Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE294184 Virus-specific effector T cells impair airway secretory cell-mediated alveolar regeneration January 22, 2026
  Contributors : Ying Xi ; Tiantian Lu ; Li Liu ; Pei WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSevere respiratory viral infection leads to extensive damage to the alveolar epithelium and also induce a robust immune response. How immune response impacts alveolar regeneration, especially how immune microenvironment […]
• GSE292377 Step-wise signal integration governs adaptive programming of lymphocytes [bulkRNA-seq and ATAC-seq] January 22, 2026
  Contributors : Simon Grassmann ; Endi Santosa ; Joseph SunSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusLymphocyte differentiation depends on activation via antigen and cytokines during the immune response to infection. How the timing and integration o […]
• GSE302362 Induction of antigen-presenting monocyte-derived dendritic cells by nanoparticles inhibits metastasis and relieves immunosuppression in the metastatic niche January 22, 2026
  Contributors : Jeffrey A Ma ; Kate V Griffin ; Kathryn Kang ; Agustina Diener ; Ian A Schrack ; Elizabeth J Bealer ; Laila M Rad ; Rebecca S Pereles ; Jacqueline S Jeruss ; Lonnie D SheaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMyeloid immune cells play a major role in establishing a suitable microenvironment for […]
• GSE297529 Discovery of Key Regulators in Classical Monocyte Phenotypes Linked to COVID-19 Severity using Single-cell Multi-omics Sequencing January 22, 2026
  Contributors : Donggun Kim ; Sin Young Choi ; Eui Tae Kim ; Jihwan ParkSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensDysregulated immune responses often accompany severe COVID-19, but the underlying epigenetic mechanisms driving monocyte heterogeneity […]
• GSE248722 Single cell transcriptome analysis of Cyfip2 knockout mouse forebrain January 22, 2026
  Contributor : Kihoon HanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo elucidate the intricate molecular alterations resulting from Cyfip2 knockout, we conducted single cell transcriptomic analysis on the forebrain tissues of E18.5 Cyfip2 knockout mice and their wild-type littermates. The E18.5 stage was selected du […]
• GSE303949 The deacetylase Sir2 is the primary sensor driving transcriptional changes in response to low NAD+ in the yeast Kluyveromyces lactis January 22, 2026
  Contributors : Mahasweta Acharjee ; Kristen Humphrey ; Vincent Lactaoen ; Charikleia Karageorgiou ; Omer Gokcumen ; Laura RuscheSeries Type : Expression profiling by high throughput sequencingOrganism : Kluyveromyces lactisThe coenzyme NAD+ (nicotinamide adenine dinucleotide) is a critical electron carrier in central metabolism and is required for cellular h […]
• GSE316596 Gene expression changes in right atrial tissue were identified through RNA-seq analysis using a monocrotaline (MCT)-induced pulmonary hypertension (PH) rat model January 22, 2026
  Contributors : Zhang Yun-Long ; He Jia-Kang ; Han XiaoSeries Type : Expression profiling by high throughput sequencingOrganism : RattusManganese(III) tetrakis(4-benzoic acid) porphyrin chloride (MnTBAP) exhibits well-documented anti-inflammatory, antioxidant, and anticancer properties. While its therapeutic potential in ameliorating pulmonary hypertension (P […]
• GSE276810 Virus-specific effector T cells impair airway secretory cell-mediated alveolar regeneration [] January 22, 2026
  Contributors : Ying Xi ; Tiantian Lu ; Zhe Chen ; Pei WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSevere respiratory viral infection leads to extensive damage to the alveolar epithelium and also induce a robust immune response. How immune response impacts alveolar regeneration, especially how immune microenvironme […]
• GSE316806 Polycyclic-fused cytochalasins with anti-liver fibrosis activity from the endophytic fungus Trichoderma harzianum [TGF-β1+ DMSO or TGF-β1 + 20 μM 8] January 22, 2026
  Contributors : Guihua Tang ; Yanjiang Zhang ; Yiling liao ; Lu GanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensA molecular networking-guided investigation of the endophytic fungus Trichoderma harzianum MLJ-4 resulted in the isolation of eight new polycyclic-fused cytochalasins, triharziachalasins A–H (1–8), along wit […]
• GSE316672 Spatial transcriptomic profiling of bronchioles using GeoMx DSP January 22, 2026
  Contributors : Akira Yamamoto ; Nobuharu FujiiSeries Type : OtherOrganism : Homo sapiensBronchiolitis obliterans (BO) is a severe, fibrotic manifestation of chronic graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation (HSCT). Macrophage-derived TGF-β is linked to GVHD-related fibrosis; however, its role in BO remains unclear. Given […]
• GSE316811 Seq-Scope-eXpanded (Seq-Scope-X): Spatial Omics Beyond Optical Resolution January 22, 2026
  Contributors : Angelo Anacleto ; Weiqiu Cheng ; Hee Sun Han ; Hyun Min Kang ; Jun Hee LeeSeries Type : OtherOrganism : Homo sapiens ; Mus musculusSequencing-based spatial transcriptomics (sST) enables transcriptome-wide gene expression mapping but falls short of reaching the optical resolution (200–300 nm) of imaging-based methods. Here, we present Seq-Scope […]
• GSE316854 Gene expression induced by DREADD activation in cultured astrocytes January 22, 2026
  Contributors : Momono Segawa ; Hajime Yanmamoto ; Kentaro AbeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAstrocytes are essential regulators of neuronal function and brain homeostasis. While chemogenetic strategies, such as DREADD (Designer Receptors Exclusively Activated by Designer Drugs), are frequently employed […]
• GSE317036 E4BP4 Safeguards Brown Fat Mitochondria from Obesity-Induced Fragmentation via Ceramide Repression January 22, 2026
  Contributors : Fernando Valdivieso-Rivera ; Vanessa O. Furino ; Carlos E. Leher ; Ariane M. Zanesco ; Monara Kaélle Cruz ; Flavia C. Gan ; Adriana Leandra Santoro ; Lara Regina-Ferreira ; Giovanna Leite Santos ; Tiago Gonçalves ; Luiz Osório Leiria ; Pedro M. Moraes-Vieira ; Roger Frigério Castilho ; Shingo Kajimura ; Marcelo A. Mori ; Licio A. Velloso ; Car […]
• GSE292293 Step-wise signal integration governs adaptive programming of lymphocytes [CUT&RUN STAT4] January 22, 2026
  Contributors : Simon Grassmann ; Hyunu Kim ; Joseph SunSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusLymphocyte differentiation depends on activation via antigen and cytokines during the immune response to infection. How the timing and integration of these signals program the epigenetic and functional fa […]
• GSE316546 A Nanopore-Based HIV-1 Reference Epitranscriptome January 22, 2026
  Contributors : Michael S Bosmeny ; Adrian A Pater ; Li Zhang ; Lydia L Larkai ; Beverly E Sha ; Zidi Lyu ; Masad J Damha ; João I Mamede ; Keith T GagnonSeries Type : OtherOrganism : Human immunodeficiency virus 1Post-transcriptional modifications to RNA, which comprise the epitranscriptome, play important roles in RNA metabolism, gene regulation, and diseas […]