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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE300971 Influence of temporal interference electrical stimulation on mRNA expression in primary rat progenitor cells in vitro. June 28, 2026Contributors : Sofia Peressotti ; Roberto Portillo Lara ; Rylie GreenSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusElectrical stimulation has been shown to modulate the proliferation and differentiation of neural progenitor cells (NPCs). Although stimulation therapies, such as deep brain stimulation (DBS) have be […]
- GSE300955 Dual Deficiency of IL4I1 and LAO1 Promotes Inflammatory Diarrhea via Disruption of L-Amino Acid Metabolism and the IDO1-Kynurenine Pathway June 28, 2026Contributors : Kentaro Nagaoka ; Hong LiuSeries Type : Expression profiling by arrayOrganism : Mus musculusThe oxidoreductases interleukin 4-induced gene 1 (IL4I1) and L-Amino acid oxidase 1 (LAO) are known to catalyze L-amino acid metabolism, yet their physiological roles in intestinal homeostasis remain largely unexplored. In this study, we investigated th […]
- GSE336175 Metabolic stress-induced astrocytic senescence and neurotoxicity are driven by LRRK2-G2019S and reversible by LED Photobiomodulation June 28, 2026Contributors : Jeehoon Lee ; Jihye HanSeries Type : Expression profiling by arrayOrganism : Mus musculusUnder metabolic stress, the LRRK2-G2019S mutation accelerates astrocytic senescence by physically sequestering DDB1. This aberrant interaction impedes the CUL4–DDB1-mediated proteasomal degradation of p21, leading to massive p21 accumulation, an exacerbate […]
- GSE303576 Rb-driven transcription limits its tumour suppressive effects in breast cancer June 28, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE336205 DUSP5 regulates ferroptosis in pancreatic cancer by down-regulating SCD1 expression via ERK1/2 June 28, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study aimed to explore the role and mechanism of DUSP5 in pancreatic ductal adenocarcinoma (PDAC). RNA sequencing was performed in DUSP5-overexpressing PANC-1 cells and control cells to identify differentially expressed genes. The results revealed that DUSP5 significa […]
- GSE336212 Transcriptomic profiling of upper incisor tissues from neural crest-specific Alx1 conditional knockout mice at embryonic day 13.5 June 28, 2026Contributors : Xi Zheng ; Hongbin Lu ; Meiyang Chen ; Ying Xu ; Chensheng Lin ; Yi Lv ; Yanding Zhang ; Xuefeng Hu ; Minkui LinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTooth morphogenesis depends on reciprocal interactions between the dental epithelium and neural crest-derived mesenchyme. ALX1 is a paired-like ho […]
- GSE336234 scRNA-seq analysis of peritoneal immune cells from NCD- and HFD-fed mice June 28, 2026Contributors : Weixuan Wang ; Linjiang Han ; Dan LvSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusTo determine how a high-fat diet (HFD) alters peritoneal immune cells, we performed single-cell RNA sequencing (scRNA-seq) to characterize the peritoneal immune microenvironment in mice fed a chow diet (CD) or HFD. […]
- GSE336354 CDK4 maintains cytoskeletal homeostasis by restraining actomyosin contractility June 28, 2026Contributors : Kanishka Parashar ; Sarah Geller ; Arianna Ravera ; Catherine Roger ; Giovanna Ambrosini ; Barney F. Drake ; Jialin Shi ; Silvia Prieto Baños ; Sévan Stroh ; David Moi ; Laia Simo Riudalbas ; Christophe Dessimoz ; Georg E. Fantner ; Dirk Fasshauer ; Dorian V. Ziegler ; Lluis FajasSeries Type : Expression profiling by high throughput sequencing […]
- GSE336483 Stress-Coping Phenotypes Shape Adipose Tissue Function and Plasticity and Modulate Metabolic Resilience June 28, 2026Contributors : Saumya Mehta ; Michaella Ben-Shachar ; Sharmila Govindaraj ; Suparna Sen ; Adrian Segev ; Oshrit Rahimi ; Valid Gahramanov ; Galia Luboshits ; Michael A Firer ; Ayala Wollman ; Albert Pinhasov ; Tovit RosenzweigSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigated how stress-coping pheno […]