 2026Contributors : Abderrezak Bouchama ; Saeed Al Mahri ; Maria GomezSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensThis study examined miRNA responses to heat exposure in peripheral blood mononuclear cells from 19 patients with heat stroke and 19 controls.
- GSE311056 Transcriptional consequences of herpes simplex virus 1 ICP4 inducible expression in uninfected cells March 13, 2026Contributors : Nora L Herzog ; Sarah Keegan ; Daniel Drafta ; Rebecca Plessel ; Liam J Holt ; Ian J Mohr ; Angus C WilsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSuccessful viral infections reflect the balanced outcome of a tightly regulated program of viral gene expression and manipulation of the host cell to fa […]