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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE301941 Fenofibrate-mediated inhibition of tumor proliferation and progression by modulating the PTPN14/MARK/Hippo signaling axis July 10, 2026Contributors : Yang Liu ; Xuedi Cao ; Tengrui Zhang ; Jianling Yang ; Xiaotong Yu ; Zixuan Zhen ; Yinjia Li ; Yang Ye ; Xin Zhou ; Kewu Zeng ; Lixiang XueSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPTPN14 is a non-receptor tyrosine phosphatase that functions as a tumor suppressor through negative regulation of the H […]
- GSE288064 RNA sequencing of HUVEC, HCMEC and human primary skeletal muscle cells in response to in vitro mechanical loading July 10, 2026Contributors : Riikka Kivela ; Erik NiemiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOur objective was to profile and compare the transcriptomes of mechanically loaded vs. static cells in three different human cell lines: Human umbilical vein endothelial cells (HUVEC), Human cardiac microendothelial cells (HCMEC) an […]
- GSE305845 CDK8 inhibition sequesters Med1 at EWS-FLI enhancers [CRISPR] July 10, 2026Contributors : James McGinnis ; Jiwoong Kim ; Yang Xie ; David McFaddenSeries Type : OtherOrganism : Homo sapiensEwing sarcoma is characterized by a chromosomal translocation resulting in the fusion protein EWSR1-FLI1. To identify small molecules that selectively impair the oncogenic transcriptional program enacted by EWS-FLI1 we employed a novel phenotypic […]
- GSE302255 Drosha in mesangial cells regulates Glomerular Capillary Tufts Formation Through Drosha/Ribosome/Gata3 Axis July 10, 2026Contributors : Zixuan Fan ; Lang Qin ; Jiajia Qin ; Tingxuan Xu ; Wenjun Xiao ; Jin Tang ; Yonghui He ; Xin Li ; Weiqian Chen ; Chuwen Lin ; Xuan JiangSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusCAKUT (congenital anomalies of the kidney and the urinary tract) […]
- GSE311879 Genotype-phenotype single-cell transcriptomics for massive parallel assessment of genetic variants [RNAseq_P63noconv] July 10, 2026Contributors : Rosa De Santis ; Lorenzo Vaccaro ; Davide CacchiarelliSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPredicting the pathogenic effect of rare genetic variants is hampered by the limited cohort of diagnosed patients and the difficulty in evaluating the effect of existing and novel variants. To address thi […]
- GSE311874 Genotype-phenotype single-cell transcriptomics for massive parallel assessment of genetic variants July 10, 2026Contributors : Rosa De Santis ; Lorenzo Vaccaro ; Davide CacchiarelliSeries Type : OtherOrganism : Homo sapiensPredicting the pathogenic effect of rare genetic variants is hampered by the limited cohort of diagnosed patients and the difficulty in evaluating the effect of existing and novel variants. To address this issue, we leveraged a protein Multiplexed A […]
- GSE337700 scRNA-seq data for nonunion fracture July 10, 2026Contributors : Tianchao Lu ; Junlin ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis single-cell RNA-seq dataset profiles clinical fracture-healing tissues from patients with fracture nonunion and normally healed fracture controls. Eight human specimens were initially collected, including five fracture nonunion […]
- GSE311938 Telomere variant sequences encode a heritable genetic blueprint for allele-specific telomere length (dataset 1) July 10, 2026Contributors : Xiaoran Chai ; Shang LiSeries Type : OtherOrganism : Homo sapiensThe ends of human chromosomes are capped by specialized nucleoprotein structures known as telomeres, which are essential for genome stability. Recent advances in long-read sequencing have enabled allele-specific telomere length measurements at nucleotide resolution, uncovering ex […]
- GSE338068 Genome-wide RRBS methylation profiling identifies NLRP7 promoter hypermethylation associated with disease severity in epidermolysis bullosa simplex July 10, 2026Contributors : Lubna Khair ; Ofer Sarig ; Rawaa Ishtewy ; Yoni Moskovitz ; Kiril Malovitski ; Angi Zenab ; Thomas Kocher ; Julia Hummel ; Josefina Hofbauer ; May Arad ; Eylon Sharoni ; Naama Adam ; Ben Avshalom ; Ulrich Koller ; Verena Wally ; Liat Samuelov ; Eli SprecherSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiens […]
- GSE338036 Spatiotemporal transcriptome atlas of water lily floral organogenesis provide insight into the evolutionary origin of novel traits of angiosperms [RNA-Seq] July 10, 2026Contributors : Chang Liu ; Ge Wang ; Binbin Cao ; Yonglong Li ; Yamao Chen ; Chunce Guo ; Ji QiSeries Type : Expression profiling by high throughput sequencingOrganism : Nymphaea colorataPetals are a key evolutionary innovation of flowers that reshaped plant-pollinator interactions and underlie the dominance of angiosperms in terrestrial ecosystems, yet thei […]
- GSE338104 Iron-Catalyzed Oxidative Stress Reveals an Exposome-Related Ferroptosis-Resistant Karyomegalic Niche in BRCA1-Linked Renal Carcinogenesis July 10, 2026Contributors : Yingyi Kong ; Yukihiro Shiraki ; Kazuhiro Furuhashi ; Shoichi Maruyama ; Tatsuhiko Imaoka ; Atsushi Enomoto ; Shinya ToyokuniSeries Type : OtherOrganism : Rattus norvegicusEarly cancer initiation under chronic oxidative stress requires the survival of epithelial cells that should otherwise be eliminated by regulated cell death. However, the sp […]
- GSE338144 Benchmarking cell-type deconvolution in cross-platform transcriptomic data [GeoMx] July 10, 2026Contributors : Aakanksha Singh ; Pinar Cakmak ; Jennifer H Lun ; Jadranka Macas ; Jonathan Schupp ; Karl H Plate ; Yvonne Reiss ; Katharina ImkellerSeries Type : OtherOrganism : Homo sapiensBackground: Transcriptomic data from diverse measurement technologies are widely used to study tissue heterogeneity. Cell-type deconvolution, which resolves mixed transcr […]
- GSE338237 The Z-granule scaffold LOTR-1 bridges piRNA recognition to small-RNA amplification in C. elegans July 10, 2026Contributors : Kehinde Abayomi ; Noah Lind ; Heath Fuqua ; Joel H Graber ; Dustin UpdikeSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Caenorhabditis elegansLOTR-1 is a Caenorhabditis elegans member of the conserved LOTUS- and Tudor-domain (TDRD5/7-like) family that resides in a germ granule subcompartment (Z granule). To […]
- GSE269556 Targeting the oncohistone-ASCL1 axis disrupts plasticity and suppresses pediatric gliomas [CUT&TAG] July 10, 2026Contributors : Alan Jiao ; Yang ShiSeries Type : OtherOrganism : Homo sapiensPhenotypic plasticity, a hallmark of cancer facilitated by epigenomic reprogramming, represents a significant challenge but also therapeutic opportunity for cancer treatment. How plasticity is regulated in diffuse midline gliomas (DMGs), incurable pediatric brain tumors characterize […]
- GSE337663 Therapy-persistent leukemia is selectively vulnerable to SLC23A1 restoration via targeting KHSRP (AML patient samples) July 10, 2026Contributors : Qingyu Luo ; Andrew A LaneSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAcute myeloid leukemia (AML) remains highly prone to relapse driven by therapy-persistent residual cells. To discover specific vulnerabilities in this population, we performed genome-wide CRISPR interference screens in AML cells tre […]