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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE292031 Senataxin promotes recombination fidelity during antigen receptor gene diversification March 14, 2026Contributors : Alice Libri ; Jinglong Wang ; Timea Marton ; Wei Yu ; François Dossin ; Gabriel Balmus ; Bernardo Reina-San-Martin ; Richard Frock ; Chloé Lescale ; Ludovic DerianoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImmunoglobulin (Ig) and T cell receptor (TCR) V(D)J gene recombination relies on non-homologou […]
- GSE292003 Targeted inhibition of de novo lipogenesis induces cancer cell senescence March 14, 2026Contributors : Àngela Llop-Hernández ; Sara Verdura ; Travis Van der Steen ; José Antonio Encinar ; Begoña Martin-Castillo ; George Kemble ; Elisabet Cuyàs ; Ruth Lupu ; Javier A. MenendezSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensConventional chemotherapeutic agents and radiation induce accelerated senescence in c […]
- GSE306739 Z-RNA drives Tau-mediated neurodegeneration of Alzheimer’s disease March 14, 2026Contributors : Boxin Zhang ; Yuenan ZhouSeries Type : OtherOrganism : Mus musculusTau aggregates lead to progressive neurodegeneration in Alzheimer’s disease (AD). Neuron death is one of the hallmarks of neurodegeneration. However, the pathological influence of neuronal death is undetermined, and the connection between Tau aggregates and neuronal death remai […]
- GSE303355 Effect of WFDC21P knockdown in BT549 cells. March 14, 2026Contributors : Zean Li ; Yi Wang ; Man-Li LuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe identify a long noncoding RNA, WFDC21P (lnc-DC), which corelates to anti-tumor immunity in triple negative breast cancer (TNBC). To investigate the pathway that mediates the role of WFDC21P in TNBC, we knock down WFDC21P in B […]
- GSE324324 A structurally dynamic chromosome 11 locus from Oryza rufipogon L. confers broad-spectrum recessive resistance to bacterial blight March 14, 2026Contributors : Zhiyuan Ji ; Shafique Muhammad SohaibSeries Type : Expression profiling by high throughput sequencingOrganism : Oryza rufipogonBacterial blight (BB), caused by Xanthomonas oryzae pv. oryzae (Xoo), is one of the most destructive diseases affecting rice production worldwide. In this study, the wild rice accession Oryza rufipogon Wild173 (UP36) e […]
- GSE306751 Z-RNA drives Tau-mediated neurodegeneration of Alzheimer’s disease [ChIP-Seq] March 14, 2026Contributor : Boxin ZhangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTau aggregates lead to progressive neurodegeneration in Alzheimer’s disease (AD). Neuron death is one of the hallmarks of neurodegeneration. However, the pathological influence of neuronal death is undetermined, and the connection bet […]
- GSE314516 Disrupting SOX2 Self-Association and Condensates to Overcome Chemotherapeutic Drug Resistance in Lung Squamous Cell Carcinoma [Cut & Run, 2] March 14, 2026Contributors : Juehan Wang ; Yulin Wen ; Sainan Huang ; Yanjiang Liu ; Hongjie YaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensChemotherapy remains one of the most important treatments for lung squamous cell carcinoma (LSCC), yet overcoming chemotherapeutic drug resistance poses a significant challenge. […]
- GSE289045 Disrupting SOX2 Self-Association and Condensates to Overcome Chemotherapeutic Drug Resistance in Lung Squamous Cell Carcinoma [RNA-Seq] March 14, 2026Contributors : Juehan Wang ; Yulin Wen ; Sainan Huang ; Yanjiang Liu ; Hongjie YaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChemotherapy remains one of the most important treatments for lung squamous cell carcinoma (LSCC), yet overcoming chemotherapeutic drug resistance poses a significant challenge. The high freq […]
- GSE315762 Reception of conspecific cues alter testicular gene expression and improve fertility: evidence in boreal chorus frogs (Pseudacris macalata) March 14, 2026Contributors : Jeffrey P Ethier ; Hyoji Lee ; Stacey A Robinson ; Vance L TrudeauSeries Type : Expression profiling by high throughput sequencingOrganism : Pseudacris maculataThe evidence for the social modulation of reproduction in vertebrates is established but poorly defined for many taxa despite the link between social cues and endocrine function. It is […]
- GSE314519 Disrupting SOX2 Self-Association and Condensates to Overcome Chemotherapeutic Drug Resistance in Lung Squamous Cell Carcinoma [RNA-Seq, 2] March 14, 2026Contributors : Juehan Wang ; Yulin Wen ; Sainan Huang ; Yanjiang Liu ; Hongjie YaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChemotherapy remains one of the most important treatments for lung squamous cell carcinoma (LSCC), yet overcoming chemotherapeutic drug resistance poses a significant challenge. The high freq […]
- GSE318076 AURKA inhibitor VIC-1911 induces mitotic defects and functional BRACness, sensitizing prostate cancer to PARP inhibition March 14, 2026Contributors : Galina Gritsina ; Qi Chu ; Jonathan C Zhao ; Jindan YuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensVIC-1911, formerly known as TAS-119, is a next-generation, ATP-competitive AURKA inhibitor with high selectivity over AURKB and AURKC. In this study, we demonstrate that VIC-1911 potently and selectively […]
- GSE319734 Identification of genes regulated by knockdown of HSF1 or CBFA2T2 March 14, 2026Contributors : Mitsuaki Fujimoto ; Ryosuke Takii ; Akira NakakiSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo examine whether the HSF1–CBFA2T2 complex regulates gene expression in human melanoma MeWo cells, DNA microarray analysis was performed.
- GSE324320 P2X4 Drives Sex-Specific Neuroprotection in Autoimmune Neuroinflammation March 14, 2026Contributors : Paloma Mata ; Marina Bosch-Juan ; Eric Bué-Grabot ; Maria DomercqSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicroglia critically influence multiple sclerosis (MS) pathophysiology through debris clearance, myelin repair, and modulation of neuroinflammation. These processes are partly regulated by ATP- […]
- GSE289048 Disrupting SOX2 Self-Association and Condensates to Overcome Chemotherapeutic Drug Resistance in Lung Squamous Cell Carcinoma March 14, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE306761 Z-RNA drives Tau-mediated neurodegeneration of Alzheimer’s disease [bulkRNA-seq] March 14, 2026Contributor : Boxin ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTau aggregates lead to progressive neurodegeneration in Alzheimer’s disease (AD) (ref). Neuron death is one of the hallmarks of neurodegeneration (ref). However, the pathological influence of neuronal death is undetermined, and the connection betwe […]