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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE289884 Inhibition of the non-lysosomal glucosylceramidase GBA2 accounts for the efficacy of sinbaglustat in a murine model of Sandhoff disease February 18, 2026Contributors : Michel A Steiner ; Kostantin Dobrenis ; Catherine Vaillant ; Jesper Ryge ; Bérengère Renault ; Richard WelfordSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSinbaglustat is a small molecule under investigation as a treatment for lysosomal storage disorders. It inhibits two enzymes involved in glycosphing […]
- GSE315062 Smad4-p65 interactions drive BMP-mediated protection against inflammatory cell death [ChIP-Seq] February 18, 2026Contributors : Shigeki Suzuki ; Shizu Hirata-TsuchiyaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusInflammation-induced osteoblast death undermines bone homeostasis and can aggravate bone-destructive diseases, yet how pro-survival BMP signaling intersects with inflammatory TNF–NF-κB signaling remains poo […]
- GSE305662 AF6 promotes lipid droplet fusion and aggravates MASH via C/EBPβ–CIDEA axis February 18, 2026Contributors : Qian Wen ; Lixing ZhanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMetabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease characterized by steatosis, inflammation, and fibrosis. However, the mechanisms linking lipid droplet (LD) metabolism to MASH progression remain poor […]
- GSE316760 Spatial transcriptomics of primary cutaneous melanoma February 18, 2026Contributor : Amaya VirósSeries Type : OtherOrganism : Homo sapiensWe performed spatial transcriptomics on primary cutaneous melanoma samples to characterise the tumour microenvironment
- GSE315066 Smad4-p65 interactions drive BMP-mediated protection against inflammatory cell death [4C-Seq] February 18, 2026Contributors : Shigeki Suzuki ; Shizu Hirata-TsuchiyaSeries Type : OtherOrganism : Mus musculusInflammation-induced osteoblast death undermines bone homeostasis and can aggravate bone-destructive diseases, yet how pro-survival BMP signaling intersects with inflammatory TNF–NF-κB signaling remains poorly defined. Here we show that BMP4 protects mouse osteobla […]
- GSE319727 The alarmone pGpp inhibits translation through GTP depletion II February 18, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Bacillus subtilis subsp. subtilis str. 168Bacteria produce the alarmone nucleotides ppGpp and pppGpp during stress to affect replication, transcription, and metabolism. ppGpp and pppGpp also attenuate translation by competitively binding translational GTPases to conserve resources dur […]
- GSE318570 Inhibition of Astrocytic MAGL Reprograms Glial Reactivity and Prevents Seizure Sequelae February 18, 2026Contributors : Chudai Zeng ; Fei Gao ; Jian Zhang ; Dexiao Zhu ; Mei Hu ; Li Sun ; Jianlu Lyu ; Mingzhe Pan ; Chu ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy and is characterized by a pathological cascade of excitotoxicity that lea […]
- GSE319533 Whole-Genome Bisulfite Sequencing Reveals Formaldehyde-Induced DNA Methylation Alterations in Chicken Embryo Liver and Skeletal Muscle February 18, 2026Contributors : Mustafa Özdemir ; Saffet Teber ; Ghulam Asghar Sajid ; Selma Büyükkılıç Beyzi ; Yunus Arzık ; Mehmet Kızılaslan ; Servet Yalçın ; Mehmet Ulas CinarSeries Type : Methylation profiling by high throughput sequencingOrganism : Gallus gallusPre-incubation formaldehyde (FA) fumigation of hatching eggs is widely implemented for microbial control, yet […]
- GSE319526 Effect of HIF-1alpha and HIF-2alpha on hypoxic response in Panc1 cells February 18, 2026Contributors : Maimon Hubbi ; Chi V Dang ; Yasir SuhailSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe hypoxic response is influence by both the tissue of origin and local environmental influences, and mediated in large part by the hypoxia-inducible transcription factors HIF-1 and HIF-2. We looked at Panc1 cells, a […]
- GSE319591 Transcriptomics of whole brain tissue in heterogeneous stock rats February 18, 2026Contributors : Francesca Telese ; Hao Chen ; Abraham A Palmer ; Patricia Montilla-Perez ; Daniel Munro ; Pejman MohammadiSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusTranscriptome-wide association studies (TWAS) integrate genome-wide association studies (GWAS) and gene expression datasets to prioritize causal ge […]
- GSE319577 Single-Cell Profiling of HDAC Inhibitor-Induced EBV Lytic Heterogeneity Defines Abortive and Refractory States in B Lymphoblasts February 18, 2026Contributors : Lauren E Haynes ; Ashley P Barry ; Micah A LuftigSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEpstein-Barr virus (EBV) is associated with multiple malignancies including Burkitt lymphoma (BL), Hodgkin’s lymphomas, nasopharyngeal carcinomas (NPC), and gastric cancers. Canonically, EBV positive tumors di […]
- GSE319676 The BOD1L subunit of the SETD1A complex sustains the expression of DNA damage repair genes despite restraining H3K4 trimethylation [paired_end_RNAseq] February 18, 2026Contributors : Giovanni Ciotta ; Sukhdeep Singh ; Andrea Kranz ; Ashish Gupta ; Davi Coe Torres ; Jun Fu ; Rupam Choudhury ; Nico Liske ; Wai Kit Chu ; Dmitrii Severinov ; Chuna Choudhary ; Lenka Gahurova ; Ali Al-Fatlawi ; Michael Schroeder ; Rein Aasland ; Anna R Poetsch ; Konstantinos Anastassiadis ; Francis A StewartSeries Type : Expression profiling by […]
- GSE319677 The BOD1L subunit of the SETD1A complex sustains the expression of DNA damage repair genes despite restraining H3K4 trimethylation [single_end_RNAseq] February 18, 2026Contributors : Giovanni Ciotta ; Sukhdeep Singh ; Andrea Kranz ; Ashish Gupta ; Davi Coe Torres ; Jun Fu ; Rupam Choudhury ; Nico Liske ; Wai Kit Chu ; Dmitrii Severinov ; Chuna Choudhary ; Lenka Gahurova ; Ali Al-Fatlawi ; Michael Schroeder ; Rein Aasland ; Anna R Poetsch ; Konstantinos Anastassiadis ; Francis A StewartSeries Type : Expression profiling by […]
- GSE319724 The alarmone pGpp inhibits translation through GTP depletion I February 18, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Bacillus subtilis subsp. subtilis str. 168Bacteria produce the alarmone nucleotides ppGpp and pppGpp during stress to affect replication, transcription, and metabolism. ppGpp and pppGpp also attenuate translation by competitively binding translational GTPases to conserve resources dur […]
- GSE243524 Extruding transcription elongation loops observed in high-resolution single-cell 3D genomes [Micro-C and CUT&TAG, Rpb1 depletion, mESC] February 18, 2026Contributors : Honggui Wu ; Jiankun Zhang ; Longzhi TanSeries Type : Other ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusInside human nuclei, genes are transcribed within a highly packed genome, whose organization is facilitated by cohesin-mediated loop extrusion. However, how cohesin folds transcribed genes and aff […]