Category: PubMeD- NCBI2

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE304591 Regulatory Mechanisms Driving the Transcriptome of E. coli under Rifampicin August 20, 2026
  Contributors : Rahul Jagadeesan ; Miguel M Azevedo ; Amir M Arsh ; Andre S RibeiroSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coli str. K-12 substr. MG1655Rifampicin hampers transcription, disrupting bacterial gene regulatory networks (GRN). Using RNA-seq, We investigated whether the GRN of susceptible E. coli has m […]
• GSE303909 Growth plate morphogens as potential modulators of cellular tissue remodeling by annulus fibrosus cells August 20, 2026
  Contributors : Kaja Stradovnik-Poikilidis ; Frank M Riemers ; Marina van Doeselaar ; Jasper Foolen ; Florencia Abinzano ; Michelle Teunissen ; Marianna A Tryfonidou ; Sebastien J Callens ; Keita ItoSeries Type : Expression profiling by high throughput sequencingOrganism : Bos taurusBackground: Adolescent Idiopathic Scoliosis (AIS) is a spinal deformity of un […]
• GSE309280 Transcriptome analysis of osteoclast differentiation in mice (single-cell RNA-seq) August 20, 2026
  Contributor : Liyan MeiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTranscriptome analysis of osteoclast differentiation in mice (single-cell RNA-seq)
• GSE306019 Genetic deletion of Usp22 in KRASG12D-p53-null driven mouse lung cancer [Visium] August 20, 2026
  Contributors : Keqiang Zhang ; Ching Ouyang ; Jinhui Wang ; Walter Tsark ; Dan RazSeries Type : OtherOrganism : Mus musculusUbiquitin-specific peptidase 22 (USP22), a deubiquitinase and component of the “Death-By-Cancer” 11-gene signature, is overexpressed in multiple cancers and linked to recurrence, therapy resistance, and poor prognosis. While its role in […]
• GSE343966 Single-Cell Transcriptomic Profiling of Immune Cells from Parental and EMP1-Deficient MB49 Bladder Tumors. August 20, 2026
  Contributors : Pengju Gong ; Jingwen Yang ; Leng Han ; Liuqing Yang ; Chunru LinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn this study, we employed a single-cell RNA sequencing (scRNA-seq) approach using the 10x Genomics platform to investigate the immune microenvironment of syngeneic mouse bladder tumors. Tumors […]
• GSE313502 Direct RNA sequencing of in vitro transcribed mRNA modified with 5-methoxyuracil August 20, 2026
  Contributors : Jonathan Miles ; Eleanor Bellows ; Sarah Masterson ; Rupert Fray ; James Button ; George Thom ; Nathan ArcherSeries Type : OtherOrganism : synthetic constructThe aim of this study was to understand potential biases in the incorporation of modified nucleotides, specifically 5-methoxyuracil, in in vitro transcription reactions by different T7 po […]
• GSE338361 Transcriptomic profiling of PBS-treated and MANF-reprogrammed mouse BMDMs August 20, 2026
  Contributors : Dongyan Zhao ; Yufang Shi ; Rui LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate whether MANF directly regulates macrophage phenotypes, we treated maturing bone marrow-derived monocytes\macrophages (BMDMs) with MANF or PBS.
• GSE275525 Redefining HexR regulatory landscape in Pseudomonas putida through integrative systems biology [RNA-Seq] August 20, 2026
  Contributors : Linh Khanh Nong ; Donghyuk KimSeries Type : Expression profiling by high throughput sequencingOrganism : Pseudomonas putidaPseudomonas putida strains are highly valued biocatalysts due to their abilities to degrade various chemicals, tolerate organic solvents, and resist environmental stressors. Fine–tuning the regulation of primary carbon met […]
• GSE343667 Lgr4 maintains Lgr5+ crypt base columnar cell identity required for intestinal homeostasis and regeneration [RNA-Seq] August 20, 2026
  Contributors : Nuray Gunduz ; Kathryn Gilroy ; Rosalin J Simpson ; Owen J SansomSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe intestinal epithelium is amongst the most rapidly self-renewing epithelia in mammals. Wnt signalling is known to be essential for intestinal homeostasis and regeneration. However, the under […]
• GSE343665 Lgr4 maintains Lgr5+ crypt base columnar cell identity required for intestinal homeostasis and regeneration [scRNA-seq] August 20, 2026
  Contributors : Nuray Gunduz ; Hannah Tovell ; Kathryn Gilroy ; Rosalin J Simpson ; Owen J SansomSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe intestinal epithelium is amongst the most rapidly self-renewing epithelia in mammals. Wnt signalling is known to be essential for intestinal homeostasis and regeneration. Ho […]
• GSE343668 P7 hippocampal bulk RNA-seq after neonatal D-betaHB replacement and early maternal TUDCA intervention August 20, 2026
  Contributors : Yu-Hang Zhang ; Hao LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis submission contains P7 mouse hippocampal bulk RNA-seq libraries used to evaluate hippocampal transcriptional states associated with neonatal beta-HB availability in a maternal MASLD model. The libraries include a D-betaHB derivati […]
• GSE343669 Multimodal analysis of CD38 in T-cell Acute Lymphoblastic Leukemia Identifies Combinatorial Therapeutic Strategies August 20, 2026
  Contributors : Rawan Shraim ; Caroline DiorioSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOutcomes for pediatric patients with refractory or relapsed T-cell acute lymphoblastic leukemia (T-ALL) are poor, underscoring the need for improved therapeutic strategies. CD38, a type II transmembrane glycoprotein, is a promis […]
• GSE343708 Single-Cell RNA Sequencing of Bone Marrow Cells with Altered CNP Signaling in Mice. August 20, 2026
  Contributors : Pengju Gong ; Yamei Chen ; Leng Han ; Liuqing Yang ; Chunru LinSeries Type : OtherOrganism : Mus musculusIn this study, we employed CellPlex single-cell RNA sequencing using the 10x Genomics Chromium Single Cell 3′ platform to investigate how altered NPR3 signaling affects the bone marrow cellular landscape. Bone marrow cells were collected fr […]
• GSE300205 Prophylactic Lalba mRNA-LNP vaccination prevents the progression of early breast lesions August 20, 2026
  Contributors : Jun Nishida ; Kornelia PolyakSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusWe hypothesized that prophylactic vaccination targeting the potential cell-of-origin of breast cancer may contribute to the suppression of early tumorigenesis. Here, we developed lipid nanoparticle (LNP)-encapsulated mRNA va […]
• GSE337979 The pth gene as a clinical biomarker for bacterial antibiotic tolerance August 20, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Escherichia coliPersister cells pose severe threats and serve as the primary driver of chronic and recurrent infections. Nevertheless, clinical laboratories rarely quantify persister fractions of pathogenic bacteria at present, due to limited detection approaches and scarce available […]