Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE303706 Gut Microbiota Profiling of Lebanese Patients with Ulcerative Colitis and Healthy Controls: A Pilot Study November 27, 2025
  Contributors : Fayez Yassine ; Hassan Abbas ; Abdallah Kurdi ; Reem Mansour ; Fadi H Mourad ; Ghassan Matar ; Melhem BilenSeries Type : OtherOrganism : Homo sapiensUlcerative colitis (UC) is a chronic inflammatory disease of the colon, associated with gut microbiota dysbiosis. While global studies have explored this link, region-specific microbial profiles r […]
• GSE282620 DGP1 family members mediate large-scale metabolic remodeling by integrating two environmental signals in rice November 27, 2025
  Contributors : Zhan Xu ; Huanfang Liu ; Mengmeng HouSeries Type : Expression profiling by high throughput sequencingOrganism : Oryza sativaLow-phosphate (LP) and red-light (RL) remould cellular metabolism in rice (Oryza sativa). Herein, DEEP GREEN PANICLE1 (DGP1) family includes DGP1, DGP1B and DGP1C. LP treatment (10 µM KH2PO4) robustly upregulates DGP1 exp […]
• GSE311547 Sensitive and unbiased genome-wide profiling of base-editor-induced off-target activity with CHANGE-seq-BE [gRNA sequencing for ABE targets] November 27, 2025
  Contributors : Varun Katta ; Yichao Li ; Shengdar TsaiSeries Type : OtherOrganism : synthetic constructTo identify potential contaminating gRNAs, we adapted a gRNA sequencing assay based on an established SMARTer smRNA sequencing technology. We evaluated five research-grade gRNAs from three synthetic gRNA manufacturer suppliers (A, B and C). We detected the […]
• GSE290147 Genomic localization and functions of MBD-2 with and without NuRD in DNA methylation-free C. elegans [ChIP-Seq] November 27, 2025
  Contributors : Hok Ning Tsui ; Wing Yee Karen YuenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Caenorhabditis elegansWhile mammalian MBD2 is a well-established 5-Methylcytosine reader and component of the essential Nucleosome Remodeling and Deacetylase (NuRD) complex, the function and binding pattern of C. elegans […]
• GSE283242 IRF4 amplifies Th2 responses through inhibition of Il31 expression November 27, 2025
  Contributors : Marlys Fassett ; K. Mark AnselSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImmune responses that control helminths and other parasites rely on type 2 CD4 T (Th2) cell cytokines IL-4, IL-5, and IL-13. IL-31 is an understudied cytokine that limits the magnitude of type 2 inflammation in skin. Here we exa […]
• GSE299933 The sleep–wake history contributes to rhythmic BMAL1 chromatin binding in the cerebral cortex but not in the liver November 27, 2025
  Contributors : Carlos Neves ; Charlotte N Hor ; Sonia Jimenez ; Paul FrankenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe timing and quality of sleep is regulated by circadian- and sleep–wake-driven processes. The core clock gene Bmal1 not only affects the circadian timing of sleep, but also the resp […]
• GSE292784 Autophagy Impairment in Retinal Ganglion Cells Following Hypoglycemia in Mice. November 27, 2025
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDiabetic retinopathy (DR), caused by hypo- and hyperglycemia, is a leading cause of blindness. Hypoglycemia induces endoplasmic reticulum stress and retinal cell death in mice, and low glucose conditions induce macroautophagy/autophagy defects in 661W photoreceptor cells a […]
• GSE311074 COPG1 Is a Selectively Essential Regulator of Cancer Progression and Chemoresistance: A Comprehensive Pan-Cancer Study November 27, 2025
  Contributors : Susmita Sen ; Van-Thanh Duong ; Youngin Hwang ; Seungmi Kim ; Euijin Lee ; Myoung-Eun Han ; Dongjun Lee ; Yun Hak Kim ; Sik Yoon ; Sae-Ock OhSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe coatomer complex, a key regulator of intracellular vesicular transport, has recently been implicated in cancer pr […]
• GSE310739 Cetacean single-nucleus RNA-sequencing positions the cardioprotective gene FHL2 as a target for advancing pig-to-human heart xenotransplantation November 27, 2025
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Steno bredanensis ; Sus scrofaDamage to the heart, an organ core to the circulation of oxygen and nutrients to the body, significantly reduces lifespan. A heart transplant from human donors (allografts) has been possible for the last four decades, but there is a severe […]
• GSE311087 Gene expression changes in mouse skin after exposure to SspA and house dust mite extract November 27, 2025
  Contributors : Toshimi Yoshida ; Jin Mo Park ; Yanek Jiménez-AndradeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe skin reprograms its gene expression during dermatitis. This transcriptome profiling examines dermatitis-associated gene expression changes in the skin of mice epicutaneously treated with the Staphyloco […]
• GSE311086 Identification of Blood-Brain Barrier Injury-Related Biomarkers in Cerebral Infarction Using Transcriptomic Analysis November 27, 2025
  Contributor : Chuyu LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Cerebral infarction leads to blood-brain barrier (BBB) disruption, exacerbating brain injury through edema, inflammation, and neuronal death. Although BBB damage is a critical event in stroke pathology, the underlying molecular mechanisms […]
• GSE311089 Hsp70-Bim interaction mediated mitophagy as a potential therapeutic target for CML stem cells November 27, 2025
  Contributors : Ting Song ; Yang Song ; Hong Zhang ; Zhiyuan Hu ; Fangkui Yin ; Zhichao ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn chronic myeloid leukemia (CML), disease persistence in patients is maintained by leukemic stem cells (LSCs), which drives tyrosine kinase inhibitor (TKI) resistance. Autophagy ha […]
• GSE311188 Prior High Fiber Intake Impinges on the Cellular Responses of Mesenteric Adipose and Intestinal Tissues to Subsequent High Fat Feeding [16s rRNA-seq] November 27, 2025
  Contributors : Zhi Peng ; Meng XieSeries Type : OtherOrganism : Mus musculusObesity, characterized by its chronic, recurrent and progressive nature, has become one of the most serious public health problems. As living standards improve, plant-based diet composed of whole grain and vegetable is gradually replaced by high-fat food of animal origin in daily lif […]
• GSE311268 Transfer RNA acetylation regulates in vivo mammalian stress signaling November 27, 2025
  Contributor : Colin WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTransfer RNA (tRNA) modifications are crucial for protein synthesis, but their physiological roles remain poorly understood. Here we investigate the impact of N4-acetylcytidine (ac4C), a highly conserved tRNA modification, using a Thumpd1 knockout mou […]
• GSE301269 Comparison of expression profiles of Control and CDDO-Im treatment microglia under IFN-gamma or Amyloid beta stimulation November 27, 2025
  Contributors : ChingTung Chu ; Akria Uruno ; Fumiki Katsuoka ; Masayuki YamamotoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlzheimer’s disease (AD) is characterized by amyloid-beta (Amyloid beta) plaques and neurofibrillary tangles, accompanied by elevated oxidative stress and inflammation. Microglia, the resident […]