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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE248301 Plasmodesmal closure triggers stress responses March 5, 2026Contributors : Estee Tee ; Andrew Breakspear ; Diana Papp ; Annalisa Bellandi ; Hannah R Thomas ; Christine FaulknerSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaPlant cells function cell autonomously, but are connected to their cellular neighbors via plasmodesmata. Changes in cellular connectivity is required […]
- GSE287747 Brucella tRNA-derived fragment tRF-Leu-CAG reprograms macrophage polarization for intracellular survival via up-regulation of IL13RA1 expression March 5, 2026Contributors : Guan Yin Zhang ; Hong Rong Hong ; Chang Xian Wu ; Feng Dong Zhu ; Yu Peng Fang ; Shuang Yan Xiao ; Zheng Fei LiuSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Brucella melitensis M5-90Outer membrane vehicles (OMVs) are secreted from gram-negative bacterium to enable bacterial survival and regulate microbial inte […]
- GSE276897 Transcriptional changes in the guts of Drosophila melanogaster upon gut specific CrebB induction March 5, 2026Contributors : Ahmed Sumit ; Shajahan Anver ; Nazif AlicSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterAdrenergic signalling is heavily implicated in human age-related disease and yet the potential for this neuroendocrine signalling pathway to modulate ageing has received little attention. Here, we use Droso […]
- GSE303363 Methylomic Analysis of Nasal Brushings Reveals Two Subgroups in Pediatric Acute Respiratory Distress Syndrome March 5, 2026Contributors : James G Williams ; Akhilesh Kaushal ; Nirmeen Elmadany ; Rashika Joshi ; Rhonda Jones ; Nathan Gregor ; Patrick Lahni ; Steven Standage ; Brian M VariscoSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensPediatric acute respiratory distress syndrome (PARDS) is a significant cause of mortality in the pediatric inte […]
- GSE297722 Genomic characterization of sub-populations in human pluripotent stem cell-derived retinal progenitor cells that drive retinal layer structure March 5, 2026Contributors : Yasusaki Iwama ; Tomohiro Masuda ; Mika Yoshimura ; Masayo Takahashi ; Itoshi Nikaido ; Michiko MandaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe mechanisms of layer formation of retinal spheroids were investigated using Rax::GFP-positive retinal progenitor cells (RPCs) obtained from human embryon […]
- GSE313366 Loss-of-function mutants of timP toxin March 5, 2026Contributors : Anaïs Le Rhun ; Nicolas J TourasseSeries Type : OtherOrganism : Escherichia coli str. K-12 substr. MG1655FASTBAC-Seq of the timP toxin mRNA to identify loss-of-function mutations. We selected and deep-sequenced surviving transformants expressing mutagenized timP under the J23106 promoter and performed differential expression analysis (compared […]
- GSE310560 Deep profiling of multiple mouse tumor microenvironments using scRNAseq March 5, 2026Contributor : Tristan CourauSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe HuMu dataset (https://www.biorxiv.org/content/10.1101/2025.07.01.661217v1) contains single-cell sequencing data from 9 mouse tumor models that we use to dissect gene expression profiles across populations and tumor models. The data can be re […]
- GSE322566 Fibro-Adipogenic Progenitor cells from murine SMA muscles are intrinsically adipogenic March 5, 2026Contributors : Yangyi E. Luo ; Elisabeth R. BartonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSpinal muscular atrophy is a neurodegenerative disorder caused by mutations in the SMN1 gene. Although classically viewed as a neurogenic disease, SMA patients exhibit poor skeletal muscle regeneration and increased fatty-f […]
- GSE322502 Gene expression during primary Hepatic Stellate Cells activation March 5, 2026Contributors : Thi Nga Ha ; Hyon-Seung YiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA-seq was conducted to investigate transcriptional dynamics during in vitro activation of primary hepatic stellate cells (HSCs). Cells were collected at Day 1, Day 4, and Day 7 of culture to represent progressive activation stages […]
- GSE322703 IRF1 rs2057656 Polymorphism Regulates IRF1-AS1 Transcription and Immune Dysfunction in ARDS via Allele-Specific Epigenetic Repression March 5, 2026Contributors : Shi Zhang ; Yuanyuan ZhangSeries Type : Other ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAcute respiratory distress syndrome (ARDS) is a severe and life-threatening variant of respiratory failure. Effective targeted therapies are lacking, and patient heterogeneity is substantial. Interferon regulat […]
- GSE322636 Transcriptionally permissive heterochromatin domains emerge from fast-evolving genetic elements March 5, 2026Contributors : Juan C Rueda-Silva ; Miguel V. Almeida ; Giulia Furlan ; Lisa Lampersberger ; Helena Santos-Rosa ; Chenming Zeng ; Enric Cata Socias ; Eric A MiskaSeries Type : Non-coding RNA profiling by high throughput sequencing ; Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : […]
- GSE322707 9-PAHSA orchestrates TCR-T cell fate to boost anti-tumor immunity [KPC] March 5, 2026Contributor : Xiaozhen ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe identify the endogenous lipid 9-PAHSA as a potent enhancer of T cell anti-tumor function and stemness, validated in murine models and a clinical trial. Mechanistically, we identify ICAM2 as a direct surface sensor for 9-PAHSA and delineate a […]
- GSE322929 Parkinson’s Disease-Associated Pink1 Loss Disrupts Ensheathing Glia And Causes Dopaminergic Neuron Synapse Loss March 5, 2026Contributors : Lorenzo Ghezzi ; Sabine Kuenen ; Ulrike Pech ; Nils Schoovaerts ; Ayse Kilic ; Suresh Poovathingal ; Kristofer Davie ; Jochen Lamote ; Roman Praschberger ; Patrik VerstrekenSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterParkinson’s disease (PD) is commonly associated with the loss of dopaminer […]
- GSE322957 Identification and biosynthesis of a novel thymidine hypermodification Na-dapT in Acinetobacter baumannii phage SH-Ab 15599 March 5, 2026Contributors : Wenjing Li ; Haoyu Ma ; Suwen ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Acinetobacter phage SH-Ab 15599Bacteriophage genomes exhibit exceptional diversity in nucleobase modifications, which primarily function to counteract host immunity and reshape DNA physicochemical properties. Recent discoveries of aGPT- […]
- GSE226992 Effect of knocking down of PTBP1 on gene expression in HSC cells March 5, 2026Contributors : Yajun Zhou ; Feifan XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the function PTBP1 in liver fibrosis, we transfected siPTBP1 and sicontrol as a control in primary HSC cells.We then performed gene expression profiling analysis using data obtained from RNA-seq.