Quick Links : Search PubMed , Finding Full Text , PubMed Advanced Search , Clinical Queries , Single Citation Matcher , FAQs & User Guide , Explore MeSH Database , Explore PubMed Journals
Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE303380 Lateral plate mesoderm directs human amnion and ventral skin organoid formation July 22, 2026Contributors : Koehler Karl R. ; Le Anh PhuongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRecently, we demonstrated that craniofacial skin, including dermis, epidermis, and hair, can be derived by manipulating signaling factors to co-induce epidermal-dermal progenitors. Here, we advance this approach by controlling […]
- GSE303288 Discovery of Translation Regulatory Features and Cross-UTR Interactions through Precise Mapping of mRNA Ends and Machine Learning July 22, 2026Contributors : Ariel Ogran ; Joseph Green ; Daniel Hayat ; Sansrity Sinha ; Ori avinoam ; Ido Azuri ; Rivka DiksteinSeries Type : OtherOrganism : Mus musculusCis-regulatory elements within 5′ and 3′ untranslated regions (UTRs) are critical for controlling mRNA translation efficiency (TE) and stability, but their coordinated functions remain poorly understood […]
- GSE310229 Identification and validation of central amygdala FGFR1 as a therapeutic target for alcohol use disorder using single nucleus sequencing in rat July 22, 2026Contributors : Estelle Barbier ; Leon Höglund ; Li Xu ; Nihal Salem ; Elizabeth Osterndorff-Kahanek ; Riccardo Barchiesi ; Antonio Lacorte ; Lief Fenno ; Robert Messing ; Dayne Mayfield ; Markus HeiligSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusUnderstanding why some individuals are more vulnerable to alcohol a […]
- GSE303402 Human induced pluripotent stem cell-derived skin organoids recapitulate donor-specific pigmentation diversity July 22, 2026Contributors : Karl R. Koehler ; Jin Kim ; Jiyoon LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSkin and hair pigmentation vary widely across individuals, but the underlying mechanisms responsible for these differences remain poorly understood. To address this, we employ a recently developed skin organoid (SkO) cul […]
- GSE334049 Melanoma-derived exosomal miRNAs and keratinocyte-derived LL-37 define an epidermal–tumor arms race in melanoma July 22, 2026Contributors : Quan Sun ; Ge Peng ; François NiyonsabaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusMelanoma progression involves dynamic interactions between tumor cells and the surrounding epidermal microenvironment. The cathelicidin antimicrobial peptide LL-37, expressed by keratinocytes, has been im […]
- GSE312794 CD73 inhibition overcomes adaptive immune resistance to PARP inhibition in models of prostate cancer July 22, 2026Contributors : Ping Xie ; Renqiang Ma ; Minghui Zhang ; Jie Fan ; Hui Tang ; longzhen Song ; Bin ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMetastatic castration-resistant prostate cancer (mCRPC) remains a major cause of cancer-related mortality in the male population. While poly(ADP-ribose) polymeraseinhibito […]
- GSE338779 Single-cell RNA-seq of synovial fluid cells from osteoarthritis control patients July 22, 2026Contributors : Xuyang Xia ; Chenjia He ; Zhinan Xue ; Yuelan Wang ; Yun Qin ; Zhixiang Ren ; Yupeng Huang ; Han Luo ; Hai-Ning Chen ; Wei-Han Zhang ; Li-Bin Huang ; Yunying Shi ; Yangjuan Bai ; Bei Cai ; Lanlan Wang ; Feng Zhang ; Maoxiang Qian ; Wei Zhang ; Yang Shu ; Geng Yin ; Heng Xu ; Qibing XieSeries Type : Expression profiling by high throughput seque […]
- GSE338377 Retina-specific glucocorticoid receptor deletion disrupts rhythmic gene expression in the mouse retina under constant dark conditions. July 22, 2026Contributor : Keisuke IkegamiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe ocular circadian clock has been thought to be regulated primarily by environmental light. In many peripheral tissues, however, circadian clocks are influenced by temporal information conveyed by adrenal glucocorticoids, while glucocorticoid […]
- GSE338984 Tumour-targeted nitric oxide nanotherapy overcomes sorafenib resistance and reprograms antitumour immunity in hepatocellular carcinoma July 22, 2026Contributors : Chen Yunching ; Yang ShengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTherapeutic responses in hepatocellular carcinoma (HCC) are often limited by resistance-associated survival signaling and immune escape. Resistance to sorafenib, a first-line tyrosine kinase inhibitor (TKI) for advanced HCC, has bee […]
- GSE338987 The stage- and sex-specific transcriptome of the striped flea beetle Phyllotreta striolata July 22, 2026Contributors : Yanyan Zhou ; Chenxue Geng ; Xin Liu ; Nianbin Wang ; Yongli Zheng ; Qian LiSeries Type : Expression profiling by high throughput sequencingOrganism : Phyllotreta striolataThe striped flea beetle (SFB), Phyllotreta striolata, is a globally devastating cruciferous pest. A key challenge to its control lies in its complex life cycle—with egg, lar […]
- GSE339049 Severe long-COVID is driven by monocyte reprogramming and broad immune dysregulation linked to herpesvirus activation July 22, 2026Contributors : Niels Velthuijs ; Berend Röring ; Laszlo GrohSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensLong-COVID (LC) continues to impose a significant burden on patients and society, yet its pathophysiology remains poorly understood. Here, we characterize the functional, transcriptomic, and epigenom […]
- GSE339083 Effect of TENT2 knockdown on miRNA profiling in human lung endothelial cells July 22, 2026Contributors : Asawari Korde ; Shervin S TakyarSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensMiRNAs are generated through a finely tuned multi-step process that includes precise cropping and cleavage of their precursors. The mature miRNA is then loaded onto an argonaute (Ago) protein to form an RNA-induced silenci […]
- GSE339098 Next Generation Sequencing of Wild Type and Gata2; Mx1-Cre Heterozygote HSCs July 22, 2026Contributors : Ali Abdelfattah ; Neil Rodrigues ; Peter GilesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusClinical GATA2 deficiency syndromes arise from germline haploinsufficiency inducing mutations in GATA2, resulting in immunodeficiency that evolves to myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML). H […]