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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE320216 Genome reorganization and its functional impact during breast cancer progression [RNA-Seq] February 25, 2026Contributors : Kathleen S Reed ; Tom Misteli ; Andrew Fritz ; Haley Greenyer ; Seth Frietze ; Janet Stein ; Gary SteinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo explore how chromatin structure and epigenetic parameters of genome architecture changes during cancer progression at a fine scale and genome-wide, we g […]
- GSE278223 Effect of IL-7 therapy on virus-specific CD8 T cell response during chronic viral infection February 25, 2026Contributors : Judong Lee ; Christina Niavi ; Eunseon Ahn ; Haydn T Kissick ; Rajesh M Valanparambil ; Donald J McGuire ; Rebecca Obeng ; Alexandra A Wolfarth ; Danielle Borgonia ; Sara Ferrando-Martinez ; Donghoon Choi ; Byung Ha Lee ; Rafi AhmedSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPD-1+TCF-1+ stem-like CD8 […]
- GSE264354 Nuclear Speckles enable processing of RNA from GC-rich Isochores February 25, 2026Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Gallus gallus ; Homo sapiens ; Pimephales promelasThis SuperSeries is composed of the SubSeries listed below.
- GSE287674 MafB is a conserved transcriptional regulator of macrophage development and identity across tissues and species [scRNA-Seq] February 25, 2026Contributors : Domien Vanneste ; Joan Abinet ; Thomas MarichalSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusResident tissue macrophages (RTM) are characterized by a remarkable diversity but also share common features that are thought to be driven by conserved transcriptional programs. While the transcription factor Ma […]
- GSE280673 Mechanosensitive Role of Snx5 in Alveolar Bone Remodeling February 25, 2026Contributor : xue jiangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe placement of implants induces a compressive effect on the adjacent bone tissue, serving as a form of mechanical stimulation. Insufficient mechanical stimulation may result in diminished bone quality or even implant failure. Nevertheless, the unde […]
- GSE295581 A bacterial CARD-NLR immune system controls the release of gene transfer agents [Tn-Seq] February 25, 2026Contributors : Emma Banks ; Tung LeSeries Type : OtherOrganism : Caulobacter vibrioidesBacteria have evolved a wide array of immune systems to detect and defend against external threats including mobile genetic elements (MGEs) such as bacteriophages, plasmids, and transposons. MGEs are often selfish, exploiting their bacterial hosts to propagate, however the […]
- GSE291409 BALF gene expression profiling reveals innate immune activation bias in persistent post-COVID-19 ILD February 25, 2026Contributors : Katerina M Antoniou ; Eliza Tsitoura ; Eirini VasarmidiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSurvivors of COVID-19 can experience long-term lung complications (pulmonary sequelae), but the underlying mechanisms remain unclear. While most patients with major COVID-19 lung injury eventually recove […]
- GSE320017 Cellular heterogeneity in hypertrophic burn scars in response to carbon dioxide laser therapy February 25, 2026Contributors : Yung-Yi Chen ; Christopher Mahony ; Jason Turner ; Charlotte G Smith ; Abdulrazak Abdulsalam ; Ezekwe Amirize ; Amberley Prince ; Adrian Heagerty ; Claudia Roberts ; Adam Croft ; Yvonne Wilson ; Naiem Moiemen ; Janet M LordSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Ablative fractional car […]
- GSE319407 Teratoma formation by Safe and Allo-Accepted Pluripotent Cells February 25, 2026Contributors : Vivian Tam ; Danny ChanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPluripotent stem cells are a promising alternative in cell and tissue transplantation as they have the potential to be differentiated into different cell types to treat various diseases. However, two major challenges have hindered thei […]
- GSE320120 Thiolutin Extends Replicative Lifespan by Rewiring Yeast Transcription and Metabolism February 25, 2026Contributors : Mateusz Mołoń ; Patrycja Kielar ; Zofia Kobylińska ; Agnieszka Mołoń ; Jarosław Winiarski ; Monika Kula-Maximenko ; Sabina GaliniakSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeThis study examines the global transcriptomic response of Saccharomyces cerevisiae strain BY4741 to short-term expo […]
- GSE320076 Natural constitutive promoters from Actinoplanes siamensis TBRC 4237 enable high-level heterologous gene expression in Streptomyces coelicolor February 25, 2026Contributors : Suranan Yoolong ; Wuttichai Mhuantong ; Jindaporn Kongsee ; Kitlada Srichomthong ; Chayaphat Wongsombat ; Pattanop Kanokratana ; Chanwit Suriyachadkun ; Vanicha Vichai ; Aiyada AroonsriSeries Type : Expression profiling by high throughput sequencingOrganism : Actinoplanes siamensisActivation of cryptic biosynthetic gene clusters (BGCs) in acti […]
- GSE320155 scRNA‑seq of human intra‑hepatic CD4⁺ T cells reveals unique Treg transcriptional identities and two steady‑state tissue‑adaptation programs across healthy and HCC liver samples February 25, 2026Contributors : Elena Perpiñán ; Nicolas Sompairac ; Shahram Kordasti ; Alberto Sanchez-Fueyo ; Niloufar SafiniaSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensWe employed a single‑cell sequencing approach using the 10x Genomics platform, including scRNA‑seq, CITE‑seq, and paired TCR libraries, to investigate the […]
- GSE320210 The interaction between virus-bound KLF4 and host-bound PARP1 directs the localization of Adeno-Associated Virus Type 2 (wtAAV2) to cellular sites of DNA damage February 25, 2026Contributors : Rhiannon Abrahams ; Clairine Larsen ; Kinjal MajumderSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensUsing a modified iteration of a circular chromosome conformation capture to map the location of viral genomes (V3Cseq), we show that the Adeno-Associated Virus genome localizes spatially with […]
- GSE320215 Genome reorganization and its functional impact during breast cancer progression [ATAC-Seq] February 25, 2026Contributors : Kathleen S Reed ; Tom Misteli ; Andrew Fritz ; Haley Greenyer ; Seth Frietze ; Janet Stein ; Gary SteinSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo explore how chromatin structure and epigenetic parameters of genome architecture changes during cancer progression at a fine scale and gen […]
- GSE300509 In vitro growth of Toxoplasma gondii tachyzoites on different host cell lines selects for changes in efficiency of invasion and parasite surface antigen gene expression February 25, 2026Contributors : Adit Naor ; John BoothroydSeries Type : Expression profiling by high throughput sequencingOrganism : Toxoplasma gondii ME49Toxoplasma gondii is remarkable for its intermediate host range which includes most warm-blooded animals so far tested. Being such a generalist poses challenges for how the parasite can be optimized for growth in cell type […]