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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE249747 Hijacking the transcriptional potential of the BAF complex for therapeutic purposes via induce proximity December 4, 2025Contributors : Lionel Chia ; David Mayhew ; Dave Lahr ; Asad TaherbhoySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe BAF (Brg/Brahma-associated factors) complex, also referred to as the mammalian Switch/Sucrose-Nonfermentable (mSWI/SNF) chromatin remodeling complex, plays a pivotal role in epigenetically regulating […]
- GSE249555 CAG repeat-selective compunds reduce abundance of expanded CAG RNAs in patient and murine models of SCAs I December 4, 2025Contributors : Hannah K Shorrock ; Asmer Aliyeva ; Jesus A Frias ; Victoria A DeMeo ; Claudia D Lennon ; Cristina C DeMeo ; Amy K Mascorro ; Sharon Shaughnessy ; Hormoz Mazdiyasni ; John D Cleary ; Kaalak Reddy ; Sweta Vangaveti ; Damian S Shin ; J A BerglundSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSpinocerebella […]
- GSE271118 Single-cell transcriptomics revealed molecular vulnerability in a human midbrain-like organoid model of Parkinson's Disease [MERFISH] December 4, 2025Contributors : Jessica Xie ; Matas Vitkauskas ; Yang Lin ; Ng H Hui ; Liu JinyueSeries Type : OtherOrganism : Homo sapiens ; synthetic constructThe human midbrain-like organoid (hMLO) is a key model system for investigating pathological features of Parkinson’s disease (PD), yet how its molecular landscape relates to cellular vulnerability in PD remains uncle […]
- GSE271115 Single-cell transcriptomics revealed molecular vulnerability in a human midbrain-like organoid model of Parkinson's Disease [RNA-Seq] December 4, 2025Contributors : Jessica Xie ; Matas Vitkauskas ; Yang Lin ; NgLast na H Hui ; Jinyue LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe human midbrain-like organoid (hMLO) is a key model system for investigating pathological features of Parkinson’s disease (PD), yet how its molecular landscape relates to cellular vul […]
- GSE287134 Methionine Restriction Alleviates Kidney Fibrosis through Epigenetic Repression of the TGF-β/Smad3/Hoxc8/P-TEFb Axis December 4, 2025Contributors : Zhiheng Liu ; Yunjing Liu ; Lirong ZhangSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Rattus norvegicusRenal fibrosis is a hallmark of chronic kidney diseases (CKDs) and a key driver of disease progression. While low-protein diets have been shown to […]
- GSE283555 Quantitative Modeling of the Short-Term Response to Nitrogen Availability that Coordinates Early Events in Lateral Root Initiation December 4, 2025Contributors : Allison Gaudinier ; Lisa Van den Broeck ; Miguel Moreno-Risueño ; Joel Rodriguez-Medina ; Rosangela Sozzani ; Siobhan BradySeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaTo find novel factors in early root system architecture responses to nitrate conditions, we performed Arabidopsis thaliana root […]
- GSE311895 Stiffness-related mitochondria transfer promotes tumor progression through metabolic reprogramming December 4, 2025Contributor : Xinran ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe physical properties of the tumor microenvironment (TME), particularly extracellular matrix stiffness, are key factors influencing cancer progression. While intercellular mitochondrial transfer is emerging as a vital mechanism for tumor metaboli […]
- GSE292738 The different genes expression in clinical para-tumor and pancreatic ductal adenocarcinoma samples December 4, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPancreatic cancer is a highly malignant tumor. Current treatments are not effective. Hence, more effective treatment methods need to be sought. We aim to identify genes that differ between clinical para-tumor and pancreatic ductal adenocarcinoma samples by RNA-seq, and sub […]
- GSE312031 Spatiotemporal remodeling of chromatin topology architecture and H3K27me3 redistribution underlies vascular pathology in Hutchinson-Gilford progeria syndrome [Hi-C] December 4, 2025Contributors : Mzwanele Ngubo ; Naveen Ahuja ; Rana Karimpour ; Amit Shrestha ; Michael J Hendzel ; Theodore J Perkins ; William L StanfordSeries Type : OtherOrganism : Homo sapiensHutchinson-Gilford progeria syndrome (HGPS) is a devastating premature aging disorder driven by the accumulation of progerin, leading to severe vascular pathology. While epigeneti […]
- GSE312029 Spatiotemporal remodeling of chromatin topology architecture and H3K27me3 redistribution underlies vascular pathology in Hutchinson-Gilford progeria syndrome [CUT&Tag] December 4, 2025Contributors : Mzwanele Ngubo ; Naveen Ahuja ; Rana Karimpour ; Amit Shrestha ; Michael J Hendzel ; Theodore J Perkins ; William L StanfordSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensHutchinson-Gilford progeria syndrome (HGPS) is a devastating premature aging disorder driven by the accumulation of prog […]
- GSE312092 Exploring the important role of PRDX proteins in FSGS: Insights from transcriptomic analysis and experimental validation December 4, 2025Contributors : Feng Wan ; Mengdan LuSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusTo elucidate the mechanistic impact of PRDX family proteins on FSGS, we employed transcriptome sequencing of 6 mice kidney samples. 4358 differentially expressed genes were identified between the FSGS and control groups, with 2414 u […]
- GSE312093 Ramulus Mori (Sangzhi) Alkaloids Attenuate Diet-Induced Obesity by Promoting White Adipose Browning and Enhancing Brown Fat Thermogenesis December 4, 2025Contributor : Nanwei TongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity is a chronic metabolic disorder characterized by excessive adipose accumulation and is closely associated with type 2 diabetes mellitus (T2DM), cardiovascular diseases, and metabolic dysfunction associated steatotic liver disease. Enhancing […]
- GSE312339 Comparative RNA-seq analysis of fetal and maternal guinea pig liver transcriptomes reveals widespread transcriptional divergence. December 4, 2025Contributors : Daniella Hasan ; Massimo BionazSeries Type : Expression profiling by high throughput sequencingOrganism : Cavia porcellusBackground: Maternal Western diet (WD) consumption during pregnancy is linked to adverse gestational and offspring metabolic outcomes. Dimethyl fumarate (DMF), a Nrf2 activator with antioxidant and anti-inflammatory properti […]
- GSE312368 A targetable developmental program co-regulates angiogenesis and immune evasion. December 4, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE311894 Effects of Selenium-mediated RUNX2 Overexpression and its Transcriptome Alterations on Chondrocyte Injury in Kashin Beck disease December 4, 2025Contributors : Di Zhang ; Yongmin Xiong ; Shiquan SunSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRunt-related transcription factor 2 (RUNX2) is a key regulator of chondrocyte differentiation and apoptosis. To investigate the downstream molecular mechanisms of RUNX2 in chondrocyte injury, we established a RUNX2 overe […]