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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE294067 SIRT6 Overexpression Counteracts Chromatin Aging [RNA-Seq] April 12, 2026Contributors : Ron Nagar ; Zacharia Scwartz ; Haim Y CohenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAging is associated with detrimental changes in chromatin structure and gene expression, contributing to inflammation, metabolic decline and tissue dysfunction. SIRT6, a histone deacetylase, plays a key role in main […]
- GSE280505 Leukaemia cell intrinsic and extrinsic factors cooperate to facilitate the survival and proliferation of KMT2A-rearranged B-ALL in the CNS niche. April 12, 2026Contributors : Alasdair Duguid ; Camille Malouf ; Katrin OttersbachSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInfant B-cell acute lymphoblastic leukaemia (B-ALL) is a rare, aggressive entity characterised by KMT2A-rearrangements and poor outcomes. One of the unique features of KMT2A-rearranged infant ALL contribute […]
- GSE298918 The role of PurR purine transcriptional repressor and Rae1 endoribonuclease in Erm-mediated macrolide resistance in methicilin-resistant Staphylococcus aureus. April 12, 2026Contributors : Alexandre Le Scornet ; Mee-Ngan F YapSeries Type : Expression profiling by high throughput sequencingOrganism : Staphylococcus aureusDifferential gene expression between six S. aureus strains were determined by RNA-seq in 3 biological replicates.The six strains are ermB_minus parental JE2(WT), ermB_proficient strain (KES29), ermB_minus rae1 mu […]
- GSE294085 SIRT6 Overexpression Counteracts Chromatin Aging [ChIP-Seq] April 12, 2026Contributors : Ron Nagar ; Zacharia Scwartz ; Haim Y CohenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusAging is associated with detrimental changes in chromatin structure and gene expression, contributing to inflammation, metabolic decline and tissue dysfunction. SIRT6, a histone deacetylase, plays a ke […]
- GSE305529 METTL3-Driven RNA Modifications: A Key Mechanism and Potential Therapeutic Target in Pancreatic Acinar Cell Carcinoma in Mice [MeRIP] April 12, 2026Contributors : Shotaro Tatekawa ; Tomoaki Hara ; Sikun Meng ; Tetsuya Sato ; Hideshi IhiiSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusPancreatic acinar cell carcinoma (ACC) represents a rare and aggressive malignancy with poorly understood molecular mechanisms. N6-methyladenosine (m6A) RNA modification, parti […]
- GSE302399 Multimodal Transcriptomic Profiling of T Cell Responses to Triple-Negative Breast Cancer-Derived Exosomes April 12, 2026Contributors : Reza Shahbazi ; Samaneh Maleknia ; Sanam Rezaei Benam ; Kent Williams ; Lionel ApetohSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensTriple-negative breast cancer (TNBC) is a highly aggressive and immunogenic subtype that lacks effective targeted th […]
- GSE322478 Leucine, Autoimmune Diseases, and Circulating Mediators Shape the Causal Landscape of Lymphoid Malignancies April 12, 2026Contributors : Dongguo Liang ; Yan Ren ; Qiong Li ; Amit Sharma ; Ingo G Schmidt-Wolf ; Jingjing PuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study investigated environmental and metabolic determinants of lymphoid malignancies (LM) using a systematic Mendelian randomization analysis of 10,090 GWAS traits from […]
- GSE306398 Blocking NKp46-CCR6-ILC3 autophagy alleviates necrotizing enterocolitis by restoring energy metabolism balance [RNA-seq] April 12, 2026Contributors : Junyu He ; Yumei He ; Yuxiong Guo ; Kai Wu ; Laiqin Peng ; Qiqiong Wang ; Xinyao LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGroup 3 innate lymphoid cells (ILC3s) play a crucial role in intestinal inflammatory disorders such as necrotizing enterocolitis (NEC) in neonates; however, the mechanisms by […]
- GSE327236 Integrated single-nucleus RNA-seq dataset of mouse brain from a multi-factorial benchmarking study April 12, 2026Contributors : Jin Ning ; Ye Li ; Minxi Shi ; Xuzhao Bian ; Shiquan SunSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSingle-nucleus RNA sequencing (snRNA-seq) is pivotal for dissecting cellular heterogeneity in the brain, yet the individual and interactive effects of technical variables on cell composition and gene ex […]
- GSE327232 Transcriptomic profiling of splenic CD4+ T cells in DSS-induced colitis mice treated with Akkermansia muciniphila April 12, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study provides a transcriptomic dataset of splenic CD4+ T cells isolated from a DSS-induced colitis mouse model. Mice were treated with Akkermansia muciniphila or PBS as control. RNA sequencing was performed to characterize gene expression changes associated with micr […]
- GSE327251 hnRNPC specifically promotes SARS-CoV-2 frameshifting April 12, 2026Contributors : Jingchen Xu ; Zonggen PengSeries Type : Expression profiling by high throughput sequencingOrganism : Human coronavirus 229EWe analyzed whether hnRNPC facilitates the expression of viral non-structural proteins, which are essential for viral RNA replication. Ribosome profiling was performed on Vector, hnRNPC1, hnRNPC2 and HSD17B13 overexpressin […]
- GSE327268 In vivo RNA sequencing identifies the lncRNA ReLoV critical for morphological transition and virulence in Candida albicans I April 12, 2026Contributors : Yi Wang ; Hao Cui ; Youzhi Zhao ; Tianxu Wang ; Gang Luo ; Yang Lu ; Chang SuSeries Type : Expression profiling by high throughput sequencingOrganism : Candida albicansCandida albicans is the most prevalent fungal pathogen of humans responsible for nosocomial infections with high mortality rates. Despite its clinical importance, mechanisms gov […]
- GSE327269 In vivo RNA sequencing identifies the lncRNA ReLoV critical for morphological transition and virulence in Candida albicans II April 12, 2026Contributors : Yi Wang ; Hao Cui ; Youzhi Zhao ; Tianxu Wang ; Gang Luo ; Yang Lu ; Chang SuSeries Type : Expression profiling by high throughput sequencingOrganism : Candida albicansCandida albicans is the most prevalent fungal pathogen of humans responsible for nosocomial infections with high mortality rates. Despite its clinical importance, mechanisms gov […]
- GSE327683 15 neurodevleopmenal disorder associated genes in development and differntiation of brain organoids [Ampliconseq] April 12, 2026Contributors : Meilin F Garcia ; Kayla Retallick-Townsley ; April Pruitt ; Elizabeth Davidson ; Novin Balafkan ; Jonathan Warrell ; Tzu-Chieh Huang ; Alfred Kibowen ; Zhiyuan Chu ; Yi Dai ; Sarah E Fitzpatrick ; Ran Meng ; Annabel Sen ; Sophie Cohen ; Olivia Livoti ; Suha Khan ; Charlotte Becker ; Andre L Silva ; Jenny Liu ; Grace Dossou ; Jen Cheung ; Susan […]
- GSE319269 Blocking NKp46-CCR6-ILC3 autophagy alleviates necrotizing enterocolitis by restoring energy metabolism balance [ATAC-Seq] April 12, 2026Contributors : Junyu He ; Yumei He ; Yuxiong Guo ; Kai Wu ; Laiqin Peng ; Qiqiong WangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusGroup 3 innate lymphoid cells (ILC3s) play a crucial role in intestinal inflammatory disorders such as necrotizing enterocolitis (NEC) in neonates; however, the mechanisms b […]