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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE312649 Microbial volatile organic compound 2,5-D enhances Arabidopsis growth through activation of nitrate and ammonium transport June 29, 2026Contributors : Theint Thida ; Mami Nampei ; Matias Siueia Júnior ; Li Jiacheng ; Hisashi Ômura ; Akihiro UedaSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaNitrogen is an essential nutrient for plant growth. We report here that 2,5-dimethylpyrazine is a key regulator of plant nitrogen and ammonium uptake throug […]
- GSE301226 KRT6A enhances radiotherapy resistance in lung squamous cell carcinoma via activation of the autophagy pathway through RAB39B [RNA-Seq 2] June 29, 2026Contributors : Zaishuang Ju ; Yutong Wu ; Zhiqi Zheng ; Eric W Lam ; Dachuan Shen ; Ruoyu WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAbstract Background: Radiotherapy is the cornerstone for lung squamous cell carcinoma (LUSC) treatment, yet its efficacy is often limited by the development of radioresistance. Un […]
- GSE330016 Bulk RNA sequencing of mono-culture and tri-culture microglia June 29, 2026Contributors : Takeshi Uenaka ; Wanhua Li ; Marius WernigSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMicroglia are the immune cells of the central nervous system and are thought to be key players in both physiological and disease conditions. Several microglial features are poorly conserved between mice and human, su […]
- GSE329548 Multiple mechanisms lead to differential loss-of-function effects of pathogenic SARS2 variants: implications for genotype-phenotype analyses II June 29, 2026Contributors : Christina Del Greco ; Stephanie M Laureano-Figueroa ; Anthony AntonellisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSeryl-tRNA synthetase 2 (SARS2) encodes the enzyme responsible for charging tRNA with serine in the mitochondria. SARS2 has been associated with a spectrum of recessive diseases includin […]
- GSE330864 Transcriptional profiling in esophageal adenocarcinoma June 29, 2026Contributor : Laura A KrestySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe goal of this project is to perform transcriptomics profiling of treatment-naïve esophageal adenocarcinoma (EAC) patients to identify genes and pathways associated with esophageal adenocarcinoma. A total of 67 samples were collected from EAC […]
- GSE330343 Histidine to glutamine substitutants, a regulated process that impacts cell survival and suggests histidine shortage in cancer June 29, 2026Contributors : Domenica Lovecchio ; Pierre-René Körner ; Lorenzo Valcanover ; Onno Bleijerveld ; Bart R.J. Blokhuis ; Abhijeet Pataskar ; Jasmine Montenegro Navarro ; Demi Wernaart ; Liesbeth Hoekman ; Daniil Anastasopoulos ; Kim Vrijland ; Xiaodong Feng ; Julien Champagne ; Karin E. de Visser ; Olaf van Tellingen ; Frank A. Redegeld ; Reuven AgamiSeries Typ […]
- GSE336418 DNMT3B plays antagonistic roles with SMARCB1 and is a targetable vulnerability in rhabdoid tumors [Methylation array] June 29, 2026Contributors : Céline Chauvin ; Ryszard Wimmer ; Ludovica Brunetti ; Joanna Cyrta ; Ana Boranijasevic ; Mamy Andrianteranagna ; Julien Masliah-Planchon ; Kévin Beccaria ; Sandrina Turczynski ; Grégory Thomson ; Maëva Veyssière ; Rachida Bouarich-Bourimi ; Zhi-Yan Han ; Owen Hoare ; Aurore Coulomb ; Mylène Bohec ; Sylvain Baulande ; Gaëlle Pierron ; Olivier D […]
- GSE336573 Aberrant OGT intron retention links phosphatase dysfunction to O-GlcNAc collapse and neuronal vulnerability [Cerebral organoids RNA-seq] June 29, 2026Contributors : Liu Yue ; Ki Myeong Na ; Mi-Ran Song ; Sung-Kyun ParkSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackgroundImpaired protein phosphatase 2A (PP2A) activity, altered RNA processing, and reduced O-GlcNAcylation are recurrent features of Alzheimer’s disease (AD), but how these processes are mechanisticall […]
- GSE336475 Human HEMK1 methylates all mitochondrial release factors and is required for mitochondrial function under stress conditions June 29, 2026Contributors : Albert Jeltsch ; Jana Kehl ; Thyagarajan T ChandrasekaranSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHEMK1 is the mitochondrial homolog of HEMK2, the enzyme that methylates the conserved glutamine in the GGQ loop of eukaryotic translation termination factor eRF1. Previous work reported altered GGQ-loo […]
- GSE336455 Noninvasive Salivary MicroRNA Signatures as Potential Prognostic Biomarkers for Bronchopulmonary Dysplasia in Extremely Preterm Infants: A Pilot Study June 29, 2026Contributors : Arailym Abilbayeva ; Iskandar IsgandarovSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiens ; synthetic constructBronchopulmonary dysplasia (BPD) is a major complication of preterm birth, with lasting effects on respiratory outcomes in extremely low birth weight (ELBW) and very low birth weight (VLBW) infants. This pilot stu […]
- GSE336489 Effect of full-length laminin 332 treatment on the transcriptome of mouse keratinocytes that express or lack integrin α3β1 June 29, 2026Contributors : Salima Lalani ; Whitney LongmateSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBasement membrane protein Laminin-332 (LN332) is upregulated after injury and promotes keratinocyte migration. It functions as a key ligand for integrin α3β1, which is highly expressed by basal keratinocytes and further induce […]
- GSE336556 Spatial transcriptomics reveals differences in bronchus-associated lymphoid tissue composition in stable and rejecting human lung allografts June 29, 2026Contributors : Alexander Wein ; Changxu Fan ; Vladimir Sukhov ; Junedh Amrute ; Jon Ritter ; Amit Bery ; Maxim Artyomov ; Alexander Krupnick ; Ruben Nava ; Andrew Gelman ; Kory Lavine ; Daniel KreiselSeries Type : OtherOrganism : Homo sapiensBackground: Lung allograft rejection is determined by pathologist grading of transbronchial biopsies (TBBx) according […]
- GSE336572 Aberrant OGT intron retention links phosphatase dysfunction to O-GlcNAc collapse and neuronal vulnerability [SH-SY5Y RNA-seq] June 29, 2026Contributors : Liu Yue ; Ki Myeong Na ; Sung-Kyun ParkSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackgroundImpaired protein phosphatase 2A (PP2A) activity, altered RNA processing, and reduced O-GlcNAcylation are recurrent features of Alzheimer’s disease (AD), but how these processes are mechanistically linked remai […]
- GSE301225 KRT6A enhances radiotherapy resistance in lung squamous cell carcinoma via activation of the autophagy pathway through RAB39B [RNA-Seq 1] June 29, 2026Contributors : Zaishuang Ju ; Yutong Wu ; Zhiqi Zheng ; Eric W Lam ; Dachuan Shen ; Ruoyu WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAbstract Background: Radiotherapy is the cornerstone for lung squamous cell carcinoma (LUSC) treatment, yet its efficacy is often limited by the development of radioresistance. Un […]
- GSE336387 Host transcriptional signatures associated with disease tolerance and environmental persistence in a mosquito-microsporidian system June 29, 2026Contributor : Luís M SilvaSeries Type : Expression profiling by high throughput sequencingOrganism : Anopheles gambiaeExperimental evolution and RNA sequencing were combined in the mosquito-microsporidian system Anopheles gambiae-Vavraia culicis to test whether parasite lineages selected for early or late transmission differ in the host transcriptional respo […]