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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE227793 H3K27ac and H3K4me3 ChIP-Seq profiling of a human paired left and right atrial cohort of atrial fibrillation and healthy sinus rhythm individuals February 16, 2026Contributors : Rodriguez Adrian ; Diego VillarSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensH3K27ac and H3K4me3 ChIP-Seq profiling was performed on atrial appendages samples from 12 individuals aged over 60 years, either classified as persistent atrial fibrillation (AF) or normal sinus rhythm (SR). For a […]
- GSE293990 NAND Hybrid Riboswtich Design by Deep Batch Bayesian Optimization February 16, 2026Contributors : Daniel Kelvin ; Erik Kubaczka ; Marianna Karava ; Heinz Koeppl ; Beatrix SuessSeries Type : OtherOrganism : Saccharomyces cerevisiaeThe design of large genetic circuits requires genetic regulatory devices capable of performing complex logic operations. Hybrid riboswitches, synthetically enhanced compact RNA elements (
- GSE290099 Immune response of human lung tissue after infection with human parainfluenza virus-3 – canonical pathways and treatment February 16, 2026Contributors : Danov O. ; Fuchs M. ; Obernolte H. ; Röpken F. ; Vollmer Barbosa P. ; Sewald K.Series Type : Expression profiling by arrayOrganism : Homo sapiensEx vivo human precision-cut lung slices (PCLS) were infected with human parainfluenza virus 3 (hPIV-3). We used microarry to explore the changes in gene expression between infected and non-infected, s […]
- GSE304354 A human-specific enhancer modulates chromosomal interactions to promote neurogenesis [human scRNA-seq] February 16, 2026Contributors : Federica Mosti ; Debra SilverSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChanges to the human genome have driven the evolution of human features including a larger neocortex and enhanced cognition. Human Accelerated Regions (HARs) are highly-conserved loci containing human-specific variants, which can […]
- GSE299505 mRNA profiling upon knockdown of circRNA-HIPK2 February 16, 2026Contributors : Thum Thomas ; Jung Mira ; Maximillian FuchsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDespite advances in drug development, global mortality rates following heart failure (HF) remain still high, underscoring the critical need for novel therapeutic strategies. Emerging evidence highlights cardiac macr […]
- GSE311025 NGS-based analysis of i6A and ms2i6A modification levels on tRNATyr in Schizosaccharomyces pombe and Escherichia coli February 16, 2026Contributors : Yu Sun ; Ann E Ehrenhofer-MurraySeries Type : OtherOrganism : Escherichia coli ; Schizosaccharomyces pombeQueuosine (Q) is a complex tRNA modification found at position 34 of four tRNAs with a GUN anticodon, and it regulates the translational efficiency and fidelity of the respective codons that differ at the Wobble position. Previous studies […]
- GSE307404 Schizophrenia-linked gene expression changes across cortical layers and cellular microenvironments in human prefrontal cortex [Xenium] February 16, 2026Contributors : Sang-Ho Kwon ; Boyi Guo ; Cindy Fang ; Madhavi Tippani ; Svitlana V Bach ; Ryan A Miller ; Sarah E Maguire ; Madeline R Valentine ; Seyun Oh ; Aarti Jajoo ; Artemis Iatrou ; Vijetha Balakundi ; Yufeng Du ; Annie B Nguyen ; Ruth Zhang ; Uma Kaipa ; Heena R Divecha ; Jashandeep S Lobana ; Joel E Kleinman ; Nikolaos P Daskalaskis ; Thomas M Hyde […]
- GSE319316 Localised negative feedback shapes genome-wide patterning of meiotic DNA breaks February 16, 2026Contributors : Luz M Lopez Ruiz ; Jon A Harper ; Dominic Johnson ; Rachal M Allison ; William H Gittens ; George G Brown ; Matthew J NealeSeries Type : OtherOrganism : Saccharomyces cerevisiaeGenetic diversity within sexually reproducing species arises via the formation and repair of programmed DNA double-strand breaks (DSBs) created by the evolutionarily co […]
- GSE319314 Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model February 16, 2026Contributors : Sydney P Sterben ; Charitha C Anamala ; Sahan B Kansakar ; Vaishnavi Koduri ; Volha LiaudanskayaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAutism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial f […]
- GSE319344 Loss of meningeal lymphatic endothelial cells results in formation of a novel vascular network with scavenging function. February 16, 2026Contributors : Katharina Uphoff ; Andreas van Impel ; Lars Muhl ; Martin Stehling ; Christer Betsholtz ; Stefan Schulte-MerkerSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioFor an extended period of time, the meninges were believed to be devoid of lymphatic vessels. The recent discovery of lymphatic vessels in the dura […]
- GSE319333 Characterization of mtdsRNA levels in Non-Small Cell Lung Carcinoma (NSCLC) February 16, 2026Contributors : Matthew R Krieger ; Sandy Che-Eun S Lee ; Maya Cielo Cornejo ; Kevin L HeSeries Type : OtherOrganism : Homo sapiensMitochondrial double-stranded RNA (mtdsRNA) is exported to the cytoplasm when mitochondrial RNA degradation is impaired, serving as a novel Damage-Associated Molecular Pattern (DAMP) for mitochondrial stress. The mtdsRNA has been […]
- GSE319347 Homo sapiens bulk RNA-seq for iMGLs and iMGL-motor neuron co-cultures with cGAS inhibitor February 16, 2026Contributors : Yajing Liu ; Li Fan ; Abulimiti Aikedan ; Weixi FengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study investigates the role of cGAS signaling in amyotrophic lateral sclerosis using human microglial-like cells (iMGLs) and iMGL-motor neuron co-cultures. Bulk RNA sequencing was performed to assess t […]
- GSE319369 Cell Atlas and Novel Signal Processing Strategy in Primate Insular Cortex [Patch-seq] February 16, 2026Contributors : Sheng Liu ; Ruifeng LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Macaca fascicularisThe anterior insular cortex (AIC) is a critical hub integrating exteroceptive and interoceptive information into high-order cognition, yet its neural basis remains incompletely understood. Here, by combining whole-cell-based sin […]
- GSE319394 RNA-seq profiling of Siniperca chuatsi MFF-1 cells under hypoxic conditions February 16, 2026Contributors : Mincong Liang ; Yang Yu ; Shaoping Weng ; Jian He ; Jianguo He ; Changjun GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Siniperca chuatsiTo investigate the molecular mechanisms underlying hypoxia adaptation in mandarin fish (Siniperca chuatsi), bulk RNA sequencing was performed on MFF-1 cells. The study compares […]
- GSE319486 Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinoma February 16, 2026Contributors : Elena Adan-Villaescusa ; Borja Castello-Uribe ; Iker Uriarte ; Eva Santamaria ; Roberto Barbero ; Miriam Belzunce ; Amaya López-Pascual ; Maria Ujue Latasa ; Jasmin Elurbide ; Emiliana Valbuena-Goiricelaya ; Agavni Mesropian ; Guillem Cano-Segarra ; Ana Hernández de Sande ; Lorenzo Nevi ; Simone Carotti ; Umberto Vespasiani-Gentilucci ; Felipe […]