Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE239608 tRNA m1A modification enhances anti-tumor immunity in macrophages by promoting translation of key interferon associated genes March 9, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE274289 Single cell analysis of a iPSC-derived glial-neurons triculture model of mitochondrial unfolded protein response (UPRmt) activation. March 9, 2026
  Contributors : Maria Jose Perez J. ; Michela DeleidiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMitochondria have developed a specialized unfolded protein response (UPRmt) to maintain proteostasis and promote recovery under stress conditions. Research in simpler organisms has demonstrated that UPRmt activation in gl […]
• GSE264304 Nuclear Speckles enable processing of RNA from GC-rich Isochores [SON_Halo_Fractionation] March 9, 2026
  Contributors : Ibrahim A Ilik ; Michal Malszycki ; Tugce AktasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNuclear Speckles are large, multi-component condensates in the mammalian nuclei that are thought to be involved in various stages of gene expression, including transcription, splicing, and export. Investigating […]
• GSE286066 Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants [YY1] March 9, 2026
  Contributors : Liudan Jiang ; Long Zhao ; Chuan HeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusIntrinsically disordered regions (IDRs) are well-known facilitators of chromatin regulation, but their role as regulatory restraints remains underexplored. Here, we reveal that the C-terminal IDR of mammalian […]
• GSE285802 Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants [MeRIP-seq] March 9, 2026
  Contributors : Liudan Jiang ; Long Zhao ; Chuan HeSeries Type : Methylation profiling by high throughput sequencing ; OtherOrganism : Arabidopsis thalianaIntrinsically disordered regions (IDRs) are well-known facilitators of chromatin regulation, but their role as regulatory restraints remains underexplored. Here, we reveal that the C-terminal IDR of mammali […]
• GSE297484 An aerosolised dual-action Autotaxin inhibitor-PPARγ agonist for the treatment of pulmonary fibrosis. March 9, 2026
  Contributors : Alexios Matralis ; Elli-Anna Stylianaki ; Eleni Ladopoulou ; Paraskevi Kanellopoulou ; Dimitris Nastos ; Stefanos Smyrniotis ; Alexandros Galaras ; Konstantinos Papavasileiou ; Sabine Willems ; Skarlatos Dedos ; Juan Pablo Rincon Pabon ; Pantelis Hatzis ; Eleanna Kaffe ; Christiana Magkrioti ; Daniel Merck ; Argyris Politis ; Antreas Afantitis […]
• GSE289971 m6A Methylation Suppresses anti-tumour immune responses in Colorectal Cancers by Inhibiting Double-stranded RNA accumulation from Alu Repeats [RNA-Seq1] March 9, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHow cancer cells evade immune detection despite expressing immunostimulatory retroelement (RE) transcripts remains an open question in tumour immunology. In cancer cells, endogenous REs that escape histone and DNA silencing are transcribed into RNA and can form double-stra […]
• GSE324029 Differential gene expression in ADGRF5 overexpression versus control in neonatal rat ventricular myocytes March 9, 2026
  Contributors : Jeanette M Einspahr ; Douglas G TilleySeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusG-Protein Coupled Receptors (GPCRs) represent one of the most targeted drug classes in the human genome, accounting for greater than 40% of all FDA-approved drugs, including gold-standard heart failure (HF) therapeu […]
• GSE323964 IRE1 drives a homeostatic response to reduced protein influx into the endoplasmic reticulum (Translation initiation interruption) March 9, 2026
  Contributors : Francesca Zappa ; Advait Subramanian ; Benjamin A Yang ; Julia E Conrad ; Tsan-Wen Lu ; Jing Wang ; Nicolas Debeaubien ; Rose Yan ; Renato Minopoli ; Tristan Croll ; Stefka Tyanova ; Mauro Costa-Mattioli ; Peter Walter ; Diego Acosta-AlvearSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIRE1, alongside AT […]
• GSE324058 A Role for Rapid Transcription Dynamics in Cytarabine Resistance in Acute Myeloid Leukemia [ATAC-seq] March 9, 2026
  Contributors : Goichi Tatsumi ; Rajni Kumari ; Yutaro Suzuku ; Shuting Li ; Russell Scharf ; Samuel Taylor ; Sriram Sundaravel ; Amit Verma ; Justin Wheat ; Ulrich SteidlSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensChemotherapy resistance remains a critical challenge in the treatment of patients with ca […]
• GSE324057 A Role for Rapid Transcription Dynamics in Cytarabine Resistance in Acute Myeloid Leukemia [RNA-seq] March 9, 2026
  Contributors : Goichi Tatsumi ; Rajni Kumari ; Yutaro Suzuki ; Shuting Li ; Russell Scharf ; Taylor Samuel ; Sriram Sundaravel ; Amit Verma ; Justin Wheat ; Ulrich SteidlSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChemotherapy resistance remains a critical challenge in the treatment of patients with cancer including […]
• GSE324142 Unveiling the Developmental and Tumor Suppressive Roles of the p53 variant, p53psi March 9, 2026
  Contributors : Chiara Gorrini ; Parameswaran Pamachandran ; Liam Hendrikse ; Tak W MakSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThrough alternative splicing, the TP53 gene can generate multiple protein isoforms with distinct biochemical properties. Among the thirteen splicing isoforms described to date, the p53psi […]
• GSE324170 A Role for Rapid Transcription Dynamics in Cytarabine Resistance in Acute Myeloid Leukemia March 9, 2026
  Contributors : Goichi Tatsumi ; Rajni Kumari ; Yutaro Suzuki ; Shuting Li ; Russell Scharf ; Samuel Taylor ; Sriram Sundaravel ; Amit Verma ; Justin Wheat ; Ulrich SteidlSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChemotherapy resistance remains a critical challenge in the treatment of patients with cancer including […]
• GSE324261 Genomic language models improve cross-species gene expression prediction and accurately capture regulatory variant effects in Brachypodium mutant lines March 9, 2026
  Contributors : Guillaume P Ramstein ; Camous Moslemi ; Behrooz Vahedi TorghabehSeries Type : Expression profiling by high throughput sequencingOrganism : Brachypodium distachyonPredicting gene expression from cis-regulatory DNA sequences is a central challenge in plant genomics. Here, we developed deep learning sequence-to-expression (S2E) models that levera […]
• GSE324301 Mitochondrial DNA heteroplasmy drives cortical neuronal disturbances in human organoids harbouring the common m.3243A>G mutation March 9, 2026
  Contributors : Denisa Hathazi ; Camilla Lyons ; Daniel Lagos ; Oliver Podmanicky ; Mariana Zarate-Mendez ; Yu Nie ; Julianne S Mueller ; Kieren Allinson ; Huw Naylor ; Majlinda Lako ; Ibrahim Elsharkawi ; Irena Muffels ; Eva Morava ; Tamas Kozicz ; Patrick Chinnery ; Andras Lakatos ; Rita HorvathSeries Type : Expression profiling by high throughput sequencin […]