Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE275981 Gene expression profile at single cell level of iPSC-derived and primary thymic epithelial cells (TECs) July 10, 2025
  Contributors : Yann Pretemer ; Yoko HamazakiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe used single cell RNA sequencing (scRNA-seq) to explore the development of heterogeneous TEC-like populations from iPSCs.
• GSE278979 Transcriptional programs of cell identity and p53-induced stress responses are associated with distinctive features of spatial genome organization [RNA-seq] July 10, 2025
  Contributors : Hsin-Jung Chou ; Tsung-Han S Hsieh ; Claudia Cattoglio ; Jack Li ; Xavier Darzacq ; Gony Shanel ; Ran ElkonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo date, most studies explored changes in 3D-genome organization between different tissues or during differentiation, which involve massive reprogrammi […]
• GSE278977 Transcriptional programs of cell identity and p53-induced stress responses are associated with distinctive features of spatial genome organization [ChIP-seq] July 10, 2025
  Contributors : Hsin-Jung Chou ; Tsung-Han S Hsieh ; Claudia Cattoglio ; Jack Li ; Xavier Darzacq ; Gony Shanel ; Ran ElkonSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo date, most studies explored changes in 3D-genome organization between different tissues or during differentiation, which involve massi […]
• GSE231643 Diabetic foot ulcers debridement SCRNA-seq showed healing association with inflammatory fibroblasts in minorities July 10, 2025
  Contributors : Manoj Bhasin ; Dahim ChoiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this pilot study, we optimized diabetic foot ulcers (DFUs) single-cell profiling from debrided DFUs of underrepresented African American (AA) patients. The healing-DFUs were significantly enriched (P=0.03) with unique heterogenous […]
• GSE285541 Gtf2i-encoded transcription factor Tfii-i regulates myelination via Sox10 and Mbp regulatory elements July 10, 2025
  Contributors : Gilad Levy ; Asaf Marco ; Boaz BarakSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe transcriptional regulatory network governing the differentiation and functionality of oligodendrocytes is essential for the formation and maintenance of the myelin sheath, and hence for the proper functio […]
• GSE271944 Spinal cord organoids derived from human amniotic fluid iPSC recapitulate the diversity of cell phenotypes during fetal neural tube morphogenesis July 10, 2025
  Contributors : Juan C Biancotti ; Hannah E Moore ; Anne M Sescleifer ; Shelby R Sferra ; Annalise B Penikis ; Jena L Miller ; Shaun M KunisakiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe developed spinal cord organoids (SCOs) as an in vitro modeling system to help understand the pathophysiology of the spinal cord […]
• GSE263649 Single nucleus RNA sequencing of the cerebral cortex from genetically diverse inbred mouse strains reveals differences in pericyte and endothelial cell composition July 10, 2025
  Contributors : Jieun Park ; James L Krantz ; Mark J ZylkaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGenetic background influences animal behavior and susceptibility to brain diseases. To evaluate how genetic background influences the relative number and/or types of cells in the brain, we performed single nucleus RN […]
• GSE301497 The human transcription factor occupancy landscape viewed using high-resolution in situ base-conversion strand-specific single-molecule chromatin accessibility mapping July 10, 2025
  Contributors : Georgi K Marinov ; William J GreenleafSeries Type : OtherOrganism : Homo sapiensChromatin accessibility profiling is a key tool for mapping the location of cis-regulatory elements (cREs) in the genome and tracking chromatin state dynamics during development, in response to various external and internal stimuli, and in disease contexts. Single- […]
• GSE301154 Preclinical efficacy of tasquinimod-based combinations in advanced myeloproliferative neoplasms (MPN) in blastic phase July 10, 2025
  Contributors : Warren Fiskus ; Kapil BhallaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe alarmins, S100A8 (A8) and S100A9 (A9), are low molecular weight proteins belonging to the S100 protein family. A8 and A9 are secreted into the extracellular space and plasma, where they interact with TLR4 (Toll like receptor 4 […]
• GSE301955 Endoplasmic Reticulum Stress-Driven Nucleotide Catabolism Fuels Prostate Cancer July 10, 2025
  Contributors : Omer F Kuzu ; Fahri Saatcioglu ; Ke Deng ; Yang Jin ; Nora Pällmann ; Marte Livgård ; Wanja Kildal ; Manohar Pradhan ; Ladan Fazli ; Paul S RennieSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe study investigates the impact of MOCOS knockdown and ER stress on transcriptomic responses and purine metabo […]
• GSE301923 Transcriptome profiles of LAM cell models exposed to oleic acid July 10, 2025
  Contributors : Roderic Espín ; Miquel Angel PujanaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusRNA-seq profiling of Tsc2-deficient mouse embryonic fibroblasts (MEFs) and TSC2-deficient 621-101 human angiomyolipoma cells exposed to oleic acid or basal condition.
• GSE302184 RNA sequencing of WT and TrIP KO P14 TCR Tg T cells stimulated in vitro July 10, 2025
  Contributors : Benjamin M Murter ; Lawrennce P KaneSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe protein PI3K-interacting protein (PIK3IP1), or transmembrane inhibitor of PI3K (TrIP), is highly expressed by T cells and can modulate PI3K activity in these cells. Several studies have also revealed that TrIP is rapid […]
• GSE302185 TCRseq of Rpl18*-specific T cells from MC38 tumor and draining lymph node July 10, 2025
  Contributors : Benjamin M Murter ; Lawrennce P KaneSeries Type : OtherOrganism : Mus musculusThe protein PI3K-interacting protein (PIK3IP1), or transmembrane inhibitor of PI3K (TrIP), is highly expressed by T cells and can modulate PI3K activity in these cells. Several studies have also revealed that TrIP is rapidly downregulated following T cell activation […]
• GSE302196 RNAseq of Rpl18*-specific T cells from MC38 tumor and draining lymph node July 10, 2025
  Contributors : Benjamin M Murter ; Lawrence P KaneSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe protein PI3K-interacting protein (PIK3IP1), or transmembrane inhibitor of PI3K (TrIP), is highly expressed by T cells and can modulate PI3K activity in these cells. Several studies have also revealed that TrIP is rapidl […]
• GSE274554 Epigenetic regulation of B cell differentiation by G9a July 10, 2025
  Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.