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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE286049 ZBP1 Senses Splicing Aberration by Z-RNA for Cell Death August 1, 2026Contributors : Boxin Zhang ; Yuenan ZhouSeries Type : OtherOrganism : Mus musculusRNA splicing, a highly regulated process performed by the spliceosome, is crucial for eukaryotic gene expression and cellular function. Numerous cellular stresses including oncogenic insults dysregulate RNA splicing, often provoking inflammatory responses and cell death. Howeve […]
- GSE279530 PHLDA2 promotes breast cancer metastasis by increasing extracellular matrix deposition and vascular permeability August 1, 2026Contributors : Paige V Halas ; Hannah Savage ; Tatyana Lev ; Angela L Samy ; Stephanie Hachey ; Connie Chan ; Radhika M Domadia ; Iana Lin ; Sharmila Mallya ; Jessica Gonzalez ; Christopher Hughes ; Dennis Ma ; Devon A LawsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThere is a critical need to define drivers of me […]
- GSE304257 Multi-omics study of small Intestine adaptation after total colectomy. August 1, 2026Contributors : Yi Luo ; Xinyuan Wu ; Yayun Xie ; Yingjun QuanSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusTranscriptomic Evidence of Colonic Metaplasia To compare whether total colon resection leads to gene changes in the ileal anastomosis site, we performed transcriptome analysis of the preoperative small intes […]
- GSE300969 A Proposed Model of Alternative Splicing of Cyclin-Dependent Kinase 8 Underlying Mechanisms of Heart Failure Secondary To Hypertension. August 1, 2026Contributors : Chad E Grueter ; Duane D Hall ; Kayla M Henry ; Christopher JunSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe regulation of eukaryotic gene expression is a multifacted system in which both gene transcription and post transcriptional modifications play a crucial role in maintaining proper gene express […]
- GSE305143 DNA-PKcs-dependent Non-homologous End Joining Repair Contributes to Ferroptosis Inhibition August 1, 2026Contributors : Min Li ; Lulu Lu ; Zhangqi Mao ; Huanhuan xu ; Yi Guo ; Jun Yang ; Yingying yuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIron-dependent ferroptosis, characterized by the accumulation of lethal lipid peroxidation, plays a critical role in various pathological conditions. Given the limited pharmacologi […]
- GSE304882 Analysis of gene expression in SKBR3 cells isolated from xenograft tumors in mice treated with radioinducible TNF producing CAR-T cells August 1, 2026Contributors : Elham Masoumi ; Paulina Walczak ; Takemasa Tsuji ; Edurne Luque ; Agnes Julia Bilecz ; Junko Matsuzaki ; Christian Fernandez ; Kunle Odunsi ; Ralph Weichselbaum ; Ainhoa ArinaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAdoptive CAR T cell therapies have limited efficacy in solid tumors due to poor inf […]
- GSE341385 Cholesterol-Dependent Metabolism Promotes Bedaquiline Tolerance in Mycobacterium tuberculosis by Limiting Energetic Disruption August 1, 2026Contributors : Qian Gao ; Chuan Wang ; Cheng Bei ; Shimin Tan ; Qian Zhang ; Peng XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mycobacterium tuberculosisBedaquiline (BDQ) is a diarylquinoline antibiotic that targets mycobacterial ATP synthase and is used in the treatment of drug-resistant tuberculosis. Cholesterol is an import […]
- GSE241678 S-phase-induced RNAs licensing DNA replication control ORC1 engagement at early DNA origin sites [RIP-seq] August 1, 2026Contributors : Simone Ummarino ; Annalisa Di Ruscio ; Daniel G Tenen ; Alex K EbralidzeSeries Type : OtherOrganism : Homo sapiensCoordinated initiation of DNA replication is essential to ensure efficient and timely DNA synthesis. Yet the mechanism governing the “initiation” process in eukaryotic cells remains elusive. Here, we present data demonstrating a no […]
- GSE341456 Transcriptomic responses of HAP1 cells to Bu-DIF-3 and CP-DIF-3 August 1, 2026Contributors : Yue Cai ; Ryu Yamada ; Taichi HaraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDictyostelium differentiation-inducing factors (DIFs) and their derivatives regulate diverse cellular functions in mammalian cells, but the molecular responses elicited by individual derivatives remain incompletely understoo […]
- GSE341447 Effect of levofloxacin on apoptosis pathways in SW48 colorectal cancer cells August 1, 2026Contributors : Jiangyang Chi ; Yongli Fan ; Chenmeng HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe profiled transcriptomic changes in SW48 cells after 5-day 100μM levofloxacin treatment. Levofloxacin induces DNA damage and moderate p53 activation biased toward DNA repair over pro-apoptotic programs, while remo […]
- GSE341526 Atractylenolide III Alleviates Cisplatin-Induced Acute Liver Injury by Regulating Gut-Liver Axis Through Inhibiting ACT1/TRAF6/NF-κB-Mediated IL-17 Pathway August 1, 2026Contributor : Guoyin KaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntroduction: Cisplatin (DDP) is a highly effective and broad-spectrum chemotherapeutic agent. However, its clinical application is limited by severe hepatotoxicity. Currently available hepatoprotective agents are often associated with insufficient […]
- GSE341587 Transcriptomic analysis of FTO knockdown in MG63 osteosarcoma cells August 1, 2026Contributor : Zhaoliang ShenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFat mass and obesity-associated protein (FTO), a key N6-methyladenosine (m6A) demethylase, plays critical roles in tumor progression and chemotherapy resistance. However, the downstream transcriptional networks regulated by FTO in osteosarcoma r […]
- GSE341621 Gene duplication of SNAPC1 generates transcription factors for snRNAs and sex-specific piRNAs August 1, 2026Contributors : Lars K Benner ; Margaret R Starostik ; Rebecca J Tay ; Ayaka Inoki ; Mindy Clark ; Suhua Feng ; Michael C Schatz ; Steven E Jacobsen ; John K KimSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Caenorhabditis elegansPiwi-interacting RNAs (piRNAs) are small non-coding RNAs essential for transposon silencing and ger […]
- GSE275034 Transcriptome analysis of a Sinorhizobium meliloti exoX deletion strain. August 1, 2026Contributors : Melanie J Barnett ; Sharon R LongSeries Type : Expression profiling by arrayOrganism : Medicago truncatula ; Sinorhizobium melilotiWe characterized the transcriptome of a Sinorhizobium meliloti exoX deletion mutant (MB1129)
- GSE341321 Vitamin B2 Sensing by the Nuclear Receptor AhR Reprograms Hepatic Metabolism [RNA-Seq] August 1, 2026Contributors : Yohei Abe ; Augustinus G Haribowo ; Ankur Garg ; Rebekah J Nicholson ; Enchen Zhou ; Christopher K Glass ; Isha H JainSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusNuclear receptors such as RAR/RXR and VDR directly sense vitamins A and D, but analogous sensing mechanisms for most other vi […]