Category: PubMeD- NCBI2

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE302049 Analysis of gene expression after RNAi (siPool)-mediated knockdown of TEDAR (LINC00302) lncRNA in primary human keratinocytes July 1, 2026
  Contributors : Andor Pivarcsi ; Lorenzo PasqualiSeries Type : Expression profiling by arrayOrganism : Long non-coding RNAs (lncRNAs) are emerging as key regulators of epidermal differentiation. To investigate the function of the skin-enriched lncRNA TEDAR (LINC00302), we performed RNAi (siPool)-mediated knockdown in 3D organotypic skin models and analyzed ch […]
• GSE336922 A thioredoxin-Serinc2-lipid signaling axis modulates mood-related behaviors in mice [ATAC-Seq] July 1, 2026
  Contributor : Chong-Lei FuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Bipolar disorder (BD) shows strong heritability and distinct symptomatic subtypes. However, the molecular basis underlying subtype-specific features remains poorly understood. Here, we showed that Serinc2, a BD susceptibility gene encoding a L-s […]
• GSE302795 Phosphorylated ubiquitin is a secondary messenger and an epigenetic mark mediating mitochondria-nucleus crosstalk July 1, 2026
  Contributors : Bence Daniel ; Daniel Le ; Mercer J ThomasSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Parkinson’s disease (PD) is commonly associated with dysfunctional mitochondrial homeostasis. PINK1, a S/T kinase mutated in early-onset PD, generates phosphoserine 65 ubiquitin (pS65Ub) on damaged mitochondria fac […]
• GSE271705 Integrated ChIP-seq and Transcriptomic Profiling of Histone Modifications Across Breast Cancer Progression in MCF10A-Derived Cell Lines July 1, 2026
  Contributors : Seth Frietze ; Cong GaoSeries Type : Expression profiling by high throughput sequencingOrganism : Cancer arises from complex epigenetic mechanisms that drive tumorigenesis. Gene regulatory elements play a pivotal role in reprogramming gene expression patterns, facilitating tumor initiation, progression, and metastasis. However, a comprehensive […]
• GSE237083 UCHL1 Maintains Microenvironmental Homeostasis of Male Germline Stem Cells by Antagonizing HSPA8 July 1, 2026
  Contributors : Mengfei Zhang ; Wenbo ChenSeries Type : Expression profiling by high throughput sequencingOrganism : To illustrate the mechanism of UCHL1 and HSPA8 affects SSCs in the testis, mGSCs-I-SB cells were used to study in vitro, we down-regulated UCHL1 and HSPA8 using shRNA in mGSCs-I-SB cells.We then performed gene expression profiling analysis usin […]
• GSE295453 Interferon-induced immune signatures are associated with suppression of HEV infection in porcine cell culture models July 1, 2026
  Contributors : Sarah Schlienkamp ; Olinda Pinto Veiga ; André Goemer ; Luca Noerthemann ; Leyla Sirkinti ; Kathrin Sutter ; Florian W. R. Vondran ; Axel Hamprecht ; Daniel Todt ; Eike Steinmann ; Volker KinastSeries Type : Expression profiling by high throughput sequencingOrganism : Hepatitis E virus genotype 3 (HEV-3) is a zoonotic pathogen with pigs repres […]
• GSE284032 Integration and annotation of spatial multi-omic data with DIRAC highlights spatial organization of lymphoid organs July 1, 2026
  Contributors : Chang Xu ; Shibo Liu ; Yang Heng ; Yuan Cao ; Junbin Gao ; Dongmei Jia ; Diyan Liang ; Chen Yang ; Yong Ma ; Siok-Bian Ng ; Ao Chen ; Xun Xu ; Sha Liao ; Qinghua Jiang ; Boxiang LiuSeries Type : OtherOrganism : Spatial multi-omics technologies enable simultaneous measurements of multiple omics modalities. Integration across spatial omics modal […]
• GSE336720 DNMT3B plays antagonistic roles with SMARCB1 and is a targetable vulnerability in rhabdoid tumors [RNA-seq] July 1, 2026
