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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE300751 CDK16 and CDK18 inhibition suppresses nuclear pore-mediated DNA repair and hepatocellular carcinoma [liver tumor] March 10, 2026Contributors : Diego Martínez-Alonso ; Marcos Malumbres ; Agustín Sánchez-BelmonteSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInhibition of cyclin-dependent kinases (CDK) 4 and 6 has become part of the current standard-of-care treatment in advanced estrogen receptor-positive breast cancer. However, many tumor types […]
- GSE227083 CDK16 and CDK18 inhibition suppresses nuclear pore-mediated DNA repair and hepatocellular carcinoma [Huh7] March 10, 2026Contributors : Diego Martínez-Alonso ; Marcos Malumbres ; Agustín Sánchez-BelmonteSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInhibition of cyclin-dependent kinases (CDK) 4 and 6 has become part of the current standard-of-care treatment in advanced estrogen receptor-positive breast cancer. However, many tumor types […]
- GSE324337 Adenosine-specific transcriptional programs in murine connective tissue type mast cells March 10, 2026Contributors : Qihua Liang ; Volodymyr Tsvilovskyy ; Anouar Belkacemi ; Merima Bukva ; Christin Richter ; Nicole Ludwig ; Andreas Keller ; Marc FreichelSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMast cells are tissue-resident immune cells that are critical for the pathogenesis of allergic and inflammatory disorders […]
- GSE286901 Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling [scRNA-Seq] March 10, 2026Contributors : Foxman Ellen ; Wang BaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRhinovirus (RV) is the most frequent cause of common colds, but also a major cause of serious respiratory illness in high-risk groups (e.g. smokers and asthmatics). The molecular mechanisms leading to disparate outcomes of infection ar […]
- GSE248025 Single-cell RNA sequencing of bone marrow celld from patients with paroxysmal nocturnal hemoglobinuria. March 10, 2026Contributors : Shouguo Gao ; Hiroki MizumakiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe performed single cell RNA sequencing of bone marrow samples (sorted Lineage+ cells, and sorted Lin-CD34+ HSPCs) from 8 patients with paroxysmal nocturnal hemoglobinuria (PNH) to understand PNH pathophysiology at high multi-dim […]
- GSE292828 Inhibition of NFAT after human uterus transplant promotes loss of tissue resident NK cells and attendant pregnancy complications [scRNA-Seq] March 10, 2026Contributors : Rebecca Asiimwe ; Brittney Knott ; Morgan E Greene ; Emma Wright ; Markayla Bell ; Daniel Epstein ; Stefani D Yates ; Michael V Gonzalez ; Samantha Fry ; Emily Boydston ; Stephanie Clevenger ; Jayme E Locke ; Brian E Brocato ; Constantine M Burgan ; Richard Burney ; Nitin Arora ; Virginia E Duncan ; Holly E Richter ; Deidre Gunn ; Aharon G Fre […]
- GSE291596 Co-targeting CDK2 and CDK9 inhibits MYC oncogenic programs and has anti-tumor effects in CIC-rearranged sarcoma March 10, 2026Contributor : Schaefer Inga-MarieSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCIC-rearranged sarcoma is an aggressive mesenchymal neoplasm characterized by capicua (CIC) gene rearrangement and molecular dependence on the CDK2-cyclin E complex. Given its high metastatic potential and poor clinical outcomes, there is a […]
- GSE323980 Diet Composition Shapes Sleep, Quality of Life, and Gene Expression in Obesity: A Randomized Trial. March 10, 2026Contributors : Elena Gangitano ; Giorgio Caratti ; Matthew Baxter ; David RaySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensObesity affects quality of life and sleep, making effective weight loss an attractive intervention. The role of diet composition on outcomes has not been determined. Our aim is to compare a ketoge […]
- GSE323976 Functional analysis of NtWRKY70 regulating tobacco defense against Rhizoctonia solani AG3-TB March 10, 2026Contributor : Yan LiSeries Type : Expression profiling by high throughput sequencingOrganism : Nicotiana tabacumRhizoctonia solani AG3-TB is a destructive soil-borne necrotrophic fungus that causes tobacco target spot disease. WRKY70 serves as a critical regulatory hub integrating salicylic acid (SA) and jasmonic acid (JA) signaling pathways to modulate defe […]
- GSE324000 Phage-encoded CasPRs transcriptionally silence diverse CRISPR-Cas systems [RNA-Seq] March 10, 2026Contributors : Edith M Sanderson ; Julieta Peralta ; Sam Nouwens ; Luke Oriolt ; Victoria M Hayes ; Brett K Kaiser ; Alexander J MeeskeSeries Type : Expression profiling by high throughput sequencingOrganism : Listeria seeligeriAnti-CRISPRs (Acrs) are diverse proteins or RNAs that protect invading phages and plasmids from host CRISPR-Cas immunity. Most Acrs […]
- GSE323985 Transcriptomic Analysis of Argon Effects on LPS-stimulated Primary Microglia March 10, 2026Contributors : Jie Cheng ; Baiyang Zheng ; Shusu Luo ; Yuan Yuan ; Xiaobo Wu ; Zhenglin Jiang ; Xia LiSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusThe role of inflammation in psychiatric disorders, such as anxiety, has gained increasing attention, with the hippocampus being identified as a key region involved in […]
- GSE324019 Surveillance of aneuploidy by oxidative stress sensing through ATPAF1 March 10, 2026Contributors : Xiaoai Lyu ; Jungseog Kang ; Xinhe XueSeries Type : OtherOrganism : Homo sapiensAneuploidy, the aberrant number of chromosomes, is a major consequence of chromosomal instability (CIN) and a hallmark of cancer. Aneuploidy imposes significant fitness costs related to proteotoxic, replicative, mitotic, and metabolic stress. However, the molecular […]
- GSE324069 Transcriptomics and experiments verified that astaxanthin reduces the apoptosis of nerve cells in ischemic stroke by inhibiting the toll-like receptor signaling pathway March 10, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusBackground and Objective. Inflammation is an important pathological process in ischemic stroke (IS). Astaxanthin (ATX) is a natural product with neuroprotection effects. However, the mechanism of ATX on anti-inflammatory after IS is not clear. The aim of this study wa […]
- GSE324247 Effects of Rg3@PACVs with NIR in a Rat Model of Pulmonary Ischemia–Reperfusion Injury March 10, 2026Contributors : Haoxiang Yuan ; Bo Zeng ; Pu Shen ; Jiancheng Deng ; Ying Chen ; Meiyu Huang ; Wentao Wu ; Xin Xu ; Xuanlin Zhang ; Xue Liu ; Xudong Zhang ; Zhijin Fan ; Jianxing HeSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusPulmonary ischemia–reperfusion injury (IRI) is characterized by excessive inflammation, […]
- GSE300032 Myosin VB is Critical for Progenitor Cell Function in the intestine March 10, 2026Contributors : Andreanna Burman ; Monica E Brown ; Yilin Yang ; Ken S Lau ; Michael Momoh ; Izumi KajiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicrovillus inclusion disease (MVID) is a congenital diarrheal disorder, caused by inactivating mutations in myosin Vb (MYO5B). MYO5B deficient mice and cell lines have de […]