Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE292835 Virus-inclusive single-nucleus RNA sequencing reveals two distinct endothelial response patterns in infectious salmon anaemia. May 30, 2026
  Contributors : Adriana Magalhaes Santos Andresen ; Richard S Taylor ; James J Furniss ; Maryam Saghafian ; Raoul V Kuiper ; Daniel J Macqueen ; Johanna H FosseSeries Type : Expression profiling by high throughput sequencingOrganism : Salmo salarThis study investigates the Atlantic salmon response to infectious salmon anemia virus (ISAV) infection using singl […]
• GSE292214 Effect of mechanical compression on gene expression in HEI-286 Schwann cells and pancreatic cancer cells MiaPaCa-2 and Panc01 May 30, 2026
  Contributors : Pavel Stupakov ; Sylvie Deborde ; Richard J WongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study we compare transcriptional changes induced by mechanical compression in Schwann cells and pancreatic cancer cells. Human HEI-286 Schwann cells and pancreatic cancer cells MiaPaCa-2 and Panc01 were […]
• GSE298573 CMPortal: a community-oriented, data-driven resource to inform protocol design for cardiac modelling from human pluripotent stem cells May 30, 2026
  Contributors : Chris Chow ; WooJun Shim ; Yuanzhao Cao ; Nathan PalpantSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensProtocol design and benchmarking is central to optimise model development using human pluripotent stem cell derived cardiomyocytes (hPSC-CMs). By applying data mining to decades of research and hundreds […]
• GSE297972 Sorbate induces lysine sorbylation through noncanonical activities of class I HDACs to regulate the expressin of inflammation genes. May 30, 2026
  Contributors : Yi-Cheng Sin ; Breann Abernathy ; Zuo-fei Yuan ; Jason L. Heier ; Justin E. Gonzalez ; Laurie L. Parker ; Douglas G. Mashek ; Chi ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEnvironmental factors may affect gene expression through epigenetic modifications of histones and transcription factors. Her […]
• GSE39069 Ikaros affects multiple lineages in hematopoietic development [RNA-Seq] May 30, 2026
  Contributors : Hilde Schjerven ; Stephen T SmaleSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIkaros is a zinc finger transcription factor critical for proper hematopoietic development and tumor suppression in the lymphoid lineage. Here, we use the newly generated Ik-ZnF1-/- and Ik-ZnF4-/- mutant mice to study hematop […]
• GSE333210 ZEB1 K80R Suppresses the NF-κB/EMT Axis and Tumor Pro-inflammatory Gene Expression May 30, 2026
  Contributors : Jingyu Luo ; Shaodong Wang ; Boxue Ren ; Wenjian Min ; Ranran Cheng ; Lingyuan Zhu ; Chang Shu ; Stephen J Weiss ; Peng Yang ; Rong Fu ; Zhaoqiu WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study demonstrates that ZEB1 K80 is a critical lysine residue acetylated by p300. Deacetylation of ZEB1 at […]
• GSE308534 RNA-seq of paraventricular thalamus (PVT) and posterior insular cortex (pIC) in a mouse model of STZ-induced painful diabetic neuropathy with anxiety-like behavior May 30, 2026
  Contributor : Min WeiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe generated poly(A)-selected, stranded mRNA-seq profiles from the paraventricular thalamus (PVT) and posterior insular cortex (pIC) of mice with streptozotocin (STZ; 200 mg/kg, i.p.)–induced painful diabetic neuropathy (PDN) and anxiety-like behavior, […]
• GSE268686 Implant renal injury-responsive cells to supplement erythropoietin and protect kidney May 30, 2026
  Contributors : Hao Nie ; Chen Liang ; Zixian Zhao ; Yingxin HeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAnemia poses a life-threatening risk to individuals with chronic kidney diseases (CKDs). Insufficient production of erythropoietin (EPO) from injured kidney is the major reason for anemia, while lack of EPO woul […]
• GSE325008 Targeting UHRF1: An Ixazomib Citrate Analogue as a Promising Therapeutic Agent for KRAS-Mutant Pancreatic Cancer May 30, 2026
  Contributor : Sivasundaram KarnanSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo investigate the effect of Ixazomib Citrate Analogue (ICA) inKRAS mutant on gene expression, we have emoloyed whole genomic microarray expression profiling using cancer cells
• GSE310378 Engineered Vesicular Stomatitis Virus for Cancer-Specific Delivery of Potent Immunotherapy Payloads May 30, 2026
  Contributors : Eileen Theune ; William Theune ; Kepeng WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe lack of tumor-specific targeting by oncolytic viruses (OVs) restricts their therapeutic potential. Here, we report a “cap-linker” strategy to modify the vesicular stomatitis virus (VSV) glycoprotein (G protein, […]
• GSE325457 Progesterone reshapes the tumor immune microenvironment towards macrophage-driven immune suppression in hormone receptor-positive breast cancer May 30, 2026
  Contributors : Eilidh I Chowanec ; Halyna Fedosyuk ; Julio C Tinoco ; Amanda Heard ; Harmony I Saunders ; Prabhakar Chalise ; Zachary C Hartman ; Mary A Markiewicz ; Jeffery Vahrenkamp ; Jason Gertz ; Christy R HaganSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHormone receptor–positive (HR⁺) breast cancers comprise ~ […]
• GSE329731 Single-nucleus RNA sequencing elucidates the protective role of mimeCM against doxorubicin-induced cardiotoxicity May 30, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Sus scrofaSingle-nucleus RNA sequencing was performed on left ventricular tissues harvested from minipigs across three groups: a blank control (Saline), a disease model (DOX), and a treatment group (mimeCM+DOX). This approach was utilized to characterize and reveal the […]
• GSE331503 Lactylation of histone variant MacroH2A1 at K134 regulates osteogenic differentiation of bone marrow mesenchymal stem cells [ATAC] May 30, 2026
  Contributors : Jianyu Liu ; Tao Wang ; Xiaoyuan XuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensOsteoporosis, a prevalent age-related bone disorder, stems from imbalanced osteoclast/osteoblast activity and skewed mesenchymal stem cell (MSC) lineage commitment. Although lactate is linked to osteoporosis p […]
• GSE292211 Effect of mechanical compression on gene expression in HEI-286 Schwann cells May 30, 2026
  Contributors : Pavel Stupakov ; Sylvie Deborde ; Richard J WongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study we present transcriptional changes in HEI-286 Schwann cells upon compression. Human HEI-286 Schwann cells were uncompressed, compressed at 5 μm height for 5 minutes or for 4 hours in 6-wells stati […]
• GSE298720 Global gene expression profiles were compared among IL1B-treated, Ad-OSCAR-treated, and control mice, with or without subsequent treatment with OSCAR inhibitors (Brivudine or Adefovir). May 30, 2026
  Contributors : Soo-Young Lee ; Jihee Kim ; Wankyu Kim ; Sera Park ; Gina RyuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the effects of OSCAR and its inhibitors (Brivudine or Adefovir) on articular chondrocytes, we generated IL1B-stimulated or OSCAR-overexpressing chondrocytes using adenoviral transduc […]