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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE237487 Polycomb and trithorax epigenetic marks regulate temperature response in the phytoplanktonic microalgae Ostreococcus tauri [RNA-seq] August 24, 2026Contributors : Francisco J Romero-Campero ; Mercedes García-González ; Christina ArvanitidouSeries Type : Expression profiling by high throughput sequencingOrganism : Ostreococcus tauriIn this study, we investigate the role of epigenetic marks, specifically Polycomb and Trithorax marks, in regulating the temperature response of the phytoplanktonic microalga […]
- GSE305319 Self-organizing human dual neural organoids model sensory ganglion-spinal cord co-development and region-specific disease defects [BulkRNA_GFP] August 24, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe have employed bulk-RNA sequencing approach using 10x Genomics RNA-seq to study hPCOs.
- GSE294518 Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell Multiomics [CUT&RUN] August 24, 2026Contributors : Laura Rueda-Gensini ; Manu Saraswat ; Moritz MallSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensGlioblastoma (GB) is incurable and resistant to therapy despite genomic stability under treatment, implicating non-genetic cellular plasticity as a central driver of progression. Whether such pla […]
- GSE306304 Transcriptomic profiling of mouse hematopoietic stem cells after myelosuppressive injury August 24, 2026Contributors : Kuan Yu ; Changhong Du ; Junping WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHematopoietic stem cell (HSCs) were isolated from the bone marrow of a mouse model of irradiation-induced myelosuppressive injury at 1 day post irradiation. To investigate the role of itaconate metabolism in HSC maintenan […]
- GSE305512 Self-organizing human dual neural organoids model sensory ganglion-spinal cord co-development and region-specific disease defects [BulkRNA_PRDM12_KO] August 24, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe have employed bulk-RNA sequencing approach using 10x Genomics RNA-seq to study hPCOs.
- GSE320129 Effect of CRISPRi-based depletion of IREB2, MRGBP, and PAX7 on gene expression in A549 dCas9-KRAB cells August 24, 2026Contributors : Thomas A O'Loughlin ; Ashir A Borah ; Luke A GilbertSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe DNA damage response (DDR) is a sophisticated network of cellular pathways whose perturbation leads to genome instability and is a key hallmark of oncogenesis. Through orthogonal CRISPRi screens wit […]
- GSE309154 Divergent cytotoxic and immunomodulatory immune programs distinguish morbilliform drug eruption from SDRIFE August 24, 2026Series Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE344329 Chromatin Level Epigenetic Reprogramming and Altered Transcriptional Dynamics by lncRNAs uc.123 and uc.382 Links Early Life Stress to Depression Vulnerability [ChIRP-Seq] August 24, 2026Contributors : Anuj Verma ; Shinichiro Ochi ; Bhaskar Roy ; Yogesh DwivediSeries Type : OtherOrganism : Rattus norvegicusEarly Life Stress (ELS) refers to exposure to adverse childhood experiences such as neglect, abuse, or parental separation. These stressors can disrupt brain development and increase susceptibility to psychiatric disorders, including major […]
- GSE344280 Effect of Imeglimin on gene expression of renal cortex from diabetic mice August 24, 2026Contributor : Hisashi YokomizoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImeglimin is an oral hypoglycemic agent marketed from Japan and has shown glucose-lowering effects in Japanese patients with type 2 diabetes in TIMES trials. However, it is not well known whether Imeglimin can affect diabetic kidney disease (D […]
- GSE344351 Ciclosonide reduces lipid droplet burden in APOE4 astrocytes August 24, 2026Contributors : Antonio Vázquez-Cobá ; Sarah A Zünd ; Marina Ruelas ; Jasmine Phénix ; Lisa M MunterSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPrior studies have shown that ApoE ε4 astrocytes display a higher LD count than ApoE ε3 astrocytes. We examined the effects of pharmacological agents on lipid droplets (LDs) […]
- GSE344336 Chromatin Level Epigenetic Reprogramming and Altered Transcriptional Dynamics by lncRNAs uc.123 and uc.382 Links Early Life Stress to Depression Vulnerability [ChIRP-Seq ELS] August 24, 2026Contributors : Anuj Verma ; Shinichiro Ochi ; Bhaskar Roy ; Yogesh DwivediSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusEarly Life Stress (ELS) refers to exposure to adverse childhood experiences such as neglect, abuse, or parental separation. These stressors can disrupt brain development and increase susceptibil […]
- GSE344362 Gene expression profiling of Venetoclax-treated HL-60 cells August 24, 2026Contributors : Yu Hang ; Zhu Xiang ; Li Wanying ; Zhu Haiyan ; Cai Bo ; Liu Yu ; Zeng Yang ; Gao ChunjiSeries Type : Expression profiling by arrayOrganism : Homo sapiensVenetoclax is a selective BCL-2 inhibitor with antileukemic activity. To investigate the transcriptional alterations induced by Venetoclax in human acute myeloid leukemia cells, HL-60 cells w […]
- GSE344363 A single-cell and spatial transcriptomic atlas provides insights into the genetic regulation of secondary growth and specialized metabolism in the carrot taproot [scRNA-seq] August 24, 2026Contributors : Xiaoyu Han ; Ye Chen ; Song Yang ; Xinyue Zhan ; Pinli Hu ; Siqi Liang ; Bao Nie ; Xing Liu ; Feiyun Zhuang ; Haojing Shao ; Cheng Li ; Li WangSeries Type : Expression profiling by high throughput sequencingOrganism : Daucus carotaCarrot (Daucus carota) is an economically important vegetable, accumulating a wealth of bioactive secondary metabo […]
- GSE344364 A single-cell and spatial transcriptomic atlas provides insights into the genetic regulation of secondary growth and specialized metabolism in the carrot taproot [Spatial Transcriptomics] August 24, 2026Contributors : Xiaoyu Han ; Ye Chen ; Xinyue Zhan ; Song Yang ; Pinli Hu ; Siqi Liang ; Bao Nie ; Xing Liu ; Feiyun Zhuang ; Haojing Shao ; Cheng Li ; Li WangSeries Type : OtherOrganism : Daucus carotaCarrot (Daucus carota) is an economically important vegetable, accumulating a wealth of bioactive secondary metabolites (SMs), and is a promising model species […]
- GSE330085 Sex-divergent skeletal muscle remodelling emerges early in cancer cachexia August 24, 2026Contributors : Chris Karagiannis ; Paul GregorevicSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCancer cachexia is often studied after overt weight and muscle loss are established, limiting insight into early initiating mechanisms and sex-dependent trajectories. This dataset profiles pre-cachectic skeletal muscle tran […]