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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE267167 CSF1R inhibition plus chemotherapy induces systemic anti-tumor immune responses in triple negative breast cancer and sensitizes tumors to anti-PD-1 therapy by relieving resident memory T cell dysfunction [tumor] February 23, 2026Contributors : Hope S Rugo ; Amanda Poissonnier ; Eivind V Egeland ; Wesley Horton ; Tiziana Cotechini ; Brian Ruffell ; Cecil Gomes ; Shamilene Sivagnanam ; Nicky Belen ; Dhaarini Murugan ; Nell Kirchberger ; Courtney Betts ; Motomi Mori ; Shivaani Kummar ; K Blackwell ; E Mayer ; Shelley E Hwang ; Lisa M CoussensSeries Type : OtherOrganism : Mus musculusTr […]
- GSE280638 Polycomb Repressive Complex 1 Primes Non-Growing Oocytes for Growth and Early Embryogenesis [RNA-Seq] February 23, 2026Contributors : Mengwen Hu ; Satoshi H NamekawaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOvarian reserve defines the female reproductive lifespan, which in humans spans decades due to the robust maintenance of meiotic arrest in non-growing oocytes residing in primordial follicles. Dynamic epigenomic reprogramming a […]
- GSE268327 Effects of blood criculating extracellular vesicles on social behaviors in mice: brain gene expression analysis February 23, 2026Contributors : Shin-ichi Kano ; David K Crossmann ; Eisuke Dohi ; Norimichi Ito ; Ken MatobaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusExtracellular vesicles (EVs) are cell-derived membrane vesicles that circulate throughout the body. Accordingly, circulating EVs and their associated molecules, such as RNAs and pro […]
- GSE299613 CBP-IDRs regulate acetylation and gene expression [CUT&Run] February 23, 2026Contributors : Katie L Gelder ; Nicola A Carruthers ; Grace Gilbert ; Laura J Harrison ; Thomas Evans ; Sophie Ball ; Mark Dunning ; Timothy D Craggs ; Alison E Twelvetrees ; Daniel A BoseSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensIntrinsically disordered regions (IDRs) have emerged as crucial regulat […]
- GSE292624 Dissociated human cerebral organoids on micro-electrode arrays develop neuronal networks February 23, 2026Contributors : Adam Pavlinek ; Deepak P SrivastavaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMicroelectrode arrays (MEAs) are increasingly used to profile the development of synchronised network activity in neural organoids, yet no organoid study has investigated the consistency of electrophysiological development […]
- GSE309812 Transcriptome-wide mapping reveals an RNA-dependent mechanism of platinum cancer drugs [Plat-RNAseq A2780] February 23, 2026Contributors : Sreejith Nair ; Weiyi Guo ; Richi ThakralSeries Type : OtherOrganism : Homo sapiensSmall molecules developed to target proteins and DNA may also bind RNA, but the extent and biological significance of these interactions remain poorly defined. Here, we systematically profiled RNA interactions of clinically approved chemotherapeutics and uncover […]
- GSE309225 The LMO2-LDB1-TAL1 complex regulates transcription networks in AML [ChIP-Seq] February 23, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensRelapsed acute myeloid leukemia (relAML) remains a clinical challenge. We have shown that epigenetic heterogeneity may contribute to transcriptional dysregulation and disease progression in AML, but the specific transcriptional programs have not been identifi […]
- GSE319957 Persistent Activation of Monocytes/Macrophages and Cell Senescence in SIV-Infected Macaques on ART February 23, 2026Contributors : Yilin Chen ; Xiaofeng Ding ; Sonalika Ray ; Siva Thirugnanam ; Robert Blair ; Ahmad Saied ; Sergiy Sukhanov ; Jay Kolls ; Woong-Ki Kim ; Patrice Delafontaine ; Jay Rappaport ; Xuebin Qin ; Namita RoutSeries Type : Expression profiling by high throughput sequencingOrganism : Macaca mulattaDespite effective viral suppression with antiretroviral […]
- GSE319955 Quiescent neural stem cells transiently become neuronal-like to coordinate long-range reactivation February 23, 2026Contributors : Jocelyn L.Y. Tang ; Andrea H. BrandSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterReactivation of quiescent neural stem cells (qNSCs) is a coordinated process that generates new neurons and glia to maintain homeostasis or enable repair post-injury. Here, we discovered that NSC reactivation in […]
- GSE320060 A Naïve RNA Sampling Core Enables Adaptive piRNA Specificity Against Transposable Elements [RNA] February 23, 2026Contributors : Dominik Handler ; W. Y. Wylan Wong ; Alexander Tsarev ; Rippei Hayashi ; Julius BrenneckeSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterHow piRNA-mediated genome defense achieves specificity against transposons while sampling a complex transcriptome has remained unresolved. Here we show that p […]
- GSE320009 Synergistic role of riboflavin-auxotrophic Enterococcus for MR1 expression and in-tra-tumoral mucosal associated invariant T (MAIT) cell activation February 23, 2026Contributors : Pakhi Birla ; Franck HousseauSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe role of mucosal invariant T (MAIT) cells in the lung tumor microenvironment re-mains poorly understood, especially in the setting of immune checkpoint inhibitors. We identified intratumoral MAIT cells from paired single cell […]
- GSE320061 A Naïve RNA Sampling Core Enables Adaptive piRNA Specificity Against Transposable Elements [CLIP] February 23, 2026Contributors : Dominik Handler ; W. Y. Wylan Wong ; Alexander Tsarev ; Rippei Hayashi ; Julius BrenneckeSeries Type : OtherOrganism : Drosophila melanogasterHow piRNA-mediated genome defense achieves specificity against transposons while sampling a complex transcriptome has remained unresolved. Here we show that piRNA biogenesis operates through pervasive, n […]
- GSE320062 A Naïve RNA Sampling Core Enables Adaptive piRNA Specificity Against Transposable Elements [smallRNA] February 23, 2026Contributors : Dominik Handler ; W. Y. Wylan Wong ; Alexander Tsarev ; Rippei Hayashi ; Julius BrenneckeSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Drosophila melanogasterHow piRNA-mediated genome defense achieves specificity against transposons while sampling a complex transcriptome has remained unresolved. Here we show th […]
- GSE320063 A Naïve RNA Sampling Core Enables Adaptive piRNA Specificity Against Transposable Elements February 23, 2026Series Type : Expression profiling by high throughput sequencing ; Other ; Non-coding RNA profiling by high throughput sequencingOrganism : Drosophila melanogasterThis SuperSeries is composed of the SubSeries listed below.
- GSE264118 Hypoxia Promotes an Adrenergic to Mesenchymal Transcriptional Program Transition in Neuroblastoma February 23, 2026Contributors : Mohansrinivas Chennakesavalu ; Kelley Moore ; Gepoliano Chaves ; Sahil Veeravalli ; Rachel TerHaar ; Tong Wu ; Ruitu Lyu ; Alexandre Chlenski ; Chuan He ; Andrea Piunti ; Mark ApplebaumSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurpose: Neuroblastoma is the most common extracranial solid tumor in chi […]