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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE298125 Atorvastatin regulates hepatic transcriptome PXR dependently but distinct from pregnenolone 16α-carbonitrile and does not induce PXR-mediated liver steatosis [ATAC-seq] May 22, 2026Contributors : Heba Nabil ; Einari A Niskanen ; Raghavendra Mysore ; Jorma Palvimo ; Jukka HakkolaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Several drugs induce liver steatosis through pregnane X receptor (PXR)-mediated mechanism. Atorvastatin is a PXR ligand but is still safe even in patients with metabolic dys […]
- GSE316911 Gene expression data from Human Nasal Epithelial Cells (hNECs) treated with 100 μM linalyl acetate (LA) May 22, 2026Contributor : Farhana FerdousiSeries Type : Expression profiling by arrayOrganism : Gene expression profiling reveals induction of target olfactory receptor gene expression in hNECs by LAWe evaluated the effects of LA on hNECs. We performed an untargeted whole-genome transcriptome analysis to explore functionality of LA in hNECs.
- GSE299220 Rifampicin time-series of Nostoc sp. PCC 7120 under different nitrogen conditions May 22, 2026Contributors : Isidro Álvarez-Escribano ; Manuel Brenes-Álvarez ; Jens Georg ; Agustín Vioque ; Alicia M. Muro-PastorSeries Type : Expression profiling by high throughput sequencingOrganism : The ability of microbes to adapt to highly dynamic environments depends on subtle post-transcriptional regulatory mechanisms. The interaction between antisense RNAs or […]
- GSE268207 Gene expression profile of Radiatiom resistant BRAFV400E type pediatric low-grade gliomas May 22, 2026Contributors : Fuyang Li ; Kathy Bondra ; Zhao Lai ; Hanzhou Wang ; Peter Houghton ; Yidong ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Inhibitors of the MAPK pathway (MAPKi) have shown significant activity in treatment of childhood BRAF-activated brain tumors. However, for tumors harboring BRAFV600E mutations, the drugs ar […]
- GSE331381 Effect of genetic background and limb immobilization on tibial metaphysis transcriptomes in 19‑week male mice May 22, 2026Contributor : Michael A FriedmanSeries Type : Expression profiling by high throughput sequencingOrganism : This study profiles tibial metaphysis RNA expression across eight inbred mouse strains subjected to unilateral hindlimb immobilization. RNA‑seq was performed on metaphyseal tissue from immobilized and contralateral control limbs to identify strain‑speci […]
- GSE298081 The genetic landscape of a human cell reveals conserved topology and principles of genetic networks [RICH] May 22, 2026Contributors : Michael Constanzo ; Maximilian Billmann ; Xiang Zhang ; Brenda Andrews ; Charles Boone ; Jason Moffat ; Chad L MyersSeries Type : OtherOrganism : We generated a genome-scale, genetic interaction network from the analysis of more than 5 million double mutants in the haploid human cell line, HAP1. The network comprises ~90,000 negative and posit […]
- GSE270028 Inner-envelope phosphatidylethanolamine promotes DNA replication and nucleoid- biogenesis in early chloroplast development May 22, 2026Contributors : Weifeng Zhang ; Qianwen SunSeries Type : OtherOrganism : Proplastid-to-chloroplast transitconversion during early plant development involves exintensive genome replication and nucleoid structurale changes of the nucleoid during plant early development. In addition, and the nucleoid distribution shifts from ring-shaped assemblies near the inner […]
- GSE331221 FK506-binding proteins, OsFKBP57 and OsFKBP73, confer salt tolerance through SOS pathway and maintain grain protein content in rice May 22, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Soil salinization poses a serious threat to rice productivity and grain quality. Although moderate increases in grain protein content enhance nutritional value, excessive protein accumulation under salt stress degrades rice quality and reduces consumer acceptability. However, the mole […]
- GSE331215 IL1R1 blockade augments CD40 agonist mediated immunity in pancreatic cancer May 22, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Pancreatic ductal adenocarcinoma (PDAC) has a poor survival rate and limited treatments. Agonistic CD40 antibodies are promising, but clinical trials have shown only modest efficacy and significant hepatotoxicity. We previously reported that IL-1 pathway blockade enhances CD40 agonist […]
- GSE331233 Impact of methionine restricted diet on chromatin accessibility in murine high-grade glioma (3xCr) [scATAC-seq] May 22, 2026Contributors : Brittney Lozzi ; Benjamin DeneenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Single-cell ATAC sequencing (scATAC-seq) was performed on tumor tissue isolated from the cortex of immunocompetent mice bearing high-grade glioma. Animals were maintained on either a control diet or a methionine-restricted d […]
- GSE331223 Δlpp Mutant E. coli Reduces Lipid Content in Caenorhabditis elegans via Phosphatidylglycerol-Mediated Inhibition of Fatty Acid Biosynthesis May 22, 2026Contributors : Dianshuang Zhou ; Zuobin ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : In this study, we integrated in vivo lipid visualization, whole-transcriptome RNA sequencing, and lipidomics to investigate the effects of the Δlpp mutant of Escherichia coli (E. coli) on Caenorhabditis elegans (C. elegans). Our results demon […]
- GSE331257 Histone succinylation directly inhibits Jumonji domain demethylases and stabilizes repressive chromatin states [RNA-Seq] May 22, 2026Contributors : Sarah Graff ; Stephanie Stransky ; Simone SidoliSeries Type : Expression profiling by high throughput sequencingOrganism : We investigate the relationship between histone succinylation and Jumonji C (JmjC) domain-containing histone demethylases, a class of enzymes that catalyzes the removal of histone methylation. By using quantitative proteom […]
- GSE331259 Histone succinylation directly inhibits Jumonji domain demethylases and stabilizes repressive chromatin states [CUT&Tag] May 22, 2026Contributors : Sarah Graff ; Stephanie Stransky ; Simone SidoliSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : We investigate the relationship between histone succinylation and Jumonji C (JmjC) domain-containing histone demethylases, a class of enzymes that catalyzes the removal of histone methylation. By using quanti […]
- GSE331299 DNA methylation either antagonizes or promotes Polycomb recruitment at transposable elements in Arabidopsis May 22, 2026Contributors : Valentin Hure ; Maghnia Kawter Elmir ; Florence Piron-Prunier ; Raphaël Guérois ; Angélique DélérisSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Methylation profiling by high throughput sequencingOrganism : Transposable elements (TEs) are usually silenced by DNA methylation and H3K9me2, but in the absence of […]
- GSE298085 The genetic landscape of a human cell reveals conserved topology and principles of genetic networks. May 22, 2026Series Type : OtherOrganism : This SuperSeries is composed of the SubSeries listed below.