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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE295680 Expression data from HeLa-Cas9 cells after TLN1 or KD2 loss-of-function April 25, 2026Contributors : Marie Buck-Wiese ; Sally Liechocki ; Vytaute StarkuvieneSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo compare on- and off-target effect of transfected antibodies to gene-editing and RNAinterference, Cas9-expressing HeLa cells were transfected with biomolecules for each method via solid-phase reverse transfectionand RNA e […]
- GSE295591 Lactate and lactylation of RNA splicing factors triggered metabolic code reverse central dogma modulates totipotency development April 25, 2026Contributors : Xingguo Liu ; Keshi Chen ; Linpeng Li ; Yingzhe DingSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTotipotent cells mark the inception of mammalian development and are present in the body for an extremely brief duration. Exploring the regulation of stem cell totipotency would help us to understand the ma […]
- GSE295690 Wnt signaling restores evolutionary loss of regenerative potential in Hydra April 25, 2026Contributors : Sergio E Campos ; Celina E JulianoSeries Type : Expression profiling by high throughput sequencingOrganism : Hydra oligactisThe regenerative potential of animals varies widely, even among closely-related species. In a comparative study of regeneration across the Hydra genus, we found that while most species exhibit robust whole-body regenerati […]
- GSE295682 Prevotella disiens Disrupts Endometrial Function via p38 MAPK-Mediated WNT Inhibition and Tryptophan Metabolism Dysregulation April 25, 2026Contributors : Jiashuo Liu ; Xiaoqin Huang ; Huijia Chen ; Heng Zou ; Shen ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Recurrent implantation failure poses a challenge in assisted reproductive technology, often linked to an imbalance in the endometrial microbiome. Prevotella disiens, a bacterium fou […]
- GSE173505 Differential gene expression during biofilm dispersal by gluocse starvation April 25, 2026Contributors : Praveen K Singh ; Nikolai Peschek ; Kai Papenfort ; Knut DrescherSeries Type : Expression profiling by high throughput sequencingOrganism : Vibrio choleraeIn this study we determined the gene expression of whole genome during glucose starvation of biofilms followed by RNA-sequencing.
- GSE328521 pH Gradient Drives Redox Reactions in the Nucleolar Caps to Modulate Nucleolar Integrity and Function April 25, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEnzymatic catalysis has long been thought of as the primary driver of redox processes in living cells. Biomolecular condensates, formed via phase separation, exhibit unique physicochemical properties that distinguish them from the surrounding milieu. Emerging evidence indi […]
- GSE319366 Detachment-induced gene expression changes in lung adenocarcinoma cell lines, A549 and H441. April 25, 2026Contributors : Toshiro Niki ; Daisuke KomuraSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe aims of the study was to analyze gene expression changes induced by detachment from culture plate.
- GSE262462 Generation of synthetic kidneys from expandable kidney progenitors [Days 5 and 9] April 25, 2026Contributors : Biao Huang ; Zipeng Zeng ; Jincan He ; Sunghyun Kim ; Kari Koppitch ; Jinjin Guo ; Chennan C.Zhang ; Nils O Lindström ; Andrew P McMahon ; Zhongwei LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusKidney is the central organs responsible for maintaining the homeostasis of our body, the sophisticated stru […]
- GSE319718 Detachment-induced gene expression changes in four lung adenocarcinoma cell lines, H2009, LC-2/ad, H2228, and HCC4006. April 25, 2026Contributors : Toshiro Niki ; Ryotaro Sakio ; Daisuke Komura ; Shumpei IshikawaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe aims of the study was to analyze gene expression changes induced by detachment from culture plate. Of the genes upregulated in detached state, we focused on MUC21, a membrane-anchored mucin, […]
- GSE319367 mRNA profile of 6 lung adenocarcinoma cell lines April 25, 2026Contributors : Toshiro Niki ; Daisuke KomuraSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo obatain mRNA profiles of 6 lung adenocarcinoma cell lines
- GSE320438 A novel nanobody-based TCR-like CAR-T therapy targeting PRAME for the treatment of acute myeloid leukemia April 25, 2026Contributors : Xintong Liu ; Jianfeng Li ; Xue Li ; Xuejiao Yang ; Jianqing Mi ; Wenbo Wang ; Yueying WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChimeric antigen receptor (CAR) T-cell immunotherapy in acute myeloid leukemia (AML) remains challenging, primarily due to the lack of specific cell surface antigens t […]
- GSE324273 Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis April 25, 2026Contributors : Vinay Sachdev ; Nienke M van Loon ; Jenina Kingma ; Roelof Ottenhoff ; Josephine Tan ; Marlene van den Berg ; Suzanne Duijst ; Aldo Jongejan ; Johannes Levels ; Patrick Rensen ; Sander Kooijman ; Jan-Freark de Boer ; Folkert Kuipers ; Katharina B Kuentzel ; Dagmar Kratky ; Yun Kwon ; Anja Zeigerer ; Sebastian Hendrix ; Noam ZelcerSeries Type : […]
- GSE327807 Transcriptomic profile of the hippocampus of rat strains with contrasting nervous system excitability April 25, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusBulk RNA sequencing of the hippocampus in male rats from two selectively bred strains differing in nervous system excitability: LT (low threshold, high-excitability) and HT (high threshold, low-excitability). The aim was to characterize baseline interstrain transcript […]
- GSE263342 CNOT3 maintains ILC2 integrity by destabilizing Tbx21 and Rorc mRNAs [RNA-seq] April 25, 2026Contributor : Megumi TatematsuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImmune responses are initiated by activation of innate lymphoid cells (ILCs), T-bet-dependent natural killer and ILC1 cells, GATA-3-dependent ILC2 cells, and RORγt-dependent ILC3 cells. Despite accumulated knowledge of translational regulation […]
- GSE295819 Transcriptional activation of the PKLR gene by novel erythroid-specific regulatory elements [ChIP-Seq] April 25, 2026Contributors : AeRi Kim ; Yew Woon KimSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe proposed that newly identified transcription regulatory elements act as enhancers for the PKLR gene transcription in erythroid cells.