  Contributors : Céline Chauvin ; Ryszard Wimmer ; Ludovica Brunetti ; Joanna Cyrta ; Ana Boranijasevic ; Mamy Andrianteranagna ; Julien Masliah-Planchon ; Kévin Beccaria ; Sandrina Turczynski ; Grégory Thomson ; Maëva Veyssière ; Rachida Bouarich-Bourimi ; Zhi-Yan Han ; Owen Hoare ; Aurore Coulomb ; Mylène Bohec ; Sylvain Baulande ; Gaëlle Pierron ; Olivier D […]
• GSE336715 Comparative RNA-seq analysis of PM2.5-induced transcriptional responses in wildtype mouse mammary epithelial cells July 1, 2026
  Contributors : Wechselberger Christian ; Tamara Lang ; David Demmel ; Johannes PröllSeries Type : Expression profiling by high throughput sequencingOrganism : Fine particulate matter (PM2.5) is an environmental pollutant associated with adverse health effects, including increased cancer risk. To investigate early transcriptional responses to PM2.5 exposure i […]
• GSE336755 Compartmentalisation of m6A (N6-methyladenosine) methylated RNA in somatic or axonal subcellular locations is dependent on Nerve Growth Factor (NGF) state in sympathetic neurons [Axon-TRAP-seq] July 1, 2026
  Contributors : Braulio Martinez De La Cruz ; Simon Galkin ; Shiqi Wang ; Yuxuan Jing ; Subramanian Raju Nurani ; Pierre-Luc Germaine ; Gerhard Schratt ; Antonella RiccioSeries Type : OtherOrganism : Sympathetic neurons were culture in compartmentalised chambers in medium with NGF (control condition). Cells were then subjected to NGF starvation for 18 hours f […]
• GSE336733 Human tubuloids from cryopreserved adult tissue: building a biobank for 3D modeling and precision medicine July 1, 2026
  Contributors : Cindy Giraldo ; Alodia Lacueva-Aparicio ; Rebeca Sanz-Pampona ; Ester Raigón-Gómez ; Laura Martínez-Gimeno ; María Pilar Torcal ; Ignacio Giménez ; Ignacio Ochoa ; Celia del Agua ; Paula Bermúdez-Javierre ; Izaskun Arenaz ; Irene Mora ; Purificación Catalina-Carmona ; José Antonio Carrillo ; Carlos Hugo Mora Cevallos ; Jorge Subirá ; Delia Rec […]
• GSE336756 Compartmentalisation of m6A (N6-methyladenosine) methylated RNA in somatic or axonal subcellular locations is dependent on Nerve Growth Factor (NGF) state in sympathetic neurons [Axon-meRIP-seq] July 1, 2026
  Contributors : Braulio Martinez De La Cruz ; Simon Galkin ; Shiqi Wang ; Yuxuan Jing ; Subramanian Raju Nurani ; Pierre-Luc Germaine ; Gerhard Schratt ; Antonella RiccioSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Sympathetic neurons were culture in compartmentalised chambers in medium with NGF (control condition). Cells […]
• GSE336776 Expression data from arsenite treated wildtype and ATF4-deficient mouse cortical neurons July 1, 2026
  Contributors : Sean P Cregan ; Matthew D DemmingsSeries Type : Expression profiling by arrayOrganism : Microarray data was used to assess ATF4-dependent gene expression and signaling pathways induced by arsenite in mouse cortical neurons.Pathway enrichment analysis of differentially expressed genes revealed several ATF4-dependent signaling pathways induced b […]
• GSE336792 Stem cell factor 248 shapes ILC2 transcriptional programs and promotes mucosal inflammation in allergic asthma July 1, 2026
  Contributors : Nobuhiro Asai ; Grace K Lombardo ; Ramon Ocadiz Ruiz ; Yao Gu ; Andrew J Rasky ; Dana S Garcia ; Angela J Montoya ; Sarita Montaño ; Kazuma Yagi ; Wendy FonsecaSeries Type : Expression profiling by high throughput sequencingOrganism : Stem cell factor (SCF), also known as Kit ligand, is a pleiotropic cytokine that Q5 signals through the c-Kit […]
• GSE301408 Mitochondrial double-stranded RNA triggers chronic stress in aged neurons July 1, 2026
  Contributors : Kevin Rhine ; Elle Epstein ; Orel Mizrahi ; Gene W YeoSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Neurodegenerative diseases are linked with dysregulation of the integrated stress response (ISR), which coordinates cellular homeostasis during and after stress events. We previously showed that aged neurons […]