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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE297777 DNMT1 loss leads to hypermethylation of a subset of late replicating domains by DNMT3A (WGBS) March 26, 2026Contributor : Duncan SproulSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensLoss of DNA methylation is a hallmark of cancer that is proposed to promote carcinogenesis through gene expression alterations, retrotransposon activation and induction of genomic instability. Cancer-associated hypomethylation does not occur acr […]
- GSE293056 Ectopic MYC Expression Reprograms Epigenetic Landscapes and Transcription Factor Networks to Drive Differentiation Block and Malignant Transformation in AML [RNA-Seq] March 26, 2026Contributors : David Dominguez-Sola ; Eirini Papapetrou ; Saul CarcamoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOverexpression of MYC is a common convergent consequence of genetic driver mutations in acute myeloid leukemia (AML). However, despite extensive research, the mechanisms by which this proto-oncogene prom […]
- GSE308165 A systematic exploration of the intrinsic mechanisms controling axon growth during development March 26, 2026Contributors : Lora Fahdan ; Oren Schuldiner ; Noa Wigoda ; Hagar MeltzerSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterThe ability of neurons to extend axons is governed by tightly regulated genetic programs that vary across developmental stages and cell types. Understanding the molecular features that cont […]
- GSE297847 DNMT1 loss leads to hypermethylation of a subset of late replicating domains by DNMT3A. March 26, 2026Series Type : Methylation profiling by high throughput sequencing ; Other ; Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE310813 PWWP-mutants of the transcriptional cofactor JASPer divert promoter and enhancer activities and suppress position effect variegation in Drosophila [Hi-C] March 26, 2026Contributors : Derek Atkinson ; Francesco Cardamone ; Yinxiu Zhan ; Thomas Jenuwein ; Nicola IovinoSeries Type : OtherOrganism : Drosophila melanogasterSu(var) genes control heterochromatin establishment and maintenance in Drosophila melanogaster. Through a new Su(var) screen, we identified Su140 and Su113 as very strong Su(var) mutants that are epistatic ov […]
- GSE309545 Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD-associated kinase LRRK2 between human and mice [multiome mouse] March 26, 2026Contributors : Alexandra Beilina ; Jae-hyeon Park ; Natalie Landeck ; Ruth Chia ; Jinhui Ding ; Xylena Reed ; Hannah Bailey ; Changyoun Kim ; Alice Kaganovich ; Dominic Acri ; Janet Brooks ; Kareem Zaghloul ; Elise Marsan ; Raphael J Gibbs ; Alex DeCasien ; Mark R CooksonSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Express […]
- GSE325617 MAF converts metabolic state into superenhancer architecture and dependency in myeloma [RPMI8226 p300 ChIP-seq] March 26, 2026Contributors : Phyllis Chong ; Julia Lim ; Wee-Joo ChngSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensLineage-specific transcription factors govern superenhancer assemblies that impose extreme transcriptional output, but how metabolic capacity sustains these regulatory hubs remains unresolved. By integrat […]
- GSE211048 Affymetrix SNP array data for adult Myelodysplastic Syndromes (MDS)/Acute Myeloid Leukemia (AML) with isolated monosomy 7 March 26, 2026Contributors : Cristina Mecucci ; Valentina Pierini ; Anair G Lema Fernandez ; Carlotta NardelliSeries Type : Genome variation profiling by SNP arrayOrganism : Homo sapiensMonosomy 7 is one of the most frequent aneuploidies in myeloid malignancies, associated to heterogeneous phenotypes. Its poor prognosis differentiates it from aberrations leading to partia […]
- GSE325662 Gene expression profiling of lung tissue from LPS-induced acute lung injury mice treated with Renshen Baidu Powder March 26, 2026Contributors : Fei Li ; Shixu Liu ; Peng Chen ; Guohu DiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis dataset presents transcriptomic profiles of lung tissue from a murine model of LPS-induced acute lung injury (ALI) following treatment with Renshen Baidu Powder (RSBD). LPS induced a robust inflammatory gene sign […]
- GSE325618 Depletion of Canonical Histones Enhances Direct Reprogramming of Scavenger Cells in vivo March 26, 2026Contributors : Ismail Özcan ; Anna Reid ; Gizem Köse ; Alexander Blume ; Baris TursunSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansDirect reprogramming is a procedure that converts the identity of differentiated cells, which can be triggered by defined transcription factors (TFs). Cellular reprogramming offe […]
- GSE325715 Gene expression in patients with pulmonary hypertension due to valve heart disease March 26, 2026Contributors : Ana I Fernandez_Avila ; Jorge Martinez-Solano ; Javier BermejoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo delve deeper into the molecular mechanisms underlying pulmonary hypertension secondary to left heart disease (PH-LHD), an essential step toward developing a comprehensive classification, reliab […]
- GSE325727 Dextran-coated Iron Oxide Nanoparticles impairs cardiac function in zebrafish larvae March 26, 2026Contributors : Giovanna M Oliveira ; Talita C Pereira ; Fernanda Trindade ; William Lautert-Dutra ; Maurício R Bogo ; Calum A MacRaeSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioIron Oxide Nanoparticles (IONPs) with no doubt are the next platform for theragnostic in the biomedical field. Cardiovascular pathologies take […]
- GSE325833 IL1R2 Identified as a Key Hub Gene Regulating Vascular Endothelial Function in Kawasaki Disease March 26, 2026Contributors : Xiaofeng Hong ; Qianwen Wang ; Tian Lan ; Jianxin Xu ; Yi Zhan ; Jiandong ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Kawasaki disease (KD) is a multisystemic vasculitis of unknown aetiology in children. KD with coronary artery lesion is now the leading acquired heart disease in childre […]
- GSE289891 Epicardial Tcf21 facilitates cardiomyocyte protrusion into the injury area during heart regeneration in zebrafish March 26, 2026Contributors : Miglė Kalvaitytė-Repečkė ; Kotryna Kvederavičiūtė ; Darius BalciunasSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioUnlike mammals, zebrafish (Danio rerio) are able to regenerate their hearts after injury, making them an excellent model organism for studying the molecular mechanisms underlying heart regene […]
- GSE325615 MAF converts metabolic state into superenhancer architecture and dependency in myeloma [shscr ChIP-Seq] March 26, 2026Contributors : Phyllis Chong ; Julia Lim ; Wee-Joo ChngSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensLineage-specific transcription factors govern superenhancer assemblies that impose extreme transcriptional output, but how metabolic capacity sustains these regulatory hubs remains unresolved. By integrat […]