Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE291234 Effect of myeloid specific Trem2 knockout in hepatocellular carcinoma after anti-PD-1 therapy [ChIP-seq] April 29, 2026
  Contributors : Zhixian Liang ; Yiling Zhang ; Siyun Chen ; Zhewen Xiong ; Yalin Tu ; Alfred Sze-Lok ChengSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusImmune-checkpoint blockade (ICB) therapies have transformed the treatment landscapes of solid malignancies, including hepatocellular carcinoma (HCC), whic […]
• GSE296416 CTCF regulates chromatin accessibility of the HBAD gene promoter during erythroid differentiation [UMI-4C] April 29, 2026
  Contributors : Gustavo Tapia Urzúa ; Hober N Núñez Martínez ; Martin Franke ; Sylvia Garza Manero ; Ángel J Cerecedo Castillo ; Carlos A Peralta Álvarez ; Georgina Guerrero ; José L Gómez Skarmeta ; Félix RecillasSeries Type : OtherOrganism : Gallus gallusChromatin structure undergoes dynamic rearrangements during cell differentiation. The architectural prot […]
• GSE295307 The mechanism of growth-promoting bacteria Enterobacter sp. CS8-gfp enhancing the degradation of atrazine-thiamethoxam in rice plants April 29, 2026
  Contributor : Liya MaSeries Type : Expression profiling by high throughput sequencingOrganism : Oryza sativaPlant-microbe interactions have been applied in the phytoremediation of pesticides to ensure food safety and reduce environmental health risks. However, the plant signaling molecules triggered by microbes to degrade pesticides remain unclear. Herein, w […]
• GSE302858 Multi-tier signaling and epigenomic reprogramming drive microglial inflammatory states and functions associated with demyelination [ATAC-seq] April 29, 2026
  Contributor : David GosselinSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe extensive heterogeneity of microglia inflammatory states accompanying neurodegenerative diseases underscores the complex molecular mechanisms that regulate these cells. Here, we report on transcriptional effectors that control […]
• GSE302115 ATAC-seq analysis of primary bronchial epithelial cells from healthy, ex-smoker COPD and current smoker COPD patients cultured in ALI conditions April 29, 2026
  Contributors : Ayaka Shiota ; Keiko Kan-o ; Yumiko Ishii ; Tomoaki KogaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensATAC-seq analysis of primary bronchial epithelial cells from healthy, ex-smoker COPD and current smoker COPD patients cultured in ALI conditions
• GSE313557 Analysis of BMDMs with or without apoptotic cell pretreatment [RNA-seq] April 29, 2026
  Contributors : Zhixian Liang ; Yiling Zhang ; Siyun Chen ; Zhewen Xiong ; Yalin Tu ; Alfred Sze-Lok ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImmune-checkpoint blockade (ICB) therapies have transformed the treatment landscapes of solid malignancies, including hepatocellular carcinoma (HCC), which is currently […]
• GSE309201 Characterization of the virus-host RNA-RNA interactome across different RNA viruses April 29, 2026
  Contributors : Nkerorema D Damas ; Stefan E Seemann ; Rui Costa ; Nicolas Fossat ; Lizandro R Rivera-Rangel ; Ulrik Fahnøe ; Louise Nielsen ; Jan Gorodkin ; Jens Bukh ; Troels K Høyer ScheelSeries Type : OtherOrganism : Homo sapiensViruses make extensive use of host cell machinery, however, most systematic studies of virus-host interactions focused on protei […]
• GSE329041 DNA:RNA ImmunoPrecipitation (DRIP) sequencing data of virtual memory T cells In vitro induced from WT and Dusp2-/- CD8+ T cells April 29, 2026
  Contributors : Wenyu Tian ; Weixuan Wang ; Yaruo Qiu ; Dan LvSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusVirtual memory CD8+ T (TVM) cells are a distinct subset of antigen-inexperienced cells with rapid effector potential, but their regulatory checkpoints remain elusive. Here, using DRIP sequencing, we […]
• GSE329039 Translesional DNA Polη Bypass of LANA-DNA Crosslinks Ensures KSHV Episome Persistence and Tumor Growth April 29, 2026
  Contributors : Jayaraju Dheekollu ; Coltin J Albitz ; Anjali Pathania ; Frederick Keeney ; Samantha S Soldan ; Paul M LiebermanSeries Type : OtherOrganism : Homo sapiens ; Human gammaherpesvirus 8The episome maintenance of DNA tumor viruses depend on their viral-encoded sequence-specific DNA binding proteins. We show here that the Kaposi’s Sarcoma- Associate […]
• GSE329187 SroA links SigS-dependent stress signaling to repression of nitrate respiration in Staphylococcus aureus April 29, 2026
  Contributors : Shahad Alqahtani ; Sagar Pasham ; Jamilah Alsulami ; Brooke R Tomlinson ; Emily A Felton ; Lindsey N Shaw ; Karl M ThompsonSeries Type : Expression profiling by high throughput sequencingOrganism : Staphylococcus aureusAnalysis of the transcriptome changes in vector control vs. sroA over-expression samples.
• GSE329173 Integrating Single-Cell and Macroscopic Transcriptomics to Decode Transcriptional and Immune Microenvironment Remodeling Associated with Extravillous Trophoblast Invasion Arrest in Severe Preeclampsia April 29, 2026
  Contributors : Qihang Zhao ; Xiao Lin ; Juanmei Gao ; Linzhen WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPreeclampsia is a pregnancy-specific systemic disorder that poses significant threats to maternal and perinatal health. The core pathological features of this condition involve shallow invasion of extravillous […]
• GSE329243 Polycomb erasers BAP1 and UTX are dispensable for rapid bivalent gene activation but essential for enhancer establishment [CUT&Tag] April 29, 2026
  Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusPolycomb group (PcG) proteins safeguard cell identity by maintaining target genes in a transcriptionally repressed state through depositing two histone marks, H2A lysine-119 ubiquitination (H2AK119ub1) and H3 lysine-27 trimethylation (H3K27me3). BAP1 and UTX […]
• GSE329244 Polycomb erasers BAP1 and UTX are dispensable for rapid bivalent gene activation but essential for enhancer establishment [ChIP-seq] April 29, 2026
  Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusPolycomb group (PcG) proteins safeguard cell identity by maintaining target genes in a transcriptionally repressed state through depositing two histone marks, H2A lysine-119 ubiquitination (H2AK119ub1) and H3 lysine-27 trimethylation (H3K27me3). BAP1 and UTX […]
• GSE329245 Polycomb erasers BAP1 and UTX are dispensable for rapid bivalent gene activation but essential for enhancer establishment [RNA-seq] April 29, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPolycomb group (PcG) proteins safeguard cell identity by maintaining target genes in a transcriptionally repressed state through depositing two histone marks, H2A lysine-119 ubiquitination (H2AK119ub1) and H3 lysine-27 trimethylation (H3K27me3). BAP1 and UTX are thought to […]
• GSE267967 Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for functional differentiation of Treg cells [RNA-seq] April 29, 2026
  Contributors : Ryuichi Murakami ; Norihito Hayatsu ; Zhenan Liu ; Shohei HoriSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMechanisms by which diverse transcription factors (TFs), particularly the master regulator Foxp3, shape the heterogeneous transcriptional and epigenetic landscape of regulatory T (Treg) cells rema […]