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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE319369 Cell Atlas and Novel Signal Processing Strategy in Primate Insular Cortex [Patch-seq] February 16, 2026Contributors : Sheng Liu ; Ruifeng LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Macaca fascicularisThe anterior insular cortex (AIC) is a critical hub integrating exteroceptive and interoceptive information into high-order cognition, yet its neural basis remains incompletely understood. Here, by combining whole-cell-based sin […]
- GSE309579 Integrative Single-Cell RNA and ATAC Sequencing Uncovers Dosage-Sensitive, Cluster-Specific Regulatory Dynamics in Glioblastoma February 16, 2026Contributors : Khoi Huynh ; Sara B Weissman ; Cheol Park ; Maria Quiloan ; Blake S Change ; Kelly Street ; Eric Chang ; David Tran ; Aram ModrekSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensGlioblastoma (GBM) is an aggressive brain tumor that inevitabl […]
- GSE294215 Single cell analysis applied to study Pth1r related skull deformity February 16, 2026Contributors : Katsuhiko Amano ; Daisuke OkuzakiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe have employed single cell RNA sequencing approach using 10XGenomics scRNAseq to elucidate roles of Pth1r in skull development. Conditional knockout mice for Pth1r exhibited unambiguous craniomaxillofacial deformity. This a […]
- GSE318654 A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences February 16, 2026Contributors : Satoshi Ishishita ; Allan-Hermann PoolSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusThe submitted dataset contains multiomic (single-nucleus RNA-seq and scATAC-seq) data from adult (p56) mouse male and female lumbar spinal cords for cros […]
- GSE316225 ZNF750 loss in junctional zone of hair follicle and sebaceous gland leads to severe seborrheic-like psoriasiform dermatitis [day 50] February 16, 2026Contributors : Uyanga Batzorig ; George SenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLoss of Zfp750 in juctional zone of hair follicle of the mice skin increased the inflammatory gene expression.
- GSE318900 Decoding and Rewiring Promoter Architecture Using Large Language Models and Diffusion Frameworks: High-Throughput Promoter Strength Sequencing Source Data February 16, 2026Contributors : Xin Lei ; Xing Wang ; Yuzhong Liu ; Yangyu Zhang ; Jiesheng Huang ; Tianjiao Peng ; Ce Liang ; Quhuan Li ; Huaiguang Jiang ; Wei XiongSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Escherichia coli DH5[alpha]High-performance promoters are essential tools for precisely regulating gene expres-sion, yet their r […]
- GSE318884 SMARCA4 Promotes Lineage Plasticity and Enzalutamide Resistance in Prostate Cancer by Regulating PROX1 via H3K27 Acetylation [RNA-Seq] February 16, 2026Contributors : Chenwei Wu ; Mayao Luo ; Shidong Lv ; Qiang WeiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEnzalutamide resistance is a dynamic process often culminating in the aggressive progression to neuroendocrine prostate cancer (NEPC). This lineage plasticity is hypothesized to be driven by underlying epigeneti […]
- GSE319307 Comprehensive analysis of plasma exosomal and non-exosomal microRNA profiles identifies potential early indicators of carcass traits in Japanese Black cattle February 16, 2026Contributors : Kevin O Amolo ; Shota Inagaki ; Yuya Adachi ; Zeng Yang ; Shinichiro Ogawa ; Norihide YokoiSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Bos taurusBackground: Plasma microRNAs (miRNAs), which exist in exosomal (EX) and non-exosomal free circulating (FC) fractions, can be utilized as blood biomarkers. To identif […]
- GSE319292 Transcriptome data of larval zebrafish exposed to continuous sub- and supra-MCL sodium arsenite and depleted uranium February 16, 2026Contributors : Kalaniopio H Phillip ; Allen S Ronald ; Salanga C MatthewSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioDepleted uranium (DU) and arsenic (As) are both ubiquitous contaminants in the American southwest, posing risks to indigenous tribes, wildlife, and the environment. DU’s chronic effects and mechanisms o […]
- GSE319316 Localised negative feedback shapes genome-wide patterning of meiotic DNA breaks February 16, 2026Contributors : Luz M Lopez Ruiz ; Jon A Harper ; Dominic Johnson ; Rachal M Allison ; William H Gittens ; George G Brown ; Matthew J NealeSeries Type : OtherOrganism : Saccharomyces cerevisiaeGenetic diversity within sexually reproducing species arises via the formation and repair of programmed DNA double-strand breaks (DSBs) created by the evolutionarily co […]
- GSE319314 Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model February 16, 2026Contributors : Sydney P Sterben ; Charitha C Anamala ; Sahan B Kansakar ; Vaishnavi Koduri ; Volha LiaudanskayaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAutism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial f […]
- GSE319333 Characterization of mtdsRNA levels in Non-Small Cell Lung Carcinoma (NSCLC) February 16, 2026Contributors : Matthew R Krieger ; Sandy Che-Eun S Lee ; Maya Cielo Cornejo ; Kevin L HeSeries Type : OtherOrganism : Homo sapiensMitochondrial double-stranded RNA (mtdsRNA) is exported to the cytoplasm when mitochondrial RNA degradation is impaired, serving as a novel Damage-Associated Molecular Pattern (DAMP) for mitochondrial stress. The mtdsRNA has been […]
- GSE319344 Loss of meningeal lymphatic endothelial cells results in formation of a novel vascular network with scavenging function. February 16, 2026Contributors : Katharina Uphoff ; Andreas van Impel ; Lars Muhl ; Martin Stehling ; Christer Betsholtz ; Stefan Schulte-MerkerSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioFor an extended period of time, the meninges were believed to be devoid of lymphatic vessels. The recent discovery of lymphatic vessels in the dura […]
- GSE319347 Homo sapiens bulk RNA-seq for iMGLs and iMGL-motor neuron co-cultures with cGAS inhibitor February 16, 2026Contributors : Yajing Liu ; Li Fan ; Abulimiti Aikedan ; Weixi FengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study investigates the role of cGAS signaling in amyotrophic lateral sclerosis using human microglial-like cells (iMGLs) and iMGL-motor neuron co-cultures. Bulk RNA sequencing was performed to assess t […]
- GSE318940 Smarca4 coordinates chromatin accessibility and metabolic programs to sustain hematopoietic stem cell function February 16, 2026Contributors : Yu Hou ; Yuanyuan Liu ; Bijie Yang ; Jiankun Fan ; Lin ZouSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHematopoietic stem cells (HSCs) sustain lifelong hematopoiesis by balancing quiescence, self-renewal, and differentiation. However, immunophenotypic definitions of HSCs often fail to cap […]