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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE345302 Spatial profiling identifies a distinct and topographically-defined tumor microenvironment that emerges during multiple myeloma evolution August 28, 2026Contributors : M Koops ; T CupedoSeries Type : OtherOrganism : Homo sapiensThe pathobiology of multiple myeloma is influenced by cells of the bone marrow, but whether tumor support is organized in a spatially-defined tumor microenvironment (TME) remains unclear. Using spatial transcriptomics and imaging mass cytometry, we show that myeloma cells initially ex […]
- GSE305870 Deep sequencing of gonadal white adipose tissue (gWAT) from Wild-type (WT), adipocyte-specific Gα13 knockout (Gα13 AKO), and Gα12/13 double knockout (Gα12/13 DKO; Gα13 AKO combined with global Gα12 deletion) mice August 28, 2026Contributors : Yun-Hee Lee ; Yeonho SonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe therapeutic relevance of GPCR-targeting drugs has expanded, yet the function of Gα12/13 in adipose tissue remain incompletely understood. This study investigated the metabolic roles of Gα12/13 in adipocytes under conditions of die […]
- GSE274156 The identification of long noncoding RNA's in various mitotic stages in A549 cells. August 28, 2026Contributors : Sagar Mahale ; Chandrasekhar KanduriSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLong non-coding RNAs (lncRNAs), the most abundant RNA type in mammalian cells, exhibit highly tissue- and cell type-specific expression. They are typically over 500 nucleotides long, with recent estimates predicting their […]
- GSE156520 Single cell analysis of de novo infection of permissive cells with MHV-68. August 28, 2026Contributors : Linda F van Dyk ; Eric T ClambeySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study sought to define the viral and cellular RNAs expressed within individual cells during de novo, in vitro infection with murine gammaherpesvirus 68 (MHV-68), a small animal model of gammaherpesvirus infection capable […]
- GSE303511 In vivo CRISPR screening identifies NF1/RASA1/TP53 co-mutations and downstream MEK signaling as a common key mechanism of sinonasal tumorigenesis - Custom Capture Sequencing of CRISPR Cas9 August 28, 2026Contributors : Kenny Vu ; Sreeni Gunti ; Ramya Viswanathan ; Nyall London ; Anjali Nandal ; Federico Comoglio ; Xiaolin WuSeries Type : OtherOrganism : Mus musculusGenomic alterations driving tumorigenesis in sinonasal malignancies remain largely unexplored. Here, we perform an in vivo loss-of-function screen using a pooled custom single-guide library delive […]
- GSE284283 Dynamic Polycomb-CBC crosstalk orchestrates mRNA production at transcriptionally active loci in plants [caRNA-seq] August 28, 2026Contributors : Yuanyuan Xie ; Lifeng Du ; Zhijuan Chen ; Xiaoyi Li ; Danhua Jiang ; Fangqing Zhao ; Zicong LiSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaHistone modifications and co-transcriptional processing play fundamental roles in regulating eukaryotic gene transcription. Active histone modifications and […]
- GSE324830 In vivo CRISPR screening identifies NF1/RASA1/TP53 co-mutations and downstream MEK signaling as a common key mechanism of sinonasal tumorigenesis - Whole Exome Sequencing of Nf1/Trp53 flox/flox August 28, 2026Contributors : Vu Kenny ; Gunti Sreeni ; Viswanathan Ramya ; London Nyall ; Nandal Anjali ; Comoglio Federico ; Wu XiaolinSeries Type : OtherOrganism : Mus musculusGenomic alterations driving tumorigenesis in sinonasal malignancies remain largely unexplored. Here, we perform an in vivo loss-of-function screen using a pooled custom single-guide library delive […]
- GSE305281 Aberrant epithelialization: A plausible factor for the development of endometrial polyps [scRNA-seq] August 28, 2026Contributors : Amruta Pathare ; Ankita Lawarde ; Katrin Täär ; Sergio Vela Moreno ; Apostol Apostolov ; Vijayachitra Modhukur ; Darja Tarassova ; Alberto Sola Leyva ; Andres Salumets ; Merli Saare ; Maire PetersSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo explore cellular heterogeneity and differentiation trajecto […]
- GSE330811 Transcriptomics profiling of gonadal white adipose tissue (gWAT) of wild-type (WT), and Gα12 knockout mice (Gα12 KO) mice fed a normal chow diet (NCD) or high-fat diet (HFD) August 28, 2026Contributors : Yun-Hee Lee ; Yeonho SonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe therapeutic relevance of GPCR-targeting drugs has expanded, yet the function of Gα12/13 in adipose tissue remain incompletely understood. This study investigated the metabolic roles of Gα12/13 in adipocytes under conditions of die […]
- GSE328466 SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cells August 28, 2026Contributor : Dan LevySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPeroxisome proliferator-activated receptor gamma (PPARγ) is a key transcriptional regulator of genes mediating adipogenesis (fat-cell differentiation) and lipid storage in several cell types like hepatocytes. As such, its regulation is crucial for cel […]
- GSE341745 Functional differences in lung neutrophil subpopulations identified by flow cytometry during acute Streptococcus pneumoniae infection in mice August 28, 2026Contributors : Pedro H Silva ; Omar P Vallejos ; Jose L Cordero ; G A Montalva ; Pablo A Gonzalez ; Hernan F Penaloza ; Alexis M Kalergis ; Nelson P Barrera ; Susan M BuenoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusStreptococcus pneumoniae (Spn) is a Gram-positive bacterium that colonizes and infects the respirator […]
- GSE344692 Placental TRPV2 supports trophoblast function and normal fetal development [MERSCOPE] August 28, 2026Contributors : Katrien De Clercq ; Vicente Pérez-García ; Amitesh Panda ; Seppe Gevaert ; Jill Witvrouwen ; Pilar Van Mechelen ; Jorge Lopez-Tello ; Katarzyna Maksym ; Anna L David ; Evy Van Den Broeck ; Katrien Luyten ; Andrei Segal ; Suresh Poovathingal ; Marta Wojno ; Yuki Katanosaka ; Rudi Vennekens ; Vincent Pasque ; Amanda N Sferruzzi-Perri ; Thomas Vo […]
- GSE344819 Cell-state plasticity of trichoblasts underlies plant root adaptation to salinity August 28, 2026Contributors : Ruishuang Wu ; Lulu Zhang ; Dongyu Zhang ; Yaobin Zhang ; Yan Guo ; Shuangtao Li ; Jingrui Li ; Jian SunSeries Type : Expression profiling by high throughput sequencingOrganism : Fragaria x ananassaWe report both raw and processed scRNA-seq data that were used to construct a reference atlas in strawberry roots subjected to a salt concentration […]
- GSE305406 ATAC-seq of IL17D-overexpressing and control H460 cells August 28, 2026Contributors : Wei Du ; Xiaofan Feng ; Weimin DengSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the regulatory role of IL17D in ferroptosis in non-small cell lung cancer (NSCLC) cells, we generated stable IL17D-overexpressing H460 cell lines and conducted ATAC-seq analysis to assess chroma […]
- GSE317815 Loss of SNORD104-guided rRNA methylation promotes early adaptation to Crizotinib in lung adenocarcinoma August 28, 2026Contributors : Julie Ripoll ; Céline Mandier ; Nour Mourksi ; Virginie Marcel ; Eric RivalsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe ribosome, long considered an invariant actor of gene expression, recently emerges as regulated by chemical modifications of ribosomal RNAs (rRNAs). These modifications are guided […]