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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE299965 Investigation of the impact of transcription factor SP1,MITF and CREB3L1 in HeLa cells May 13, 2026Contributors : De Cegli Rossella ; Abete DomenicoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOur previous studies on golgi biogenesis identified candidate Transcription Factors(TFs) that can support this process. Further bioinformatical ad in-vitro analysis revealed that MITF,SP1 and CREB3L1 emerged as the mayor TFs […]
- GSE298830 NSD1 governs H3K36me2-mediated DNA methylation and drives differentiation of human iPSCs by regulating lncRNA expression [RNA-seq] May 13, 2026Contributors : Anna Hansknecht ; Martina Mankarious ; Monica Varona Baranda ; Esra Dursun Torlak ; Wolfgang Wagner ; Kira Zeevaert ; Deepika PuriSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEpigenetic regulatory mechanisms, which include histone modifications and DNA methylation, play a central role in development an […]
- GSE330062 Hepatocyte FAM210A deficiency disrupts mitochondrial function and triggers juvenile steatosis with compensatory repair in adulthood May 13, 2026Contributors : Yubo Wang ; Leah Chu ; Feng YueSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMitochondrial dynamics are central to maintaining liver metabolic homeostasis, yet the mechanisms that safeguard mitochondrial integrity during development and metabolic dysfunction remain poorly defined. Here, we identify Fami […]
- GSE325258 Residual p53 in HPV positive cervical cancer cells has gain of function properties May 13, 2026Contributors : Sannia Farrukh ; Nezka Kavcic ; Giulia Canarutto ; Silvano Piazza ; Lawrence BanksSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman papillomavirus (HPV)-positive cervical cancer cells retain residual p53 despite E6-mediated degradation. To investigate whether this residual p53 has gain-of-function pro […]
- GSE288395 De novo Golgi biogenesis requires orchestrated transactivation of Golgi genes May 13, 2026Contributors : Roman Polishchuk ; Rossella De Cegli ; Xabier Bujanda CundinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGolgi biogenesis is a crucial cellular process, yet its study has been hindered by the lack of easy methods to induce massive production of new Golgi units. In this study, we optimized an enzyme ina […]
- GSE330120 HMGB proteins modulate chromatin accessibility to coordinate translational capacity in malaria parasites [ATAC-seq_HMGB] May 13, 2026Contributors : Vera Mitesser ; Adina Heinberg ; Manish Dash ; Victoria Bonnell ; Manuel Llinas ; Ron DzikowskiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Plasmodium falciparumPlasmodium falciparum, the causative agent of the most severe form of human malaria, undergoes a complex life cycle that requires rapid adap […]
- GSE330454 Mechanistic insights into RAN translation within the Huntingtin coding sequence May 13, 2026Contributors : Amy Krans ; Richard M Albertson ; Connor Maltby ; Peter K ToddSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNucleotide repeat expansions support the production of toxic peptides from putatively non-coding regions of the human genome in the absence of an AUG initiation codon. This process, known as repea […]
- GSE297089 The lncRNA BAMBOO decoys NF-YA2 transcription factor from the promoter of its targets in Arabidopsis lateral roots May 13, 2026Contributors : Andana Barrios ; Aurélie Christ ; Natanael Mansilla ; Moussa Benhamed ; Jérémie Bazin ; Martin Crespi ; Federico ArielSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaPlant developmental plasticity emerges from transcriptional repro […]
- GSE330517 RNA-seq analysis of BMDMs from WT and Lcn10-KO mice May 13, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBone marrow-derived macrophages (BMDMs) were isolated from wild-type (WT) and Lipocalin 10 knockout (Lcn10-KO) mice and subjected to RNA-seq to investigate the transcriptional alterations associated with Lcn10 deficiency in macrophages. Total RNA was extracted from culture […]
- GSE330455 Systems analysis reveals alternate metabolic states adopted by Mycobacterium tuberculosis across species May 13, 2026Contributors : Jonathan Padilla-Gomez ; Rachel A McGinn ; Yisha Liang ; Kendra Libby ; Alison E Ringel ; Charles Evavold ; Bryan D BrysonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculus ; Mycobacterium tuberculosisMycobacterium tuberculosis (Mtb) persists within macrophages, yet how different host species […]
- GSE330527 Full length transcriptome sequencing of salivary glands of Pteromalus puparum May 13, 2026Contributors : Chun He ; Jiamin ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Pteromalus puparumAnimal saliva provides an excellent model for studying adaptive evolution, yet the functional significance of alternative mRNA isoforms in parasitoid salivary systems remains poorly understood. Here, using integrative full-length tr […]
- GSE330550 CRISPR-mediated engineering of bovine satellite cells for AGS-compatible cultivated meat May 13, 2026Contributors : Susan D’Costa ; Shailesh K Choudhary ; Grace E Kenney ; Jacqueline Shine ; Brian Diekman ; Scott P Commins ; Douglas H PhanstielSeries Type : Expression profiling by high throughput sequencingOrganism : Bos taurusAlpha-gal Syndrome (AGS) is a potentially life-threatening allergy caused by an IgE-mediated immune response to galactose-α-1,3-gala […]
- GSE330551 Th2-primed innate immune amplification defines a distinct atopic dermatitis endotype May 13, 2026Contributors : Matthias Hübenthal ; Ellen van den Bogaard ; Teemu Rintala ; Heming Xing ; Vittorio Fortino ; Péter Oláh ; Jan Hartmann ; Merrick Strotton ; Nora Langreder ; Jaimy Klijnhout ; Rowann Bowcutt ; Sandro Bruno ; Virendra Chaudhri ; Ilka Hoof ; Erin Macdonald-Dunlop ; Wouter Ouwerkerk ; Juan Luis Trincado ; Martin Pook ; Thomas Litman ; Klemens Vie […]
- GSE298153 SOX4 Mediated Differentiation of Specific T Lymphocyte Subsets at the Maternal-Fetal Interface Contributes to Preterm Labor May 13, 2026Contributors : Kaiyi Sun ; Lu GaoSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe initiation of labor and preterm labor is a complex and precise physiological process involving a well-orchestrated dialogue between the mother and fetus. Immunological t […]
- GSE330449 Reprogramming Bacterial Energetics Reverse Lactate-Mediated Immunosuppression for Synergistic Cancer Immunotherapy May 13, 2026Contributors : Jing Zhao ; Nuo Zhang ; Lingfeng Qin ; Wei Wei ; Xiuxiu Wang ; Jingjing Liu ; Jing WangSeries Type : Expression profiling by high throughput sequencingOrganism : Shewanella oneidensis MR-1The immunosuppressive tumor microenvironment (TME), driven by lactate accumulation, critically limits cancer immunotherapy efficacy. Here, we engineered Shew […]