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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE298572 From degraded to deciphered: Applying ATAC-seq to forensic molecular diagnosis under degradation conditions June 4, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCurrent molecular diagnostic techniques in forensic science are significantly hindered by DNA degradation, underscoring the urgent need for robust molecular tools with resistance to degradation. In our previous study using a murine traumatic brain injury (TBI […]
- GSE296819 Targeting transcriptional addiction to pro-proliferative programs in pancreatic cancer [ChIPmentation] June 4, 2026Series Type : OtherOrganism : Homo sapiensThe pancreas is a special organ which is considered both endocrine and exocrine. The exocrine pancreas gives rise to pancreatic ductal adenocarcinoma (PDAC), which accounts for the majority of pancreatic cancer cases. In recent years, various new therapeutic options for cancer patients have resulted in increased surv […]
- GSE253448 snRNAseq of mouse kidney from proximal tubule ACE KO mice June 4, 2026Contributors : Jonathan Nelson ; Jacqueline Emathinger ; Susan GurleySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusACE2, a membrane-bound monocarboxypeptidase with high affinity for angiotensin II (AngII), is highly expressed in the renal proximal tubule (PT). Previously, we reported elevated renal AngII levels associ […]
- GSE298973 Transcriptomic Profiling of HRMVPC and HRMEC Co-culture Under Normal and High Glucose Conditions June 4, 2026Contributors : Xiaoqin Shi ; Siyan Liu ; Hongmei Deng ; Zhiyuan Wang ; Hongbin LvSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe investigated the transcriptomic alterations in human retinal microvascular pericytes (HRMVPC-Immortalized) exposed to normal and high glucose conditions, with or without co-culture with hum […]
- GSE280179 The restricted N-glycome of neurons is programmed during differentiation June 4, 2026Contributors : Cetinbas Murat ; Sadreyev Ruslan ; Mealer RobertSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe protein glycome of individual cell types in the brain is unexplored, despite the critical function of these modifications in development and disease. In aggregate, the most abundant asparagine (N-) linked g […]
- GSE264037 Pcbp1 is crucial for Naïve-to-Primed pluripotency transition due to regulation of carbohydrate and amino acid metabolism June 4, 2026Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE333874 Small RNA sequencing reveals placental miRNAs linked to congenital transmission of Trypanosoma cruzi June 4, 2026Contributors : Andrea Diestra ; Alejandra Pando-Caciano ; Fredy Tinajeros ; Carla A Apaza-Quiroz ; Viviana Pinedo ; Vanessa Adaui ; Robert Gilman ; Natalie Bowman ; Mónica Pajuelo-TravesañoSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensBackground: Congenital transmission remains an important source of new Chagas di […]
- GSE296808 Targeting transcriptional addiction to pro-proliferative programs in pancreatic cancer [RNAKD] June 4, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe pancreas is a special organ which is considered both endocrine and exocrine. The exocrine pancreas gives rise to pancreatic ductal adenocarcinoma (PDAC), which accounts for the majority of pancreatic cancer cases. In recent years, various new therapeutic options for ca […]
- GSE334206 STK25 m6A modification regulates CD4+ T cell glycolysis mediated immune imbalance in systemic lupus erythematosus June 4, 2026Contributors : Ming Li ; Yunfei Li ; Lijun Pang ; Junjie Chen ; Shuangshuang Shang ; Chuanbing HuangSeries Type : OtherOrganism : Homo sapiensSystemic lupus erythematosus (SLE) is a complex autoimmune disease with an incompletely understood pathogenesis. N6-methyladenosine (m6A) has been implicated in immune regulation and disease progression, yet its role i […]
- GSE333959 m6A reader IGF2BP3 promotes endometrial cancer progression through modification circ-EPB41L2 June 4, 2026Contributor : Shanrong ShuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEndometrial cancer ranks as the primary contributor to cancer related fatalities on a global scale. IGF2BP3 is a reader protein of m6A modification and plays an important role in the carcinogenesis of many solid tumors. Here, we explored the role […]
- GSE334209 Gene expression during overexpression of ArPHR2/4 in Anoectochilus roxburghii Leaves June 4, 2026Contributors : Shuguang Wang ; Aimin Lv ; Yi Zhang ; Hao LiSeries Type : Expression profiling by high throughput sequencingOrganism : Anoectochilus roxburghiiArPHR2/4 acts as the core transcription factors in response to phosphorus starvation. They regulate the responsive signaling pathways, especially the phosphorus signaling cascade, thereby modulating the […]
- GSE334279 RPL27 promotes gastric cancer progression by enhancing oxidative phosphorylation via FMC1 June 4, 2026Contributor : Yan ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGastric cancer remains one of the leading causes of cancer-related mortality worldwide, highlighting the urgent need for novel biomarkers and therapeutic targets. Ribosomal proteins have emerged as critical regulators of tumorigenesis beyond their ca […]
- GSE334363 PDE5a Inhibition Restricts Cancer Metastasis by Disrupting NPC1-Mediated Cholesterol Trafficking Through a Non-canonical cGMP-Dependent Pathway June 4, 2026Contributors : Yarden Ariav ; Ray Lipika ; Sinha Sanju ; Ruppin Eytan ; Crawford David ; Erez AyeletSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo evaluate the effects of Sildenafil Citrate on the transcriptome, we performed differential gene expression profiling on three different cancer cell lines: 4T1 (breast car […]
- GSE296816 Targeting transcriptional addiction to pro-proliferative programs in pancreatic cancer [ChIPmentation organoid] June 4, 2026Series Type : OtherOrganism : Homo sapiensThe pancreas is a special organ which is considered both endocrine and exocrine. The exocrine pancreas gives rise to pancreatic ductal adenocarcinoma (PDAC), which accounts for the majority of pancreatic cancer cases. In recent years, various new therapeutic options for cancer patients have resulted in increased surv […]
- GSE333851 Spatial Glyco-Codes Define Human Liver Pathology and Progression June 4, 2026Contributor : Xiaolong TianSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensGlycosylation is a relatively underexplored aspect of the central dogma of biology, yet a key determinant of biological function and encodes disease-associated cellular states. However spatial glycomics is limited primarily by workflows t […]