Category: PubMeD- NCBI2

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE228309 RNA sequencing transcriptome analysis of lesional to perilesional cortex at 5 days after traumatic brain injury December 21, 2025
  Contributors : Michael K Schäfer ; Matthias Klein ; Irmgard TegederSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusC57BL6/N male mice (14-week-old) were subjected to a controlled cortical impact (CCI) to induce a unilateral traumatic brain injury (TBI). After surgery, mice were treated and monitored for 5 days after TBI […]
• GSE192441 Pulmonary B lymphocytes ameliorate Alzheimer's disease-like neuropathology December 21, 2025
  Contributors : Weixi Feng ; Yanli Zhang ; Ming XiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIncreasing evidences reveal that the peripheral immune system is involved in the pathogenesis of Alzheimer's disease (AD). Here, we report that pulmonary B lymphocytes mitigated beta-Amyloid (Aβ) pathology in 5xFAD mi […]
• GSE284423 RNA-seq analysis of ex vivo microtumor models comprising control or Arpc4 knockout (KO) PDAC cells December 21, 2025
  Contributors : Xiufen Yang ; Yina Qiao ; Yifeng Sun ; Tamer Abdelaal ; Kathleen Schuck ; Hend Abdelrasoul ; Eduard Ryschich ; Carolina De La Torre ; Yan Dong ; Jingxiong Hu ; Chao Fang ; Xiaoyan Huang ; Christoph Kahlert ; Malte Hermes ; Ingrid Herr ; Christoph W Michalski ; Bo KongSeries Type : Expression profiling by high throughput sequencingOrganism : Mu […]
• GSE261223 Cytoplasmic DIS3 degrades circular RNAs independently of the exosome December 21, 2025
  Contributors : Claudia Latini ; Si-Nan Zhai ; Gerhard Lehmann ; Li Yang ; Gunter MeisterSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensCircular RNAs (circRNAs) are frequently generated during splicing. Their physiological roles, however, remain largely elusive. S […]
• GSE295270 NONO Deficiency Impairs HOXA1 Chromatin Association to Disrupt Wnt-Driven Cardiomyocyte Differentiation in Human iPSCs [ChIP-Seq] December 21, 2025
  Contributors : Wei Sheng ; Feizhen Wu ; Guoying Huang ; Zhiyu Feng ; Yuan GaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNONO is recognized as a critical molecular scaffold involved in both transcriptional and posttranscriptional regulation. Mutations in NONO are frequently linked to congenital heart d […]
• GSE290558 Mapping breakome of multiple cancer cell-lines December 21, 2025
  Contributors : Osama Hidmi ; Sara Oster ; Diala Shatleh ; Jonathan Monin ; Rami AqeilanSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensCancer is characterized by uncontrolled proliferation accompanied by the hypertranscription of oncogenes, leading to transcription stress, a key source of DNA doubl […]
• GSE300321 3D fractal topography attenuates inflammation and confers resilience to glomerular podocytes December 21, 2025
  Contributors : Ying Wang ; Karl T Wagner ; Shira Landau ; Chuan Liu ; Sargol Okhovatian ; David F Bodenstein ; Daniel Vosoughi ; Yimu Zhao ; Karen Shen ; Qinghua Wu ; Milica RadisicSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn vivo, podocytes wrap around a looping capillary forming interdigitations required to esta […]
• GSE313986 Overactivation of Cdc42 GTPase Impairs the Cytotoxic Function of NK Cells from Old Individuals towards Senescent Fibroblasts December 21, 2025
  Contributor : Pallab MaitySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSenescent fibroblasts accumulate in the connective tissue of all organs and promote organ aging and aging-related diseases. The underlying mechanisms for the accumulation of senescent fibroblasts are poorly understood. Natural killer (NK) cells of […]
• GSE307218 The cytotoxicity of gomesin peptides is mediated by the glycosphingolipid pathway and lipid-cholesterol interactions December 21, 2025
  Contributors : Matthew A Waller ; Naomi McKinnon ; Felicity Chung ; Graham G NeelySeries Type : OtherOrganism : Homo sapiensGomesins (AgGom and HiGom) are therapeutically promising spider-derived peptides that target a specific phospholipid composition (3PC:1PS:1Chol) to disrupt melanoma cell membranes and induce cytotoxicity. Their antiproliferative propert […]
• GSE305670 RNA sequencing of ex vivo microtumor models embedded in different matrices and constructed from either control or Arpc4-knockout cells. December 21, 2025
  Contributors : Yina Qiao ; Xiufen Yang ; Yifeng Sun ; Christoph W Michalski ; Bo KongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe loss of Arpc4 resulted in reduced expression of other Arp2/3 complex components, rendering the Arp2/3 complex nonfunctional. The ex vivo microtumor(3D) models were composed of either c […]
• GSE311977 Single-cell sequencing data of brain tissue in septic mice December 21, 2025
  Contributors : Jiayu Song ; Qile Ye ; Rong Tang ; Yuwen Wang ; Mengmeng Zhang ; Rui Zhao ; Jie LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo explore the specific molecular mechanisms underlying brain injury caused by sepsis, we conducted single-cell transcriptomic analysis on mouse brain tissues. In the experime […]
• GSE313561 RNA-seq data of the kidneys of diabetic nephropathy rats treated with TSK December 21, 2025
  Contributors : Na Zhao ; Ran Wei ; Nuan Wen ; Jian Ma ; Xicheng Jiang ; Huijun Chen ; Bingmei Wang ; Chuwen Feng ; Lei Zheng ; Shanshan Zheng ; Wei Zhou ; Zeyu YuSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusTSK (TangShenKang) is a compound traditional Chinese medicine. To explore the core corresponding program o […]
• GSE313748 Gemcitabine and nab-paclitaxel with or without the VDR agonist paricalcitol for metastatic pancreatic cancer: A randomized, multi-arm, phase I trial December 21, 2025
  Contributors : Andressa Dias Costa ; Alexander Jordan ; Jonathan Nowak ; Brian WolpinSeries Type : OtherOrganism : Homo sapiensVitamin D receptor (VDR) agonists promote quiescence of cancer-associated fibroblasts and improve efficacy of chemotherapy in preclinical models of pancreatic cancer. We conducted a phase I trial (NCT03520790) with primary endpoint o […]
• GSE189886 GABPα2β2 tetramer deficiency alters transcriptional profiles in NK cells December 21, 2025
  Contributor : Shuyang YuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNatural killer (NK) cells are critical innate lymphocytes with the capacity to elicit the early defense against pathogens and the immune surveillance of tumor cells. The complex transcriptional network involved in NK cells is still many unknowns. By […]
• GSE299709 Longitudinal monitoring of Type 1 Diabetes progression to disease onset December 21, 2025
  Contributors : Jessica L King ; Lonnie D SheaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPreventing autoimmune type 1 diabetes (T1D) necessitates improved monitoring for disease progression prior to symptom onset. Current diagnostic methods assess circulating autoantibodies, C-peptide levels, or dysglycemia, yet the […]