Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE301853 Restoring NK cell cytotoxicity post-cryopreservation via synthetic IL-2-presenting cells July 6, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNatural killer (NK) cells are critical components of the first-line immune defense, responsible for eliminating tumorigenic cells. NK cell-based adoptive immunotherapy has gained increasing attention; however, cryopreservation, a standard technique for NK cell storage, sig […]
• GSE302442 A multi-functional oral small molecule targeting energy and lipid metabolism as a treatment for diet-induced obesity [Exp 3] July 6, 2026
  Contributors : Justin Y Lee ; Chi Zhu ; Anders M Näär ; Gracia Bonilla ; Ruslan SadreyevSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity and related metabolic disorders have surged globally, representing a significant public health burden. These diseases are mechanistically interconnected through complex pathways […]
• GSE302440 A multi-functional oral small molecule targeting energy and lipid metabolism as a treatment for diet-induced obesity [Exp 1] July 6, 2026
  Contributors : Justin Y Lee ; Chi Zhu ; Anders M Näär ; Gracia Bonilla ; Ruslan SadreyevSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity and related metabolic disorders have surged globally, representing a significant public health burden. These diseases are mechanistically interconnected through complex pathways […]
• GSE303840 Racial discrepancies in placental gene expressions between Black and White healthy and preeclampsia patients of equivalent BMI and blood pressure in a Southeastern USA cohort July 6, 2026
  Contributors : Madison Ives ; Gibson Cooper ; Cayman Bickerstaff ; Mona Elgazzaz ; Cassie Sam ; Amalia Brawley ; Safia Ogbi ; Elisabeth Mellott ; Desmond Moronge ; Stephanie Stokes ; Joanna Hitchings ; Luis V Zarate ; Sravankumar Kavuri ; Padmashree Woodham ; James Maher ; Jessica L FaulknerSeries Type : Expression profiling by high throughput sequencingOrga […]
• GSE302445 A multi-functional oral small molecule targeting energy and lipid metabolism as a treatment for diet-induced obesity [Exp 5] July 6, 2026
  Contributors : Justin Y Lee ; Chi Zhu ; Anders M Näär ; Gracia Bonilla ; Ruslan SadreyevSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity and related metabolic disorders have surged globally, representing a significant public health burden. These diseases are mechanistically interconnected through complex pathways […]
• GSE314562 Transcription co-repressors Panky and Panky-like are essential for retinal cone photoreceptor integrity and survival by modulating ganglioside metabolism July 6, 2026
  Contributors : Hung-Ya Tu ; Daichi Gyoten ; Takahisa FurukawaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the in vivo functions of mouse Panky and its paralog, Panky-like (Ankrd33b), we generated and analyzed the Panky/Panky-like double knockout (PPL DKO) mice. PPL DKO mice exhibited decreased light-ev […]
• GSE306025 Dosage-dependent role of Gata3 in primitive endoderm and trophectoderm specification in embryonic stem cells [ChIP-seq] July 6, 2026
  Contributors : Yeejin Jang ; Mijeong Kim ; Jonghwan KimSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTranscription factors (TFs) are critical regulators of cell fate decisions, and their intricate balance determines lineage specification during early development. Gata3 is a well-established TF in the tro […]
• GSE337265 Cross-species single cell transcriptomics in fly and beetle reveals the genetic core of brain neuroblast specification July 6, 2026
  Contributors : Noel Cabañas ; Gregor BucherSeries Type : Expression profiling by high throughput sequencingOrganism : Tribolium castaneumThis work defines the conserved core of TFs involved in insect brain NB specification by cross-species comparison of single-cell transcriptomics of NBs from, the red flour beetle, Tribolium castaneum, and the vinegar fly, D […]
• GSE337197 Fear-triggered reactive astrocytes orchestrate selective aversive memory decay via IL-3–CSF2RB2 signaling July 6, 2026
  Contributors : Chang-Fei Tang ; Xian-Dong Liu ; Wu-Bo Han ; Xin-Rong Wu ; Yi-Ning Gao ; Zheng-Kai Lao ; Han-Yu Xu ; Yulei Deng ; Yanqiang Hou ; Tian-Le Xu ; Zhang-Peng Chen ; Suya Sun ; Nan-Jie XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusForgetting is a fundamental component of the memory system. While existing st […]
• GSE337275 Pioneer transcription factor TAL1 reshapes chromatin architecture to direct erythroid cell fate commitment [ATAC-Seq 2] July 6, 2026
  Contributors : Lixiang Chen ; Ying Cheng ; Lei Sun ; Hengchao Zhang ; Xiuyun WuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensPioneer transcription factors critically regulate chromatin organization and hematopoietic cell lineage commitment. During erythropoiesis, hematopoietic stem cells undergo dynamic […]
• GSE337274 Pioneer transcription factor TAL1 reshapes chromatin architecture to direct erythroid cell fate commitment [CUT&Tag] July 6, 2026
  Contributors : Lixiang Chen ; Ying Cheng ; Lei Sun ; Hengchao Zhang ; Xiuyun WuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensPioneer transcription factors critically regulate chromatin organization and hematopoietic cell lineage commitment. During erythropoiesis, hematopoietic stem cells undergo dynamic […]
• GSE337276 DNA methylation maintenance by DNMT1 is essential for human trophoblast stem cell homeostasis and differentiation [RNA-seq] July 6, 2026
  Contributors : Sanam Kavari ; YuJin Jang ; Jonghwan Kim ; Winifred Mak ; Jennifer KalishSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensProliferation of cytotrophoblasts (CTBs) and their differentiation into invasive extravillous trophoblasts (EVTs) are critical processes in early placental development. Defects in these […]
• GSE337277 DNA methylation maintenance by DNMT1 is essential for human trophoblast stem cell homeostasis and differentiation [RRBS] July 6, 2026
  Contributors : Sanam Kavari ; YuJin Jang ; Jonghwan Kim ; Winifred Mak ; Jennifer KalishSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensProliferation of cytotrophoblasts (CTBs) and their differentiation into invasive extravillous trophoblasts (EVTs) are critical processes in early placental development. Defects in thes […]
• GSE337280 Transcriptome-wide m6A methylation profiling of penile tissues in a rat model of hypospadias July 6, 2026
  Contributors : Jingmin Zhang ; Shan Wang ; Xianghui XieSeries Type : OtherOrganism : Rattus norvegicusRNA modifications are an important component of epigenetic regulation and play essential roles in embryonic development. Among these modifications, N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic messenger RNA, regulates diver […]
• GSE279193 BHLHE40 Orchestrates TL1A-Driven ILC3 Effector Programs and RORγt⁺ APC-Mediated Tolerance July 6, 2026
  Contributors : Wei Yang ; Randy LongmanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA central feature of the intestinal immune system is the ability to protect against pathogens while maintaining antigen-specific tolerance to the gut bacteria that coat its surface. Here, we identified Bhlhe40 as a central regulator o […]