Category: PubMeD- NCBI2

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE189489 RNAseq data of mouse B16-F10 melanoma cell lines after siEzh2 knockdown or GSK126 methyl-transferase inhibitor or DZNep treatment July 2, 2026
  Contributors : Gamze K Abali ; Peinan Zhao ; Nicholas C Wong ; Mark ShackletonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEnhancer of zeste homolog 2 (EZH2) plays critical roles in the progression of many malignancies including melanoma. The most well-known EZH2 mechanism is regulating gene expression through cataly […]
• GSE271348 Mapping the Immune Modulation Landscape Induced by Sanguisobae Radix at Single-Cell Resolution July 2, 2026
  Contributors : Dale Guo ; Lijun Huang ; Yumei Wang ; Fang Deng ; Yan Zhang ; Yun Deng ; Dong WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSanguisorbae radix (SR), a traditional Chinese medicine, is commonly used in China to enhance human immunity. Yet, its effects and underlying mechanisms on various types of imm […]
• GSE271310 Role of RXRg in NSC-derived OPCs and their differentiation July 2, 2026
  Contributor : Vito BaldassarroSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRXRg is positive regulator of oligodendrocyte progenitor (OPC) differentiation. To address molecular underpinnings of this regulation we performed analyses of the effects of RXRg deletion (RXRgKO) as a function of 24hrs T3 treatment (different […]
• GSE307781 T follicular helper 1 cells in blood potentially mirror salivary gland-infiltrating T cells in Sjögren’s disease July 2, 2026
  Contributors : Saori Abe ; Hiroto Tsuboi ; Hiroyasu AokiSeries Type : OtherOrganism : Homo sapiensUnderstanding the intricate relationship between peripheral blood immune profiles and the inflammatory environment within affected tissues is pivotal for uncovering mechanisms driving autoimmune diseases. This study aimed to characterize CD4+ T cell subsets in p […]
• GSE301483 HT-29 cells exposed to lead ion by transcriptome July 2, 2026
  Contributors : Suwei Jiang ; Hailiang HuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe study involved dividing cells into two distinct groups: a treatment group (T) exposed to 8 mM lead acetate, based on previous literature, and a control group (C) treated with a solution that did not contain lead acetate. Transcri […]
• GSE332845 Expression data of hippocampal neural stem cells from rat July 2, 2026
  Contributors : Itsuki Kageyama ; Hiroya Yamada ; Mirai Yamazaki ; Takuya Wakasugi ; Yuri Kamiya ; Masaki Ohshiro ; Manaka Ito ; Yoshiki Tsuboi ; Takashi Watanabe ; Genki Mizuno ; Yoshitaka Ando ; Hiroaki Ishikawa ; Koji Suzuki ; Koji Ohashi ; Eiji MunetsunaSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusNeural stem cells (NSCs) are ess […]
• GSE309674 STING deficiency does not rescue short-telomere mediated aging phenotypes and longevity in TERC or TERT telomerase deficient mice July 2, 2026
  Contributors : Rosa M. Marión ; José Carlos González ; Maria A. BlascoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe c-GAS-STING pathway is proposed to have a key physiological role in the response to viral genomes and other types of endogenous DNA byproducts by inducing inflammatory pathways. More recently a role […]
• GSE333973 Topical Vascular Organoid Therapy Promotes Microvascular Regeneration and Functional Recovery in Porcine Ischemic Cardiomyopathy July 2, 2026
  Contributors : John A Farag ; Yujiro Kawai ; Koji Kawago ; Eric Pfrender ; Umayr Syed ; Yasuhiro ShudoSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaBackground: Ischemic heart disease (IHD) remains a leading cause of morbidity and mortality worldwide, with microvascular dysfunction playing a key role in the progression t […]
• GSE336821 Establishment and characterization of patient-derived in-vitro and in-vivo models of penile squamous cell carcinoma July 2, 2026
  Contributors : Linxweiler Johannes ; Ayoubian Hiresh ; Skowron A Margaretha ; Mink Jan ; Stöckle Michael ; Petzsch Patrick ; Heckt Jochen ; Nettersheim Daniel ; Junker KerstinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusTissue samples from patients with penile squamous cell carcinoma were used to gener […]
• GSE336827 Alpha-melanocyte-stimulating hormone and its impact on myeloid-derived suppressor cells July 2, 2026
  Contributors : Anna-Galina Arndt ; Karin LoserSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMyeloid-derived suppressor cells (MDSCs) are key mediators of tumor-associated immune suppression. Alpha-melanocyte-stimulating hormone (α-MSH) is a neuropeptide with immunomodulatory properties that has been shown to reduce MD […]
• GSE336861 ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer [scRNA-seq] July 2, 2026
  Contributors : Feiya Ou ; Kenneth M MurphySeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThe transcriptional regulator ID2 is required for type 1 classical dendritic cell (cDC1) specification, yet the mechanism has remained obscure. We previously identified the Zeb2 -165-kb enhancer as key to normal hematopoies […]
• GSE337180 Tbx3 controls retinal angiogenesis by driving retinogenesis July 2, 2026
  Contributors : Joao-Carlos Ribeiro-Silva ; Nikita Shah ; Mark L Derbyshire ; Sruti Akula ; Rachel Burt ; Zoe Boyd ; Carmen Lee-Bennett ; Anne S Moon ; Michael E Zuber ; Andrea S ViczianSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRetinal angiogenesis relies on a tightly coordinated sequence of retinogenesis, astrocyt […]