Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE216038 Effect of continued exposure to drugs on gene expression in human pancreatic cells October 17, 2025
  Contributors : Jos van Pelt ; Veerle Janssens ; Chris VerslypeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPancreatic ductal adenocarcinoma (PDAC) has a bad prognosis, a fast progression and is difficult to treat, highlighting the need for new therapeutic targets. Aggressive tumors mostly show Epithelial-to-Mesenchym […]
• GSE245652 NLN Depletion Enhances WNT3A Secretion and Therapy Resistance in mCRPC via KIF11-Mediated Cellular Trafficking October 17, 2025
  Contributor : Ping MuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWNT signalling, an integral orchestrator in an assortment of developmental and pathological pathways, exhibits aberrant regulation in a variety of human malignancies, encompassing prostate cancer (PCa). Particularly, in metastatic castration-resistant […]
• GSE216280 Single-cell RNA sequencing of peripheral blood mononuclear cell of human osteosarcoma October 17, 2025
  Contributors : Wenyu Feng ; Mingwei HeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe performed the scRNA-seq anakysis of 3 osteosarcoma peripheral blood mononuclear cell based on the 10X Genomics platform.
• GSE279675 The enedioic acid analogue 326E alleviates MASH in preclinical studies and its signatures in patients via dual targeting at ACLY and PPARα [RNA-Seq] October 17, 2025
  Contributors : Jingya Li ; Long ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe alarming rise in the prevalence of metabolic dysfunction-associated steatohepatitis (MASH) is attributed significantly to dysregulated lipid metabolism. The present study discovered that a novel enedioic acid ACLY inhibitor 326E, an […]
• GSE279673 The enedioic acid analogue 326E alleviates MASH in preclinical studies and its signatures in patients via dual targeting at ACLY and PPARα [ATAC-seq] October 17, 2025
  Contributors : Jingya Li ; Long ChengSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe alarming rise in the prevalence of metabolic dysfunction-associated steatohepatitis (MASH) is attributed significantly to dysregulated lipid metabolism. The present study discovered that a novel enedioic acid ACLY inhi […]
• GSE288918 Dual PAX3 and PAX7 transcriptional activities spatially encode spinal cell fates through distinct gene networks October 17, 2025
  Contributors : Robin Rondon ; Théaud Hezez ; Julien Richard Albert ; Shinichiro Hayashi ; Bernadette Drayton-Libotte ; Gloria Gonzalez Curto ; Frédéric Auradé ; Elie Balloul ; Claire Dugast-Darzacq ; Frédéric Relaix ; Pascale Gilardi-Hebenstreit ; Vanessa RibesSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profili […]
• GSE280263 Actin Dysregulation Induces Neuroendocrine 1 Plasticity and 2 Immune Evasion: A Vulnerability of Small Cell Lung Cancer October 17, 2025
  Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusSmall cell lung cancer (SCLC) is aggressive with limited therapeutic options. Despite recent advances in targeted therapies and immunotherapies, therapy resistance is a recurring issue, which might be partly due to tumor cell plasticity, a change in cell fate […]
• GSE296904 PAGE4, upregulated in a novel iPSC-derived hepatoblastoma model, promotes hepatoblastoma progression October 17, 2025
  Contributors : Issei Kawakita ; Shohei Honda ; Yuta Yamada ; Shugo Tanaka ; Yuko Katayama ; Takeshi Shionoiri ; Asuka Ishii ; Hiroyuki Kurosu ; Kazuya Hamada ; Kentaro Kumagai ; Kensuke Nakazono ; Rino Saito ; Chihiro Terasaka ; Ryo Takahashi ; Insu Kawahara ; Momoko Ara ; Sari Iwasaki ; Satoshi Tanaka ; Atsushi Niida ; Eiso Hiyama ; Akinobu Taketomi ; Koji […]
• GSE299069 Actin Dysregulation Induces Neuroendocrine 1 Plasticity and 2 Immune Evasion: A Vulnerability of Small Cell Lung Cancer October 17, 2025
  Series Type : OtherOrganism : Mus musculusSmall cell lung cancer (SCLC) is aggressive with limited therapeutic options. Despite recent advances in targeted therapies and immunotherapies, therapy resistance is a recurring issue, which might be partly due to tumor cell plasticity, a change in cell fate. Nonetheless, the mechanisms underlying tumor cell plastic […]
• GSE300497 Tissue Engineered Elastic Cartilage-Mimetic Auricular Grafts for Microtia Reconstruction October 17, 2025
  Contributors : Philipp Fisch ; Sandra Kessler ; Simone Ponta ; Anna Puiggali-Jou ; Guoliang Lyu ; Killian Flégeau ; Anastasiya Martyts ; Florian Roth ; David Fercher ; Filippo M Rijli ; Daniel Simmen ; Eva Novoa Olivares ; Thomas Linder ; Marcy Zenobi-WongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMicrotia, the con […]
• GSE304527 Mitochondrial dysfunction in PRRSV-2 infected macrophages October 17, 2025
  Contributors : Thien-Phong Vu Manh ; Alba Frias-De-Diego ; Abigail Williams ; John J. Byrne ; Chaitawat Sirisereewan ; Julie Hicks ; Liu Hsiao-Ching ; Elisa CrisciSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaPorcine Reproductive and Respiratory Syndrome Virus (PRRSV) is one of the most economically devastating viruses […]
• GSE308113 L-Chiral Hydrogel Accelerates Wound Healing via Lactate-Mediated RNF123 K57 Lactylation October 17, 2025
  Contributor : Ruizhe HeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Rattus norvegicusChronic wounds, characterized by delayed healing and persistent inflammation, represent a major clinical burden with limited effective therapies. Inspired by the stereoselective interactions in biological systems, we developed an […]