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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE293401 ZMYM3 mutations modulate histone acetylation and cooperate with NOTCH1 mutations in chronic lymphocytic leukemia August 19, 2026Contributors : Alberto Rodríguez-Sánchez ; Claudia Pérez-Carretero ; Luis A Corchete-Sánchez ; Cristina Miguel-García ; Sandra Santos-Mínguez ; Ángela Villaverde-Ramiro ; Julio Dávila ; Alfonso García-Coca ; Josefina Galende ; Rocío Benito-Sánchez ; Ana E Rodríguez Vicente ; Miguel Quijada-Álamo ; Jesús M Hernández-RivasSeries Type : Expression profiling by […]
- GSE270300 N-glycosylation inhibition hinders immunosuppressive tumor microenvironment cells improving CAR T cell efficacy [scRNA-seq] August 19, 2026Contributors : Camilla Sirini ; Chiara Balestrieri ; Monica CasucciSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAdoptive transfer of CAR T cells demonstrated impressive results against B-cell malignancies, but still limited efficacy against solid tumors. In this context, multiple challenges need to be overcome, inclu […]
- GSE305647 The Drosophila SWI/SNF complex sub-unit Bap60 is required for training-induced gene transcription during long-term memory formation August 19, 2026Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterThis SuperSeries is composed of the SubSeries listed below.
- GSE303816 Striatal lesion induce the re-emergence and integration of transient LGE-class interneurons from local astrocytes August 19, 2026Contributors : Federico Luzzati ; Giulia Nato ; Marco Fogli ; Valentina Proserpio ; Salvatorie Oliviero ; Ivan MolinerisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAt the end of development, cortical and striatal progenitor domains converge to generate lateral ganglionic eminence (LGE)-class interneurons that differ […]
- GSE313211 CELF1 regulates lens development through direct repression of target mRNAs August 19, 2026Contributors : Justine Viet ; Matthieu Duot ; Agnès Méreau ; Yann Audic ; Salil A Lachke ; Carole Gautier-Courteille ; Luc PaillardSeries Type : OtherOrganism : Mus musculusPrecise post-transcriptional regulation of gene expression is essential for vertebrate lens development. Disruption of the gene encoding the RNA-binding protein CELF1 leads to early-onset […]
- GSE308217 Single cell RNA-seq of normal enterocytes and erebotic cells from Drosophila melanogaster midgut R4 region August 19, 2026Contributors : Motohiro Morikawa ; Tetsutaro Hayashi ; Yuko Ikegawa ; Tomomi Takano ; Kazuya Wata ; Hirohisa Kyogoku ; Mariko Kuse ; Mika Yoshimura ; Hiroshi Nishida ; Rahul Parit ; Linh M Dao ; Kanta Kawai ; Tasuku Hirayama ; Sy Chun Wang ; Kan Eto ; Itoshi Nikaido ; Sa Kan YooSeries Type : Expression profiling by high throughput sequencingOrganism : Drosop […]
- GSE343654 Pyramiding panicle-level heat avoidance and grain-level heat tolerance improves rice grain appearance under high-temperature grain filling August 19, 2026Contributors : Hirofumi Fukuda ; Toshihiro Sakamoto ; Jun-ichi Yonemaru ; Daisuke OgawaSeries Type : Expression profiling by high throughput sequencingOrganism : Oryza sativaHigh temperature during grain filling increases rice grain chalkiness and deteriorates grain appearance under climate warming. Although several loci that reduce chalkiness have been iden […]
- GSE318117 Hsa_circ_0000231 accelerates cell proliferation, invasion, and MAPK pathway activation in cervical cancer via CACNA1H August 19, 2026Contributors : Shaofeng Ma ; Jianbiao Lin ; Xueli Deng ; Zheli Li ; Hui ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Circular RNAs (circRNAs) are key regulators in tumorigenesis, including cervical cancer (CC), but their specific roles and molecular mechanisms in CC are not fully understood. This stud […]
- GSE343866 Immune Activation and Candidate Prognostic Marker Discovery in Bladder Cancer: A Preclinical Mouse Study of Recombinant M. smegmatis August 19, 2026Contributors : Dongwook Song ; Jae Won Park ; Hyunho Han ; Gisub Choi ; Baek Gil Kim ; Young Deuk ChoiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigated transcriptomic alterations associated with rSmeg-hMIF-hIL-7 treatment in a syngeneic MBT-2 bladder cancer mouse model. Female C3H/He mice bearing s […]
- GSE343846 HIF-1 Signaling Contributes to Lenvatinib Resistance in Patient-Derived HCC Organoids August 19, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensResistance to lenvatinib remains an important limitation in the treatment of hepatocellular carcinoma (HCC). In this study, six patient-derived HCC organoid lines were established and classified as lenvatinib-sensitive or lenvatinib-resistant according to their ex vivo dru […]
- GSE343913 Secondary lymphoid organs T cells - [I13, I14] August 19, 2026Contributors : Ian Magill ; David Zemmour ; Christophe BenoistSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis study is part of the immgenT Open Source Project, specifically from IGT13 and IGT14, which focuses on characterizing T cells from secondary lymphoid organs. T cells were isolated from spleen, inguin […]
- GSE343956 Transcriptional co-regulator Med15 is required to maintain functional maturation in adult β-cells August 19, 2026Contributors : Rachel J Spencer ; Sara P Cristiano ; Stefan TaubertSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTranscriptional coregulators, such as the Mediator complex, partner with transcription factors to regulate gene transcription throughout all stages of life. Subunit Med15 is required for pre-natal developme […]
- GSE344008 Effect of extracellular fluid viscosity in macrophages August 19, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusExtracellular fluid (ECF) viscosity as a novel and vital mechanical cue in TME. However, it remains elusive how immune cells, particularly macrophages, respond to a hyperviscous TME. Macrophages likely perceive changes in fluid viscosity as a mechanical stress at the cell […]
- GSE242319 Novel transcription factor BTNL9 enhances tumor suppression and drug sensitivity in non-small cell lung cancer through cell cycle regulation [RNA-seq] August 19, 2026Contributors : Pedram Yadollahi ; Wooi L Ng ; Hwa J Cho ; Mi S Kang ; Inhak ChoiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBTNL9 (butyrophilin-like 9), an immune-regulating BTN/BTNL family member, has shown an emerging yet underexplored role in cancer biology. Our study uncovers a novel role for BTNL9 as a novel tr […]
- GSE343642 Single-cell RNA sequencing of peripheral blood and brain immune cells in mouse models of ischemic stroke August 19, 2026Contributors : Lu Jianan ; Zhang Jianmin ; Shi LigenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIschemic stroke induces profound alterations in peripheral and brain immune responses, but the cellular and transcriptional heterogeneity underlying these responses remains incompletely understood. To characterize immune- […]