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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE294274 Tumor-resident T cells and dendritic cells form an in situ archetype for immunotherapy response in melanoma [scTCR-seq] June 8, 2026Contributors : Andrea Di Pietro ; Patrick Crock ; Niko Thio ; Sara Alei ; David Yoannidis ; Timothy SempleSeries Type : OtherOrganism : Homo sapiensTumor-resident (TR) T cells participate in immunosurveillance of melanoma, but their role in determining response to immune checkpoint inhibitors (ICI) has not been comprehensively explored. We performed spatial […]
- GSE303908 Cancer immunotherapy targeting myeloid cells requires endosomal pattern recognition June 8, 2026Contributors : Yueyun Pan ; Shengduo Pei ; Heng Liang ; Mikael KarlssonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImmunotherapy is now an established and efficient treatment option for many cancer patients, but unfortunately, a proportion of the patients still experience poor outcomes due to resistance to treatment […]
- GSE298800 An AI-integrated workflow maps the latent interactome of molecular glue degraders June 8, 2026Contributors : Pius Galli ; Shuhao Xiao ; Yanxiang Meng ; Alexander Hanzl ; Alexandra M Bendel ; Regina Baur ; Jacob Aguirre ; Anna M Diaz-Rovira ; Georg Kempf ; Lukas Kater ; Kenji Shimada ; Ye Wie ; Andreas Scheck ; Dominique Klein ; Siomne Cavadini ; Ben Lehner ; Guillaume Diss ; Bruno E Correia ; Nicolas H ThomäSeries Type : OtherOrganism : Saccharomyces […]
- GSE317411 Macrophages drive inguinal fat pad and lymph node remodelling in response to peripheral inflammation. June 8, 2026Contributors : Robin Bartolini ; Deepika Sharma ; Gillian J Wilson ; Gillian Dunphy ; Jonathan Cavanagh ; Heba A Halawa ; John Cole ; Stefan Weidt ; Jennifer Barrie ; Kirstyn Gardner-Stephen ; Gerard J GrahamSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAdaptive immune responses are intensely energy-dependent and rely […]
- GSE309187 Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency June 8, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE334376 Single-cell RNA-seq of healthy human epidermal cells from adult abdominal skin June 8, 2026Contributors : Hannes Kühtreiber ; Polina Kalinina ; Michael MildnerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSingle-cell RNA sequencing was performed on viable epidermal cells isolated from healthy adult human abdominal skin samples obtained during abdominoplasty. Epidermal cell suspensions were generated by enzy […]
- GSE317810 Histone H3 availability is more important for development than H3.2 versus H3.3 subtype identity June 8, 2026Contributors : McPherson Jeanne-Marie ; McKay Daniel ; Duronio RobertSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterThe distinct contributions of replication-dependent (RD) and replication-independent (RI) histones to development and genome function remain unclear. We investigate how the RI exp […]
- GSE334233 ECM1/SQSTM1 Axis Remodels Colorectal Cancer Immune Microenvironment via CXCL1-CXCR2-Dependent Neutrophil Recruitment and NETosis (scRNA-seq) June 8, 2026Contributor : Jian WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusExtracellular matrix protein 1 (ECM1) has been implicated in tumorigenesis; however, its precise role in modulating the immunosuppressive tumor microenvironment (ITM) in colorectal cancer (CRC) remains inadequately elucidated.
- GSE334223 Integrative multi-omics analyses reveal that exogenous indole-3-lactic acid enhances growth by modulating various metabolic pathways in Lemna aequinoctialis culture June 8, 2026Contributors : SoHee Park ; Hyung-Kyoon ChoiSeries Type : Expression profiling by high throughput sequencingOrganism : Lemna aequinoctialisBackground: Lemna aequinoctialis is an aquatic plant with high potential for feed, food, and pharmaceutical resources due to its rapid propagation and rich metabolite profile. In this study, we investigated the effects of […]
- GSE334274 Comparative Tnseq of Vibrio cholerae grown without and with tobramycin at 2% MIC for 50 generation June 8, 2026Contributor : Didier MazelSeries Type : OtherOrganism : Vibrio choleraeAntibiotics at 2% of the MIC are not lethal for bacteria but cause stress. We studied the contribution of each gene in the fitness of V. cholerae for growth in tobramycin 2%MIC.
- GSE334234 ECM1/SQSTM1 Axis Remodels Colorectal Cancer Immune Microenvironment via CXCL1-CXCR2-Dependent Neutrophil Recruitment and NETosis (Spatial transcriptomics) June 8, 2026Contributor : Jian WangSeries Type : OtherOrganism : Mus musculusExtracellular matrix protein 1 (ECM1) has been implicated in tumorigenesis; however, its precise role in modulating the immunosuppressive tumor microenvironment (ITM) in colorectal cancer (CRC) remains inadequately elucidated.
- GSE334289 Host transcriptional responses reveal molecular signatures of immune regulation and blood-brain barrier remodelling in porcine neurocysticercosis June 8, 2026Contributors : Carla A Apaza-Quiroz ; Cielo C Rojas-Portocarrero ; Sneider A Gutierrez ; Emily K Ponce-Nakatahara ; Javier A Bustos ; Gianfranco Arroyo ; Robert H Gilman ; Héctor H García ; Mirko ZimicSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofa domesticusNeurocysticercosis, caused by the establishment of Taenia soliu […]
- GSE334323 Custom Probe-Based Spatial Transcriptomics Enables Microbiome Detection in FFPE Colorectal Cancer Tissue June 8, 2026Contributors : Rayyan Aburajab ; Jennifer Karmouch ; Robert Jenq ; David W CraigSeries Type : OtherOrganism : Homo sapiensWe describe a custom probe design pipeline targeting the variable regions of bacterial 16S rRNA, compatible with the probe-based chemistry of the 10X Genomics Visium CytAssist platform, enabling spatially resolved bacterial profiling in F […]
- GSE334345 Exploratory investigation of changes in blood transcriptome following mepolizumab treatment for asthma June 8, 2026Contributors : Mitchell Pitlick ; Mrunal K Dehankar ; Chantal E McCabe ; Sergio E Chiarella ; Kathleen Bartemes ; Kay A Bachman ; Chung-Il Wi ; Young J Juhn ; Thanai PongdeeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensObjective: To evaluate the effects of mepolizumab therapy on the blood transcriptome in patients wit […]
- GSE294272 Tumor-resident T cells and dendritic cells form an in situ archetype for immunotherapy response in melanoma [bulk RNA-seq] June 8, 2026Contributors : Andrea Di Pietro ; Patrick Crock ; Niko Thio ; Angela Pizzolla ; Thu Ngoc Nguyen ; Sean Macdonald ; Stuart BencraigSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTumor-resident (TR) T cells participate in immunosurveillance of melanoma, but their role in determining response to immune checkpoint inhibito […]