Category: pubmed

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE242244 CarS2 mediated cysteine catabolism drives brown fat development and thermogenesis through persulfidating EBF2 March 20, 2026
  Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE262992 Chronic stress induces neural stem cell quiescence in the hippocampus by repressing Ascl1 expression [RNA-seq] March 20, 2026
  Contributors : Wan Zhang ; Jialan Yuan ; Hang Peng ; Huanhuan Dong ; Jing Liu ; Feng ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChronic stress inhibits neurogenesis, yet its impact on neural stem cells (NSCs) remains poorly understood. Here, using the 5-bromo-2′-deoxyuridine (BrdU) label-retaining assay, we fo […]
• GSE262365 ZNF638 represses HBV covalently closed circular DNA transcription involving HUSH complex epigenetic silencing March 20, 2026
  Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensHepatitis B virus (HBV) infection represents a significant public health burden worldwide. Covalently closed circular DNA (cccDNA) is the transcriptional template of HBV, which interacts with both host and viral proteins to form minichromosome in the nucleus […]
• GSE287612 p53 safeguards chemical reprogramming of human somatic cells towards pluripotency [bulk RNA-seq] March 20, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCell fate manipulation is powerful for generating desired cell types through reprogramming, such as induced pluripotent stem cells (iPSCs), with broad biological applications. However, reprogramming can be risky due to dramatic changes in cell identity, necessitating stric […]
• GSE276119 Hyperinnervation inhibits organ-level regeneration in mammalian skin March 20, 2026
  Contributors : Hannah T Tam ; Jingyu Peng ; Rebecca Freeman ; Yulia Shwartz ; Shlomi Brielle ; Sakshi Garg ; Siti Rahmayanti ; Stephen Crocker ; Devin Coon ; Ya-Chieh HsuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSome mammalian tissues can replace lost cells within one lineage, but organ-level regeneration—restorin […]
• GSE194141 Landscape of mitochondrial RNA binding proteome March 20, 2026
  Series Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE325371 SlCAX3 drives the formation of crystal idioblasts for tomato ion compartmentalization under salt stress March 20, 2026
  Contributor : Ruiqiang XuSeries Type : Expression profiling by high throughput sequencingOrganism : Solanum lycopersicumSoil salinization is a primary constraint on global agricultural productivity. While the mechanisms of root ion exclusion and whole-plant long-distance transport are well established, how photosynthetic leaf tissues complexly adapt to high- […]
• GSE323969 The RNA-binding protein TRA2B promotes colon cancer progression by modulating Dicer-dependent miRNA biogenesis. March 20, 2026
  Contributor : Yuki KuwanoSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensTo identify TRA2B-related miRNAs in colon cancer cells, we examined the miRNA expression profiles of TRA2B-knockdown HCT116 cells
• GSE322740 Dynamin-related protein AoVps1 mediating mitochondrial fission in complex with AoMdv1 is necessary for mitochondrial morphology, mitophagy, conidiation, trap formation, and energy metabolism of Arthrobotrys oligospora March 20, 2026
  Contributors : Xuemei Li ; Le Yang ; Lirong Zhu ; Xuewei Yang ; Meichen Zhu ; Jinkui YangSeries Type : Expression profiling by high throughput sequencingOrganism : Orbilia oligosporaMitochondrial fission is critical for organelle homeostasis and cellular differentiation. Here, we functionally characterized the mitochondrial fission-related proteins AoMdv1 an […]
• GSE324746 Multi-omics profiling reveals systemic rejuvenation of the aged kidney through senolytic therapy March 20, 2026
  Contributor : Yao XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCellular senescence is a key driver of kidney aging, leading to functional decline and increased susceptibility to chronic kidney disease. While the senolytic combination of dasatinib and quercetin (D+Q) has shown promise in mitigating age-related patho […]
• GSE324634 Effect of L-PGDS loss on cellular response during cuprizone induced demyelination March 20, 2026
  Contributors : Takese McKenzie ; Jian HuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusL-PGDS is a secretory oligodendrocyte protein; we aimed to determine how the loss of this protein affected the transcriptome of different cell populations during demyelination. We found that very distinct changes in the microglial tr […]
• GSE324926 GLS1 governs vascular smooth muscle cell phenotypic switching and aortic dissection via glutamate metabolism March 20, 2026
  Contributors : Wei Xie ; Hailong CaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo evaluate the roles of glutaminase 1 (GLS1) in vascular smooth muscle cells (VSMCs) phenotypic switching and aortic dissection (AD). Integrative transcriptomic analyses were performed to identify the candidate genes involved in VSMC ph […]
• GSE324980 Mackerel muscle cell lines (Mack1 and Mack2) before and after immortalization and in different phenotypes March 20, 2026
  Contributors : Saad Michael K ; Bromberg Benjamin HSeries Type : Expression profiling by high throughput sequencingOrganism : Scomber scombrusBulk RNA sequencing data was obtained from two Atlantic mackerel (Scomber scombrus) muscle cell lines, Mack1 and Mack2, at pre-immortalization and post-immortalization passages. Mack1 cells were at passages 27 and 77 a […]
• GSE325281 Adenovirus phagocytosis by neutrophils triggers a pro-inflammatory response March 20, 2026
  Contributors : Laurans Salomé ; Remy Jeulin ; Benihoud Karim ; Dupré-Crochet SophieSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo determine if transcriptional changes also occur during human neutrophils adenoviruses interaction, a single-cell RNA sequencing study was performed on blood purified PMNs exposed to human […]
• GSE242242 CarS2 mediated cysteine catabolism drives brown fat development and thermogenesis through persulfidating EBF2 [AKO and wt Acute cold] March 20, 2026
  Contributors : Xuyun Zhao ; Hongyong Song ; Xin PengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTargeting transcriptional regulatory complex is a promising strategy to activate thermogenic fat and treat obesity. In this study, we focus on identifying critical and special metabolic pathways enriched during brown adip […]