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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE287269 IWC immunization induces reprogramming of AMs via chromatin remodeling August 12, 2026Contributor : Yun ShiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusWe found the IWC of Acinetobacter baumannii intranasal immunization could induce alveolar macrophases training to exert the protection for bacterial infection. To characterize the epigenetic landscape of IWC treated TR-AMs and CD13+ cell […]
- GSE302586 Pharmacological inhibition of METTL1 as a therapy against solid and haematological cancers August 12, 2026Series Type : Non-coding RNA profiling by high throughput sequencing ; Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE296372 Paternal methamphetamine exposure enhances methamphetamine susceptibility in male rat offspring August 12, 2026Contributors : Chris Pierce ; Sarah Swinford-JacksonSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Rattus norvegicusWe previously demonstrated that male progeny of cocaine-experienced sires resisted cocaine, expressed as delayed acquisition of cocaine self-administ […]
- GSE309029 TNFR1 expression on cancer cell is critical for immunoescape, shaping an immunosuppressive tumor microenvironment. August 12, 2026Contributors : Elixabet Bolaños ; Lorena Cañas-Zabala ; Irene Olivera ; David Ruiz-Guillamón ; Ignacio MeleroSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTNFα reportedly mediates multiple protumor and immunosuppressive functions acting on stromal cells in cancer-bearing hosts as a result of enhancing activation immun […]
- GSE305832 UBA1 knockdown impairs muscle function in Drosophila and mice and dysregulates the levels of UBA1-sensitive proteins [Drosophila] August 12, 2026Contributors : Michelle Curley ; Yong-Dong Wang ; Fabio DemontisSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterGene expression changes induced by knockdown of UBA1 in the skeletal muscle of Drosophila and mice
- GSE242935 DNA-replication stress induced transcriptome of Human Burkitt’s lymphoma cells identifies MBD1 as a novel suppressor of Germinal center derived B-lymphomagenesis [ChIP] August 12, 2026Contributors : Santosh Kumar Gothwal ; Susumu Kohno ; Chiaki Takahashi ; Atsuyasu SatoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensGerminal center (GC) derived B-lymphomas (GCDBL) are concomitantly generated with high-affinity B cells during humoral immune response. Among GCDBLs are Burkitt’s lymphoma ( […]
- GSE310599 Spatiotemporal development of deep excitatory neuronal types within the mouse neocortex August 12, 2026Contributors : Shalini Iyer ; Mark S CembrowskiSeries Type : OtherOrganism : Mus musculusHere, we investigate the developmental spatiotemporal properties of distinct cortical cell types, specifically the subplate and claustrum using single-cell spatial transcriptomics.
- GSE343371 MSKCC Study 2- A dual barcoding system for pooled analysis of gene knockouts in polyclonal populations (30KO) August 12, 2026Contributors : Huangfu Danwei ; Xianming Wang ; Nan HuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study characterizes gene knockout phenotypes of 30 genes in a human pluripotent stem cell (hPSC)-directed islet differentiation system. Samples were collected at six differentiation stages from hPSCs to SC-islet ce […]
- GSE343370 MSKCC Study 3- A dual barcoding system for pooled analysis of gene knockouts in polyclonal populations (30KO_GEM-X) August 12, 2026Contributors : Huangfu Danwei ; Xianming Wang ; Nan HuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study characterizes gene knockout phenotypes of 30 genes in a human pluripotent stem cell (hPSC)-directed islet differentiation system. Samples were collected at stage definitive endoderm (DE, Day 3).
- GSE343455 VEGFR1-Blocking Antibody Improves Endothelial Structure, Kidney Function, and GFR in Diabetic Mice August 12, 2026Contributors : Jingjun Li ; Matthew BreyerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDiabetic kidney disease remains the major cause of kidney failure. VEGFA neutralizing antibodies also cause kidney disease in normal people. The present studies explored whether endogenous VEGFA deficiency might contribute to DKD. […]
- GSE343400 Gelated Apoptotic Extracellular Vesicles via Enzyme-Instructed Self-Assembly with Multifunctional Microcapsule for Targeted Atherosclerosis Therapy August 12, 2026Contributors : Xian Li ; Tianzi Chen ; Shichun Li ; Xiaoling Fu ; Yingjun WangSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Mus musculusWhile current atherosclerosis therapies control lipid levels, they poorly regulate macrophages, key drivers of plaque progression. Apoptotic extracellular vesicles (apoEVs) offer a cell-f […]
- GSE343488 Human myeloid ontogeny determines inflammatory identity and neurodegenerative potential August 12, 2026Contributors : Nathan R Zemke ; Jing Wang ; Nicole G CoufalSeries Type : Methylation profiling by high throughput sequencing ; OtherOrganism : Homo sapiensMicroglia, the resident macrophages of brain, arise from yolk sac hematopoietic progenitor cells (HPCs) that migrate into the brain during early embryonic development and differentiate in response to micro […]
- GSE343489 CpG Hypermethylation and WNT/AP-1 cooperativity Define the Epigenetic Landscape and a Clinical Subgroup of High-Risk Pediatric Adrenocortical Carcinoma August 12, 2026Contributors : Victoria E Fincke ; Mauice Loßner ; Marina Kunstreich ; Nic G Reitsam ; Irmengard Sax ; Marlena Mucha ; Felix Dorn ; Lorenz C Helmschrott ; Maria D Hernandez Ramirez ; Sebastian Dintner ; Konstantin Okonechnikov ; Martin Sill ; Ina Oehme ; Heike Peterziel ; Enrique Blanco-Carmona ; Eva Sipos ; Stefan Wudy ; Christoph Slavetinsky ; Jörg Fuchs ; […]
- GSE343503 Longitudinal single-cell and spatial transcriptomics reveals intratumor heterogeneity, therapeutic response, and comparative value of canine marginal zone lymphoma [scRNAseq data] August 12, 2026Contributors : Grace E Walker ; Marissa Macchietto ; Kelly Reid ; Lauren E Burt ; Amber Winter ; Sara Pracht ; Michelle Buettner ; Velia Penza ; Caitlin Yung ; Rose Dicovitsky ; Alana Kuzmik ; Daniel A Vallera ; Kim Demos-Davies ; Davis M Seelig ; Antonella Borgatti ; Mike Henson ; Caitlin Feiock ; Jaime F Modiano ; Shruthi Naik ; Aaron L Sarver ; Amy E Tree […]
- GSE283953 DNMT1 Facilitates the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease August 12, 2026Contributors : Hanyong GO ; Mirang KimSeries Type : Methylation profiling by genome tiling arrayOrganism : Mus musculusMetabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by notable epigenetic changes, such as alterations in DNA methylation. However, research on epigenetic modifications in human patient and animal models remains […]