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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE291088 CytoSignal Detects Locations and Dynamics of Ligand-Receptor Signaling at Cellular Resolution from Spatial Transcriptomic Data April 21, 2026Contributors : Jialin Liu ; Hiroaki Manabe ; Joshua Welch ; Noriaki OnoSeries Type : OtherOrganism : Mus musculusNearby cells within tissues communicate through ligand-receptor signaling interactions. Emerging spatial transcriptomic technologies provide a tremendous opportunity to systematically detect ligand-receptor signaling, but no method operates at cel […]
- GSE284151 Multisensory integration at the dawn of land plant evolution April 21, 2026Contributors : Bruno Catarino ; Fernando Rodríguez-Marín ; Cristina Úrbez ; Christina Arvanitidou ; Eva Álvarez ; Federico Valverde ; José M Franco-Zorrilla ; Francisco Romero-Campero ; Miguel A BlázquezSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thaliana ; Marchantia polymorpha ; Mesotaenium endlicherianum ; Ostreo […]
- GSE295236 Excitatory neurons and astrocytes-specific dysregulation and aberrant interactions are vulnerable to FCDI as suggested by single-cell spatial transcriptomics [snRNA-seq] April 21, 2026Contributors : Yaqian Zhang ; Qihang Zou ; Yingying Liu ; Liemin ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFocal cortical dysplasia (FCD) is a common neurodevelopmental disorder characterized by malformations of cortical development and is a leading cause of drug-resistant epilepsy. In this study, we employed […]
- GSE294576 The effect of menin-inhibition on the human AML cell line MV4-11 [ATAC-seq] April 21, 2026Contributors : Geoffroy Andrieux ; Eyleen Corrales ; Viktor Fetsch ; Schwobel Lennard ; Robert Zeiser ; Melanie BoerriesSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAllogeneic hematopoietic stem cell transplantation remains the most efficacious treatment for many hematological malignancies. However, its […]
- GSE297988 HNF1B integrates signals in a feed-forward loop driving kidney disease progression [RNAseq_P60d2] April 21, 2026Contributors : Pierre Isnard ; Munevver P Makinistoglu ; Michel Leibovici ; Serge Garbay ; Fabiola Terzi ; Marco PontoglioSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChronic kidney disease (CKD) is a complex disorder with substantial unexplained heritability. While GWAS have identified common variants, rare variants […]
- GSE296030 Conservation and divergence of UVR8 photoreceptor-mediated UV-B signaling in Marchantia polymorpha April 21, 2026Contributors : Yuanke Liang ; Roman Podolec ; Roman UlmSeries Type : Expression profiling by high throughput sequencingOrganism : Marchantia polymorphaUltraviolet-B radiation (UV-B) poses a major challenge to all forms of plant life. The liverwort Marchantia (Marchantia polymorpha) serves as a key model organism for studying signaling pathways and inferring […]
- GSE328276 Host-pathogen dual targeting with repurposed drugs identifies a synergistic therapy for intracellular Staphylococcus aureus April 21, 2026Contributors : Blanca Lorente-Torres ; Helena Á. Ferrero ; Pablo Castañera ; Jesús Llano-Verdeja ; Sergio Fernández-Martínez ; Amanda Herrero-González ; Farzaneh Javadimarand ; Jesús F. Aparicio ; Andrew M. Edwards ; Volker Behrends ; Luis M. Mateos ; Álvaro Mourenza ; Michal LetekSeries Type : Expression profiling by high throughput sequencingOrganism : Hom […]
- GSE233849 The effect of menin-inhibition on the human AML cell line MV4-11 [gene expression] April 21, 2026Contributors : Andrieux Geoffroy ; Viktor Fetsch ; Lennard Schwobel ; Zeiser Robert ; Boerries MelanieSeries Type : Expression profiling by arrayOrganism : Homo sapiensAllogeneic hematopoietic stem cell transplantation remains the most efficacious treatment for many hematological malignancies. However, its therapeutic potential is affected by the most promin […]
- GSE328306 SFTSV exploits PPM1K to inhibit apoptosis through the Bcl-2/BAX/Caspase-3 axis for efficient replication April 21, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study, transcriptomic profiling identified PPM1K as a prominently induced host factor in SFTSV-infected THP-1 cells. We further demonstrate that SFTSV infection promotes endoplasmic reticulum–mitochondria coupling, enabling the viral glycoprotein GC to interact wit […]
- GSE328302 Identification of two genes associated with recurrence in Paget’s disease and construction of a predictive model April 21, 2026Contributor : Pengfei ChaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn summary, RNA‑seq analysis revealed distinct functional profiles between MPD and EMPD, with recurrence in MPD associated with developmental and differentiation pathways, while EMPD recurrence was linked to immune and inflammatory processes. Using […]
- GSE328312 Stable global repertoire architecture masks short- term clonal remodeling in intratumoral TCR repertoires April 21, 2026Contributors : Pernille G Pedersen ; Odd L Gammelgaard ; Sofie Traynor ; Christina Ruhlmann ; Aida S Hansen ; Henrik J Ditzel ; Morten F Gjerstorff ; Mikkel G TerpSeries Type : OtherOrganism : Mus musculusBackground: Tumor-in ltrating T cell receptor repertoires are increasingly pro led to assess intratumoral T cell dynamics and inform prognosis and treatmen […]
- GSE328334 Forming a Precise and Reproducible Hypoxic Tumor Microenvironment in Glioblastoma by High Cell Density Bioprinting April 21, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlioblastoma (GBM) is the most common and malignant brain tumor, characterized by its highly aggressive and rapidly proliferative behavior. In this study, we created a high throughput GBM model with a cell density modulated hypoxic niche to investigate the important role o […]
- GSE328448 Spatiotemporal transcriptomics characterizes immune microenvironment during mouse liver aging [Spatial Transcriptomics] April 21, 2026Contributors : Jiahua Lu ; Yuqian Wang ; Wenxue Zhao ; Zihao Zhao ; Zhaoya Gao ; Jin Gu ; Cheng Li ; Jie ChengSeries Type : OtherOrganism : Mus musculusThe liver is a major metabolic organ, responsible for synthesizing and breaking down diverse metabolites. Recently, the liver's immunological functions have gradually been unveiled: combating pathogens a […]
- GSE262917 Inosine suppresses liver A-to-I RNA editing to promote cancer-associated cachexia in a riboswitch-like manner. April 21, 2026Contributors : Wei Yan ; Xiao-Ting WuSeries Type : OtherOrganism : Mus musculusCancer-associated cachexia (CAC) is a devastating syndrome and a major cause of morbidity and mortality in advanced cancer patients while liver is emerging as a key organ during CAC progression1. However, how tumor dysregulates liver function to promote CAC remains largely unknown […]
- GSE328236 Transcriptomic profiling of Carfilzomib (CFZ) treatment in HSV-1 infected BV2 microglial cells April 21, 2026Contributors : Yaoxing Wu ; Weishan ShenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigates the molecular mechanisms underlying the interaction between Carfilzomib (CFZ) and Herpes Simplex Virus type 1 (HSV-1) infection in microglial cells. Using the BV2 microglial cell line, we performed RNA sequenc […]