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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE303759 Human U2 snRNA BSL sequence mediates splicing efficiency driven by branchpoint sequence complementarity February 13, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the global effects of perturbing U2 snRNA sequence on splicing and gene expression, we carried out transcriptomic analysis of HEK293T cell lines stably expressing U2 snRNA mutants C28U in the branchpoint interacting stem loop or T34A/ A35C/G36T to create an […]
- GSE300637 Bulk RNA-seq datasets supporting analysis of the MYC–USP10–SOX4 pathway in thymocytes and T-ALL February 13, 2026Contributors : Bin Zhao ; Mengdi ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study presents bulk RNA-seq datasets generated from thymocytes of C57BL/6J mice to elucidate the transcriptional impact of thymus-specific loss of the deubiquitinase USP10. Total RNA was isolated from age-matched wild-type (WT) an […]
- GSE304885 Intestinal plasmacytoid dendritic cells preferentially produce interferon lambda [scRNA-seq] February 13, 2026Contributors : David A Constant ; Timothy J NiceSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThe healthy intestine mounts immune responses to microbiota to maintain homeostasis, which includes basal production of interferon cytokines. Previous work showed that Type III Interferon (IFN-λ) stimulates localized […]
- GSE304776 LGR5⁺ Stem Cells Maintain Apex Position in Regenerative Hierarchy of the Intestinal Epithelium During Homeostasis and Injury February 13, 2026Contributors : Julian Chua ; Lucy Driver ; Masahiro Narimatsu ; Mardi Fink ; Lixia Luo ; Jordan Tran ; Jatin Roper ; David G Kirsch ; Jeff Wrana ; Chang-Lung Lee ; Arshad AyyazSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusThe cellular origin of intesti […]
- GSE269537 Distinct roles of tip progenitor subpopulation in shaping the murine lung February 13, 2026Contributors : Kuan Zhang ; Madhuri Basak ; Erica Yao ; Pao-Tien ChuangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA gradient SOX9+ distal progenitor cell differentiation impacts the patterning of the lung during branching morphogenesis. Although the heterogeneity of this population has been suggested, the specific […]
- GSE240483 NAD+ controls circadian rhythmicity during cardiac aging February 13, 2026Contributors : Bryce J Carpenter ; Margaux Lecacheur ; Yannick N Mangold ; Kai Cui ; Stefan Günther ; Marit W Vermunt ; Pieterjan DierickxSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDisruption of the circadian clock as well as reduced NAD+ levels are both hallmarks of aging. While circadian rhythms and NAD+ metaboli […]
- GSE318830 LncRNA NAS1 deficiency drives cisplatin resistance in non-small cell lung cancer February 13, 2026Contributors : Xianrong Lin ; Wenjun TaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCisplatin resistance remains a major obstacle in non-small cell lung cancer (NSCLC) treatment. Long non-coding RNAs (lncRNAs) have been implicated in chemotherapy resistance, yet their specific roles and mechanisms are not fully unde […]
- GSE290299 Antibiotic sensitization of pathogenic Pseudomonas aeruginosa via negative hysteresis in the cell envelope February 13, 2026Contributors : Espen E. Groth ; Roderich Roemhild ; Sören Franzenburg ; Hinrich SchulenburgSeries Type : Expression profiling by high throughput sequencingOrganism : Pseudomonas aeruginosa PA14Antimicrobial resistance (AMR) is a major challenge for global health. Multi-drug treatments can help to reduce AMR and be implemented through the sequential administr […]
- GSE318881 RNA-Seq quantitative analysis of the regulatory effects of plasma exosomes from CML patients on CML cell transcriptomes February 13, 2026Contributors : Fei Li ; Qing ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDrug resistance frequently results in treatment failure for leukemia and leads to the progression of chronic myeloid leukemia (CML) into an accelerated or blast phase. Although new tyrosine kinase inhibitors (TKIs) and combined TKI therapi […]
- GSE318864 Eurycomanone from Eurycoma longifolia Jack roots regulates dopamine secretion via transsynaptic GABA signalling in differentiated SH-SY5Y human neuroblastoma cells: a transcriptomic study February 13, 2026Series Type : Expression profiling by arrayOrganism : Homo sapiensWe employed microarray-based transcriptomic analysis to uncover potential molecular pathways associated with the dopaminergic effect of the quassinoid compound from the plant. The transcriptomic insights generated from this work may provide a deeper molecular basis for the long-debated aphrodi […]
- GSE319266 Identification of target genes and regulatory networks for bone mineral density GWAS loci through systematic targeting and inhibition [hFOB BMD STING-seq] February 13, 2026Contributor : John A MorrisSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensOsteoporosis is characterized by low bone mineral density (BMD) and elevated fracture risk. Most BMD-associated GWAS variants lie in noncoding regions, complicating efforts to identify causal genes and mechanisms. To overcome this variant […]
- GSE319326 Identification of target genes and regulatory networks for bone mineral density GWAS loci through systematic targeting and inhibition February 13, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE319445 Phagocytes as Plaque Catalysts: Human Macrophages Generate Seeding-Competent Aβ42 Fibrils with Cross-Seeding Activity February 13, 2026Contributors : Katerina Konstantoulea ; Meine Ramakers ; Sarah C Borrie ; Dries T’syen ; Daan Moechars ; Malgorzata A Sliwinska ; Brajabandhu Pradhan ; Giulia Albertini ; Grigoria Tsaka ; Bert Houben ; Mark Fiers ; Maarten Dewilde ; Dietmar R Thal ; Michael Willem ; Jonas J Neher ; Bart De Strooper ; Frederic Rousseau ; Joost SchymkowitzSeries Type : Express […]
- GSE297859 Caspases 3 and 7 restrict intestinal inflammation by regulating stem cell function and gsdmd-mediated pyroptosis February 13, 2026Contributors : Xie Wei ; Verstraeten Bruno ; Vandenabeele PeterSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAberrant intestinal epithelial cell (IEC) death is a hallmark of inflammatory bowel disease (IBD), observed in patient samples and animal models of colitis. While multiple cell death pathways contribute to dise […]
- GSE318666 Decoding interactions in a soil microbiome Streptomyces community through multi-omics: functional insights into siderophore ecology February 13, 2026Contributors : F Del Carratore ; J A Connolly ; K Schmidt ; A Bisesi ; J N Martinson ; J Chua ; M Kuhs ; M Boneza ; S Heinsch ; L Kinkel ; M Smanski ; W R Harcombe ; R Breitling ; E TakanoSeries Type : Expression profiling by high throughput sequencingOrganism : unclassified StreptomycesBackgroundStreptomyces are key contributors to soil microbiome function, […]