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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE285391 Incorporating histone H2B variants into chromatin modifies chromatin accessibility to induce the epithelial-to-mesenchymal transition in breast cancer [RNA] February 11, 2026Contributors : Hejer Dhahri ; Kin LauSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHistones scaffold genomic DNA and regulate access to the transcriptional machinery. However, naturally occurring histone variants can alter histone-DNA interactions, DNA and histone modifications, and the chromatin interactome. Hence, a […]
- GSE281632 Compartmentalization of mRNA and translation by cell adhesions February 11, 2026Contributors : D'Alessandro Alec ; Terry LechlerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSubcellular compartmentalization allows cells to concentrate and locally regulate functions. Here we identify translational compartmentalization in epidermal cells, with ribosomes, a subset of mRNAs, and the RNA-Induced […]
- GSE291210 Spatial transcriptomics profile of mammary gland tumours in MMTV-PyMT mouse model of breast cancer [MERFISH] February 11, 2026Contributors : Nitin Narwade ; Raúl Jiménez-Castaño ; Khalil K Youssef ; Angela NietoSeries Type : OtherOrganism : Mus musculus ; synthetic constructDisseminated cancer cells rarely succeed in forming macrometastases, yet they continue to be the most life-threatening cause of patient mortality. The determinants driving metastatic competence, however, are sti […]
- GSE289388 Timosaponin AIII enhances CAR-T cell potency and prevents relapse through impairing CAR-Tregs February 11, 2026Contributors : Mingqi Hou ; Jing Yang ; Wenjun Zhang ; Xiaochen Tang ; Rui Jin ; Husheng MeiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChimeric antigen receptor (CAR)-T cell therapy has become the standard treatment for refractory and relapsed (r/r) DLBCL in recent years. However, more than half of these patients d […]
- GSE299397 gene expression profiling identifies ferroptosis-related genes in human colon cancer cell lines February 11, 2026Contributors : B K Sinha ; Erik TokarSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe used microarray gene expression profiling to identify ferroptosis related biomarker genes in colon cancer cells and several uniquely expressed gene were identified that were highly expressed during ferroptosis induced by Erastin.
- GSE295002 H1299 cells, DLG-41- or DLG-41nc- treated differential gene expression February 11, 2026Contributors : Alyssa Winkler ; Tomasz CierpickiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGene expression data for H1299 cells treated with DMSO or GAS41 YEATS domain inhibitors 1.5µM DLG-41 (lead compound) or 1.5µM DLG-41nc (chemical negative control) for 7 days.
- GSE319110 Antiviral and anti-inflammatory effects of Tabamide A derivative, TA25, against human rhinovirus and multiple zoonotic viruses in vitro and in silico February 11, 2026Contributors : Bohyeon Kim ; Altanzul Bat Ulzii ; Taehun Lim ; Jin Woo Kim ; Wonkyun Ronny Im ; Shivani Rajoriya ; Augustine Natasha ; Divya Misra ; Hennisa Hennisa ; Na Young Kwag ; Daewoon Yoon ; Gyunghee Jo ; Young Bin Park ; Jinkyu Park ; Jeong Tae Lee ; Sung Ho Jeon ; Won-Keun KimSeries Type : Expression profiling by high throughput sequencingOrganism : […]
- GSE242544 The intrinsically disordered region of the E3 ubiquitin ligase TRIP12 induces the formation of chromatin condensates and interferes with DNA damage response. February 11, 2026Contributors : Jérôme Torrisani ; Claire Vargas ; Marlène DufresneSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChromatin compaction is crucial for the expression and the integrity of the genome. We previously showed that the nuclear HECT-type E3 ubiquitin ligase TRIP12 (Thyroid hormone Receptor Interacting Protein 12 […]
- GSE319141 Quantification of the effects of single nucleotide variants in NKX2.1 transcription factor binding sites February 11, 2026Contributors : Freyda Lenihan-Geels ; Markus SchuelkeSeries Type : OtherOrganism : synthetic constructTranscription factors recognise and bind specific DNA sequence patterns in promoters and enhancers thereby regulating gene expression. Variations in the DNA sequence of transcription factor binding sites (TFBSs) can alter gene regulation and may disrupt deve […]
- GSE319137 Genomic and genetic insights into speciation and pigment pattern diversification in Danio fishes February 11, 2026Contributors : Jianguo Lu ; Marco Podobnik ; Junrou Huang ; Braedan M McCluskey ; Shane A McCarthy ; Jonathan Wood ; Joanna Collins ; James Torrance ; Ying Sims ; Dong Gao ; Jing Huang ; Jia Liu ; Wenyu Fang ; Peilin Huang ; Chunlei Ma ; David Parichy ; Uwe Irion ; Jian Liu ; Kerstin Howe ; John H PostlethwaitSeries Type : Expression profiling by high throug […]
- GSE319148 Targeting IGF2BP1 reverses immune evasion in CTL-enriched pancreatic cancer February 11, 2026Contributors : Nadine Bley ; Alexander Rausch ; Khursheed Mir ; Markus GlaßSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPancreatic ductal adenocarcinoma (PDAC) remains poorly responsive to immune checkpoint therapy. To investigate tumor-intrinsic immune evasion mechanisms, we performed RNA-sequencing of the basal-lik […]
- GSE319155 Single-cell profiling of tumor lineage plasticity and the immune microenvironment in transformed small cell lung cancer February 11, 2026Contributors : Jie Huang ; Zhenhua Zhang ; Guodi Cai ; Junjian WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground The transformation of non-small cell lung cancer (NSCLC) into small cell lung cancer (SCLC) is a recognized treatment resistance mechanism, most often arising from EGFR-mutant lung adenocarcinoma […]
- GSE319241 Control of human mesenchymal stromal cell gene expression levels by sound-guided assembly and stimulation February 11, 2026Contributors : Elena Della Bella ; Farah Daou ; Alessandro Cianciosi ; Junxuan Ma ; Riccardo Tognato ; Mauro Alini ; Andrea Cochis ; Lia Rimondini ; Martin J Stoddart ; Tiziano SerraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman bone marrow mesenchymal stromal cells (hBMSCs) play a pivotal role in regenerative me […]
- GSE270826 AMPK promotes TFEB transcriptional activity through dephosphorylation at both mTORC1-dependent and -independent sites February 11, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE319106 RNAsequencing comparing WT S. aureus and an evolved mutant EVOL-A and EVOL-A ∆sarA February 11, 2026Contributors : Kowalski Caitlin H ; Barber Matthrew FSeries Type : Expression profiling by high throughput sequencingOrganism : Staphylococcus aureusThe goals of this experiment were to understand the basal changes in transcription between the EVOL-A strain that is an evolved strain in the NRS193 background with a mutation in Rel (Q672*) that has unknown imp […]