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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE303854 Conserved and lineage-specific mechanisms drive chromatophore differentiation in reptiles May 28, 2026Contributors : Pierre-Yves Helleboid ; Athanasia TzikaSeries Type : Expression profiling by high throughput sequencingOrganism : Pantherophis guttatus ; Pogona vitticepsWe employed single-cell RNA sequencing using the 10X Genomics platform to study chromatophore development in reptilian embryonic skin. Pigment cells have been well characterized in fish, but […]
- GSE307582 Transcription initiation drives dosage compensation establishment and maintenance in male Drosophila [TTseq_S2_MSL1_MSL2] May 28, 2026Contributors : Ronald Oellers ; Anastasios AlexiadisSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Drosophila melanogasterDosage compensation (DC) in Drosophila equalizes X chromosome-linked gene expression via the Male-Specific Lethal (MSL) complex, which acetylates histone 4 lysine 16 on the male X-chromosome. How DC is […]
- GSE307467 Transcription initiation drives dosage compensation establishment and maintenance in male Drosophila May 28, 2026Contributors : Ronald Oellers ; Anastasios AlexiadisSeries Type : OtherOrganism : Drosophila melanogasterDosage compensation (DC) in Drosophila equalizes X chromosome-linked gene expression via the Male-Specific Lethal (MSL) complex, which acetylates histone 4 lysine 16 on the male X-chromosome. How DC is established during early embryogenesis remains obscur […]
- GSE313849 RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity [RNAseq in REXO4-dTAG HeLa cells] May 28, 2026Contributors : Jieyou Zhang ; Kaiwen Bao ; Qi Chen ; Lei ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo determine if REXO4 depletion directly induces R-loop accumulation independent of transcription, we generated a HeLa cell line expressing endogenous REXO4 tagged with an N-terminal HA-FKBP12/F36V degron (REXO4-d […]
- GSE310666 The Role of Supraoptic Hypothalamic Arginine Vasopressin Neurons in Aging-Associated Water Balance and Thermoregulatory Deficits May 28, 2026Contributors : Nancy Morones ; Predrag Jovanovic ; Edward Novinbakht ; Joshua J Breunig ; Celine E RieraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAging disrupts physiological homeostasis, impairing thermoregulation, metabolism, and water balance, but the underlying neural mechanisms remain unclear. Here, we identi […]
- GSE291757 Multiplexed transcriptomics to screen drug combination and define therapeutic mechanism of action at single-cell resolution May 28, 2026Contributor : Mengmeng JiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCompared to classical drug screening, single-cell screening not only significantly enhances throughput but also provides richer transcriptional response information. In this study, we employed the high-throughput single-cell sequencing technolog […]
- GSE318007 Single-cell RNA sequencing of E18.5 mouse hindstomach epithelium and bulk RNA sequencing of its derived 3D organoids across distinct YAP activity states [bulk RNA-seq] May 28, 2026Contributors : Yongchun Zhang ; Rongzi MuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHippo signaling plays a crucial role in the development of multiple organs. This study consists of two transcriptomic datasets.Single-cell RNA sequencing was conducted on E18.5 mouse hindstomach epithelial cells of littermate contro […]
- GSE333421 A Novel CRYBB2 Splicing Mutation Is Associated with Lens Extracellular Matrix Remodeling and Vascular Alterations in Congenital Cataract May 28, 2026Contributors : Xing Wei ; Jing Wang ; Yanyun Wang ; Cong Zhou ; Zhaoyi Chen ; Shanling Liu ; Huaqin Sun ; Bin Zhou ; Lin ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioPurpose: We identify the genetic cause of autosomal dominant congenital cataract in a large family and to define how a CRYBB2 splice-site variant pe […]
- GSE333397 Depletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [ChIP-Seq] May 28, 2026Contributors : Matasha Dhar ; Edwin Vázquez-Rosa ; Kalyani Chaubey ; Emiko Miller Sofia Corella ; Suwarna Chakraborty ; Sunil J Tripathi ; Tapatee Das ; Xudong Liao ; Mohamed Alkassem Alosman ; Hua Fang Yeojung Koh ; Preethy S Sridharan ; Kathryn Franke ; Coral J Cintrón-Pérez ; Adrian Cintrón-Pérez ; Taylor Tomco ; Vidya Indrakumar ; Phoebe Rubin ; Justin G […]
- GSE333477 Dynamicity of Topoisomerase 1 binding at super-enhancers regulates TLR-responsive gene expression program in macrophages May 28, 2026Contributors : Harshdeep Kaur ; Vanshika Sood ; Ashlesha Gogate ; Kushagra BansalSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusToll-like receptor (TLR) activation elicits an effective innate immune response by inducing the expression of […]
- GSE333449 Loss of Endothelial ZEB1 enhances neovascularisation during choroidal neovascularisation May 28, 2026Contributors : Nicholas Beazley-Long ; Joseph L Horder ; Kathryn R Green ; Joshua H Bourne ; Amy P Lynch ; Nada S Ahmed ; Zarah B Tabrizi ; Guillermo Diez-Pinel ; Christopher P Carroll ; Claire L Allen ; Charles T Cresswell ; Poppy E Harris ; Isabela Ferreira ; Diogo Mosqueira ; Julie Rayes ; Nigel P Mongan ; John King ; Chris Denning ; Alan P McIntyre ; Mar […]
- GSE333506 Temporal regulation of EPAS1 and whole-blood lncRNA-mRNA expression during four weeks of altitude training in Han Chinese and Tibetan endurance athletes May 28, 2026Contributors : Qing-Qing Su ; Yan-Lin Sun ; Fu-Hai Ma ; Jian Wang ; Yan-Chang Shen ; Xiao-Wei Ma ; Ben-Jian Lyu ; Su-Li Guo ; Jiang-Long Zhang ; Yang Zhang ; Erik R SwensonSeries Type : Expression profiling by arrayOrganism : Homo sapiensThis study examined temporal hypoxia-responsive gene expression during a four-week naturalistic altitude-training camp. Wh […]
- GSE333519 Targets of SPEECHLESS and FAMA control guard cell division and expansion in the late stomatal lineage May 28, 2026Contributors : Pablo González-Suárez ; Margot SmitSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaPlant tissue development often relies on the specification of cell type initials with stem cell-like properties. These later undergo differentiation, losing division potential and acquiring specific identities and f […]
- GSE333531 TPX2-mediated autophagy maintains cancer stemness in LUAD May 28, 2026Contributors : Mingzheng Jiang ; Hongli Ye ; Jiwei Li ; Zhancheng Gao ; Yali ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTargeting protein for Xklp2 (TPX2) is a mitotic regulator frequently overexpressed in lung adenocarcinoma (LUAD), while its role in cancer stemness and autophagy remains incompletely understo […]
- GSE298624 Shifts in embryonic oxygen levels cue heterochrony in limb initiation [scRNA-seq] May 28, 2026Contributors : Meng Zhu ; ChangHee Lee ; Rinaldo Catta-Preta ; Clifford J TabinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHeterochrony, or the alteration of developmental timing, is an important mechanism of evolutionary change. Avian species display synchronized growth of the forelimbs and hindlimbs, while mammali […]