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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE285125 SUV39H1/2-mediated H3K9me3 restricts TE-induced immune response in Acute Myeloid Leukemia [RNA-Seq] June 17, 2026Contributors : Yue Feng ; Wong Josiah Hiu-yuen ; Yu Shaojun ; Cheng Yang ; Zhao Hengqiang ; Chen Xintong ; Fu Yihao ; Wang Ping ; Lyu Huijue ; Swaroop AlokSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHistone 3 Lysine 9 tri-methylation (H3K9me3) is a heterochromatin-associated histone mark deposited broadly across the […]
- GSE299461 Processing and release of the maize phytocytokine Zip1 June 17, 2026Contributors : Maurice König ; Zarah Sorger ; Melissa Mantz ; Andreas Perrar ; Carmen Castell ; Pitter Huesgen ; Simon Stael ; Johana Misas-Villamil ; Gunther DoehlemannSeries Type : Expression profiling by high throughput sequencingOrganism : Zea maysPhytocytokines are peptide signaling molecules in plant immunity. Several extracellular phytocytokines and t […]
- GSE291186 Emergency Myelopoiesis in Murine Arthritis Results in Cell-Intrinsic Changes in Dendritic Cell Development and Function June 17, 2026Contributors : Lin Tze Tung ; Roselyn R Jiang ; Bianca Pozzebon ; Mathieu Mancini ; Lucie Droin ; Mitra Yousefi ; Joo Eun (June) Kim ; Marwah Moussa ; Yue Liang ; Connie M Krawczyk ; Ines Colmegna ; Danielle Malo ; David Langlais ; Silvia M Vidal ; Anastasia NijnikSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRheumato […]
- GSE302775 FABP4 binding cancer cells exhibit an invasive phenotype via PKC-mitoROS signaling June 17, 2026Contributors : Shanshan Liu ; Jiaqing Hao ; Jianyu Yu ; Bing LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUsing several high-fat diet-induced murine obesity models, we demonstrate that obesity promotes breast cancer lung metastasis through elevated levels of adipocyte-derived circulating FABP4. Circulating FABP4 di […]
- GSE301495 Transient YAP/TAZ inhibition exposes therapeutic vulnerabilities in advanced cancers [scRNA-Seq 2] June 17, 2026Contributors : Marco Jessen ; Björn von EyssSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusYAP and TAZ, key effectors of the Hippo pathway, are frequently hyperactivated in cancer, where they drive tumor progression and resistance to therapy. Their oncogenic activity relies on interaction with TEAD transcription factor […]
- GSE212329 Evaluating the cis-regulatory potential of full-length LINE-1 elements June 17, 2026Contributors : Anne-Valerie Gendrel ; Yuvia A Pérez-RicoSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusLong interspersed element-1 (L1) retrotransposons constitute the largest transposable element (TE) family in mammalian genomes and contribute prominen […]
- GSE311363 Quiescent tumor cells shape the immunosuppressive microenvironment in pancreatic ductal adenocarcinoma [RNA-Seq] June 17, 2026Contributors : Bryan McClellan ; Quiju Wang ; William MatsuiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImmunotherapy, including chimeric antigen receptor (CAR) T-cell therapy, has limited activity in pancreatic ductal adenocarcinoma (PDAC). Using orthotopic PDAC mouse models, we identified a rare population of quie […]
- GSE335434 P-SSP7 infection of Prochlorococcus MED4 under standard light, high light, and darkness June 17, 2026Contributors : Pavlo Bohutskyi ; Zachary Johnson ; Lindsey N Anderson ; Margaret CheungSeries Type : Expression profiling by high throughput sequencingOrganism : Prochlorococcus marinus subsp. pastoris str. CCMP1986Cyanophage infection outcomes depend strongly on host physiological state, yet the transcriptional dynamics of the P-SSP7–Prochlorococcus MED4 in […]
- GSE335432 Glial cell states bias the regeneration of neuron types across the newt life cycle June 17, 2026Contributors : Alonso Ortega Gurrola ; Mayra Kalaora ; Dreyton Amador ; Jamie Woych ; Maria Antonietta ToschesSeries Type : Expression profiling by high throughput sequencingOrganism : Pleurodeles waltlSalamanders have outstanding regenerative abilities, which tend to decline in post-metamorphic life stages. Among various tissues, these amphibians can regene […]
- GSE335579 Alternative splicing generates a constitutively active Fn14 isoform that signals independently of TWEAK June 17, 2026Contributors : Nathan M Main ; Melissa K Eccles ; Rodrigo Carlessi ; Sara Pasic ; Giuseppe Verdile ; Grant A Ramm ; John K Olynyk ; Benjamin J Dwyer ; Pieter J Eichhorn ; Janina E Tirnitz-ParkerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFibroblast growth factor-inducible 14 (Fn14) is a tumour necrosis factor (TNF) […]
- GSE335569 Targeting the translation complex eIF4F disrupts BCR::ABL1 tranlstion and overcomes drug resistance in CML June 17, 2026Contributors : Ryan Yen ; Lambert Yue ; Steven Pelech ; Xiaoyan JiangSeries Type : Protein profiling by protein arrayOrganism : Mus musculusChronic myeloid leukemia (CML) is driven by the constitutively active BCR::ABL1 kinase, which promotes uncontrolled cell proliferation. While tyrosine kinase inhibitors (TKIs) such as imatinib (IM) have revolutionized CM […]
- GSE335699 Continuous evolution of gene libraries towards arbitrary functions reveals the versatility of biomolecular evolution in vivo June 17, 2026Contributors : Alireza Tanoori ; Alexander Pisera ; Chang LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeLife relies on constant biomolecular innovation, but the slowness of natural evolution limits our ability to witness new gene functions emerging in real-time. Consequently, much remains unknown about […]
- GSE335700 RNA sequencing of vtRNA-knockout HEK293T cell lines June 17, 2026Contributors : Wayne O Hemphill ; Thomas R CechSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHEK293T cell lines lacking one or more of the human VTRNA1 paralogs, alongside wild-type parental cells, had their RNA sequenced by Plasmidsaurus (poly-A enrichment) and/or Genewiz (rRNA depletion). Differential expression was […]
- GSE335716 High-resolution transcriptome analysis reveals a multilayered and dynamic transcriptional architecture in the archaeal virus SSV1 June 17, 2026Contributors : Wouter Magnus ; Maarten Boon ; Jorien Poppeliers ; Jonathan Abshier ; Kenneth Stedman ; Rob Lavigne ; Eveline PeetersSeries Type : OtherOrganism : Saccharolobus solfataricus ; Sulfolobus spindle-shaped virus 1Fuselloviridae infecting thermoacidophilic Sulfolobales are among the best-studied archaeal viruses, with the Saccharolobus Spindle Shap […]
- GSE281758 RNA-seq of bnp Cheek injection model with skin tbx20 knockout mouse June 17, 2026Contributors : Xiaolong Dai ; Jianghui MengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDifferential gene expression of skin tbx20 knockout in bnp Cheek injection induced acute pruritus model