Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE298230 Phosphorylation of Barrier-to-Autointegration Factor (BAF) regulates anchoring of centromeric heterochromatin to the nuclear envelope (NE) January 13, 2026
  Contributors : Carbonell Albert ; Escudero-Ferruz Paula ; Serrat Martina ; Zhang Chong ; Reina Oscar ; Medina-Giró Sònia ; Moreno-Moreno Olga ; Lipinski Zoltan ; Fernando AzorínSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterIn eukaryotes, the spatial segregation of heterochromatin and euchromat […]
• GSE297432 Systemic comparison of dCas9-based DNA methylation editing systems for specificity and stability [Bisulfite-Seq (reduced representation)_TMS2] January 13, 2026
  Contributors : Majid Pahlevan Kakhki ; Fatemeh Rangani ; Ewoud Ewing ; Chiara Starvaggi Cucuzza ; Galina Zheleznyakova ; Tejaswi Venkata S. Badam ; Maria Kalomoiri ; Ruxandra Covacu ; Ioanna Andreou ; Maria Needhamsen ; Lara Kular ; Maja JagodicSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensManipulating epigenetic lay […]
• GSE271283 Cohesin-mediated chromatin remodeling controls the differentiation and function of conventional dendritic cells (RNA-seq of SMC3 KO splenic cDCs) January 13, 2026
  Contributors : N Adams ; E Esteva ; B ReizisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe cohesin protein complex extrudes chromatin between CTCF binding sites and organizes it into topologically associated domains (TADs), yet the biological implications of this regulatory mechanism are poorly understood. We show […]
• GSE202762 Receptor Tyrosine Kinases phosphorylate RNA polymerase II at signal-responsive genes [RNA-seq] January 13, 2026
  Contributors : Preeti Dabas ; Wojciech Rosikiewicz ; Beisi Xu ; Aseem Z AnsariSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensReceptor Tyrosine Kinases phosphorylate RNA polymerase II and associate with distinct set of signal-responsive genes at different genomic loci.
• GSE277423 Regulation of the type I interferon response by chromatin organization (RNA-seq of L929 fibroblasts +/- SEV) January 13, 2026
  Contributors : Nicholas Adams ; Eduardo Esteva ; Ai Ra ; Boris ReizisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAntiviral type I interferons (IFN-I) including IFN-β and multiple subtypes of IFN-α are encoded within a single locus. Whereas most cell types produce primarily IFN-β, plasmacytoid dendritic cells (pDCs) […]
• GSE276936 Lipid metabolism in primary microglia January 13, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSpinal cord injury (SCI) profoundly affects functional capacity and the immune system plays a crucial role in recovery. In this study, we investigated the effects of SCI on macrophages and microglia in mice. We observed that macrophages infiltrated the spinal cord shortly […]
• GSE315896 Expression data from mice spleens January 13, 2026
  Contributors : Hyun J Kim ; Kyung-Ah Cho ; So-Youn WooSeries Type : Expression profiling by arrayOrganism : Mus musculusFemale C57BL/6J mice, 8 weeks old, were DNCB-induced dermatitis on skin. For the effect of tonsil-derived mesenchymal stem cells (T-MSCs)treatment, cells were added to dermatitis model.After 10 days, spleen cells were isolated for RNA expre […]
• GSE291050 Transcriptome-wide profiling of human stromal cells in mouse xenografts during preclinical treatment involving chemotherapy and/or the novel senomorphic agent dihydromyricetin January 13, 2026
  Contributor : Yu SunSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAging is a major risk factor for the vast majority of geriatric conditions, including various malignancies. Although cancer development can be generally attributed to the accumulation of genetic mutations, biological processes associated with aging also […]
• GSE315968 Targeting the Alk4 pathway protects against age-related bone loss. January 13, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOsteoporosis is a chronic age-related condition where imbalanced activities between bone-forming osteoblasts and bone-resorbing osteoclasts result in the progressive loss of bone volume and reduced bone quality. While drugs that target osteoclast activity have been develop […]
• GSE315946 As2S2 restores erythroid maturation in sf3b1-deficient zebrafish by upregulating smad7 January 13, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Danio rerioSF3B1 is among the most frequently mutated genes in myelodysplastic syndromes (MDS) and is closely associated with aberrant erythropoiesis, yet strategies to restore terminal erythroid maturation in SF3B1-linked disease are limited. Using a zebrafish sf3b1 knockdown model, […]
• GSE315987 M-cadherin regulates the formation of adherens junctions and secondary myofibers during fetal myogenesis to determine adult myofiber number and muscle mass January 13, 2026
  Contributors : David R. Golann ; Patrick J. Ferrara ; Naveen P. Khan ; Margaret Hung ; Virgiinia Hughes ; Samer Nuwayhid ; Jonas Bovijn ; Peter Dornbos ; Luca Lotta ; Peisheng Shi ; Qi Su ; Yajun Tang ; Mark W. Sleenman ; Michael J. StecSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCadherin-mediated adhesion of skelet […]
• GSE316061 Hawaiian bobtail squid symbiont, Leisingera sp. ANG-M7, uses a “combined arms” strategy to overcome competitor resistance January 13, 2026
  Contributors : Andrea M Suria ; Alecia N SepterSeries Type : Expression profiling by high throughput sequencingOrganism : Leisingera sp. ANG-M7Competition between bacteria can impact the ability to colonize a host. In the accessory nidamental gland (ANG) reproductive symbiosis of the Hawaiian bobtail squid, Euprymna scolopes, symbionts colonize various epith […]
• GSE316069 Single-cell Profiling Reveals Diverse γδ T Cell Subsets in Ulcerative Colitis January 13, 2026
  Contributor : Jakob ArnoldSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensγδ T cells maintain intestinal immune homeostasis, but their contributions to human ulcerative colitis (UC) are poorly understood. We characterized γδ T cells in intestinal biopsies obtained from patients with UC and healthy donors using s […]
• GSE296999 Novel syngeneic cell lines for studying high-risk BRAFV600E-driven colorectal cancer in vivo [RNA-seq_organoids] January 13, 2026
  Contributors : Jasmin Traichel ; Ariane Metzger ; Maria Walz ; Reinhild Feuerstein ; Nadine Wohlfeil ; Patrick Metzger ; Lisa Marx ; Célia Asdih ; Agnes Lindenthal ; Alina Seger ; Jule Schrimpf ; Luigi L Nardella ; Silke Kowar ; Ian J Frew ; Sebastian Halbach ; Rebecca Kesselring ; Melanie Boerries ; Ricarda Griffin ; Tilman BrummerSeries Type : Expression p […]
• GSE315883 Lack of synergy between AR targeted therapies and PARP inhibition in homologous recombination- proficient prostate cancer [ATAC-seq] January 13, 2026
  Contributors : Nicole A Traphagen ; Myles BrownSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensRecent clinical trials have explored the combination of androgen receptor (AR) pathway inhibitors and poly (ADP-ribose) polymerase (PARP) inhibitors as a potential treatment for castration-resistant prostate canc […]