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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE260675 Next Generation Sequencing Facilitates Quantitative Analysis of WT and edf1 mutant Transcriptomes in W22 Background May 17, 2026Contributors : Hongtao Liu ; Zhiwei Zhao ; Huafeng Liang ; Jianbing Yan ; Chengxiu WuSeries Type : Expression profiling by high throughput sequencingOrganism : Zea maysAnalysis of all gene expression in WT and edf1 in W22 background.The hypothesis tested in the present study was genes were regulated by EDF1.
- GSE330894 RTT109 regulates Polycomb-repressed genes independently from H3K56 acetylation status May 17, 2026Contributors : Rochelle E Yap ; Felicia Ebot-Ojong ; Abigail J Ameri-Solanki ; Zachary A LewisSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Neurospora crassaIn animals, plants, and some fungi, Polycomb Repressive Complex 2 (PRC2) catalyzes trimethylation of histone H3 lysine 27 (H3K27me3) to establish transcriptiona […]
- GSE298502 The landscape of gain and loss of function mutations in melanoma May 17, 2026Contributors : Noam Auslander ; Meenhard Herlyn ; Jayamanna Wickramasinghe ; Bryant Duong ; Konstantinos TsingasSeries Type : Protein profiling by protein arrayOrganism : Homo sapiensMelanoma is a common and aggressive cancer, with a rising incidence in most developed countries. Major discoveries in melanoma biology have been rapidly translated, allowing cur […]
- GSE297199 The landscape of gain and loss of function mutations in melanoma [RNA-seq] May 17, 2026Contributors : Noam Auslander ; Meenhard Herlyn ; Jayamanna Wickramasinghe ; Bryant Duong ; Konstantinos TsingasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMelanoma is a common and aggressive cancer, with a rising incidence in most developed countries. Major discoveries in melanoma biology have been rapidly translat […]
- GSE306443 The IL-10/IL-10Ra axis in fibroblasts limits large intestinal pathology by suppressing type I interferon signaling [RNA-Seq, part2] May 17, 2026Contributors : Bo Li ; Daisuke Motooka ; Hisako KayamaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn the intestines, stromal cells are essential for epithelial homeostasis, supplying both stem cell niche signals and differentiation factors. Recent studies have shown that they play crucial roles not only in epithelia […]
- GSE306433 The IL-10/IL-10Ra axis in fibroblasts limits large intestinal pathology by suppressing type I interferon signaling [RNA-Seq] May 17, 2026Contributors : Takayoshi Ito ; Daisuke Motooka ; Hisako KayamaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn the intestines, stromal cells are essential for epithelial homeostasis, supplying both stem cell niche signals and differentiation factors. Recent studies have shown that they play crucial roles not only in e […]
- GSE330529 Transcriptomic Profiling Identifies GPNMB as a Key Driver of Gastric Cancer Aggressiveness May 17, 2026Contributors : Long Cheng ; Daiyuan MaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe aimed to define the role of GPNMB in gastric cancer (GC) progression and its underlying mechanisms. Stable GPNMB-knockdown/overexpression GC cell models were established, and transcriptomic profiling identified the cAMP signaling pa […]
- GSE318880 Genome-wide identification of transcriptional targets for RUNX2 in MC3T3-E1 cells May 17, 2026Contributor : Lin HeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTo investigate the genome-wide transcription targets of RUNX2 in MC3T3-E1 cells, cleavage under targets and tagmentation (CUT&Tag) was performed using antibody against RUNX2. Following CUT&Tag, DNAs were amplified using non-biased […]
- GSE330741 In Vivo Massively Parallel Reporter Assay Reveals Sequence Determinants of mRNA Localization in Astrocytes May 17, 2026Contributors : Sarah K Koester ; Kristina Sakers ; Gareth M Rurak ; Stephen P Plassmeyer ; Kelli McFarland White ; Sebastian Alves Ferreira Dias ; Peter Baird ; Dina J Kornbluth ; Joseph D DoughertySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSubcellular mRNA localization and local translation are essential mechanism […]
- GSE330687 PD-L1 drives metabolic reprogramming and mitochondrial remodeling in NSCLC cells May 17, 2026Contributors : Xiangjun Shi ; Chenglong Liu ; Siqi Mou ; Junsheng Li ; Peicong Ge ; Xuebin LiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTumor metabolism is governed by a complex network of processes that can influence immune evasion. Metabolic dysregulation in tumor cells often result in the accumulation of bypro […]
- GSE330761 CD25 expression marks an activated mast cell population in human nasal polyposis May 17, 2026Contributors : Daniel F Dwyer ; Rizza U SantosSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground- Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is a Th2 disease characterized by heterogeneous mast cell hyperplasia. We previously used transcriptomics to identify discrete gene expression linked with intr […]
- GSE330780 Dissection of innate-immune-ligand- and interferon-protein-mediated transcriptional responses in human THP1 cell states May 17, 2026Contributors : Lama Lodoe ; Morozov PavelSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInterferon regulatory factors (IRFs) are essential for transcription of interferons (IFNs), interferon-stimulated genes (ISGs), and pro-inflammatory cytokines. We profile the transcriptome of human monocyte THP1 cells challenged wit […]
- GSE330859 Differential recognition of C. neoformans by male and female human macrophages elicits contrasting immune responses May 17, 2026Contributor : Erin E McClellandSeries Type : Expression profiling by high throughput sequencingOrganism : Cryptococcus neoformans ; Homo sapiensCryptococcus neoformans (Cn) is a pathogenic yeast and the cause of cryptococcosis, a life-threatening fungal disease. Strikingly, ~70% of patients that develop cryptococcosis are male. Here, we investigated decrease […]
- GSE327243 A CSF Disease-Associated Macrophage Signature defines Progressive Multiple Sclerosis [Frozen] May 17, 2026Contributors : Gerd Meyer zu Hörste ; Anna-Lena BörschSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensObjective: Progression in multiple sclerosis (MS) often corresponds to irreversible disability in MS patients. Cellular changes in the cerebrospinal fluid (CSF) have provided biomarkers and mechanisms in relapsing-remit […]
- GSE330346 Photoproximity labeling of c-Myc reveals SLK as a cancer-specific co-regulator [RNA-Seq] May 17, 2026Contributors : Ryan R Milione ; Feifei Tong ; Kelsey L Wolfe ; Cameron J Douglas ; Sara B Linker ; Xinmeng Jasmine Mu ; James V Oakley ; Andrew R Nager ; Michalina Janiszewska ; Ciaran P SeathSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTranscription factors (TFs) have long been aspirational therapeutic targets for t […]