Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE292882 FANCM is Required for the PAX3::FOXO1-Driven Oncogenic Program in Rhabdomyosarcoma [CRISPR Screen] August 4, 2026
  Contributors : Christopher D Delaney ; Kris C WoodSeries Type : OtherOrganism : Homo sapiens ; unidentifiedAlveolar rhabdomyosarcoma (ARMS) is a highly aggressive pediatric soft tissue sarcoma driven by the PAX3::FOXO1 fusion protein. Despite multipronged treatment approaches, survival rates for patients with fusion-positive (FP) ARMS remain poor, underscori […]
• GSE304540 Mutagenicity of N-nitrosodiethylamine and its mechanism of action in liver and bone marrow of Big Blue rats evaluated using in vivo mutation assays and gene expression analysis August 4, 2026
  Contributors : Li Xia ; Jian Yan ; Tao ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusN-Nitrosodiethylamine (NDEA) has been extensively studied as a carcinogen especially in liver. The detection of NDEA as a contaminant in widely used drugs has led to numerous product recalls in recent years, highlighting the […]
• GSE294384 Transcriptome profiling analysis of heat-adapted breeder hen jejunal mucosal tissues in response to acute heat stress August 4, 2026
  Contributors : Yongcai Zhu ; Satoshi Kubota ; Phocharapon Pasri ; Sutisa KhempakaSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusHeat stress (HS) can weaken the intestinal integrity and damage the intestinal barrier function of poultry, disrupting nutrient digestion and absorption. However, the underlying molecular mec […]
• GSE307145 CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity August 4, 2026
  Contributors : Eduardo Bonavita ; Victoria S Pelly ; Maria Koufaki ; Richard Reeves ; Sudhakar Sahoo ; Santiago ZelenaySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSingle-cell transcriptomics identifies a convergent activation state of conventional dendritic cells (cDCs) shared by type 1 and type 2 cDCs (cDC1s and cD […]
• GSE306256 Cell-intrinsic functions of PD-L1 activate autophagy and prevent cytokine-induced apoptosis August 4, 2026
  Contributors : Mihaela Stefan-Lifshitz ; Nicola Viola ; Olga Meshcheryakova ; Crystal Nieves Garcia ; Pamela Mattar ; Zhengzi Yi ; Marie Louise Aoun ; John C. McAuliffe ; Jonathan Smith ; Vikas Mehta ; Richard V. Smith ; Adam J. Gersten ; Weijia Zhang ; Rajat Singh ; Yaron TomerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus mu […]
• GSE264237 Age-dependent alterations in the human striatum identify a PPP1R15B-miR-196a node as a modifier of Huntington’s disease phenotypes August 4, 2026
  Contributors : V A Church ; A S YooSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPolyglutamine expansion in Huntingtin (HTT) causes its aggregation and progressive loss of striatal neurons in Huntington’s disease (HD). HD is a mostly adult-onset neurodegenerative disorder with no disease-modifying therapies. Here we f […]
• GSE330626 CXCL10 contributes to female-specific pathological progression in tauopathy model mice August 4, 2026
  Contributors : Ryohei Uenishi ; Masanori Hijioka ; Takashi SaitoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeuroinflammation plays a central role in the progression of tauopathy via the glial activation and T cell accumulation in the brain parenchyma. However, the key molecular mediators that link these processes t […]
• GSE341913 Single-cell transcriptomic atlas of intestinal segments from KM mice August 4, 2026
  Contributors : Tailiang Chai ; Yang Chen ; Weiming Liang ; Ruizhen Zhao ; Yifei Sheng ; Fuhua Lu ; Fangxiao DongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study generated a single-cell transcriptomic atlas of multiple intestinal segments (jejunum, ileum, cecum, and colon) from specific pathogen-free (SPF) and […]
• GSE341912 Single-cell transcriptomic validation of B cell, T cell, and myeloid subsets in colon from C57BL/6 mice August 4, 2026
  Contributors : Tailiang Chai ; Yang Chen ; Weiming Liang ; Ruizhen Zhao ; Yifei Sheng ; Fuhua Lu ; Fangxiao DongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis dataset serves as a validation cohort for single-cell transcriptomic changes observed in germ-free (GF) and specific pathogen-free (SPF) mice. Single-cell R […]
• GSE341961 Acoustic Cavitation-Enhanced Remodeling of Lymph Node Microenvironment Enables Deep Infiltration for Potent Cancer Vaccination August 4, 2026
  Contributors : Bihan Wu ; Xiaodan Xu ; Peile Jin ; Yijie Chen ; Xia Fang ; Yue Song ; Guowei Wang ; Jiajia Zhou ; Huaimin Wang ; Pintong HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe efficacy of peptide-based tumor vaccines is often constrained by the size-exclusion barrier of the subcapsular sinus (SCS), whi […]
• GSE341914 Spatial transcriptomic atlas of intestinal segments from KM mice August 4, 2026
  Contributors : Tailiang Chai ; Yang Chen ; Weiming Liang ; Ruizhen Zhao ; Yifei Sheng ; Fuhua Lu ; Fangxiao DongSeries Type : OtherOrganism : Mus musculusThis study generated spatial transcriptomic profiles of ileum, cecum, and colon from specific pathogen-free (SPF) and germ-free (GF) Kunming (KM) mice using the BGI Stereo-seq platform. The dataset captures […]
• GSE341964 Gene duplication of SNAPC1 generates transcription factors for snRNAs and sex-specific piRNAs [ChIP-Seq] August 4, 2026
  Contributors : Lars K Benner ; Margaret R Starostik ; Rebecca J Tay ; Ayaka Inoki ; Mindy Clark ; Suhua Feng ; Michael C Schatz ; Steven E Jacobsen ; John K KimSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Caenorhabditis elegansPiwi-interacting RNAs (piRNAs) are small non-coding RNAs essential for transposon silenci […]
• GSE341968 TSPAN8 a plasticity marker is transcriptionally regulated through DUSP19 BRD4 crosstalk in Prostate Cancer cells August 4, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo identify upstream regulators of TSPAN8 transcription, we screened a library of 298 phosphatases using a GFP reporter under the control of the TSPAN8 promoter in PC3 cells. DUSP19 emerged as the strongest negative regulator. Unexpectedly, DUSP19-mediated regulation of TS […]
• GSE341970 Exploring the m6A modification profile after METTL16 overexpression in BEAS-2B cells. August 4, 2026
  Contributors : Mingshun Zhang ; Tingting Xu ; Ningfei Ji ; Mao HuangSeries Type : OtherOrganism : Homo sapiensAllergic asthma is a common disease. We aimed to investigate the role of METTL16, an N6-methyladenosine (m6A) writer, in allergic asthma and epithelial homeostasis. Here we show that pulmonary METTL16 expression was decreased in patients with allergi […]
• GSE292872 FANCM is Required for the PAX3::FOXO1-Driven Oncogenic Program in Rhabdomyosarcoma [RNA-Seq] August 4, 2026
  Contributors : Christopher D Delaney ; Kris C WoodSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMany cancers are driven by mutationally altered transcription factors (TFs) that rewire cells to an oncogenic state. Cells must activate specific mechanisms to tolerate the burden of oncogenic TF activity. To define such me […]