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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE314119 IL1A promotes inflammation while safeguarding epithelial basal cell identity and barrier function August 14, 2026Contributors : Evelien Eenjes ; Li Lei ; Maria GenanderSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe ability of barrier epithelia to sense physiological changes and initiate local inflammation is essential, as this process facilitates subsequent progenitor-mediated epithelial repair. Herein, we combine analysis of […]
- GSE312874 Targeting DKC1-mediated pseudouridylation combined with PARPi induces synthetic lethality in HR-proficient tumors [ATAC-seq] August 14, 2026Contributors : Xiaoyang Liu ; Xiaoyang Gu ; Zhangxian ZhouSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensPoly(ADP-ribose) polymerase inhibitors (PARPi) have revolutionized the treatment landscape of BRCA-mutant tumors by exploiting synthetic lethality arising from homologous recombination (HR) deficiency. […]
- GSE284364 Rest-phase light disrupts hippocampal clock function and impairs object recognition memory August 14, 2026Contributors : Xuebing Zhang ; Changwei Yang ; Wenyi Jin ; Nan Zhang ; Liang Zhang ; Xingqi Meng ; Jin Young Kim ; Yool LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLight exposure during the circadian rest phase is common during shift work and late-night activity, but its effects on memory remain unclear. Here, we […]
- GSE343715 Effect of CBP/P300 inhibition on extravillous trophoblast differentiation August 14, 2026Contributors : Fangxu Lin ; Souad Boussata ; Remco Keijser ; Gijs B AfinkSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTreatment of trophoblast stem cells (TSCs) with the CBP/P300 inhibitors A‑485 and CPI blocks their differentiation into extravillous trophoblasts (EVTs) and syncytiotrophoblasts. In this project, we e […]
- GSE304894 CITE-seq of circulating CD4+ T cells and monocytes from BMT recipients treated with or without Tocilizumab August 14, 2026Contributors : Cameron G Williams ; Hyun Jae Lee ; Jessica A Engel ; Antiopi Varelias ; Geoffrey R Hill ; Ashraful HaqueSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensAllogeneic hematopoietic stem cell transplantation (SCT) is a curative treatment for hematological cancers but outcomes are limited by graft-vers […]
- GSE289369 Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcriptional program in mouse and human [scRNA-seq brain macrophages] August 14, 2026Contributors : Simone Brioschi ; Julia A Belk ; Marco ColonnaSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusBrain perivascular macrophages maintain brain physiology, yet their transcriptional regulators and functions in health and disease remain unclear. Using single-cell multi-omics and functional experiments, […]
- GSE342879 Mouse neocortical transcriptome of layer 2/3 cortical projection neurons August 14, 2026Contributors : Jakub Ziak ; Alex L KolodkinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBulk RNA expression is analyzed in layer 2 and layer 3 cortical projection neurons (CPNs) at postnatal day 3 (P3) and P7.
- GSE306648 Physiological UPR induction drives gametogenesis through coordination of protein synthesis and ER structure August 14, 2026Contributors : Constantine Bartolutti ; Gloria BrarSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeAlthough stress responses, such as the unfolded stress response (UPR), have been extensively studied upon induction by harsh stressors, endogenous functions of these protective pathways remain less well underst […]
- GSE343104 Single-cell Transcriptomics Reveals the Heterogeneous Landscape of Innate Lymphoid Cells in Zebrafish August 14, 2026Contributors : Kefan Cheng ; Thi Huong Trinh ; Ying Cao ; Shachuan Feng ; Jiaxin Liang ; Shizheng Zhao ; Jiaxu Yin ; Tao Dong ; Zilong WenSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioInnate lymphoid cells (ILCs) are a class of lymphocytes whose activation is independent of antigen receptors. They constitute a major ly […]
- GSE342881 Transcriptomic signatures induced by single versus dual lipoparticle-formulated adjuvants August 14, 2026Contributors : Pierre-Olivier Vidalain ; Valentine Ginet ; Bernard VerrierSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAdjuvant delivery using lipid-polymer hybrid nanoparticles (Lipoparticles) represents a promising strategy to modulate immune cell activation. This study investigates whether the combination of two a […]
- GSE343247 Engineering Large Meniscal Tissues via 3D Printed Multipart Molds August 14, 2026Contributors : Alysse T DeFoe ; Seth J Ack ; Arkodip Mandal ; Braden Johnson ; Lorin C Danielson ; Robert L Mauck ; Jason A BurdickSeries Type : Expression profiling by high throughput sequencingOrganism : Bos taurusThe menisci are highly organized fibrocartilaginous tissues that provide load distribution, shock absorption, and joint lubrication in the knee. […]
- GSE343594 Sublethal envelope-targeting silver nanoparticles induce ethanolamine-mediated cross-feeding and stabilize competitive pathogens August 14, 2026Contributors : Rui Sun ; Tianmin ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coliEnvelope-targeting antimicrobials are widely detected in wastewater and engineered water systems, yet their potential to reshape interspecies interactions through membrane-derived metabolites remains poorly understood. Here, we inve […]
- GSE343705 m6A depletion attenuates the macrophage type I interferon response August 14, 2026Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE312606 Enrichment of CD4-CD8- cytotoxic Vδ1/3 T cells in pulmonary tuberculosis disease August 14, 2026Contributors : Kendall Kearns ; Rashmi Tippalagama ; Ashu Chawla ; Jason Greenbaum ; Aruna Dharshan De Silva ; Wathsala Gunasinghe ; Judy Perera ; Hansani Gunasekera ; Darsha D Senevirathne ; Thomas J Scriba ; Julie G Burel ; Cecilia S Lindestam Arlehamn ; Bjoern PetersSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sa […]
- GSE342773 Single-nucleus and bulk transcriptomic atlas of human visceral adipose tissue across metabolic disease states identifies THBS1 as a fibro-inflammatory driver August 14, 2026Contributors : Jisu Jung ; Eun Seo Park ; Na Keum Lee ; Jung-Jae Lee ; Uijin Juang ; Qingzhi Huang ; Young Suk Park ; Hyung Joon Kim ; Jung-Kwon Kim ; Tae Jung Oh ; Jae Myoung Suh ; Jae Bum Kim ; Joon Ho Moon ; Jong Kyoung Kim ; Sung Hee ChoiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe cellular complexity of adip […]