Category: PubMeD- NCBI2

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE278979 Transcriptional programs of cell identity and p53-induced stress responses are associated with distinctive features of spatial genome organization [RNA-seq] July 10, 2025
  Contributors : Hsin-Jung Chou ; Tsung-Han S Hsieh ; Claudia Cattoglio ; Jack Li ; Xavier Darzacq ; Gony Shanel ; Ran ElkonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo date, most studies explored changes in 3D-genome organization between different tissues or during differentiation, which involve massive reprogrammi […]
• GSE287742 Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage July 10, 2025
  Contributors : Daisy A Hoagland ; Patricia Rodríguez-Morales ; Alexander O Mann ; Ruth A FranklinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM […]
• GSE279021 Transcriptional programs of cell identity and p53-induced stress responses are associated with distinctive features of spatial genome organization [SuperSeries] July 10, 2025
  Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
• GSE241724 B3GALT6 mutations trigger sequential molecular events leading to compromised connective tissue biomechanics in Ehlers-Danlos syndrome July 10, 2025
  Contributors : Sébastien Hergalant ; Catherine Bui ; Sylvie Fournel-GigleuxSeries Type : Expression profiling by arrayOrganism : Homo sapiensEhlers-Danlos syndromes (EDS) comprise a genetically and clinically heterogenous group of rare disorders that severely affect connective tissues, often leading to death. The molecular background underlying EDS affects c […]
• GSE302185 TCRseq of Rpl18*-specific T cells from MC38 tumor and draining lymph node July 10, 2025
  Contributors : Benjamin M Murter ; Lawrennce P KaneSeries Type : OtherOrganism : Mus musculusThe protein PI3K-interacting protein (PIK3IP1), or transmembrane inhibitor of PI3K (TrIP), is highly expressed by T cells and can modulate PI3K activity in these cells. Several studies have also revealed that TrIP is rapidly downregulated following T cell activation […]
• GSE272035 Gene community-regulated pathway analysis successfully deciphers pathogenesis and biomarkers of viral versus metabolic hepatocellular carcinoma July 10, 2025
  Contributors : Yu-Hsin Wu ; Jung-Yu Lee ; Chih-Yuan Chou ; Po-Wei Wang ; Jinn-Moon YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHepatocellular carcinoma (HCC) is a leading cause of cancer deaths globally. Understanding its mechanisms is crucial, despite advancements in gene identification. To address the variabil […]
• GSE271940 FAK regulates trophoblast functions of invasion and proliferation through Rap1 pathway in preeclampsia July 10, 2025
  Contributors : Tingting Wang ; Hai Tong ; Chen Zhang ; Xue Zhang ; Hongbo QiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo explore the potential role of focal adhesion kinase (FAK) in trophoblast functions in early-onset preeclampsia (EOPE).We first examined expression and localization in placental tissue as well as […]
• GSE300466 KPHS_28080 Emerges as a Novel Virulence Factor in Klebsiella pneumoniae through CpxR-Dependent Transcriptional Activation July 10, 2025
  Contributors : Zhiyuan Liu ; Runze Wang ; Jiahao Guan ; Hong-Yu OuSeries Type : Expression profiling by high throughput sequencingOrganism : Klebsiella pneumoniaeKlebsiella pneumoniae is an important human pathogen, causing various infections. Apart from traditional virulence factors, there remains a significant gap in the discovery and research of new chrom […]
• GSE300127 Serdemetan enhances bone regeneration by coordinated regulation of osteoblast and osteoclast activity through the p53 pathway July 10, 2025
  Contributors : Sol Jeong ; Seung-Chan An ; Hyun-Ju An ; Sungjoon Lim ; Jin Man Kim ; Soonchul LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusSerdemetan, an MDM2 inhibitor traditionally known for anticancer activity, demonstrates dual pro-osteogenic and anti-osteoclastic effects via p53 activation, sho […]
• GSE301497 The human transcription factor occupancy landscape viewed using high-resolution in situ base-conversion strand-specific single-molecule chromatin accessibility mapping July 10, 2025
  Contributors : Georgi K Marinov ; William J GreenleafSeries Type : OtherOrganism : Homo sapiensChromatin accessibility profiling is a key tool for mapping the location of cis-regulatory elements (cREs) in the genome and tracking chromatin state dynamics during development, in response to various external and internal stimuli, and in disease contexts. Single- […]
• GSE301154 Preclinical efficacy of tasquinimod-based combinations in advanced myeloproliferative neoplasms (MPN) in blastic phase July 10, 2025
  Contributors : Warren Fiskus ; Kapil BhallaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe alarmins, S100A8 (A8) and S100A9 (A9), are low molecular weight proteins belonging to the S100 protein family. A8 and A9 are secreted into the extracellular space and plasma, where they interact with TLR4 (Toll like receptor 4 […]
• GSE301923 Transcriptome profiles of LAM cell models exposed to oleic acid July 10, 2025
  Contributors : Roderic Espín ; Miquel Angel PujanaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusRNA-seq profiling of Tsc2-deficient mouse embryonic fibroblasts (MEFs) and TSC2-deficient 621-101 human angiomyolipoma cells exposed to oleic acid or basal condition.
• GSE301955 Endoplasmic Reticulum Stress-Driven Nucleotide Catabolism Fuels Prostate Cancer July 10, 2025
  Contributors : Omer F Kuzu ; Fahri Saatcioglu ; Ke Deng ; Yang Jin ; Nora Pällmann ; Marte Livgård ; Wanja Kildal ; Manohar Pradhan ; Ladan Fazli ; Paul S RennieSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe study investigates the impact of MOCOS knockdown and ER stress on transcriptomic responses and purine metabo […]
• GSE302184 RNA sequencing of WT and TrIP KO P14 TCR Tg T cells stimulated in vitro July 10, 2025
  Contributors : Benjamin M Murter ; Lawrennce P KaneSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe protein PI3K-interacting protein (PIK3IP1), or transmembrane inhibitor of PI3K (TrIP), is highly expressed by T cells and can modulate PI3K activity in these cells. Several studies have also revealed that TrIP is rapid […]
• GSE278978 Transcriptional programs of cell identity and p53-induced stress responses are associated with distinctive features of spatial genome organization [Micro-C] July 10, 2025
  Contributors : Hsin-Jung Chou ; Tsung-Han S Hsieh ; Claudia Cattoglio ; Jack Li ; Xavier Darzacq ; Gony Shanel ; Ran ElkonSeries Type : OtherOrganism : Homo sapiensTo date, most studies explored changes in 3D-genome organization between different tissues or during differentiation, which involve massive reprogramming of transcriptional programs. Much fewer st […]