Category: PubMeD- NCBI2

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE297553 Loss of endothelial ALK1 signaling induces the emergence of a KIT+ angiogenic endothelial cluster driving brain arteriovenous malformations June 11, 2026
  Contributors : Elise Drapé ; Gael Cagnone ; Alexandre DubracSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground Hereditary Hemorrhagic Telangiectasia type 2 (HHT2) is a genetic disorder caused by mutations in the Alk1 (Acvrl1) gene, encoding a receptor for Bone Morphogenetic Proteins 9 and 10 (BMP9/BMP10). HHT2 p […]
• GSE302417 Distinct roles of COPI proteins attenuated with cell senescence June 11, 2026
  Contributors : Krystyna Mazan-Mamczarz ; Eleanor J Wind ; Apala Pal ; Kyoung-Mi Kim ; Rachel Munk ; Chang-Hoon Shin ; Jennifer L Martindale ; Jixiang Lang ; Qiong Meng ; Martina Rossi ; Marika Oksanen ; Sarah Buchman ; Braden Daugherty ; Yulan Piao ; Jinshui Fan ; Supriyo De ; Lu Chen ; Madhu Lal-Nag ; Myriam GorospeSeries Type : Expression profiling by high […]
• GSE299590 Clonal dynamics reveal cancer resistance arises from adaptive programs [CROP-Seq] June 11, 2026
  Contributors : Haiyin Li ; Yeqing Chen ; Jessica Kaster ; Maggie Dunne ; Min Xiao ; Ling Li ; Monzy Thomas ; Nazifa Promi ; Dylan Fingerman ; Gregory S Brown ; Xingyue Zhu ; Meenhard HerlynSeries Type : OtherOrganism : Homo sapiensMost advanced cancers initially respond to targeted therapies but eventually relapse1. Rather than acquiring new mutations, resis […]
• GSE304040 Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway that Can Rejuvenate RPEs and Restore Vision [GSTA4_RNA-seq_3] June 11, 2026
  Contributor : Yuancheng Ryan LuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOct4, Sox2, and Klf4 (OSK) Yamanaka factors induce pluripotency and reverse age-related epigenetic changes, yet the mechanisms by which they promote rejuvenation remain poorly explored. Oxidative stress contributes to CNS aging and retinal pi […]
• GSE303750 A systemic role of macrophage-derived BMP2/4 homolog Dpp in controlling sterol hormone synthesis under dietary stress June 11, 2026
  Contributors : Sergio Juarez-Carreño ; Marco MilánSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterHigh-caloric diets, prevalent in Western societies, are characterized by their affordability, yet they hinder overall development and compromise adult physiological performance. Unfortunately, children consuming […]
• GSE256044 IRG1/itaconate axis modulates lung tumor microenvironment via pentose phosphate pathway [sav25] June 11, 2026
  Contributors : Siavash Mansouri ; Rajkumar SavaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTumor-associated macrophages (TAMs) are an important component of the immune milieu within the lung tumor microenvironment (TME) and have both tumor-promoting and tumor-inhibiting functions. However, the exact mechanisms unde […]
• GSE304044 Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway that Can Rejuvenate RPEs and Restore Vision June 11, 2026
  Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE331511 Screening and functional study of genes related to tuberculous ulcers June 11, 2026
  Contributor : Zihui HuangSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensTranscriptome analysis was performed to systematically compare human tuberculous ulcers with non-tuberculous skin ulcers. Focusing on the former, this study aimed to identify key associated genes, elucidate their expression profiles and functional attributes, and p […]
• GSE331146 Ketohexokinase deletion on liver and small intestine transcriptome June 11, 2026
  Contributor : Ming SongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDietary fructose is a major risk factor driving the progression of metabolic dysfunction-associated steatohepatitis (MASH) and hepatocellular carcinoma (HCC). However, the underlying fructose-induced nutrient-sensing pathway has remained unclear. Her […]
• GSE334383 Genome-wide RNA binding landscapes of PABPC1 and CCT3 in GC-2spd(ts) and verification of their direct interactions with lncRNA Tug1 June 11, 2026
  Contributors : Lingxiu Tong ; Yiting Ye ; Ke ZhengSeries Type : OtherOrganism : Mus musculusVerification of direct interactions between lncRNA Tug1 and RNA-binding proteins PABPC1 and CCT3 and genome-wide RNA binding maps of PABPC1 and CCT3 in GC-2spd(ts)
• GSE333880 Stromal-immune interactions promote immune suppression in intraperitoneal metastasis of ovarian carcinoma June 11, 2026
  Contributors : Neta Solomon ; Lea Monteran ; Dan Grisaru ; Neta ErezSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHigh-grade serous (tubo-ovarian) carcinoma (HGSC) is the most lethal gynecological malignancy and the most common form of ovarian cancer. Most patients (75%) are diagnosed at advanced disease stages, with […]
• GSE334608 Genome-wide characterization of extrachromosomal circular DNA and its functional role in colon cancer carcinogenesis and progression [miRNA] June 11, 2026
  Contributors : Ji Wang ; Kehan Wang ; Wenbo JiaSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensExtrachromosomal circular DNAs (eccDNAs) are defined as distinct genomic entities of circular and mobile DNA molecules, but their molecular functions in and impact on breast cancer (BC) are rarely known. This study used Ci […]
• GSE334701 Targeting chordoma via an Isocitrate Dehydrogenase-1 dependent susceptibility to redox metabolism June 11, 2026
  Contributor : Sriram VennetiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChordomas are rare cancers that arise along the axial skeleton. Alterations in metabolism are a hallmark of cancer, and we sought to identify metabolic vulnerabilities in chordoma. We discovered that the tricarboxylic acid (TCA)-related enzyme i […]
• GSE334975 Glucokinase activity suppresses hepatic cholesterol synthesis and triglyceride accumulation: A new model for the effects of the GKRP P466L common human variant June 11, 2026
  Contributors : Santoleri Dominic ; Traynor Sarah ; Calhoun Ryan ; Gavin Matthew J. ; Merrick David ; Seale Patrick ; Titchenell Paul M.Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObjective: Glucokinase Regulatory Protein (GKRP) controls the activity of Glucokinase (GCK) to regulate liver glucose uptake and storage. […]
• GSE292770 Prenatal exposure to particulate matter impairs behavior in offspring by reduction of NMDA receptors in hippocampus: Evidence from in vivo and ex vivo studies June 11, 2026
  Contributors : Sung Hoon Lee ; Hye Kyung LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAccumulating evidences with epidemiological and experimental animal studies elicited concerns of environmental exposure to particulate matter (PM) as a risk of neurodevelopmental- and neurodegenerative disorders. Given that the s […]