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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE289388 Timosaponin AIII enhances CAR-T cell potency and prevents relapse through impairing CAR-Tregs February 11, 2026Contributors : Mingqi Hou ; Jing Yang ; Wenjun Zhang ; Xiaochen Tang ; Rui Jin ; Husheng MeiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChimeric antigen receptor (CAR)-T cell therapy has become the standard treatment for refractory and relapsed (r/r) DLBCL in recent years. However, more than half of these patients d […]
- GSE289322 Formyl peptide receptor 2 determines sex differences in pulmonary hypertension-associated right ventricular dysfunction February 11, 2026Contributors : Jiafei Lu ; Yu Hao ; Xiaoyan Chen ; Xinyu Li ; Huating Xie ; Jialin Wang ; Man LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAims Pulmonary hypertension (PH) involves structural and functional changes in pulmonary vessels due to various diseases, leading to increased vascular resistance and arterial p […]
- GSE308682 Pooled CRISPRi screen with scRNA-seq to knockdown 7 transcription factors in k562 cells February 11, 2026Contributors : Hong Zhang ; Peifen Zhang ; Eric Bindels ; Eskeatnaf MulugetaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo systematically investigate the gene regulatory networks in K562 cells, we performed CROP-seq—a pooled CRISPRi screen combined with single-cell RNA-seq—targeting seven transcription factors. To e […]
- GSE296165 Single-cell RNA sequencing of non-cardiomyocytes obtained from wild-type mouse hearts 20 days after transverse aortic constriction or sham surgery February 11, 2026Contributors : Haruya Kawase ; Nina Wettschureck ; Stefan GuentherSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSingle-cell RNA sequencing of non-cardiomyocytes obtained from wild-type mouse hearts 20 days after transverse aortic constriction or sham surgery
- GSE318329 RNA-Seq quantitative analysis of the regulation of imatinib-resistant cell-derived exosomes on CML cell transcriptomes February 11, 2026Contributors : Fei Li ; Qing ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDrug resistance frequently results in treatment failure for leukemia and leads to the progression of chronic myeloid leukemia (CML) into an accelerated or blast phase. Although new tyrosine kinase inhibitors (TKIs) and combined TKI therapi […]
- GSE317224 A GCLC Inhibitor Enhances the Antitumor Efficacy of Glutathione Metabolic Pathway Inhibition in SMARCB1-Deficient Rhabdoid Tumors February 11, 2026Contributor : Hideaki OgiwaraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMalignant rhabdoid tumors and epithelioid sarcomas, characterized by SMARCB1 deficiency, are aggressive cancers with limited effective treatments, necessitating development of therapeutic strategies. This study investigated the therapeutic effi […]
- GSE318804 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease. [macro_senescence] February 11, 2026Contributors : Anthony J Covarrubias ; Ivan A Salladay-Perez ; Lizeth EstradaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCellular senescence drives chronic sterile inflammation during aging via the senescence-associated secretory phenotype (SASP); however, the cell types responsible for this pathology remain poorly […]
- GSE318442 TRIM28 orchestrates SUMO-ubiquitin crosstalk to stabilize PPARG and drive bladder cancer progression February 11, 2026Contributors : Dexin Shen ; Jun XiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBladder cancer (BLCA) is a growing health burden with rising incidence and limited therapeutic options. To define the role of the Tripartite Motif (TRIM) family in BLCA, we integrated multi-cohort transcriptomic analyses with functional […]
- GSE318863 Ex vivo long-term expansion of human hematopoietic stem and progenitor cells as a tool for modeling vector integration sites and clonality February 11, 2026Contributors : Jenni Fleischauer ; Philipp John-Neek ; Maike Kosanke ; Oliver Dittrich-Breiholz ; Michael RotheSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe small molecules A83-01, pomalidomide, and UM171 (APU) were used for the ex vivo expansion, lentiviral transduction, and long-term cultivation of umbilical cor […]
- GSE318806 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease. [Blood] February 11, 2026Contributors : Anthony J Covarrubias ; Ivan A Salladay-Perez ; Anika DhingriSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCellular senescence drives chronic sterile inflammation during aging via the senescence-associated secretory phenotype (SASP); however, the cell types responsible for this pathology remain poorly d […]
- GSE319015 mtDNA leakage promotes neuron-glia crosstalk to induce epilepsy by cGAS-STING-driven neuroinflammation and serine metabolic reprogramming February 11, 2026Contributors : Jie Jiang ; Meiling Zuo ; Kehan Zhao ; Zhihao Ling ; Zhida Wu ; Dongfang Xue ; Shouyong Mo ; Yuanhui Liu ; Yongjun Chen ; Jie Wang ; Bin Lu ; Chuanzhou Li ; Yaqi Duan ; He He ; Zhiyin SongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEpilepsy is increasingly recognized as a disorder involving metabolic […]
- GSE319106 RNAsequencing comparing WT S. aureus and an evolved mutant EVOL-A and EVOL-A ∆sarA February 11, 2026Contributors : Kowalski Caitlin H ; Barber Matthrew FSeries Type : Expression profiling by high throughput sequencingOrganism : Staphylococcus aureusThe goals of this experiment were to understand the basal changes in transcription between the EVOL-A strain that is an evolved strain in the NRS193 background with a mutation in Rel (Q672*) that has unknown imp […]
- GSE319110 Antiviral and anti-inflammatory effects of Tabamide A derivative, TA25, against human rhinovirus and multiple zoonotic viruses in vitro and in silico February 11, 2026Contributors : Bohyeon Kim ; Altanzul Bat Ulzii ; Taehun Lim ; Jin Woo Kim ; Wonkyun Ronny Im ; Shivani Rajoriya ; Augustine Natasha ; Divya Misra ; Hennisa Hennisa ; Na Young Kwag ; Daewoon Yoon ; Gyunghee Jo ; Young Bin Park ; Jinkyu Park ; Jeong Tae Lee ; Sung Ho Jeon ; Won-Keun KimSeries Type : Expression profiling by high throughput sequencingOrganism : […]
- GSE281632 Compartmentalization of mRNA and translation by cell adhesions February 11, 2026Contributors : D'Alessandro Alec ; Terry LechlerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSubcellular compartmentalization allows cells to concentrate and locally regulate functions. Here we identify translational compartmentalization in epidermal cells, with ribosomes, a subset of mRNAs, and the RNA-Induced […]
- GSE318802 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease. [Trem2ko] February 11, 2026Contributors : Anthony J Covarrubias ; Ivan A Salladay-Perez ; Ronal HedgeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCellular senescence drives chronic sterile inflammation during aging via the senescence-associated secretory phenotype (SASP); however, the cell types responsible for this pathology remain poorly def […]