Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE307222 Patient-derived cornea organoids as drug repurposing models for aniridia-associated keratopathy July 16, 2026
  Contributors : Ali C Koc ; Gamze Kocak ; Burak Kahveci ; Adil Mardinoglu ; Gokhan Karakulah ; Canan A Utine ; Sinan GuvenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground and aim: Aniridia-associated keratopathy (AAK) is a serious ocular surface disease resulting from PAX6 haploinsufficiency due to mutations in […]
• GSE305221 Lineage Tracing Reveals a Common Ancestor of Supraclavicular Brown and Inguinal Beige Adipocytes July 16, 2026
  Contributors : Qianxing Mo ; Hari Krishna Yalamanchili ; Miao-Hsueh ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLike human scBAT, supraclavicular brown adipose tissue (scBAT) consists of loosely connected thin strips of brown adipocyte islands and is located in the mouse neck. We traced the origin of scBAT to Me […]
• GSE308206 PAN2 Maintains mRNA Poly(A) Tail Homeostasis and Regulates RNA Degradation During Early Embryonic Development in Mice [PAIso-seq] July 16, 2026
  Contributors : Yuke Wu ; Xuan WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA homeostasis regulators and surveillance factors function in the global transcriptome of oocytes and early embryos. Among them, the CNOT6L and CNOT7 proteins of the BTG4, PABPN1L, and CCR4-NOT subunits, as well as TUTs, are involved in th […]
• GSE307964 MiR-342 suppression of an E2F signaling network limits metastatic outgrowth of triple negative breast cancer [RNA-Seq] July 16, 2026
  Contributors : Philip A Gregory ; Katherine A Pillman ; John Toubia ; Kate Dredge ; Andrew G BertSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMetastasis occurs with high frequency in patients with triple negative breast cancer (TNBC) and its aetiology remains poorly understood. Through integrated analysis of metastat […]
• GSE287826 Hepatocytes spatial transcriptomics analysis of healthy and MASH patients July 16, 2026
  Contributors : FENG WANG ; Ekihiro Seki ; Yoon Seok RohSeries Type : OtherOrganism : Homo sapiensSpatial transcriptomics of hepatocytes was employed to identify differentially expressed genes between healthy tissues and those from MASH patients.
• GSE338465 Impact of SPOP mutations on gene expression in prostate cancer July 16, 2026
  Contributors : Di Zhao ; Yue LuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo determine SPOP mutations' effects on gene transcriptome in prostate cancer, we introduced wildtype versus F133V mutation of SPOP into DU145 cells, followed by RNA-sequencing
• GSE337851 Transglutaminase 2 Deletion Enhances Astrocyte-to-Neuron Metabolic Support and Attenuates Subacute Pathology Following Repetitive Mild Traumatic Brain Injury July 16, 2026
  Contributors : T Delgado ; T Arefin ; T Arefin ; J Rodwell-Bullock ; M R Chowdhury ; A B Crum ; B Weekley ; I Maze ; P S Brookes ; J P Meeks ; G JohnsonSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMild traumatic brain injury (mTBI) is the most common form of central nervous system (CNS) injury and is of […]
• GSE299376 Regulation of neurogenesis and neuronal migration by Rrm2 and Timp3 following seizures July 16, 2026
  Contributors : Adebayo O Adeyeye ; Parul Varma ; Nico Enerlan ; Marissa Coppin ; Jenny HsiehSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTemporal lobe epilepsy is associated with aberrant neurogenesis and ectopic migration of adult-born granule cells (abGCs), yet the molecular mechanisms driving these changes remain […]
• GSE338354 PRMT1-mediated arginine methylation redirects a metastasis-promoting transcriptional output of SMAD4 in pancreatic cancer July 16, 2026
  Contributors : Yizhou Liu ; Xueyi Liang ; Ruozheng Wei ; Yuhan Zhao ; HeShui Wu ; Yingke ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPancreatic ductal adenocarcinoma (PDAC) is characterized by early metastatic dissemination and poor clinical outcomes. Although SMAD4 is frequently altered in PDAC, the majority of […]
• GSE338003 Transcriptomic Analysis Identifies Transient Mesendodermal State and Lineage Divergence in Human Pluripotent Stem Cell Differentiation July 16, 2026
  Contributors : Alice C Borges ; Mariana A Branco ; João P Cotovio ; Ana R Gomes ; Joana E Saraiva ; Leonilde M Moreira ; Joaquim M Cabral ; Domingos Henrique ; Maria M Diogo ; Tiago G FernandesSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman pluripotent stem cells serve as a vital model for studying early human lin […]
• GSE338387 Effect of TGF-beta on SMAD2/3 and YAP/TAZ in HOVX human vocal fold fibroblasts {ChIP-seq] July 16, 2026
  Contributor : Ryosuke NakamuraSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensSMAD2/3 and YAP/TAZ are activated by TGF-beta signaling in human vocal fold fibroblasts. This study provides ChIP-seq data regarding chromatin occupancy of SMAD2/3 and YAP/TAZ in these cells in response to TGF-beta treatment. […]
• GSE338388 Effect of TGF-beta and K-975 in HOVX human vocal fold fibroblasts [RNA-seq] July 16, 2026
  Contributor : Ryosuke NakamuraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSMAD2/3 and YAP/TAZ are activated by TGF-beta signaling in human vocal fold fibroblasts. This study provides transcriptomic data regarding altered gene expression following TGF-beta treatment and YAP/TAZ inhibition.
• GSE338455 Transcriptome sequencing of wide type COS7 cell and ATL2/3 double knockout COS7 cells. July 16, 2026
  Contributors : Hanchi Miao ; Yuqi Wasng ; Yingying Huang ; Haoyang Zhang ; Lexin Zheng ; Xin Zhou ; Xiaoqun Wang ; Qing Xie ; Lei Xue ; Junjie HuSeries Type : Expression profiling by high throughput sequencingOrganism : Chlorocebus sabaeusTo investigate different gene expression in wide type COS7 cell and ATL2/3 double knockout COS7 cells, we carried out tra […]
• GSE303027 Effect of SOX11 knock-out and rescue on the gene expression profile of Z138 cells July 16, 2026
  Contributors : Virginia Amador ; Anna de BolòsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFastq transcriptomic sequencing files from Z138 MCL cell line with differential SOX11 expression. Samples include SOX11 wild-type (WT), SOX11 knockout (KO), and SOX11 re-expression (resc) in the KO background. The dataset inclu […]
• GSE337660 RNA-seq of cold stressed C. elegans animals, of four genotypes July 16, 2026
  Contributors : Piyush Gupta ; Gang WuSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Caenorhabditis elegansCold stressed and non-stressed wild type, sgk-1(ok538), pqm-1(ok485) and pqm-1(ok485); sgk-1(ok538) animals are collected for RNA-seq analysis, to reveal transcripteome changes. Cold stress triggers fat reallocation from i […]