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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE235792 Body weight at weaning is the main predictor for diabetic phenotype in male TallyHo/JngJ mice June 2, 2026Contributors : Sieglinde Hastreiter ; Martin Irmler ; Kerstin Richter ; Sandra Hoffmann ; Raffaele Gerlini ; Helmut Fuchs ; Valérie Gailus-Durner ; Martin Hrabé de Angelis ; Johannes BeckersSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTallyHo/JngJ (TallyHo) mice are a polygenic mouse model for type 2 diabetes (T2D), […]
- GSE333737 MERFISH spatial transcriptomic profiling of extracellular matrix and vascular-associated populations in the adult human pancreas June 2, 2026Contributors : Luisa K Meneses ; Zev J Gartner ; Julie B SneddonSeries Type : OtherOrganism : Homo sapiens ; synthetic constructThe extracellular matrix (ECM) and basement membrane (BM) are critical structural and signaling components of the human pancreatic endocrine niche. To define the cellular sources and spatial organization of vascular ECM programs in […]
- GSE280655 Single cell transcriptome of cortical inhibitory neurons from the developing mouse brain June 2, 2026Contributors : Jessica Xinyun Du ; Giordano LippiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe used single cell RNA-sequencing (scRNAseq) to assess the maturation of inhibtory neurons in and migrating into the developing cortical plate of E18 mouse embryos, in an effort to understand gene expression programs that a […]
- GSE255166 The ERBB4 agonist JK07 Mitigates Atrial Remodeling and Inducibility of Atrial Fibrillation in Mice and Minipigs June 2, 2026Contributors : Jens van Fraeyenhove ; Michiel R Tubeeckx ; Bo Govaerts ; Yile Fu ; Juan Zhang ; Arthur Bezerra ; Tim De Coster ; Julie Cools ; Eike M Wülfers ; Siel Van den Bogaert ; Samuel L Murphy ; Antoine A de Vries ; Erik Fransen ; Nele Vandersickel ; Daniel A Pijnappels ; Guido Y De Meyer ; Hein Heidbuchel ; H. Llewelyn Roderick ; Vincent F Segers ; Gi […]
- GSE293170 Extracellular stiffness regulates site-specific lung development [AWO] June 2, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensExtracellular matrix (ECM) stiffness plays a crucial role in regulating cell fate and maturation, but its influence on lung development is limited known. Here we utilized stiffness-tunable gelatin methacryloyl (GelMA) hydrogels to investigate how ECM stiffness influences s […]
- GSE290681 Nuclear class 3 PI3K co-activates fasting-specific chromatin remodeling June 2, 2026Contributors : Nathaniel F Henneman ; Genki Kawamura ; Ying Luo ; Arianna Segaloni ; Ivan Nemazanyy ; Samuel le Cam ; Calvin Steve Rodrigues ; Nicolas Kuperwasser ; Nicolas Cagnard ; Raphaël Margueron ; Dominik Lutter ; Takeaki Ozawa ; Ganna Panasyuk ; Catia O Dias ; Karim Hnia ; Jiaqi SuSeries Type : Genome binding/occupancy profiling by high throughput seq […]
- GSE326720 Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy [RNASeq_MAVA] June 2, 2026Contributors : Laura Sen Martín ; Lucía Sánchez García ; Jon Sicilia ; Fàtima Sánchez CaboSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMyosin inhibitor mavacamten is the first targeted treatment available for hypertrophic cardiomyopathy (HCM), a disease caused by hundreds of genetic variants that affect mainly sarcom […]
- GSE298331 Effect of depletion of p38α and p38β on gene expression in naïve CD8+ T cells June 2, 2026Contributor : Lichen HuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusp38 MAPK is activated during CD8+ T cell primary response. p38 activation promotes effector CD8+ T cell terminal differentiation but represses MPEC formation. p38α/β-deficient mice possess a similar number of virus-specific effector CD8+ T cells as w […]
- GSE331440 Anti-PD-1 Treatment in an HFD/CCl4-Accelerated MASH-Fibrosis Mouse Model June 2, 2026Contributors : Panuwat Promsorn ; Takashi Yamaguchi ; Eriko Yamamoto ; Syunsuke Shiba ; Katsunori Yoshida ; Noriyo Yamashiki ; Koichi Tsuneyama ; Shinji Shimoda ; Makoto NaganumaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImmune checkpoint inhibitors (ICIs) show variable efficacy in hepatocellular carcinoma (HCC) de […]
- GSE326721 Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy [RNASeq_LSM] June 2, 2026Contributors : Laura Sen Martín ; Lucía Sánchez García ; Jon Sicilia ; Fàtima Sánchez CaboSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMyosin inhibitor mavacamten is the first targeted treatment available for hypertrophic cardiomyopathy (HCM), a disease caused by hundreds of genetic variants that affect mainly sarcom […]
- GSE333392 Transcriptomic analysis of U-373MG exposed to synthetic ShK-like peptide from the Jellyfish June 2, 2026Contributors : Jeong-In Park ; Seungshic Yum ; Youn-Jung KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensJellyfish-derived ShK-like peptides are potent blockers of the voltage-gated potassium channel Kv1.3, which plays key roles in immune cell activation and glioblastoma cell physiology. In this study, we investigate […]
- GSE333588 Single-cell mapping portrays the distinct expression features between chronic phase and B-lymphoblastic crisis samples from patients with CML June 2, 2026Contributors : Shuheng Yan ; Xuehong ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Chronic myeloid leukemia (CML) is a biphasic clonal hematopoietic stem cell disorder driven by the Philadelphia chromosome (Ph)-encoded BCR::ABL1 oncogene. The blast phase (BP) in CML progressed from indolent chronic ph […]
- GSE333609 Scutellarein accelerates diabetic wound healing by inhibiting P2RX1 and rescuing mitochondrial dysfunction and oxidative stress in fibroblasts June 2, 2026Contributors : Huang Yizhuo ; Shan Shengzhou ; Chang Mengling ; Yang Jun ; Liu FeiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Diabetic wounds are a major complication of diabetes mellitus and heal poorly due to persistent inflammation, fibroblast dysfunction, oxidative stress, mitochondrial injury, and i […]
- GSE298774 Spatial gene expression and microenvironmental changes in the transition of nevus to melanoma June 2, 2026Contributors : Inger Kreuger ; Veerle Merkus ; Sanne de Haan ; Anne Schrader ; Ferenc Scheeren ; Sjoerd van der Burg ; Tim van Groningen ; Roderick Slieker ; Remco van DoornSeries Type : OtherOrganism : Homo sapiensApproximately one-third of melanomas arise from benign nevi, yet the transcriptional and microenvironmental changes accompanying this transition […]
- GSE322778 Nuclear class 3 PI3K co-activates fasting-specific chromatin remodeling June 2, 2026Contributors : Nathaniel F Henneman ; Genki Kawamura ; Ying Luo ; Catia Dias ; Jiaqi Su ; Arianna Segaloni ; Ivan Nemazanyy ; Samuel le Cam ; Calvin Steve Rodrigues ; Nicolas Kuperwasser ; Nicolas Cagnard ; Karim Hnia ; Raphaël Margueron ; Dominik Lutter ; Takeaki Ozawa ; Ganna PanasyukSeries Type : Expression profiling by high throughput sequencingOrganism […]