Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE244427 mRNA expression profiling of A549 cells treated with TSA at different time points April 26, 2026
  Contributors : Lifei Ma ; Huiyang Li ; Xiaoman Wang ; Houzao ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCellular senescence (CS) refers to a stable arrest of the cell cycle characterized by an altered profiles of gene expression networks. However, a reliable strategy to quantify senescent levels is lacking. Her […]
• GSE328617 Early-life nutritional imbalance impairs colonic epithelial regeneration through gut microbiota dysbiosis and metabolic suppression April 26, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChildhood malnutrition represents a major global health burden that extends beyond caloric deficiency to include dietary imbalance. The early-life gut microbiome functions as a dynamic ecosystem whose structure and metabolic output are intimately linked to host development […]
• GSE245231 Epigenetic profiling of A549 cells treated with TSA [ATAC-seq] April 26, 2026
  Contributors : Lifei Ma ; Huiyang Li ; Xiaoman Wang ; Hou-Zao ChenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCellular senescence (CS) refers to a stable arrest of the cell cycle characterized by an altered profiles of gene expression networks. However, a reliable strategy to quantify senescent levels […]
• GSE328645 Transcriptomic profiling of mouse subgranular zone-derived neural stem cells exposed to cadmium April 26, 2026
  Contributors : Xutong Qin ; Yuwei Zhang ; Longfei Feng ; Xiuli ChangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed RNA-seq to investigate the effects of cadmium (Cd) exposure on the transcriptome of primary mouse neural stem cells (NSCs) isolated from the subgranular zone (SGZ) of the hippocampus. NSCs at […]
• GSE328626 Transcriptome Analysis of Palmitic Acid-treated Human Primary Hair Follicle Stem Cells April 26, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe effect of palmitic acid (PA) on human primary hair follicle stem cells (HFSCs) remains unclear. In this study, HFSCs were treated with PA or vehicle control, and transcriptome sequencing was performed to investigate the molecular alterations. Our results indicate that […]
• GSE328646 Image Tracing of Inflammatory Intestinal Organoids via Computational Clearing April 26, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGene expression of dextran sulfate sodium (DSS)-treated mouse intestinal organoids (mIOs) was examined by RNA-seq to characterize the inflammatory response. Gene set enrichment analysis (GSEA) revealed the upregulation of inflammatory pathways, including TNF-α signaling vi […]
• GSE328649 Lineage 2-Beijing Mycobacterium tuberculosis strains suppress BCG-trained innate immunity early after infection April 26, 2026
  Contributors : Naomi Daniels ; Todia Setiabudiawan ; Taru Dutt ; Philip Hill ; Marcela Henao-Tamayo ; Reinout van Crevel ; Joanna KirmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGenetically distinct lineages of Mycobacterium tuberculosis differ in their virulence, transmissibility, and immune evasion capacity. The […]
• GSE328715 Cell autonomous control of CAR signaling and receptor shedding via ADAM17-mediated proteolysis April 26, 2026
  Contributors : Jeremy R Bjelajac ; Adrià C Socias ; Preeti Nehra ; Kevin Reynolds ; Meena Malipatlolla ; Naiara Martinez-Velez ; Diane C Manjarrez ; Katie Ho ; Peng Xu ; Jennifer L Hamad ; Sean A Yamada-Hunter ; Louai Labanieh ; Elena Sotillo ; Crystal L MackallSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe sought t […]
• GSE328758 Targeting Cyclin K-CDK12 Synergizes with ATR Inhibition by Limiting RPA Chromatin Loading in Triple-Negative Breast Cancer April 26, 2026
  Contributors : Eun-Bee Choi ; Sophia Podeszwa ; Geoffrey I ShapiroSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCyclin K-CDK12 inhibition has emerged as a promising therapeutic strategy to induce homologous recombination deficiency (HRD). However, clinical and genomic studies have not clearly linked CDK12 inactivation […]
• GSE328779 Single cell RNA-seq characterization of non-fibrotic stromal wound repopulation in the rabbit April 26, 2026
  Contributors : Borner Katherine ; Yu Ze ; Xing Chao ; Petroll W. MatthewSeries Type : Expression profiling by high throughput sequencingOrganism : Oryctolagus cuniculusFollowing injury or surgery, quiescent stromal keratocytes can transition into fibroblasts or myofibroblasts leading to either transient or protracted corneal haze. In this study, we investiga […]