Category: PubMeD- NCBI2

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE295599 Combinatorial delivery of low-dose irradiation and immunotherapy to patients with immune-excluded tumors effectively enhances CD8+ T cell functionality in tumors with homologous recombination repair deficiency [bulk RNA-seq] April 7, 2026
  Contributors : Nicolas Rayroux ; Maria Ochoa-de-Olza ; Fernanda Herrera ; Denarda D LanitiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensImmune-checkpoint blockade (ICB) has shown significant efficacy across various tumor types. However, tumors with low intraepithelial T-cell infiltration, often referred to as "co […]
• GSE302811 RNA-seq of mononuclear immune cells isolated from breast cancer wound fluid after IORT or surgery alone April 7, 2026
  Contributors : Nikko Brix ; Benedek Dankó ; Martin SelmansbergerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis dataset comprises RNA-seq profiles from mononuclear immune cells purified from wound fluid of breast cancer patients who received intraoperative radiotherapy (IORT) or surgery only (control). Samples were […]
• GSE301179 Bulk RNA sequencing of ovarian tumor samples from high-grade serous ovarian cancer patients [RNA-Seq] April 7, 2026
  Contributors : Luyao Wang ; Breeshey Roskams-Hieter ; Nancy Zaarour ; Ahmed AhmedSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHigh-grade serous ovarian cancer (HGSOC) is thought to originate from the fallopian tube (FT), highlighting the importance of studying molecular features across tumor samples.This dataset cont […]
• GSE312076 Zone-specific hepatocytes orchestrate the early onset of host defence mechanisms during Staphylococcus aureus bloodstream infection April 7, 2026
  Contributors : Obiageli Vivian Nwofor ; Alexander Leipold ; Qian Chen ; Robert Geffers ; Antoine-Emmanuel Saliba ; Oliver Goldmann ; Eva MedinaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBloodstream infections (BSI) cause substantial morbidity and mortality, with Staphylococcus aureus among the most lethal pathogens […]
• GSE307959 Membrane Fusion Inhibition, Immune Modulation, and Cholesterol Synthesis Dysregulation During Dengue Virus Inhibition by 25-Hydroxycholesterol April 7, 2026
  Contributors : Debayani Chakraborty ; Achinta Sannigrahi ; Mahammed Kaif ; Arijit Patra ; Deep Thakkar ; Debarati Chakraborty ; Rahul RoySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPhysicochemical properties and composition of cellular membranes are crucial for regulating broad cellular responses including signaling […]
• GSE231474 Infiltration of monocyte-derived cells perturbs CNS metabolism, licensing arginine catabolism augmenting neuroinflammation April 7, 2026
  Contributors : Martina Kerndl ; Andrea Vogel ; Andrea Komljenovic ; Omar Sharif ; Gernot SchabbauerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammatory responses are associated with recruitment of monocyte-derived cells (Mdcs) into tissues. While tissue-specific Mdc reprogramming is well-established, how Mdc inf […]
• GSE318736 Simultaneous orthogonal cell engineering by a single CRISPR-Cas9 polyfunctional editor [CAST-seq] April 7, 2026
  Contributors : Deborah Cipria ; Tania Baccega ; Miriana Rizzo ; Piergiuseppe Quarato ; Alice Reschigna ; Rita El Khoury ; Martino A Cappelluti ; Sandra Ammann ; Valeria Mollica Poeta ; Matteo Conti ; Sara Valsoni ; Pietro Spinelli ; Ivan Merelli ; Toni Cathomen ; Monica Casucci ; Angelo L LombardoSeries Type : OtherOrganism : Homo sapiensThe parallel disrupt […]
• GSE326854 Gene expression profile at single cell level of different phenotypic tumors derived from human non-muscle invasive bladder carcinoma cell lines April 7, 2026
  Contributor : Yan ZeqinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe cellular states of bladder carcinoma change dynamically as tumor recurrence evolves under Gemcitabine treatment, facilitating phenotypic transitions. Thus, we employed single-cell RNA sequencing (scRNA-seq) to gain a high-resolution view of the c […]
• GSE326853 Transcriptome analysis of treated and control samples from bladder carcinoma April 7, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusWe provide bulk RNA-seq data for the following: (1) Relapsed tumors after Gemcitabine treatment and their corresponding control tumors, derived from a genetically engineered mouse model (GEMM) of bladder carcinoma. (2) IGFBP5 knockout (KO) MP-MGH-U3-LT and C […]
• GSE326883 TLR9 Agonists Potentiate Adoptive T Cell Therapy in Cancer through a B Cell–CD2 Costimulatory Axis April 7, 2026
  Contributors : Ayana Ruffin ; Chrystal PaulosSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAdoptive T cell transfer (ACT) therapy offers curative potential for some patients with cancer. Toll-like receptor (TLR) agonists improve the efficacy of ACT therapy, but the underlying mechanism of potency remains poorly unders […]
• GSE326861 Ocy454 cell gene expression changes with PTH, FAK inhibitor and PDE8A deletion April 7, 2026
  Contributors : Garyfallia Papaioannou ; Courney M MazurSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCells from the osteocyte cell line Ocy454 were treated with vehicle (DMSO), +/- PTH (100nM), +/- FAK inhibitor (PF431396 10uM) or underwent PDE8A deletion via CRISPR/Cas9. The goal of this study is to determine the sim […]
• GSE326928 Phylogenetic information of different phenotypic tumors derived from human non-muscle invasive bladder carcinoma cell lines April 7, 2026
  Contributor : Yan ZeqinSeries Type : OtherOrganism : Homo sapiensEvolutionary principles govern cancer relapse. This process involves defined phylogenetic signatures at each step and is initiated by the acquisition of therapeutic resistance to form relapsed tumours. Exploring this process, particularly by real-time monitoring, has been challenging because re […]
• GSE326929 Chromatin accessibility profile at single cell level of different phenotypic tumors derived from the human non-muscle invasive bladder carcinoma cell line, MGH-U3 April 7, 2026
  Contributor : Yan ZeqinSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo understand the genetic mechanisms by which IGFBP5 regulates aggressive progression and squamous traits, we performed whole-exome sequencing (WES) on three distinct cell lines: CTR-MGH-U3-LT, UCSD-MGH-U3-LT, and MP-MGH-U3-LT. WES reve […]
• GSE327017 Multimodal profiling reveals a Notch-responsive regenerative subpopulation of cochlear supporting cells April 7, 2026
  Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE293509 Effect of Rnf111 S254D mutant on gene expression at intestine tissues April 7, 2026
  Contributors : Zhiqiang Peng ; Lingqiang Zhang ; Cuihua LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTranscriptome analysis of RNAs extracted from intestine tissues of wild type or Rnf111 S254D heterozygous mice