Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE297436 Autoinhibition of ASXL1 Condensation via Opposing-Charge Blocks in Its Disordered Region April 9, 2026
  Contributor : Xiao FangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Long intrinsically disordered regions (IDRs) are prevalent in chromatin regulators, yet how they encode regulatory logic remains unclear. Here, we show that ASXL1, a frequently mutated scaffold protein in myeloid malignancies, employs a charge-base […]
• GSE295468 Single-cell and spatial transcriptomics uncover the role of B chromosomes in driving plant invasiveness April 9, 2026
  Contributors : Cui Wang ; James Ord ; Mengxiao Yan ; Yunfei Cai ; Hongjin Shao ; Lele Lin ; Jarkko Salojärvi ; Lele Liu ; Weihua GuoSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Invasive plants can significantly disrupt native biodiversity, yet the genetic mechanisms driving their success remain poorly understood. This st […]
• GSE327428 GPR34 regulation of disease-associated microglial states in mice April 9, 2026
  Contributors : Ana Geller ; Min Jee Kwon ; Sean Simmons ; Qihong Xu ; William Martenis ; Jordan Doman ; Sahana Natarajan ; Katherine Stalnaker ; Constanze Depp ; Steven Carr ; David McKinney ; Alexandra Gould ; Evan Lebois ; Michel Weiwer ; Matthew Johnson ; Joshua Levin ; Yan-Ling Zhang ; Nader Morshed ; Deeksha Misri ; Diana Bohannon ; Elena Longhi ; Hasmi […]
• GSE304564 Transcriptome analyses of Arabidopsis natural accessions Col-0 and IP-Svi-0 at different tempearatures April 9, 2026
  Contributors : Nasim Zeeshan ; Karim Nouroz ; Ahn Ji-HoonSeries Type : Expression profiling by high throughput sequencingOrganism : Plants are sessile organisms; thus they developed sophisticated endogenous mechanisms to detect and respond to various environmental cues . Our planet has diverse light and temperature conditions, to adopt in such a wide range o […]
• GSE292734 Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration April 9, 2026
  Contributors : Kelly Hu ; Hanrong Hu ; Aztekin CanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Why mammals cannot regenerate limbs, unlike amphibians, presents a longstanding puzzle in biology. We show that exposing ex vivo amputated embryonic mouse limbs to subatmospheric oxygen environment, or stabilizing oxygen- […]
• GSE279112 Screening Genes related to Bur Lignification Development in field sandbur (Cenchrus pauciflorus Benth.) Based on Full-Length Transcriptome Sequencing April 9, 2026
  Contributor : Yujie ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Full-length transcriptome of field sandbur (Cenchrus pauciflorus Benth.) was constructed, and high-throughput sequencing was conducted on mixed samples from four stages (BS1-BS4) of bur development and the root, stem, and leaf organs using the PacBio platform. […]
• GSE327076 The mechanism of circular RNA circ0061693 and its encoded peptide P385 in improving neural injury in Parkinson's disease April 9, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Parkinson’s disease (PD) is the second most common neurodegenerative disorder, pathologically characterized by the loss of dopaminergic neurons and abnormal accumulation of α-synuclein (α-syn). Circular RNAs (circRNAs) are a unique class of stable closed-loop RNA molecules that exert […]
• GSE293981 The molecular architecture of incidental meningiomas April 9, 2026
  Series Type : Expression profiling by array ; Methylation profiling by genome tiling arrayOrganism : This SuperSeries is composed of the SubSeries listed below.
• GSE327359 Motif-directed chromatin repression by BCL11B shapes ectopic targeting and lineage commitment [CUT&RUN] April 9, 2026
  Contributors : Lindsey E Montefiori ; Qingsong Gao ; Charles G MullighanSeries Type : OtherOrganism : BCL11B encodes a critical T-lineage transcription factor that is implicated as both an oncogene and a tumor suppressor in acute leukemia. Despite its central role in development and malignancy, a basic understanding of the sequence determinants of BCL11B act […]
• GSE327332 JAX Study 13- RNA-seq of male KOLF2.2J hiPSC-derived endoderm and mesoderm homozygous null for ten different transcription factors April 9, 2026
  Contributors : Juliana A Diniz ; Bill Skarnes ; Paul RobsonSeries Type : Expression profiling by high throughput sequencingOrganism : This study aims to phenotype iPSC-derived early endoderm and mesoderm that contain homozygous null alleles for the following transcription factors: CITED1, HOXB8, GATA6, GSC, HES6, SP5, TBXT, LHX1, SOX17 and MSX1. Null alleles […]
• GSE327360 Motif-directed chromatin repression by BCL11B shapes ectopic targeting and lineage commitment [ATAC-seq] April 9, 2026
  Contributors : Lindsey E Montefiori ; Qingsong Gao ; Charles G MullighanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : BCL11B encodes a critical T-lineage transcription factor that is implicated as both an oncogene and a tumor suppressor in acute leukemia. Despite its central role in development and malignancy, a bas […]
• GSE327361 Motif-directed chromatin repression by BCL11B shapes ectopic targeting and lineage commitment [RNA-seq] April 9, 2026
  Contributors : Lindsey E Montefiori ; Qingsong Gao ; Charles G MullighanSeries Type : Expression profiling by high throughput sequencingOrganism : BCL11B encodes a critical T-lineage transcription factor that is implicated as both an oncogene and a tumor suppressor in acute leukemia. Despite its central role in development and malignancy, a basic understandi […]
• GSE327367 Motif-directed chromatin repression by BCL11B shapes ectopic targeting and lineage commitment April 9, 2026
  Series Type : Other ; Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : This SuperSeries is composed of the SubSeries listed below.
• GSE294373 Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells [RNA-Seq] April 9, 2026
  Contributors : Xinlong Guo ; Xuelian Ren ; Cong Yan ; He HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Multiple myeloma (MM) is a hematologic malignancy characterized by abnormal plasma cell proliferation, with lenalidomide emerging as a primary treatment. However, prolonged use often leads to drug resistance, underscoring t […]
• GSE327047 Identification and integration of LRG1-Induced differentially Expressed Gene (DEG) Hub Profiles in breast cancer cell April 9, 2026
  Contributors : Federico Osorio-Antonio ; Daniela M Díaz-González ; Gabriela E Campos-Viguri ; José M Sánchez-López ; José L Cortez-Sánchez ; Francisco Castelán ; Jesús R Chávez-Ríos ; Paola Maycote-González ; Paulina Cortés-Hernández ; Oscar Peralta-Zaragoza ; Elizabeth B RodríguezSeries Type : Expression profiling by arrayOrganism : Breast carcinoma is a ma […]