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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE279063 Identification of mRNAs as potential blood based biomarekrs for diagnosis and therapeutic monitoring of active tuberculosis December 19, 2025Contributors : Eunsol Ahn ; Young Ae Kang ; Hyejon Lee ; Jungho KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo identify potential mRNA candidates for biomarkers for using a transcriptome-based approach, we extracted total RNAs from blood samples of study participants, including a complete set from patients with A […]
- GSE277703 LOXL2 identifies inflammation-associated myofibroblasts predicting kidney allograft dysfunction and fibrosis December 19, 2025Contributors : Konrad Buscher ; Rebecca Rixen ; Carolin Walter ; Paula SchützSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChronic allograft nephropathy (CAN) is a major obstacle in kidney transplantation, often leading to long-term graft failure. Early identification of patients at high risk for CAN could be instrume […]
- GSE285002 Vaccine Delivery Platforms Affect Heterologous Protection by Hemagglutinin-Based Influenza Vaccines in Pigs December 19, 2025Contributors : The N Nguyen ; Danh C Lai ; Hung Q Luong ; Sushmita Kumari ; Kassandra D Matinez ; Sarah Sillman ; Hiep VuSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaVaccine-associated enhanced disease (VAED) poses a significant challenge in vaccine development for certain diseases. Vaccine-associated enhanced respirat […]
- GSE284023 Enhanced non-enzymatic H2S generation extends lifespan and healthspan in male mice December 19, 2025Contributors : María Ángeles Cáliz-Molina ; Raúl López-Fernández Sobrino ; Inmaculada Pino-Pérez ; Concepción Panadero-Morón ; Maria del Carmen Vilches-Pérez ; María Camacho-Cabrera ; Almudena García-Ruíz ; Leopoldo Pérez-Rosendo ; Isabel Espadas ; Alejandro Sola-García ; Mario Soriano-Navarro ; Franz Martin ; Mónica Venegas-Calerón ; Joaquin José Salas ; En […]
- GSE296492 Single-cell mapping of regulatory DNA:Protein interactions II December 19, 2025Contributors : Wei-Yu Chi ; Sang-Ho Yoon ; Evrim Goksel ; Levan Mekerishvili ; Joe Pelt ; Yiyun Lin ; Saravanan Ganesan ; Catherine Potenski ; Franco Izzo ; Dan A. Landau ; Ivan RaimondiSeries Type : OtherOrganism : Homo sapiensGene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome is directed through multip […]
- GSE288602 Atherosclerosis licenses for an exceeding immune response in COVID-19 disease by interferon priming in circulating myeloid cells December 19, 2025Contributors : Julian Leberzammer-Deuster ; Carsten Kuenne ; Sebastian CremerSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAims: Patients with cardiovascular disease (CVD) have an increased risk of developing severe respiratory infections, including COVID-19. However, the underlying molecular mechanisms […]
- GSE312846 Molecular characterisation of circannual interval timing in the preoptic area and anteroventral periventricular nucleus in a rodent. December 19, 2025Contributors : Calum Stewart ; Christopher Marshall ; Tyler J StevensonSeries Type : Expression profiling by high throughput sequencingOrganism : Phodopus sungorusMost temperate animals exhibit seasonal rhythms in reproductive physiology and behaviour. Gonadotropin-releasing hormone (GnRH) cells in the preoptic area (POA) and kisspeptin (Kiss) cells in the a […]
- GSE314344 HIV inhibits Warburg metabolism in human macrophages infected with Mycobacterium tuberculosis December 19, 2025Contributors : Gina Leisching ; Aaron M WalshSeries Type : Expression profiling by arrayOrganism : Homo sapiensHIV inhibits Warburg metabolism in human macrophages infected with Mycobacterium tuberculosis
- GSE313769 SATB1 Condensates Reinforce Super-Enhancer Architecture to Lower the Threshold of Thymocyte Positive Selection December 19, 2025Contributors : Wei Xue ; Bingtao HaoSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Other ; Expression profiling by high throughput sequencingOrganism : Mus musculusThe generation of mature CD4⁺ helper and CD8⁺ cytotoxic T cells from double-positive (DP) thymocytes is a central step in building an effective adaptive immune sy […]
- GSE313521 Distinct Transcriptomes for Cardiac Repair following multidose intramyocardial administration of Umbilical Cord Blood Mononuclear cells(UCB-MNCs) December 19, 2025Contributors : Nkechi M Odogwu ; Timothy NelsonSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaCardiac regeneration remains a major therapeutic challenge, and cell-based strategies offer a promising avenue. In this study, we investigated the transcriptional responses to single versus multidose intramyocardial administrati […]
- GSE313840 Single-Cell Sequencing Reveals the Immune Characteristics of Coxsackievirus A6-Associated Hand, Foot and Mouth Disease in Children December 19, 2025Contributors : Meng Zhang ; Huiling Deng ; Chenrui Liu ; Na Huang ; Ling He ; Yaping LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHand, foot, and mouth disease (HFMD) is a clinically significant pediatric infection with potential neurological complications, and coxsackievirus A6 (CA6) is increasingly recognized as […]
- GSE314114 Single-cell mapping of regulatory DNA:Protein interactions IV December 19, 2025Contributors : Wei-Yu Chi ; Sang-Ho Yoon ; Evrim Goksel ; Levan Mekerishvili ; Joe Pelt ; Yiyun Lin ; Saravanan Ganesan ; Catherine Potenski ; Franco Izzo ; Dan A. Landau ; Ivan RaimondiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensGene expression is coordinated by a multitude of transcription factors (T […]
- GSE314254 Optimized multidrug therapy remodels the tumor microenvironment and enhances antitumor immunity in microsatellite-stable colorectal cancer December 19, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFour low-dose tyrosine kinase inhibitor (TKI)–based ODCs were evaluated in murine AKP CRC organoids, co-culture systems with tumor-associated endothelial cells and immune cells, and in vivo syngeneic models. Among these, ODCDLD1 (regorafenib, vemurafenib, erlotinib HCl, se […]
- GSE263247 Co-transcriptomic analysis of group A Streptococcus (GAS; Streptococcus pyogenes) invasions of human endothelial cells December 19, 2025Contributors : Marcia Shu-Wei Su ; Jiunn-Jong WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Streptococcus pyogenesGroup A Streptococcus (GAS, aka Streptococcus pyogenes) causes an array of human diseases from mild pharyngitis to life-threatening necrotizing fasciitis. Invading host cells is a strategy for GAS to […]
- GSE311704 Regenerating Skeletal Muscle of Ovariectomized Mice December 19, 2025Contributors : Barbara St. Pierre Schneider ; Juli PetereitSeries Type : Expression profiling by arrayOrganism : Mus musculusIn this study, we found more stable Siglec1 expression and stronger CD169+ macrophage staining in the muscle of 17-β-estradiol-treated mice than in that of the placebo-treated mice. However, Siglec1 was correlated with more interferon- […]