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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE297320 The mRNA levels of Ly6G+ cells from the bone marrow of septic mice after IFN-gamma stimulation. May 15, 2026Contributors : Zhenhao Yu ; Caiyan ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCurrently, immunotherapy represents a promising therapeutic approach for patients with sepsis in the refractory immunosuppressive phase. The pro-inflammatory cytokine interferon-gamma (IFN-γ) has been investigated in both septic pati […]
- GSE304292 Oxidative stress alters miRNA content in stressed granulosa cells and their derived extracellular vesicles May 15, 2026Contributors : Judith Diaz-Muñoz ; Yulia N Cajas ; Karina Cañón-Beltrán ; Lena Arévalo ; Sonia Gago ; María Iniesta-Cuerda ; Ana Josefa Soler ; Dimitrios Rizos ; Teresa MogasSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Bos taurusGranulosa cells (GCs) play a central role in oocyte maturation and follicular development, and th […]
- GSE301840 Life-saving left ventricular assist devices promote a transcriptomic signature favoring cardiac fatty acid metabolism, repair and anti-inflammation May 15, 2026Contributors : Pauline Mury ; Olina Dagher ; Pierre-Emmanuel Noly ; Anique Ducharme ; Shreya Gramolini ; Filio Billia ; Eric ThorinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study, we performed single-nuclei RNA sequencing on heart samples from 6 end-stage heart failure patients (3 ischemic cardiomyopathy a […]
- GSE266417 Female Mice with an Xist Deletion in B Cells Can Develop Lupus-Associated Phenotypes May 15, 2026Contributors : Lovell Claudia ; Jiwrajka Nikhil ; Amerman Hayley ; Cancro Michael ; Anguera Montserrat ; Natalie ToothacreSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSystemic lupus erythematosus (SLE) is a female-biased autoimmune disease. X-Chromosome Inactivation (XCI) dosage compensates X-linked genes in females. […]
- GSE214527 Histone chaperon ASF1B recruits distinct epigenetic factors in regulation of histone variant H3.3 during the fetal and adult erythropoiesis [ChIP-seq] May 15, 2026Contributor : Xiang GuoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTo identify the role of ASF1B in regulation of histone modification during murine erythropoiesis, H3K27ac and H3.3 ChIP-seq was performed in the WT and ASF1B KO E14.5 fetal liver and bone marrow cells. ASF1B was found bind to the promot […]
- GSE290548 Transcriptomic analysis and experimental verification reveal the involvement of PI3K/AKT signaling pathway in high-altitude cognitive dysfunction May 15, 2026Contributors : Yu Xin ; Chenyu Yang ; Gege Wang ; Huiping MaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCognitive impairment is a common symptom for these people entering high altitude. Unfortunately, the potential molecular mechanisms are not totally clear. This study aimed to identify the genes and signaling pathw […]
- GSE277393 Temporal misexpression of En1 during limb development causes distinct phenotypes [RNA-seq] May 15, 2026Contributors : Alessa Ringel ; Andreas Magg ; Lila AllouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe precise spatiotemporal regulation of developmental genes is required for proper organogenesis. Engrailed-1 (En1) is essential for dorsal-ventral patterning during mouse limb development from embryonic day E9.5 to […]
- GSE331024 An IRF3-POLR2G axis represses liver FGF21 and metabolic transcriptional programs [CUT&Tag Liver IRF3-2D] May 15, 2026Contributors : Neethu S Alex ; Ashutosh Shukla ; Suraj J PatelSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusInflammatory signaling in the liver reshapes numerous transcriptional programs, but the mechanisms by which innate immune pathways actively repress metabolic gene expression remain poorly understoo […]
- GSE331023 An IRF3-POLR2G axis represses liver FGF21 and metabolic transcriptional programs [CUT&Tag Hepatocytes IRF3-2D] May 15, 2026Contributors : Neethu S Alex ; Ashutosh Shukla ; Suraj J PatelSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusInflammatory signaling in the liver reshapes numerous transcriptional programs, but the mechanisms by which innate immune pathways actively repress metabolic gene expression remain poorly understoo […]
- GSE331026 An IRF3-POLR2G axis represses liver FGF21 and metabolic transcriptional programs [PRO-seq] May 15, 2026Contributors : Neethu S Alex ; Ashutosh Shukla ; Suraj J PatelSeries Type : OtherOrganism : Mus musculusInflammatory signaling in the liver reshapes numerous transcriptional programs, but the mechanisms by which innate immune pathways actively repress metabolic gene expression remain poorly understood. Here we show that IRF3, a master regulator of innate imm […]
- GSE331025 An IRF3-POLR2G axis represses liver FGF21 and metabolic transcriptional programs [CUT&Tag Liver POLR2G] May 15, 2026Contributors : Neethu S Alex ; Ashutosh Shukla ; Suraj J PatelSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusInflammatory signaling in the liver reshapes numerous transcriptional programs, but the mechanisms by which innate immune pathways actively repress metabolic gene expression remain poorly understoo […]
- GSE331028 An IRF3-POLR2G axis represses liver FGF21 and metabolic transcriptional programs [RNA-seq Liver POLR2G] May 15, 2026Contributors : Neethu S Alex ; Ashutosh Shukla ; Suraj J PatelSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammatory signaling in the liver reshapes numerous transcriptional programs, but the mechanisms by which innate immune pathways actively repress metabolic gene expression remain poorly understood. Here we sho […]
- GSE331029 An IRF3-POLR2G axis represses liver FGF21 and metabolic transcriptional programs [RNA-seq Liver IRF3-2D] May 15, 2026Contributors : Neethu S Alex ; Ashutosh Shukla ; Suraj J PatelSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammatory signaling in the liver reshapes numerous transcriptional programs, but the mechanisms by which innate immune pathways actively repress metabolic gene expression remain poorly understood. Here we sho […]
- GSE331036 An IRF3-POLR2G axis represses liver FGF21 and metabolic transcriptional programs May 15, 2026Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE295779 The whole-genome duplication is a barrier for iPSCs reprogramming from mouse fibroblasts May 15, 2026Contributors : Junqi Kuang ; Duanqing PeiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWhole-genome duplication (WGD) -induced tetraploidization represents a pivotal genetic event widely investigated in the contexts of tumorigenesis, developmental processes, and evolutionary biology, whereas its functional consequence […]