Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE290656 MYC-FACT Interactions Drive Z-DNA Formation to Modulate Transcriptional Dynamics November 18, 2025
  Series Type : OtherOrganism : Homo sapiensDNA topology is critical for regulating transcription and maintaining cellular homeostasis. Z-DNA is a left-handed DNA helix in regions with high transcriptional activity. Its physiological function remains poorly understood. Here, we demonstrate that oncoprotein MYC induces the formation of Z-DNA by recruiting the c […]
• GSE288723 Age deceleration and reversal gene patterns in dauer diapause November 18, 2025
  Contributors : Khrystyna Totska ; João C. V. V. Barata ; Walter Sandt ; David Meyer ; Bjoern SchumacherSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansThe aging process is characterized by a general decrease in physical functionality and poses the biggest risk factor for a variety of diseases such as cancer, c […]
• GSE256392 The effect of a cottonseed oil-enriched diet on lipid profiles November 18, 2025
  Contributors : Chad M Paton ; Yura Son ; Leah S HallsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study was designed to validate cottonseed oil as a bioactive lipid in a mouse model
• GSE218454 RNA-seq of B16F10 tongue xenografts with or without inhibition of LN-innervating nociceptive nerves November 18, 2025
  Contributors : Yu Zhang ; Tong JiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe analyzed the transcriptomes of murine B16F10 tongue xenografts from immune-competent C57/B6J mice with or without inhibition of LN-innervating nociceptive nerves using AAV2/retro-Trpv1-hM4D(Gi)-mCherry and Deschloroclozapine.
• GSE278811 EZHIP-mediated PRC2 inhibition is required to maintain H3K27me3-dependent imprinting post fertilization [ChIP-Seq] November 18, 2025
  Contributors : Raphael Margueron ; Seynabou Diop ; Katia Ancelin ; Laia Richart ; Ambre Petitalot ; Patricia LegoixSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusZygote inherits parental genomes with distinct chromatin structure. In eutherian mammals, this asymmetry is seen as crucial for embryonic develo […]
• GSE266205 Epigenetic changes by EZH2 inhibition increase translocations in B cells with high AID activity or DNA repair deficiency [Cut&Tag for H3K27me3] November 18, 2025
  Contributors : Jianli Tao ; Alessandri Luca ; Roberto ChiarleSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe EZH2 histone methyltransferase inhibitors tazemetostat and valemetostat have recently received approval for clinical use in follicular lymphoma and adult T-cell leukemia/lymphoma, respectively. […]
• GSE310235 Canopy1/Cnpy1 is required for proper V2R processing and transport; its functional loss impairs basal/V2R vomeronasal sensory neurons function and circuit organization. November 18, 2025
  Contributors : Nick A Mathias ; Nikki M Dolphin ; Anthony Ruquet ; Paolo E ForniSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe Vomeronasal Organ (VNO) of rodents is populated by different types of Vomeronasal Sensory Neurons (VSNs). Apical VSNs, located near the lumen, express the transcription factor(TF) Meis2, V1 […]
• GSE282760 Epigenomic manipulation reveals the relationship between locus specific chromatin dynamics and gene expression [ChIP-seq] November 18, 2025
  Contributors : Vrinda Venu ; Eric M Small ; Cullen Roth ; Samantha H Adikari ; Anna Vlot ; Kyle A Sullivan ; Chanaka Abeyratne ; Daniel Jacobson ; Shawn R Starkenburg ; Karissa Y Sanbonmatsu ; Christina R SteadmanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensDysregulation of epigenetic processes leads to […]
• GSE310316 Nox4 inhibitor treatment ameliorates cardiac function in mouse models of Duchenne Muscular Dystrophy November 18, 2025
  Contributors : Rui Deng ; Tabatha De Oliveira Silva ; Xiang Liu ; Cheng Fan ; Hee Young Seok ; Jingjing Wu ; Haipeng Guo ; Tian Lin ; Shiju Zhang ; Nihan Gunay ; Yao Wei Lu ; Zhan-Peng Huang ; John D Mably ; Mingxiang Teng ; Hong Chen ; Gabriela P Diniz ; Da-Zhi WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDuchen […]
• GSE310306 Transcriptomic analysis of SW620-conditioned medium-treated THP-1 macrophages November 18, 2025
  Contributors : Lin Kuan-Yu ; Chang Yung-ChiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSiglec-5 and Siglec-14, expressed on myeloid cells, share ligand-binding domains but have opposing signaling functions. While these paired receptors regulate macrophage immune responses against bacterial infection, their role in t […]
• GSE310332 Inhibition of Acetyl-CoA metabolic enzymes by EVT0185 impairs hepatic stellate cell activation and reverses MASH and fibrosis in mouse models [nanostring] November 18, 2025
  Contributors : Fiorella Di Pastena ; Jaya Gautam ; James Lally ; Russta Fayyazi ; Gregory R SteinbergSeries Type : Expression profiling by arrayOrganism : Mus musculusMetabolic Dysfunction-Associated Steatohepatitis (MASH) is characterized by liver steatosis and inflammation which lead to fibrosis following hepatic stellate cell (HSC) activation. Acetyl-CoA […]
• GSE310346 Epigenetic changes by EZH2 inhibition increase translocations in B cells with high AID activity or DNA repair deficiency [LAM-HTGTS for MEC-1 cell] November 18, 2025
  Contributors : Jianli Tao ; Luca Alessandri ; Roberto ChiarleSeries Type : OtherOrganism : Homo sapiensThe EZH2 histone methyltransferase inhibitors tazemetostat and valemetostat have recently received approval for clinical use in follicular lymphoma and adult T-cell leukemia/lymphoma, respectively. In follicular lymphoma, the expression of AID is responsibl […]
• GSE310354 Bi-directional regulation between NAD/NAMPT and IFN-γ/PD-L1 axes via BRD4/IRF1 and mitochondrial respiration in metastatic cutaneous melanoma November 18, 2025
  Contributors : Irene Fiorilla ; Lidia Avalle ; Valentina AudritoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme in NAD biosynthesis and is frequently upregulated in tumors, including melanoma, where it drives disease progression and resistance to targeted th […]
• GSE286513 Diversity and Heterogeneity of Extracellular Vesicles and Brain-Penetrating Amembranous Non-Vesicular Nanoparticles in Glioblastoma November 18, 2025
  Contributor : Al CharestSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAdvances in understanding intercellular communication through extracellular vesicles (EVs) and non-vesicular extracellular nanoparticles (NVEPs) have been limited by their cellular heterogeneity and unclear origins. Using sequential ultracentrifugat […]
• GSE310114 The Underlying Dermal Scaffold Affects Molecular Differentiation Markers in Three-Dimensional Human Epidermal Equivalents November 18, 2025
  Contributors : Ryland D Mortlock ; Michael Zhao ; Lilianne Sutton ; Keith A ChoateSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe undertook a study to compare two commonly used dermal scaffolds for three-dimensional human epidermal equivalents (HEEs): contracted collagen (CC) and acellular dermis (ACD). Using the sam […]