Category: PubMeD- NCBI2

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE302373 Nociceptive innervation limits tertiary lymphoid structures to promote lung cancer May 19, 2026
  Contributors : Ya-Hsuan Ho ; Giacomo Bregni ; Paola Peinado ; Leanne LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSensory innervation regulates lung physiology and pathology, but its role in lung cancer is poorly understood. We show that lung adenocarcinoma (LUAD) progression locally amplifies nociceptive sensory i […]
• GSE297644 Atorvastatin regulates hepatic transcriptome PXR dependently but distinct from pregnenolone 16α-carbonitrile and does not induce PXR-mediated liver steatosis May 19, 2026
  Contributors : Heba Nabil ; Jukka HakkolaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSeveral drugs induce liver steatosis through pregnane X receptor (PXR)-mediated mechanism. Atorvastatin is a PXR ligand but is still safe even in patients with metabolic dysfunction-associated steatotic liver disease. To reveal diff […]
• GSE312294 Nur77 agonism invigorates Natural Killer cell immunity against hepatocellular carcinoma [ChIP-Seq] May 19, 2026
  Contributors : Shi Yong Neo ; Menaka P RajapakseSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensDNA binding motifs of Nur77 in NK cells
• GSE310858 Different effects of 3-week disuse on the phenotype and gene expression of the calf and thigh muscles May 19, 2026
  Contributors : Daniil V Popov ; Pavel A MakhnovskiiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDisuse, like several other pathological conditions, has specific effects on various skeletal muscles. The mechanisms underlying these responses remain unclear. Three-week bed rest resulted in a greater decrease in lean mas […]
• GSE331097 The extreme diversity of retinal amacrine cells has deep evolutionary roots [rat] May 19, 2026
  Contributors : Tommasini Dario ; Monavarfeshani Aboozar ; Dinesh Vishruth ; Hahn Josh ; Tangeman Jared ; Blackshaw Seth ; Puthussery Teresa ; Sanes Josh ; Shekhar KarthikSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusAmacrine cells (ACs) comprise a heterogeneous class of inhibitory neurons in the vertebrate retina […]
• GSE313031 LRRK2-G2019S Impairs Astrocyte Differentiation and Triggers a senescence-like phenotype in Parkinson's Disease Models - Midbrain organoids May 19, 2026
  Contributors : Lisa Smits ; Stefano Magni ; Jens C Schwamborn ; Silvia BologninSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAstrocytes are increasingly recognised as essential contributors to both physiological brain function and neurodegenerative diseases. Here, we describe how the Parkinson’s disease (PD)-associate […]
• GSE328291 Resolving METTL5 Specificity: Direct RNA Sequencing Reveals No Evidence for METTL5 mediated mRNA m6A Methylation in mESCs May 19, 2026
  Contributors : Samuel Le Cam ; Magdalena Valenta ; Robert SchneiderSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe methyltransferase-like 5 (METTL5) has been shown to catalyze m6A deposition on 18S ribosomal RNA. However, whether it also methylates mRNAs remains unclear. To address this, we employed direct RNA seque […]
• GSE278368 Differences of gene expression in liver of WT mice, Con A mice and FMT-Con A mice May 19, 2026
  Contributor : Mengyi XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusClinical data have shown that decreased diversity and total number of gut microbiotas are associated with an increased prevalence of AIH. The gut microbiota serves as a critical link between the external environment and our internal environment, with […]
• GSE330973 Long-term effects of sperm cryopreservation on zebrafish (Danio rerio) offspring May 19, 2026
  Contributors : Xinqing Cai ; Jiamin Wang ; Hongkuan Song ; Xiaohui Chen ; Junfang Zhang ; Bingshe HanSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioSperm cryopreservation is widely used in zebrafish conservation, but its long-term impacts on offspring impacts remains unclear. This study aims to evaluate whether cryopres […]
• GSE330970 SlWRKY2 orchestrates cold tolerance via phytochromes interaction and SlPIF4 stabilization in tomato May 19, 2026
  Contributors : Jiachen Hong ; Xiujuan Wang ; Xin Liu ; Xinjie Sun ; Hannah R Thomas ; Jingquan Yu ; Huijia Kang ; Yanhong ZhouSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Solanum lycopersicumPlants orchestrate stress responses through the integration of light and temperature signals, yet the molecular mechanisms in […]
• GSE330985 Positive and Negative Selection of abT cells (OT-I and OT-II) in the thymus 2 - scRNA-seq, CITE-seq and TCRab May 19, 2026
  Contributors : Melanie Vacchio ; Alexander Clark ; Ian Magill ; David Zemmour ; Christophe Benoist ; Rémy BosselutSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis study is part of the immgenT Open Source Project, specifically IGT59, which characterizes activated CD4 and CD8 T cells in the spleen and brain du […]
• GSE331053 SRSF3 plays a key role in liver cancer sex disparity by facilitating hepatocyte expression of ERα and FOXA May 19, 2026
  Contributors : Lulu Yu ; Masahiko Ajiro ; Vladimir Majerciak ; Zhi-Ming Zheng ; Yafeng HeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensSRSF3 (SRp20) is an essential RNA splicing factor. By conditional knockout (KO) of Srsf3, we discovered Srsf3 at its physiological level plays a tumor-suppressive role in […]
• GSE331070 Inflammatory reprogramming of immature oligodendrocytes perturbs myelination and neurodevelopment in a dual-hit model of preterm brain injury May 19, 2026
  Contributors : Xueling Ma ; Wen Jia ; Xingdao Zhang ; Yuan ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusBackground: Preterm infants are highly susceptible to white matter injury, in part due to exposure to perinatal inflammation and/or hypoxia. These insults dis_x0002_rupt oligodendrocyte (OL) lineage maturat […]
• GSE297492 Transcriptomic profiling of monocytes and microglia in WNV encephalitis May 19, 2026
  Contributors : Wishart Claire L. ; Sptieri Alanna G. ; King Nicholas JCSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicroglia and monocyte-derived cells are key players in West Nile virus (WNV) encephalitis. We used single-cell RNA sequencing (scRNA-seq) using the Rhapsody system to analyse the functional profiles of […]
• GSE320059 Nur77 agonism invigorates Natural Killer cell immunity against hepatocellular carcinoma [Spatial Transcriptomics] May 19, 2026
  Contributors : Shi Yong Neo ; Nicholas Ang ; Menaka Rajapakse ; Kong-Peng LamSeries Type : OtherOrganism : Homo sapiens ; synthetic constructDespite promising development as emerging “off-the-shelf” therapeutics against cancer, natural killer (NK) cells still faced considerable challenges in the solid tumor microenvironment (TME) including poor penetrance an […]