Category: PubMeD- NCBI2

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE294010 Cord-derived iNKT cells are enriched with human NKT10 and exert the immunosuppressive function through the interaction with NRP1 [scMultiomics-seq] March 24, 2026
  Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensInvariant Natural Killer T (iNKT) cells are a unique subset of T lymphocytes that recognize glycolipid antigens presented by the non-polymorphic MHC class I-like molecule CD1d through a semi-invariant T cell antigen receptor. In mice, this receptor consists of the […]
• GSE303590 Ellagic Acid as a Novel YTHDF Inhibitor Triggers Tumor-Suppressive in Triple-Negative Breast Cancer II March 24, 2026
  Contributors : Jianheng Zhou ; Jun ZhangSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThe m⁶A reader proteins YTHDF1–3 are key post-transcriptional regulators of m⁶A-modified transcripts in mammalian cells, and have emerged as critical contributors to the pathogenesis of triple-negative breast cancer (TNBC). G […]
• GSE303283 eIF4E2 Deficiency Drive Cisplatin Resistance in NSCLC March 24, 2026
  Contributors : Xianrong Lin ; Rui Zhang ; Wenjun Tao ; Jun ZhangSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensCisplatin resistance remains a major obstacle in treating non-small cell lung cancer (NSCLC). Mechanistic insights into the translational control of cisplatin resistance remain sparse. This study ident […]
• GSE277118 A sRNA ncBCG427 of Bacillus Calmette-Guérin enhances intracellular bacterial survival likely through inhibition of inflammatory response and apoptosis March 24, 2026
  Contributors : Kailun Zhang ; Zejin Du ; Chao Wang ; Zijian WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mycobacterium tuberculosis variant bovis BCGWe use high-throughput sequencing to validate and screen the target genes predicted earlier, and conduct inflammation and apoptosis related experiments based on the screened gen […]
• GSE325716 The MEK/MYC/p21 Axis Drives Senescence Bypass and BCL-xL Dependence in Vincristine-Resistant Rhabdomyosarcoma March 24, 2026
  Contributors : Yadong Wang ; Andrea D Largent ; Dorothy Lee ; Paulomi Modi ; Long Wang ; Anshu Bandhlish ; Myron Ignatius ; Eleanor Y ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma, with outcomes for relapsed or metastatic disease remaining poo […]
• GSE293083 CTHRC1 promotes bone metastasis in prostate cancer March 24, 2026
  Contributors : Yuuki Imai ; Yuichiro SawadaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensProstate cancer causes a high frequency of bone metastases. The purpose of this study was to identify molecules that regulate prostate cancer bone metastasis as potential therapeutic and/or prognostic targets in prostate cancer, u […]
• GSE278518 A hierarchical Rorc(γt) cis-regulatory cascade orchestrates differentiation of RORγt⁺ innate immune cells [BulkRNA-seq_vitro] March 24, 2026
  Contributors : Takuma Fukui ; Miyuki Watanabe ; Satoshi Kojo ; Eriko Sumiya ; Shinichiro SawaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlthough ILC3s are known to differentiate in RORγt-dependent manner, besides ILC3s, RORγt-dependent developmental program is shared among several lymphocytes.However, little is kno […]
• GSE325456 Rejuvenation of the Aged Cerebrovascular System via Protein Corona–Guided Fusogenic Liposome Delivery March 24, 2026
  Contributors : Anna Csiszar ; Agnes Csiszar ; Roland Patai ; Tripti Gautam ; Tae-Gyu Oh ; Jenny R Gipson ; Makayla L FosterSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBrain vascular aging is increasingly recognized as a critical therapeutic target for age-related cognitive decline. Oxidative stress, bioenergetic dys […]
• GSE325439 Expression data from CD4+CD25- T cells of VAVcreKeapfl/fl mice March 24, 2026
  Contributors : C Neullens ; K OhlSeries Type : Expression profiling by arrayOrganism : Mus musculusThe transcription factor NRF2 regulated oxidative stress responses. Deletion of Keap1 results in constitutive NRF2 activation. We analyzed the consequences of NRF2 activation for gene expression in T cells.
• GSE325488 Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)-induced chemobrain March 24, 2026
  Contributors : Anna Csiszar ; Zoltan Ungvari ; Roland Patai ; Tripti Gautam ; Tamas KissSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChemotherapy-induced cognitive impairment ("chemobrain") is a frequent side-effect in cancer survivors treated with paclitaxel (PTX). The mechanisms responsible for PTX-induce […]
• GSE325464 Influence of lateral compression on epithelium and role of lamin A in this process March 24, 2026
  Contributors : Sanna Korpela ; Anna Rekonen ; Sini Hakkola ; Jenni Karttunen ; Anni Pörsti ; Sanni Erämies ; Fábio Tadeou Arrojo Martins ; Roselia Davidsson ; Markus J Ojanen ; Satu A Hakanen ; Peipei Wang ; Joonas Uusi-Mäkelä ; Alice Anais Varlet ; Maija Vihinen-Ranta ; Daniel E Conway ; Keijo Viiri ; Matti Nykter ; Jan LammerdingSeries Type : Expression pr […]
• GSE325515 H2AC19 acts as a novel regulator of angiogenesis to promote the progression of lung adenocarcinoma March 24, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Angiogenesis is a significant character of lung adenocarcinoma (LUAD) and is an important reason leading to high mortality rates of LUAD patients. Identification of potential therapeutic targets for regulating angiogenesis has clinical importance for the treatm […]
• GSE325678 Impact of ATEVs on transcriptional profile of pancreatic tumor tissues derived from a poorly immunogenic pancreatic cancer cell clone March 24, 2026
  Contributor : Mengying HuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAntigen processing and presentation (APP) is essential for adaptive immunosurveillance. We uncover a mechanism whereby activated T cell-derived extracellular vesicles (ATEVs) drive a positive feedback loop that enhances antigen presentation and imm […]
• GSE325703 PAX3-SIX2 muscle stem cell heterogeneity drives muscle-specific repair dynamics diversification March 24, 2026
  Contributors : Virginia Zoglio ; Sarah Chebouti ; Fayez Issa ; Théo Massard ; Benjamin Polin ; Sylvie Manin ; Pascal Maire ; Dawon Choi ; Indigo T.C. Chan ; Tom H Cheung ; Joana Esteves de Lima ; Frederic RelaixSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSkeletal muscle regeneration relies on muscle-specific stem ce […]
• GSE293268 Comparative single cell genomics of facial signaling centers of avian and murine embryos [ME11_scATAC-seq] March 24, 2026
  Contributors : Stella Kyomen ; Louk SetonSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMorphogens are crucial in craniofacial development, directing cellular processes that shape facial features in vertebrates. In this study, we used single-cell RNA and ATAC sequencing to investigate the genomic regulati […]