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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE298940 Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcriptional program in mouse and human August 13, 2026Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE292825 Methylated eEF1A Selectively Decodes mRNA to Shape Cancer Proteomes August 13, 2026Contributor : Shuo LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDifferences in mRNA decoding efficiency influence protein synthesis. However, whether the translation elongation machinery harbors an intrinsic mechanism that selectively decodes codons, and how this shapes proteomes in homeostasis and disease, remain […]
- GSE305378 BET inhibition synergizes with Golcadomide by suppressing MYC and E2F pathways in diffuse large B-cell lymphoma [RNA-Seq] August 13, 2026Contributors : Junfei Zhao ; Hsu Chih-Chao ; Patrick HagnerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGolcadomide is a potential first-in-class Aiolos/Ikaros-degrading CRBN E3 ligase modulator (CELMoD) agent designed for the treatment of non-Hodgkin lymphoma (NHL) including diffuse large B-cell lymphoma (DLBCL). Ai […]
- GSE305315 Transcriptomic profiling of blood neutrophils from preterm infants with bronchopulmonary dysplasia August 13, 2026Contributors : Sen Li ; Wenhao Zhou ; Huayan Zhang ; Xiaohui WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBronchopulmonary dysplasia (BPD) is a major complication of preterm birth, yet its immune mechanisms remains poorly understood. To explore the role of neutrophils in the pathogenesis of BPD, a prospective stu […]
- GSE305429 CXXC Finger Protein 1 drives BMP signaling and progenitor cell differentiation during limb development August 13, 2026Contributor : Diana L CarloneSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe mechanisms mediating endochondral bone formation remain incompletely understood. Here, we show that CXXC Finger Protein 1 (CFP1) is required for the onset of chondrogenesis during forelimb development. CFP1-deficient mesenchymal progenitor […]
- GSE305381 BET inhibition synergizes with Golcadomide by suppressing MYC and E2F pathways in diffuse large B-cell lymphoma [ATAC-Seq] August 13, 2026Contributors : Junfei Zhao ; Hsu Chih-Chao ; Patrick HagnerSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensGolcadomide is a potential first-in-class Aiolos/Ikaros-degrading CRBN E3 ligase modulator (CELMoD) agent designed for the treatment of non-Hodgkin lymphoma (NHL) including diffuse large B-cell lympho […]
- GSE342713 Epigenetic repressor TRIM28 coordinates myocardial trabeculation and compaction for cardiac chamber formation [CUT&Tag] August 13, 2026Contributors : Xing Liu ; Shasha Zhang ; Yuze Wang ; Juntao LinSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusBACKGROUND: Left ventricular non-compaction (LVNC) is a prevailing subtype of cardiomyopathy manifested with excessive trabeculation and spongy-like ventricular wall. LVNC is associated with sever […]
- GSE343158 Methionine-driven PPARγ N⁶-methyladenosine Modification in Infiltrating Macrophages Promotes Immunosuppression in Glioblastoma August 13, 2026Contributors : Hong Hu ; Yishuai Huang ; Jiafeng Li ; Honglei Li ; Sha Luan ; Jiaqi Liu ; Ruijie Liu ; Meng Cai ; Hao Chen ; Ning Wang ; Weichen Liu ; Cong Li ; Zhenfeng Jiang ; Kaikai Wang ; Lei Teng ; Huailei LiuSeries Type : OtherOrganism : Homo sapiensGlioblastoma (GBM) is characterized by a methionine-enriched metabolic microenvironment and extensive in […]
- GSE343016 Epitranscriptomic Profiling Reveals N7-Methylguanosine Modification as a Novel Regulator in Recurrent Spontaneous Abortion August 13, 2026Contributors : Jiangping Tang ; Shuqiong He ; Yuhong Guo ; Hailong Huang ; Xiaoqing Wu ; Liangpu Xu ; Shixin ChenSeries Type : OtherOrganism : Homo sapiensRecurrent spontaneous abortion (RSA) is a severe pregnancy disorder with heterogeneous etiologies. Emerging evidence has suggested a functional role of epigenetic modification in RSA development. N7-methyl […]
- GSE342714 Epigenetic repressor TRIM28 coordinates myocardial trabeculation and compaction for cardiac chamber formation [RNA-Seq] August 13, 2026Contributors : Xing Liu ; Shasha Zhang ; Yuze Wang ; Juntao LinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBACKGROUND: Left ventricular non-compaction (LVNC) is a prevailing subtype of cardiomyopathy manifested with excessive trabeculation and spongy-like ventricular wall. LVNC is associated with severe clinical pre […]
- GSE343056 Whole-brain transcriptomic profiling of control, diabetic neuropathic pain, and baclofen-treated mice August 13, 2026Contributors : Kaisheng Ye ; Qun Wang ; Haishao Chen ; Sizhuang Xie ; Kangyu YeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigated central transcriptional alterations associated with diabetic neuropathic pain and baclofen treatment. Whole-brain RNA sequencing was performed in control mice, untreated […]
- GSE343103 RNA-seq analysis of FOXA1 and TRIM28 knockdown in LNCaP prostate cancer cells August 13, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study investigates transcriptomic changes following knockdown of FOXA1 or TRIM28 in LNCaP prostate cancer cells. LNCaP cells were transduced/transfected with shRNAs targeting FOXA1 or TRIM28, along with corresponding negative control shRNAs. Total RNA was extracted fr […]
- GSE343122 Imaging and Molecular Mechanisms of Pelvic Floor Electrical Stimulation in Improving Pelvic Floor Muscle Injury in Stress Urinary Incontinence Rats August 13, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusPurpose: This study aimed to investigate the imaging characteristics and molecular mechanisms by which pelvic floor electrical stimulation (PFES) improves pelvic floor muscle injury in a rat model of stress urinary incontinence (SUI). Methods: An SUI model was establi […]
- GSE283283 Spatiotemporal transcriptomic niches of complement pathway and serine protease inhibitor activation in aging and infection August 13, 2026Contributors : Fabian Kern ; Viktoria Wagner ; Vanessa Wahl ; Nicole Ludwig ; Simon Graf ; Jeremy Amand ; Aulden Foltz ; Micaiah Atkins ; Blen Kedir ; Alexandros Hadjilaou ; Matthias Flotho ; Friederike Grandke ; Philipp Wartenberg ; Monika I Hollenhorst ; Hanna Lotter ; Rolf Müller ; Thomas Jacobs ; Gabriela Krasteva-Christ ; Ulrich Boehm ; Oliver Hahn ; To […]
- GSE339052 Hepatocyte-derived sIL1RAP restrains chronic inflammation under dietary August 13, 2026Contributors : Xiezong Hu ; Shurao Li ; Qiujing Jin ; Qingsong HuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMetabolic dysfunction-associated steatohepatitis (MASH) is characterized by hepatic lipid accumulation, injury, inflammation, and fibrosis, but the endogenous hepatocyte-derived secretory signals that restrai […]