Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE299658 Scalable expansion and hepatic zone maturation of hepatic progenitor cells from human pluripotent stem cells June 11, 2026
  Contributors : Ogawa Mina ; Liu Jeff C. ; McGilvray Ian ; MacParland Sonya ; Bader Gary ; Ogawa ShinichiroSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe devised a method for large-scale manufacturing of hepatocytes derived from human pluripotent stem cells by modulating levels of FGF19, TGFβ and NOTCH. We further em […]
• GSE306203 Highly efficient and low-mosaicism piggyBac transgenesis platform for rapid founder phenotyping [single-cell RNA-seq] June 11, 2026
  Contributors : Shoma Matsumoto ; Eiichi Okamura ; Masatsugu EmaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPronuclear microinjection is the most widely used method for producing transgenic (Tg) animals. Because its efficiency is typically
• GSE303750 A systemic role of macrophage-derived BMP2/4 homolog Dpp in controlling sterol hormone synthesis under dietary stress June 11, 2026
  Contributors : Sergio Juarez-Carreño ; Marco MilánSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterHigh-caloric diets, prevalent in Western societies, are characterized by their affordability, yet they hinder overall development and compromise adult physiological performance. Unfortunately, children consuming […]
• GSE289584 Visible traits demonstrate that crispant founder mice can be used for phenotypic assessment June 11, 2026
  Contributors : Rebekah Tillotson ; Marina Gertsenstein ; Li-Hsin Chang ; Julie Ruston ; Fernando Bellido Molias ; Lauri G Lintott ; Christine Taylor ; Philippe Gautier ; James Davies ; Lauryl M Nutter ; Monica J JusticeSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Mus musculusGenes can be knocked out in model organisms by […]
• GSE334608 Genome-wide characterization of extrachromosomal circular DNA and its functional role in colon cancer carcinogenesis and progression [miRNA] June 11, 2026
  Contributors : Ji Wang ; Kehan Wang ; Wenbo JiaSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensExtrachromosomal circular DNAs (eccDNAs) are defined as distinct genomic entities of circular and mobile DNA molecules, but their molecular functions in and impact on breast cancer (BC) are rarely known. This study used Ci […]
• GSE299517 Curcumin Attenuates Liver Fibrosis and Inflammation by Modulating Slamf8-Mediated TNF/NF-κB Signaling June 11, 2026
  Contributors : Ling Liu ; Ye Wang ; Jintao Zheng ; Lixin Zhou ; Chenao Yang ; Jiachen Zhang ; Yuqiang ShanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLiver fibrosis (LF) is characterized by inflammation and fibrosis following liver injury. Curcumin has anti-inflammatory, antioxidant, and cytoprotective properties, w […]
• GSE297493 Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells triggers pre-clinical autoimmunity June 11, 2026
  Contributors : Grozdan Cvijetic ; Mladen Mitrovic ; Daniel Martin ; Roxane TussiwandSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusConventional dendritic cells (cDC) are key sentinels at epithelial barriers, regulating immunity to microbial pathogens and commensals while preserving tissue integrity. NOTCH2 deficiency i […]
• GSE315923 From encounter to memory: molecular dynamics of heterospecifc recognition in cleaner wrasse June 11, 2026
  Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Labroides dimidiatusHeterospecific individual recognition, the capacity to identify and remember specific members of another species, guides partner choice in mutualisms, reduces costly misclassification, and supports community stability. Yet the molecular machinery enab […]
• GSE309826 Highly efficient and low-mosaicism piggyBac transgenesis platform for rapid founder phenotyping [Transgene-specific scRNA-seq] June 11, 2026
  Contributors : Shoma Matsumoto ; Eiichi Okamura ; Hideto Mori ; Nozomu Yachie ; Masatsugu EmaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPronuclear microinjection is the most widely used method for producing transgenic (Tg) animals. Because its efficiency is typically
• GSE326772 Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells triggers pre-clinical autoimmunity June 11, 2026
  Contributors : Grozdan Cvijetic ; Daniel Martin ; Siqi Zhao ; Roxane TussiwandSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusConventional dendritic cells (cDC) are key sentinels at epithelial barriers, regulating immunity to microbial pathogens and commensals while preserving tissue integrity. NOTCH2 deficiency in CD11 […]
• GSE323336 From iPSC to manufactured iNK cells using CombiCult® screening platform June 11, 2026
  Contributors : Giuseppe D'Agostino ; Lam Lam ; Marina Tarunina ; Tatyana PonomaryovSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe used Parse Biosciences scRNAseq to characterize human induced pluripotent stem cell (iPSC)-derived NK cells (iNKs) at transcriptional level. Gene expression profiles of iNKs were com […]
• GSE330395 Clinical development of tacrolimus-resistant regulatory T cells to enable simultaneous immunosuppression and support of immune regulation June 11, 2026
  Contributors : Ghazaleh Zarrinrad ; Lisa-Marie Burkhardt ; Claudia Beltran-Mestres ; Silvina Romero-Suárez ; Dimitrios Laurin Wagner ; Stephan Schlickeiser ; Maik Stein ; Désirée Jacqueline Wendering ; Iván Juky Carrera Diaz de la Cebosa ; Lukas Ehlen ; Frederik Hamm ; Gavin L Kurgan ; Pawel Durek ; Frederik Heinrich ; Anamika Giri ; Yaolin Pu ; Kristy Ou ; […]
• GSE331511 Screening and functional study of genes related to tuberculous ulcers June 11, 2026
  Contributor : Zihui HuangSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensTranscriptome analysis was performed to systematically compare human tuberculous ulcers with non-tuberculous skin ulcers. Focusing on the former, this study aimed to identify key associated genes, elucidate their expression profiles and functional attributes, and p […]
• GSE334383 Genome-wide RNA binding landscapes of PABPC1 and CCT3 in GC-2spd(ts) and verification of their direct interactions with lncRNA Tug1 June 11, 2026
  Contributors : Lingxiu Tong ; Yiting Ye ; Ke ZhengSeries Type : OtherOrganism : Mus musculusVerification of direct interactions between lncRNA Tug1 and RNA-binding proteins PABPC1 and CCT3 and genome-wide RNA binding maps of PABPC1 and CCT3 in GC-2spd(ts)
• GSE299590 Clonal dynamics reveal cancer resistance arises from adaptive programs [CROP-Seq] June 11, 2026
  Contributors : Haiyin Li ; Yeqing Chen ; Jessica Kaster ; Maggie Dunne ; Min Xiao ; Ling Li ; Monzy Thomas ; Nazifa Promi ; Dylan Fingerman ; Gregory S Brown ; Xingyue Zhu ; Meenhard HerlynSeries Type : OtherOrganism : Homo sapiensMost advanced cancers initially respond to targeted therapies but eventually relapse1. Rather than acquiring new mutations, resis […]