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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE290072 Thyroid hormones act as a timer for the postnatal maturation of parvalbumin neurons in mouse neocortex [RUN125] April 22, 2026Contributors : Juan Ren ; Suzy Markossian ; Romain Guyot ; Denise Aubert ; Jiemin Wong ; Frédéric Flamant ; Sabine RichardSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA finely tuned balance between excitation and inhibition is essential for proper brain function. Disruptions in the GABAergic system, which alter this […]
- GSE284102 Suppression of UCP2 alleviates leukemogenesis by enhancing branched amino acids induced oxidative stress via activating PI3K/AKT/mTOR signaling April 22, 2026Contributors : Ma Jiao ; Innocent-Okohi Agida ; Zizhen XuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlthough the cellular role of uncoupling protein 2 (UCP2) in tumorigenesis have been reported in various solid tumor models, its role in leukemogenesis remain elusive. Here, we demonstrated that UCP2 was highly expre […]
- GSE298347 Single-cell RNA sequencing of microglia/macrophages in zebrafish pde6c mutant eyes April 22, 2026Contributors : Darshini Ravishankar ; Yuki Takeuchi ; Ichiro MasaiSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioWe performed single-cell RNA sequencing of microglia/macrophages from eyecups of zebrafish pde6c mutant and their siblings at two time points, 5 days post fertilization and 4 weeks post fertilization using th […]
- GSE295400 Engineering perfusable vascular networks in organoids-on-chip [bulk RNA-seq] April 22, 2026Contributors : Clement Quintard ; Josef M PenningerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensVascular networks are critical for the development and maintenance of human tissues, as they support metabolism and regulate tissue growth and function. In vitro models such as organoids and organs-on-chip often have a lim […]
- GSE307522 Comprehensive Molecular and Functional Analysis of NUTM1-Rearranged Leukemia [methylation array] April 22, 2026Contributors : Koutarou Nishimura ; Masaki Nomura ; Weijia Zang ; Daichi InoueSeries Type : Methylation profiling by arrayOrganism : Mus musculusNUTM1-rearrangement (NUTM1-r) defines a significant subset of B-cell acute lymphoblastic leukemia (B-ALL), particularly in infants lacking KMT2A-rearrangements (KMT2A-r), yet its underlying molecular characteristics […]
- GSE303312 Expression profiling of human gastric cancer cells after glucose deprivation April 22, 2026Contributor : Jide WangSeries Type : Non-coding RNA profiling by array ; Expression profiling by arrayOrganism : Homo sapiensGlucose deprivation is a common feature in tumors. To investigate the differential expression of ncRNAs and protein-coding genes under glucose-deprivation conditions, human gastric cancer cells were cultured in low-glucose or normal-gl […]
- GSE328461 Osteopontin links acquired resistance to hypoxia-inducing antiangiogenics with refractoriness to anti-PD-L1 agents in breast cancer April 22, 2026Contributors : José Luis Ruiz-Sepúlveda ; Verónica Jiménez-Renard ; Rebeca Jimeno ; Miguel Quintela-FandinoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusResistance to antiangiogenics is a major challenge in cancer therapy. These agents can either normalize or exacerbate tumor vascular abnormality and hypoxia. The mech […]
- GSE261942 Identification of PLXNC1 as a novel biomarker for Consensus Molecular Subtype 4 in colorectal cancer April 22, 2026Contributors : Min Yang ; Weiqi Wang ; Mingxuan ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusColorectal cancer (CRC) is the third most diagnosed cancer worldwide. Tumor heterogeneity often causes inconsistent outcomes and drug responses among patients with CRC. Although a recent unified transcriptomic classificat […]
- GSE328504 CBFA2T3-GLIS2 fusion-mediated mSWI/SNF chromatin remodeler disruption generates cancer-specific dependencies in AMKL [ATAC-Seq] April 22, 2026Contributors : Gabe Boyle ; Alexander W Ying ; Jay SarthySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTranscription factor (TF) fusion oncoproteins are frequently associated with poor prognosis and remain challenging therapeutic targets. Here we show that the CBFA2T3-GLIS2 (C/G) fusion oncoprotein prese […]
- GSE328503 CBFA2T3-GLIS2 fusion-mediated mSWI/SNF chromatin remodeler disruption generates cancer-specific dependencies in AMKL [RNA-Seq fhd286] April 22, 2026Contributors : Gabe Boyle ; Alexander W Ying ; Jay SarthySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTranscription factor (TF) fusion oncoproteins are frequently associated with poor prognosis and remain challenging therapeutic targets. Here we show that the CBFA2T3-GLIS2 (C/G) fusion oncoprotein present in lethal p […]
- GSE328578 CBFA2T3-GLIS2 fusion-mediated mSWI/SNF chromatin remodeler disruption generates cancer-specific dependencies in AMKL April 22, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE328635 PFKFB3 promotes kidney fibrosis through histone lactylation-mediated HIPK2 activation in diabetic kidney disease April 22, 2026Contributors : Mingkun Xu ; Linhang Fu ; Yulong Zhang ; Xiuli Guo ; Han Wu ; Sijing Gao ; Fei XiaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensPersistently enhancement of glycolytic activity has been increasingly implicated as a key contributor to the development of diabetic kidney disease (DKD). Lactat […]
- GSE328660 Lactate-Induced H3K18 Lactylation Drives CX3CL1-Mediated Immune Cell Recruitment in Sepsis-Associated ARDS April 22, 2026Contributors : Shi Zhang ; Yuanyuan ZhangSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensSepsis is characterized by lactate accumulation and immune dysfunction, but the molecular mechanisms linking lactate to chemokine expression remain unclear. Here, we […]
- GSE277513 A novel histone H3K27 reader, CBFA2T2, inhibits H3K27me3 demethylation and tumor growth by regulating metabolic genes and metabolite levels [RNA-seq] April 22, 2026Contributors : Shengfei He ; Rui GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHistone H3.1/3.2K27M and H3.3K27M mutation are driver mutations frequently identified in diffuse midline glioma (DMG). However, the precise mechanism by which H3K27M mediates tumorigenesis remains incompletely understood. By carrying out […]
- GSE328432 Transcriptomic analysis of HEK-293 cells subjected to prolonged mild acidification (pH 6.6) and treatment with an SR protein kinase inhibitor (SRPIN340) April 22, 2026Contributors : Anastasia N Kazakova ; Margarita E Bogomiakova ; Iuliia I PavlovaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAcidosis, the hallmark of aggressive cancer and chronic inflammation, is associated with altered transcription and alternative splicing. These alterations may be due to the repressed release of […]