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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE303329 Systematic investigation reveals extensive Epstein-Barr virus transcriptional regulation of the human genome [ATAC-seq] June 8, 2026Contributors : Matthew Weirauch ; Leah KottyanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe systematically investigate interactions between Epstein-Barr virus (EBV) transcriptional regulators (vTRs) and the human genome. Starting with 16 known and candidate vTRs, we identify nine whose introduction in […]
- GSE306577 Fasting primes small intestinal regeneration after damage via a microbiome-metabolite-chromatin axis [Cut & Tag] June 8, 2026Contributors : Praveen Barrodia ; Ajay Saw ; Helen Piwnica-Worms ; Kunal RaiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusFasting protects the small intestine epithelial cells from high-dose radiation injury, yet the mechanisms linking fasting to epithelial regeneration remain incompletely understood. Ak […]
- GSE303605 Rbm5 Sustains Leukemia Stem Cells Through a Myc-driven Transcriptional Circuitry June 8, 2026Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE190886 single-cell analysis of PA14-treated control and roX2 depleted ISCs (PA14 treated) June 8, 2026Contributor : K L LiSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterTo investigate if roX2 is involved in pathogen induced gene silencing, we perfomed the single-cell analysis. We show that depletion of roX2 resulted in 2780 genes up-regulated, supporting a repressive role of roX2 in transcription.
- GSE308086 Altered expression profile of miRNAs in canine inguinal testes June 8, 2026Contributors : Joanna Nowacka-Woszuk ; Arkadiusz Kajdasz ; Izabela Szczerbal ; Monika Stachowiak ; Marek SwitonskiSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Canis lupus familiarisCryptorchidism is a major disorder of sex development (DSD) in dogs, with a complex, polygenic background. It is known that in canine undescended […]
- GSE292576 XPO1 R749Q Mutation Drives Endometrial Cancer Progression by Activating HIF-1/2α–AXL–PI3K/MAPK Signaling June 8, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe tumor driver gene XPO1 (exportin-1) exhibits high-frequency mutations in endometrial cancer (approximately 6%), with two hotspot mutation sites identified as E571K and R749Q. However, the molecular mechanisms by which XPO1 mutations influence the initiation and progres […]
- GSE269289 ATR inhibition affects RNA Polymerase II transcription during S-phase June 8, 2026Contributors : Jianming Wang ; Marco SaponaroSeries Type : OtherOrganism : Homo sapiensTranscription and replication are the key processes in cell growth and division that utilize DNA as their template. Concurrently, conflicts between the two processes increase genome instability levels. Evidence in the literature indicate that transcription and replication […]
- GSE334323 Custom Probe-Based Spatial Transcriptomics Enables Microbiome Detection in FFPE Colorectal Cancer Tissue June 8, 2026Contributors : Rayyan Aburajab ; Jennifer Karmouch ; Robert Jenq ; David W CraigSeries Type : OtherOrganism : Homo sapiensWe describe a custom probe design pipeline targeting the variable regions of bacterial 16S rRNA, compatible with the probe-based chemistry of the 10X Genomics Visium CytAssist platform, enabling spatially resolved bacterial profiling in F […]
- GSE334289 Host transcriptional responses reveal molecular signatures of immune regulation and blood-brain barrier remodelling in porcine neurocysticercosis June 8, 2026Contributors : Carla A Apaza-Quiroz ; Cielo C Rojas-Portocarrero ; Sneider A Gutierrez ; Emily K Ponce-Nakatahara ; Javier A Bustos ; Gianfranco Arroyo ; Robert H Gilman ; Héctor H García ; Mirko ZimicSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofa domesticusNeurocysticercosis, caused by the establishment of Taenia soliu […]
- GSE334369 Paradoxical Phenotype of Fibromyalgia Neutrophils: Elevated Baseline Inflammation but Blunted Response to Stimulation June 8, 2026Contributors : Sahel Jahangiri Esfahani ; Mohamad Karaky ; Marc Parisien ; Francesca Montagna ; Carolina B Meloto ; Jeffrey S Mogil ; Luda DiatchenkoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFibromyalgia (FM) is a long-term pain condition of unknown etiology. We investigated transcriptomic responses of FM and heal […]
- GSE334345 Exploratory investigation of changes in blood transcriptome following mepolizumab treatment for asthma June 8, 2026Contributors : Mitchell Pitlick ; Mrunal K Dehankar ; Chantal E McCabe ; Sergio E Chiarella ; Kathleen Bartemes ; Kay A Bachman ; Chung-Il Wi ; Young J Juhn ; Thanai PongdeeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensObjective: To evaluate the effects of mepolizumab therapy on the blood transcriptome in patients wit […]
- GSE334376 Single-cell RNA-seq of healthy human epidermal cells from adult abdominal skin June 8, 2026Contributors : Hannes Kühtreiber ; Polina Kalinina ; Michael MildnerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSingle-cell RNA sequencing was performed on viable epidermal cells isolated from healthy adult human abdominal skin samples obtained during abdominoplasty. Epidermal cell suspensions were generated by enzy […]
- GSE334384 Enhanced vasoactive intestinal peptide signaling prevents the development of Duchenne muscular dystrophy-associated cardiomyopathy through inhibition of NF-κB signaling June 8, 2026Contributors : Jian Huang ; Terry Gemelli ; Xuan Jiang ; Yunbeen Bae ; Xiang Luo ; John Shelton ; Bret Evers ; Sue Arnoldf ; John Lee ; Pradeep P.A. MammenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDuchenne muscular dystrophy (DMD) is an X-linked recessive neuromuscular disorder caused by mutations in the dystrophi […]
- GSE334588 Single-cell transcriptomic atlas of adult dermatomyositis, cutaneous lupus erythematosus and healthy skin June 8, 2026Contributors : Ksenia Anufrieva ; Kevin WeiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAdult-onset dermatomyositis (DM) is a systemic autoimmune disease associated with an elevated risk of malignancy, yet the cellular and molecular features distinguishing cancer-associated DM from non-cancer DM remain poorly defined […]
- GSE298800 An AI-integrated workflow maps the latent interactome of molecular glue degraders June 8, 2026Contributors : Pius Galli ; Shuhao Xiao ; Yanxiang Meng ; Alexander Hanzl ; Alexandra M Bendel ; Regina Baur ; Jacob Aguirre ; Anna M Diaz-Rovira ; Georg Kempf ; Lukas Kater ; Kenji Shimada ; Ye Wie ; Andreas Scheck ; Dominique Klein ; Siomne Cavadini ; Ben Lehner ; Guillaume Diss ; Bruno E Correia ; Nicolas H ThomäSeries Type : OtherOrganism : Saccharomyces […]